Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase C28.001: foot-and-mouth disease virus L-peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, M Mutation, I Inhibitor, P Specificity, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Litz,B., Sehl-Ewert,J., Breithaupt,A., Landmesser,A., Pfaff,F., Romey,A., Blaise-Boisseau,S., Beer,M. and Eschbaumer,M.
    Leaderless foot-and-mouth disease virus serotype O did not cause clinical disease and failed to establish a persistent infection in cattle
    Emerg Microbes Infect2348526-2348526. PubMed  Europe PubMed DOI
    2. 2021
  2. Saiz,M. and Martinez-Salas,E.
    Uncovering targets of the Leader protease: Linking RNA-mediated pathways and antiviral defense
    Wiley Interdiscip Rev RNAe1645-e1645. PubMed  Europe PubMed DOI  V
  3. Sui,C., Jiang,D., Wu,X., Liu,S., Li,F., Pan,L., Cong,X., Li,J., Yoo,D., Rock,D.L., Miller,L.C., Lee,C., Du,Y. and Qi,J.
    Inhibition of Antiviral Innate Immunity by Foot-and-Mouth Disease Virus L(pro) through Interaction with N-terminal Domain of Swine RNase L
    J Virol PubMed  Europe PubMed DOI
    4. 2020
  4. Medina,G.N., Azzinaro,P., Ramirez-Medina,E., Gutkoska,J., Fang,Y., Diaz-San Segundo,F. and de los Santos,T.
    Impairment of the deISGylation activity of FMDV Lpro causes attenuation in vitro and in vivo
    J Virol PubMed  Europe PubMed DOI
  5. Visser,L.J., Aloise,C., Swatek,K.N., Medina,G.N., Olek,K.M., Rabouw,H.H., de Groot,R.J., Langereis,M.A., de los Santos,T., Komander,D., Skern,T. and van Kuppeveld,F.J.M.
    Dissecting distinct proteolytic activities of FMDV Lpro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression
    PLoS Pathog16, e1008702-e1008702. PubMed  Europe PubMed DOI
    6. 2018
  6. Rodriguez Pulido,M., Sanchez-Aparicio,M.T., Martinez-Salas,E., Garcia-Sastre,A., Sobrino,F. and Saiz,M.
    Innate immune sensor LGP2 is cleaved by the leader protease of foot-and-mouth disease virus
    PLoS Pathog14, e1007135-e1007135. PubMed  Europe PubMed DOI
  7. Swatek,K.N., Aumayr,M., Pruneda,J.N., Visser,L.J., Berryman,S., Kueck,A.F., Geurink,P.P., Ovaa,H., van Kuppeveld,F.J.M., Tuthill,T.J., Skern,T. and Komander,D.
    Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies
    Proc Natl Acad Sci U S A115, 2371-2376. PubMed  Europe PubMed DOI  P  S
  8. Visser,L.J., Medina,G.N., Rabouw,H.H., de Groot,R.J., Langereis,M.A., de los Santos,T. and van Kuppeveld,F.J.M.
    Foot-and-mouth disease virus leader protease cleaves G3BP1 and G3BP2 and inhibits stress granule formation
    J Virol93, e00922-18-e00922-18. PubMed  Europe PubMed DOI
    9. 2017
  9. Guan,S.H. and Belsham,G.J.
    Separation of foot-and-mouth disease virus leader protein activities; identification of mutants that retain efficient self-processing activity but poorly induce eIF4G cleavage
    J Gen Virol98, 671-680. PubMed  Europe PubMed DOI
  10. Medina,G.N., Knudsen,G.M., Greninger,A.L., Kloc,A., Diaz-San Segundo,F., Rieder,E., Grubman,M.J., DeRisi,J.L. and de los Santos,T.
