Literature for peptidase C28.001: foot-and-mouth disease virus L-peptidase

(Topics flags: S Structure, M Mutation, I Inhibitor, P Specificity, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Skern,T.
   The leader proteinase of foot-and-mouth disease virus: Efficiency through exosites
   Virology (2025) 604, 110420-110420. PubMed  Europe PubMed DOI
2024
2. Litz,B., Sehl-Ewert,J., Breithaupt,A., Landmesser,A., Pfaff,F., Romey,A., Blaise-Boisseau,S., Beer,M. and Eschbaumer,M.
   Leaderless foot-and-mouth disease virus serotype O did not cause clinical disease and failed to establish a persistent infection in cattle
   Emerg Microbes Infect (2024) , 2348526-2348526. PubMed  Europe PubMed DOI
2021
3. Saiz,M. and Martinez-Salas,E.
   Uncovering targets of the Leader protease: Linking RNA-mediated pathways and antiviral defense
   Wiley Interdiscip Rev RNA (2021) , e1645-e1645. PubMed  Europe PubMed DOI  V
4. Sui,C., Jiang,D., Wu,X., Liu,S., Li,F., Pan,L., Cong,X., Li,J., Yoo,D., Rock,D.L., Miller,L.C., Lee,C., Du,Y. and Qi,J.
   Inhibition of Antiviral Innate Immunity by Foot-and-Mouth Disease Virus L(pro) through Interaction with N-terminal Domain of Swine RNase L
   J Virol (2021) PubMed  Europe PubMed DOI
2020
5. Medina,G.N., Azzinaro,P., Ramirez-Medina,E., Gutkoska,J., Fang,Y., Diaz-San Segundo,F. and de los Santos,T.
   Impairment of the deISGylation activity of FMDV Lpro causes attenuation in vitro and in vivo
   J Virol (2020) PubMed  Europe PubMed DOI
6. Visser,L.J., Aloise,C., Swatek,K.N., Medina,G.N., Olek,K.M., Rabouw,H.H., de Groot,R.J., Langereis,M.A., de los Santos,T., Komander,D., Skern,T. and van Kuppeveld,F.J.M.
   Dissecting distinct proteolytic activities of FMDV Lpro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression
   PLoS Pathog (2020) 16, e1008702-e1008702. PubMed  Europe PubMed DOI  PMC  EPMC
2018
7. Rodriguez Pulido,M., Sanchez-Aparicio,M.T., Martinez-Salas,E., Garcia-Sastre,A., Sobrino,F. and Saiz,M.
   Innate immune sensor LGP2 is cleaved by the leader protease of foot-and-mouth disease virus
   PLoS Pathog (2018) 14, e1007135-e1007135. PubMed  Europe PubMed DOI
8. Swatek,K.N., Aumayr,M., Pruneda,J.N., Visser,L.J., Berryman,S., Kueck,A.F., Geurink,P.P., Ovaa,H., van Kuppeveld,F.J.M., Tuthill,T.J., Skern,T. and Komander,D.
   Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies
   Proc Natl Acad Sci U S A (2018) 115, 2371-2376. PubMed  Europe PubMed DOI  P  S
9. Visser,L.J., Medina,G.N., Rabouw,H.H., de Groot,R.J., Langereis,M.A., de los Santos,T. and van Kuppeveld,F.J.M.
   Foot-and-mouth disease virus leader protease cleaves G3BP1 and G3BP2 and inhibits stress granule formation
   J Virol (2018) 93, e00922-18-e00922-18. PubMed  Europe PubMed DOI
2017
10. Guan,S.H. and Belsham,G.J.
    Separation of foot-and-mouth disease virus leader protein activities; identification of mutants that retain efficient self-processing activity but poorly induce eIF4G cleavage
    J Gen Virol (2017) 98, 671-680. PubMed  Europe PubMed DOI
11. Medina,G.N., Knudsen,G.M., Greninger,A.L., Kloc,A., Diaz-San Segundo,F., Rieder,E., Grubman,M.J., DeRisi,J.L. and de los Santos,T.
