$VAR1 = undef;

Summary for peptidase C30.001: coronavirus picornain 3C-like peptidase-1

Names
MEROPS Name	coronavirus picornain 3C-like peptidase-1
Other names	3CLpro, 3CL-PRO, MHV picornain 3C-like endopeptidase, mouse hepatitis coronavirus picornain 3C-like endopeptidase, mouse hepatitis coronavirus nsp5

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(C) >> Family C30 >> Subfamily (none) >> C30.001
Holotype	coronavirus picornain 3C-like peptidase-1 (murine hepatitis virus), Uniprot accession P0C6V1 (peptidase unit: 3337-3639), MERNUM MER0002029
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Cysteine
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (29 cleavages)
Physiology	Viral polyprotein processing in replication.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	vstp/rv/L/QSan/-/-/- (based on 44 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	0	0	2	8	6	1
Pro	6	0	0	0	0	0	0	0
Ala	3	4	0	0	8	5	4	4
Val	13	8	3	0	0	5	0	6
Leu	0	0	36	0	0	3	5	5
Ile	0	1	3	0	0	1	2	1
Met	0	0	0	0	0	0	0	0
Phe	0	2	2	0	0	1	4	0
Tyr	0	0	0	0	0	0	0	0
Trp	0	0	0	0	0	0	1	1
Ser	12	2	0	0	28	1	1	3
Thr	8	4	0	0	0	3	5	9
Cys	0	0	0	0	2	1	0	0
Asn	0	2	0	0	4	4	0	7
Gln	2	6	0	44	0	0	0	2
Asp	0	1	0	0	0	0	4	2
Glu	0	0	0	0	0	3	8	0
Lys	0	3	0	0	0	7	2	1
Arg	0	11	0	0	0	2	2	1
His	0	0	0	0	0	0	0	1