    Interaction between FMDV Lpro and transcription factor ADNP is required for optimal viral replication
    Virology505, 12-22. PubMed  Europe PubMed DOI
    11. 2015
  11. Aumayr,M., Fedosyuk,S., Ruzicska,K., Sousa-Blin,C., Kontaxis,G. and Skern,T.
    NMR analysis of the interaction of picornaviral proteinases Lb and 2A with their substrate eukaryotic initiation factor 4GII
    Protein Sci24, 1979-1996. PubMed  Europe PubMed DOI
  12. Liu,Y., Zhu,Z., Zhang,M. and Zheng,H.
    Multifunctional roles of leader protein of foot-and-mouth disease viruses in suppressing host antiviral responses
    Vet Res46, 127-127. PubMed  Europe PubMed DOI
  13. Nsamba,P., de Beer,T.A., Chitray,M., Scott,K., Vosloo,W. and Maree,F.F.
    Determination of common genetic variants within the non-structural proteins of foot-and-mouth disease viruses isolated in sub-Saharan Africa
    Vet Microbiol177, 106-122. PubMed  Europe PubMed DOI  M
    14. 2014
  14. Moral-Lopez,P., Alvarez,E., Redondo,N., Skern,T. and Carrasco,L.
    L protease from foot and mouth disease virus confers eIF2-independent translation for mRNAs bearing picornavirus ires
    FEBS Lett588, 4053-4059. PubMed  Europe PubMed DOI
  15. Steinberger,J. and Skern,T.
    The leader proteinase of foot-and-mouth disease virus: structure-function relationships in a proteolytic virulence factor
    Biol Chem395, 1179-1185. PubMed  Europe PubMed DOI
  16. Steinberger,J., Grishkovskaya,I., Cencic,R., Juliano,L., Juliano,M.A. and Skern,T.
    Foot-and-mouth disease virus leader proteinase: structural insights into the mechanism of intermolecular cleavage
    Virology468-470, 397-408. PubMed  Europe PubMed DOI  S  I
    17. 2013
  17. Steinberger,J., Kontaxis,G., Rancan,C. and Skern,T.
    Comparison of self-processing of foot-and-mouth disease virus leader proteinase and porcine reproductive and respiratory syndrome virus leader proteinase nsp1alpha
    Virology443, 271-277. PubMed  Europe PubMed DOI
  18. Uddowla,S., Pacheco,J.M., Larson,C., Bishop,E., Rodriguez,L.L., Rai,D.K., Arzt,J. and Rieder,E.
    Characterization of a chimeric foot-and-mouth disease virus bearing a bovine rhinitis B virus leader proteinase
    Virology447, 172-180. PubMed  Europe PubMed DOI
    19. 2012
  19. Diaz-San Segundo,F., Weiss,M., Perez-Martin,E., Dias,C.C., Grubman,M.J. and de los Santos,T.
    Inoculation of swine with foot-and-mouth disease SAP-mutant virus induces early protection against disease
    J Virol86, 1316-1327. PubMed  Europe PubMed DOI
  20. Grubman,M.J. and de los Santos,T.
    Foot-and-mouth disease virus L-peptidase
    [ISSN:978-0-12-407743-0]3, 2183-2186. DOI
  21. Nogueira Santos,J.A., Assis,D.M., Gouvea,I.E., Judice,W.A., Izidoro,M.A., Juliano,M.A., Skern,T. and Juliano,L.
    Foot and mouth disease leader protease (Lbpro): investigation of prime side specificity allows the synthesis of a potent inhibitor
    Biochimie94, 711-718. PubMed  Europe PubMed DOI  I
  22. Pineiro,D., Ramajo,J., Bradrick,S.S. and Martinez-Salas,E.
    Gemin5 proteolysis reveals a novel motif to identify L protease targets
    Nucleic Acids Res40, 4942-4953. PubMed  Europe PubMed DOI  P
    23. 2011
  23. Piccone,M.E., Segundo,F.D., Kramer,E., Rodriguez,L.L. and de los Santos,T.
    Introduction of tag epitopes in the inter-AUG region of foot and mouth disease virus: effect on the L protein