    Interaction between FMDV Lpro and transcription factor ADNP is required for optimal viral replication
    Virology (2017) 505, 12-22. PubMed  Europe PubMed DOI
2015
12. Aumayr,M., Fedosyuk,S., Ruzicska,K., Sousa-Blin,C., Kontaxis,G. and Skern,T.
    NMR analysis of the interaction of picornaviral proteinases Lb and 2A with their substrate eukaryotic initiation factor 4GII
    Protein Sci (2015) 24, 1979-1996. PubMed  Europe PubMed DOI
13. Liu,Y., Zhu,Z., Zhang,M. and Zheng,H.
    Multifunctional roles of leader protein of foot-and-mouth disease viruses in suppressing host antiviral responses
    Vet Res (2015) 46, 127-127. PubMed  Europe PubMed DOI  PMC  EPMC
14. Nsamba,P., de Beer,T.A., Chitray,M., Scott,K., Vosloo,W. and Maree,F.F.
    Determination of common genetic variants within the non-structural proteins of foot-and-mouth disease viruses isolated in sub-Saharan Africa
    Vet Microbiol (2015) 177, 106-122. PubMed  Europe PubMed DOI  M
2014
15. Moral-Lopez,P., Alvarez,E., Redondo,N., Skern,T. and Carrasco,L.
    L protease from foot and mouth disease virus confers eIF2-independent translation for mRNAs bearing picornavirus ires
    FEBS Lett (2014) 588, 4053-4059. PubMed  Europe PubMed DOI
16. Steinberger,J. and Skern,T.
    The leader proteinase of foot-and-mouth disease virus: structure-function relationships in a proteolytic virulence factor
    Biol Chem (2014) 395, 1179-1185. PubMed  Europe PubMed DOI
17. Steinberger,J., Grishkovskaya,I., Cencic,R., Juliano,L., Juliano,M.A. and Skern,T.
    Foot-and-mouth disease virus leader proteinase: structural insights into the mechanism of intermolecular cleavage
    Virology (2014) 468-470, 397-408. PubMed  Europe PubMed DOI  S  I
2013
18. Steinberger,J., Kontaxis,G., Rancan,C. and Skern,T.
    Comparison of self-processing of foot-and-mouth disease virus leader proteinase and porcine reproductive and respiratory syndrome virus leader proteinase nsp1alpha
    Virology (2013) 443, 271-277. PubMed  Europe PubMed DOI
19. Uddowla,S., Pacheco,J.M., Larson,C., Bishop,E., Rodriguez,L.L., Rai,D.K., Arzt,J. and Rieder,E.
    Characterization of a chimeric foot-and-mouth disease virus bearing a bovine rhinitis B virus leader proteinase
    Virology (2013) 447, 172-180. PubMed  Europe PubMed DOI
2012
20. Diaz-San Segundo,F., Weiss,M., Perez-Martin,E., Dias,C.C., Grubman,M.J. and de los Santos,T.
    Inoculation of swine with foot-and-mouth disease SAP-mutant virus induces early protection against disease
    J Virol (2012) 86, 1316-1327. PubMed  Europe PubMed DOI
21. Grubman,M.J. and de los Santos,T.
    Foot-and-mouth disease virus L-peptidase
    [ISSN:978-0-12-407743-0] (2012) 3, 2183-2186. DOI
22. Nogueira Santos,J.A., Assis,D.M., Gouvea,I.E., Judice,W.A., Izidoro,M.A., Juliano,M.A., Skern,T. and Juliano,L.
    Foot and mouth disease leader protease (Lbpro): investigation of prime side specificity allows the synthesis of a potent inhibitor
    Biochimie (2012) 94, 711-718. PubMed  Europe PubMed DOI  I
23. Pineiro,D., Ramajo,J., Bradrick,S.S. and Martinez-Salas,E.
    Gemin5 proteolysis reveals a novel motif to identify L protease targets
    Nucleic Acids Res (2012) 40, 4942-4953. PubMed  Europe PubMed DOI  P
2011
24. Piccone,M.E., Segundo,F.D., Kramer,E., Rodriguez,L.L. and de los Santos,T.
    Introduction of tag epitopes in the inter-AUG region of foot and mouth disease virus: effect on the L protein
    Virus Res (2011) 155, 91-97. PubMed  Europe PubMed DOI
25. Wang,D., Fang,L., Bi,J., Chen,Q., Cao,L., Luo,R., Chen,H. and Xiao,S.
    Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced RANTES transcription in PK-15 cells
    Virus Genes (2011) 42, 388-393. PubMed  Europe PubMed DOI
26. Wang,D., Fang,L., Li,P., Sun,L., Fan,J., Zhang,Q., Luo,R., Liu,X., Li,K., Chen,H., Chen,Z. and Xiao,S.
    The leader proteinase of foot-and-mouth disease virus negatively regulates the type I interferon pathway by acting as a viral deubiquitinase
    J Virol (2011) 85, 3758-3766. PubMed  Europe PubMed DOI
27. Wang,D., Fang,L., Liu,L., Zhong,H., Chen,Q., Luo,R., Liu,X., Zhang,Z., Chen,H. and Xiao,S.
    Foot-and-mouth disease virus (FMDV) leader proteinase negatively regulates the porcine interferon-lambda1 pathway
    Mol Immunol (2011) 49, 407-412. PubMed  Europe PubMed DOI
2010
28. Wang,D., Fang,L., Luo,R., Ye,R., Fang,Y., Xie,L., Chen,H. and Xiao,S.
    Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced type I interferon transcription by decreasing interferon regulatory factor 3/7 in protein levels
    Biochem Biophys Res Commun (2010) 399, 72-78. PubMed  Europe PubMed DOI
29. Zhu,J., Weiss,M., Grubman,M.J. and Santos Tde,L.
    Differential gene expression in bovine cells infected with wild type and leaderless foot-and-mouth disease virus
    Virology (2010) 404, 32-40. PubMed  Europe PubMed DOI
2009
30. de los Santos,T., Segundo,F.D., Zhu,J., Koster,M., Dias,C.C. and Grubman,M.J.
    A conserved domain in the leader proteinase of foot-and-mouth disease virus is required for proper subcellular localization and function
    J Virol (2009) 83, 1800-1810. PubMed  Europe PubMed DOI  PMC  EPMC
31. Santos,J.A., Gouvea,I.E., Judice,W.A., Izidoro,M.A., Alves,F.M., Melo,R.L., Juliano,M.A., Skern,T. and Juliano,L.
    Hydrolytic properties and substrate specificity of the foot-and-mouth disease leader protease
    Biochemistry (2009) 48, 7948-7958. PubMed  Europe PubMed DOI  P  I
2008
32. Mayer,C., Neubauer,D., Nchinda,A.T., Cencic,R., Trompf,K. and Skern,T.
    Residue L143 of the foot-and-mouth disease virus leader proteinase is a determinant of cleavage specificity
    J Virol (2008) 82, 4656-4659. PubMed  Europe PubMed DOI  PMC  EPMC  P
2007
33. Cencic,R., Mayer,C., Juliano,M.A., Juliano,L., Konrat,R., Kontaxis,G. and Skern,T.
    Investigating the substrate specificity and oligomerisation of the leader protease of foot and mouth disease virus using NMR
    J Mol Biol (2007) 373, 1071-1087. PubMed  Europe PubMed DOI  S
34. de los Santos,T., Diaz-San Segundo,F. and Grubman,M.J.
    Degradation of nuclear factor kappa B during foot-and-mouth disease virus infection
    J Virol (2007) 81, 12803-12815. PubMed  Europe PubMed DOI  PMC  EPMC
2006
35. de los Santos,T., de Avila Botton,S., Weiblen,R. and Grubman,M.J.
    The leader proteinase of foot-and-mouth disease virus inhibits the induction of beta interferon mRNA and blocks the host innate immune response
    J Virol (2006) 80, 1906-1914. PubMed  Europe PubMed DOI  PMC  EPMC
2005
36. Foeger,N., Kuehnel,E., Cencic,R. and Skern,T.
    The binding of foot-and-mouth disease virus leader proteinase to eIF4GI involves conserved ionic interactions
    FEBS J (2005) 272, 2602-2611. PubMed  Europe PubMed DOI
2004
37. Gradi,A., Foeger,N., Strong,R., Svitkin,Y.V., Sonenberg,N., Skern,T. and Belsham,G.J.
    Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro
    J Virol (2004) 78, 3271-3278. PubMed  Europe PubMed DOI  PMC  EPMC  P
38. Grubman,M.J.
    Foot-and-mouth disease virus L-peptidase
    [ISSN:0-12-079610-4] (2004) 2, 1259-1261.  V
39. [YEAR:14-9-2004]Kuehnel,E., Cencic,R., Foeger,N. and Skern,T.