    Virus Res155, 91-97. PubMed  Europe PubMed DOI
  24. Wang,D., Fang,L., Li,P., Sun,L., Fan,J., Zhang,Q., Luo,R., Liu,X., Li,K., Chen,H., Chen,Z. and Xiao,S.
    The leader proteinase of foot-and-mouth disease virus negatively regulates the type I interferon pathway by acting as a viral deubiquitinase
    J Virol85, 3758-3766. PubMed  Europe PubMed DOI
  25. Wang,D., Fang,L., Liu,L., Zhong,H., Chen,Q., Luo,R., Liu,X., Zhang,Z., Chen,H. and Xiao,S.
    Foot-and-mouth disease virus (FMDV) leader proteinase negatively regulates the porcine interferon-lambda1 pathway
    Mol Immunol49, 407-412. PubMed  Europe PubMed DOI
  26. Wang,D., Fang,L., Bi,J., Chen,Q., Cao,L., Luo,R., Chen,H. and Xiao,S.
    Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced RANTES transcription in PK-15 cells
    Virus Genes42, 388-393. PubMed  Europe PubMed DOI
    27. 2010
  27. Wang,D., Fang,L., Luo,R., Ye,R., Fang,Y., Xie,L., Chen,H. and Xiao,S.
    Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced type I interferon transcription by decreasing interferon regulatory factor 3/7 in protein levels
    Biochem Biophys Res Commun399, 72-78. PubMed  Europe PubMed DOI
  28. Zhu,J., Weiss,M., Grubman,M.J. and Santos Tde,L.
    Differential gene expression in bovine cells infected with wild type and leaderless foot-and-mouth disease virus
    Virology404, 32-40. PubMed  Europe PubMed DOI
    29. 2009
  29. de los Santos,T., Segundo,F.D., Zhu,J., Koster,M., Dias,C.C. and Grubman,M.J.
    A conserved domain in the leader proteinase of foot-and-mouth disease virus is required for proper subcellular localization and function
    J Virol83, 1800-1810. PubMed  Europe PubMed DOI
  30. Santos,J.A., Gouvea,I.E., Judice,W.A., Izidoro,M.A., Alves,F.M., Melo,R.L., Juliano,M.A., Skern,T. and Juliano,L.
    Hydrolytic properties and substrate specificity of the foot-and-mouth disease leader protease
    Biochemistry48, 7948-7958. PubMed  Europe PubMed DOI  P  I
    31. 2008
  31. Mayer,C., Neubauer,D., Nchinda,A.T., Cencic,R., Trompf,K. and Skern,T.
    Residue L143 of the foot-and-mouth disease virus leader proteinase is a determinant of cleavage specificity
    J Virol82, 4656-4659. PubMed  Europe PubMed DOI  P
    32. 2007
  32. Cencic,R., Mayer,C., Juliano,M.A., Juliano,L., Konrat,R., Kontaxis,G. and Skern,T.
    Investigating the substrate specificity and oligomerisation of the leader protease of foot and mouth disease virus using NMR
    J Mol Biol373, 1071-1087. PubMed  Europe PubMed DOI  S
  33. de los Santos,T., Diaz-San Segundo,F. and Grubman,M.J.
    Degradation of nuclear factor kappa B during foot-and-mouth disease virus infection
    J Virol81, 12803-12815. PubMed  Europe PubMed DOI
    34. 2006
  34. de los Santos,T., de Avila Botton,S., Weiblen,R. and Grubman,M.J.
    The leader proteinase of foot-and-mouth disease virus inhibits the induction of beta interferon mRNA and blocks the host innate immune response
    J Virol80, 1906-1914. PubMed  Europe PubMed DOI
    35. 2005
  35. Foeger,N., Kuehnel,E., Cencic,R. and Skern,T.
    The binding of foot-and-mouth disease virus leader proteinase to eIF4GI involves conserved ionic interactions
    FEBS J272, 2602-2611. PubMed  Europe PubMed DOI
    36. 2004
  36. Gradi,A., Foeger,N., Strong,R., Svitkin,Y.V., Sonenberg,N., Skern,T. and Belsham,G.J.
    Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro
    J Virol78, 3271-3278. PubMed  Europe PubMed DOI  P
  37. Grubman,M.J.
    Foot-and-mouth disease virus L-peptidase
    [ISSN:0-12-079610-4]2, 1259-1261.  V
  38. [YEAR:14-9-2004]Kuehnel,E., Cencic,R., Foeger,N. and Skern,T.