    Foot-and-mouth disease virus leader proteinase: specificity at the P2 and P3 positions and comparison with other papain-like enzymes
    Biochemistry (14-9-2004) 43, 11482-11490. PubMed  Europe PubMed DOI
40. Strong,R. and Belsham,G.J.
    Sequential modification of translation initiation factor eIF4GI by two different foot-and-mouth disease virus proteases within infected baby hamster kidney cells: identification of the 3Cpro cleavage site
    J Gen Virol (2004) 85, 2953-2962. PubMed  Europe PubMed DOI
41. Tosh,C., Mittal,M., Sanyal,A., Hemadri,D. and Bandyopadhyay,S.K.
    Molecular phylogeny of leader proteinase gene of type A of Foot-and-mouth disease virus from India
    Arch Virol (2004) 149, 523-536. PubMed  Europe PubMed DOI
2002
42. [YEAR:15-11-2002]Foeger,N., Glaser,W. and Skern,T.
    Recognition of eukaryotic initiation factor 4G isoforms by picornaviral proteinases
    J Biol Chem (15-11-2002) 277, 44300-44309. PubMed  Europe PubMed DOI
43. Hinton,T.M., Ross-Smith,N., Warner,S., Belsham,G.J. and Crabb,B.S.
    Conservation of L and 3C proteinase activities across distantly related aphthoviruses
    J Gen Virol (2002) 83, 3111-3121. PubMed  Europe PubMed
44. [YEAR:25-9-2002]Kronovetr,J. and Skern,T.
    Foot-and-mouth disease virus leader proteinase: a papain-like enzyme requiring an acidic environment in the active site
    FEBS Lett (25-9-2002) 528, 58-62. PubMed  Europe PubMed DOI
45. [YEAR:1-5-2002]Schlick,P., Kronovetr,J., Hampoelz,B. and Skern,T.
    Modulation of the electrostatic charge at the active site of foot-and-mouth-disease-virus leader proteinase, an unusual papain-like enzyme
    Biochem J (1-5-2002) 363, 493-501. PubMed  Europe PubMed DOI  PMC  EPMC
46. [YEAR:1-5-2002]van Rensburg,H., Haydon,D., Joubert,F., Bastos,A., Heath,L. and Nel,L.
    Genetic heterogeneity in the foot-and-mouth disease virus Leader and 3C proteinases
    Gene (1-5-2002) 289, 19-29. PubMed  Europe PubMed DOI
2001
47. [YEAR:21-9-2001]Glaser,W., Cencic,R. and Skern,T.
    Foot-and-mouth disease virus leader proteinase: involvement of C-terminal residues in self-processing and cleavage of eIF4GI
    J Biol Chem (21-9-2001) 276, 35473-35481. PubMed  Europe PubMed DOI
2000
48. [YEAR:1-9-2000]Glaser,W. and Skern,T.
    Extremely efficient cleavage of eIF4G by picornaviral proteinases L and 2A in vitro
    FEBS Lett (1-9-2000) 480, 151-155. PubMed  Europe PubMed DOI
49. [YEAR:6-10-2000]Guarne,A., Hampoelz,B., Glaser,W., Carpena,X., Torma,J., Fita,I. and Skern,T.
    Structural and biochemical features distinguish the foot-and-mouth disease virus leader proteinase from other papain-like enzymes
    J Mol Biol (6-10-2000) 302, 1227-1240. PubMed  Europe PubMed DOI  S
1999
50. Seipelt,J., Guarne,A., Bergmann,E., James,M., Sommergruber,W., Fita,I. and Skern,T.
    The structures of picornaviral proteinases
    Virus Res (1999) 62, 159-168. PubMed  Europe PubMed DOI
1998
51. Chinsangaram,J., Mason,P.W. and Grubman,M.J.
    Protection of swine by live and inactivated vaccines prepared from a leader proteinase-deficient serotype A12 foot-and-mouth disease virus
    Vaccine (1998) 16, 1516-1522. PubMed  Europe PubMed DOI
52. [YEAR:15-12-1998]Guarne,A., Tormo,J., Kirchweger,R., Pfistermueller,D., Fita,I. and Skern,T.
    Structure of the foot-and-mouth disease virus leader protease: a papain-like fold adapted for self-processing and eIF4G recognition
    EMBO J (15-12-1998) 17, 7469-7479. PubMed  Europe PubMed DOI  PMC  EPMC  S
53. Skern,T., Fita,I. and Guarne,A.
    A structural model of picornavirus leader proteinases based on papain and bleomycin hydrolase
    J Gen Virol (1998) 79, 301-307. PubMed  Europe PubMed  S
1996
54. Brown,C.C., Piccone,M.E., Mason,P.W., McKenna,T.S. and Grubman,M.J.
    Pathogenesis of wild-type and leaderless foot-and-mouth disease virus in cattle
    J Virol (1996) 70, 5638-5641. PubMed  Europe PubMed  PMC  EPMC
55. Guarne,A., Kirchweger,R., Verdaguer,N., Liebig,H.D., Blaas,D., Skern,T. and Fita,I.
    Crystallization and preliminary X-ray diffraction studies of the Lb proteinase from foot-and-mouth disease virus
    Protein Sci (1996) 5, 1931-1933. PubMed  Europe PubMed DOI  PMC  EPMC  S
1995
56. Piccone,M.E., Sira,S., Zellner,M. and Grubman,M.J.
    Expression in Escherichia coli and purification of biologically active L proteinase of foot-and-mouth disease virus
    Virus Res (1995) 35, 263-275. PubMed  Europe PubMed DOI  E
57. Piccone,M.E., Zellner,M., Kumosinski,T.F., Mason,P.W. and Grubman,M.J.
    Identification of the active-site residues of the L proteinase of foot-and-mouth disease virus
    J Virol (1995) 69, 4950-4956. PubMed  Europe PubMed  PMC  EPMC
58. Piccone,M.E., Rieder,E., Mason,P.W. and Grubman,M.J.
    The foot-and-mouth disease virus leader proteinase gene is not required for viral replication
    J Virol (1995) 69, 5376-5382. PubMed  Europe PubMed  PMC  EPMC
59. Roberts,P.J. and Belsham,G.J.
    Identification of critical amino acids within the foot-and- mouth disease virus leader protein, a cysteine protease
    Virology (1995) 213, 140-146. PubMed  Europe PubMed DOI
60. Ziegler,E., Borman,A.M., Kirchweger,R., Skern,T. and Kean,K.M.
    Foot-and-mouth disease virus Lb proteinase can stimulate rhinovirus and enterovirus IRES-driven translation and cleave several proteins of cellular and viral origin
    J Virol (1995) 69, 3465-3474. PubMed  Europe PubMed  PMC  EPMC
1994
61. Kirchweger,R., Ziegler,E., Lamphear,B.J., Waters,D., Liebig,H.D., Sommergruber,W., Sobrino,F., Hohenadl,C., Blaas,D., Rhoads,R.E. and Skern,T.
    Foot-and-mouth disease virus leader proteinase: purification of the Lb form and determination of its cleavage site on eIF-4 gamma
    J Virol (1994) 68, 5677-5684. PubMed  Europe PubMed  PMC  EPMC
1993
62. Medina,M., Domingo,E., Brangwyn,J.K. and Belsham,G.J.
    The two species of the foot-and-mouth disease virus leader protein, expressed individually, exhibit the same activities
    Virology (1993) 194, 355-359. PubMed  Europe PubMed DOI
1992
63. Kleina,L.G. and Grubman,M.J.
    Antiviral effects of a thiol protease inhibitor on foot-and-mouth disease virus
    J Virol (1992) 66, 7168-7175. PubMed  Europe PubMed  PMC  EPMC  I
1991
64. Gorbalenya,A.E., Koonin,E.V. and Lai,M.M.C.
    Putative papain-related thiol proteases of positive-strand RNA viruses. Identification of rubi- and aphthovirus proteases and delineation of a novel conserved domain associated with proteases of rubi-, alpha- and coronaviruses
    FEBS Lett (1991) 288, 201-205. PubMed  Europe PubMed DOI
1989
65. Ryan,M.D., Belsham,G.J. and King,A.M.
    Specificity of enzyme-substrate interactions in foot-and-mouth disease virus polyprotein processing
    Virology (1989) 173, 35-45. PubMed  Europe PubMed
1988
66. Devaney,M.A., Vakharia,V.N., Lloyd,R.E., Ehrenfeld,E. and Grubman,M.J.
    Leader protein of foot-and-mouth disease virus is required for cleavage of the p220 component of the cap-binding protein complex
    J Virol (1988) 62, 4407-4409. PubMed  Europe PubMed  PMC  EPMC
1986
67. Strebel,K. and Beck,E.
    A second protease of foot-and-mouth disease virus
    J Virol (1986) 58, 893-899. PubMed  Europe PubMed  PMC  EPMC