    Foot-and-mouth disease virus leader proteinase: specificity at the P2 and P3 positions and comparison with other papain-like enzymes
    Biochemistry43, 11482-11490. PubMed  Europe PubMed DOI
  39. Strong,R. and Belsham,G.J.
    Sequential modification of translation initiation factor eIF4GI by two different foot-and-mouth disease virus proteases within infected baby hamster kidney cells: identification of the 3Cpro cleavage site
    J Gen Virol85, 2953-2962. PubMed  Europe PubMed DOI
  40. Tosh,C., Mittal,M., Sanyal,A., Hemadri,D. and Bandyopadhyay,S.K.
    Molecular phylogeny of leader proteinase gene of type A of Foot-and-mouth disease virus from India
    Arch Virol149, 523-536. PubMed  Europe PubMed DOI
    41. 2002
  41. [YEAR:15-11-2002]Foeger,N., Glaser,W. and Skern,T.
    Recognition of eukaryotic initiation factor 4G isoforms by picornaviral proteinases
    J Biol Chem277, 44300-44309. PubMed  Europe PubMed DOI
  42. Hinton,T.M., Ross-Smith,N., Warner,S., Belsham,G.J. and Crabb,B.S.
    Conservation of L and 3C proteinase activities across distantly related aphthoviruses
    J Gen Virol83, 3111-3121. PubMed  Europe PubMed
  43. [YEAR:25-9-2002]Kronovetr,J. and Skern,T.
    Foot-and-mouth disease virus leader proteinase: a papain-like enzyme requiring an acidic environment in the active site
    FEBS Lett528, 58-62. PubMed  Europe PubMed DOI
  44. [YEAR:1-5-2002]Schlick,P., Kronovetr,J., Hampoelz,B. and Skern,T.
    Modulation of the electrostatic charge at the active site of foot-and-mouth-disease-virus leader proteinase, an unusual papain-like enzyme
    Biochem J363, 493-501. PubMed  Europe PubMed DOI
  45. [YEAR:1-5-2002]van Rensburg,H., Haydon,D., Joubert,F., Bastos,A., Heath,L. and Nel,L.
    Genetic heterogeneity in the foot-and-mouth disease virus Leader and 3C proteinases
    Gene289, 19-29. PubMed  Europe PubMed DOI
    46. 2001
  46. [YEAR:21-9-2001]Glaser,W., Cencic,R. and Skern,T.
    Foot-and-mouth disease virus leader proteinase: involvement of C-terminal residues in self-processing and cleavage of eIF4GI
    J Biol Chem276, 35473-35481. PubMed  Europe PubMed DOI
    47. 2000
  47. [YEAR:1-9-2000]Glaser,W. and Skern,T.
    Extremely efficient cleavage of eIF4G by picornaviral proteinases L and 2A in vitro
    FEBS Lett480, 151-155. PubMed  Europe PubMed DOI
  48. [YEAR:6-10-2000]Guarne,A., Hampoelz,B., Glaser,W., Carpena,X., Torma,J., Fita,I. and Skern,T.
    Structural and biochemical features distinguish the foot-and-mouth disease virus leader proteinase from other papain-like enzymes
    J Mol Biol302, 1227-1240. PubMed  Europe PubMed DOI  S
    49. 1999
  49. Seipelt,J., Guarne,A., Bergmann,E., James,M., Sommergruber,W., Fita,I. and Skern,T.
    The structures of picornaviral proteinases
    Virus Res62, 159-168. PubMed  Europe PubMed DOI
    50. 1998
  50. Chinsangaram,J., Mason,P.W. and Grubman,M.J.
    Protection of swine by live and inactivated vaccines prepared from a leader proteinase-deficient serotype A12 foot-and-mouth disease virus
    Vaccine16, 1516-1522. PubMed  Europe PubMed DOI
  51. [YEAR:15-12-1998]Guarne,A., Tormo,J., Kirchweger,R., Pfistermueller,D., Fita,I. and Skern,T.
    Structure of the foot-and-mouth disease virus leader protease: a papain-like fold adapted for self-processing and eIF4G recognition
    EMBO J17, 7469-7479. PubMed  Europe PubMed DOI  S
  52. Skern,T., Fita,I. and Guarne,A.
    A structural model of picornavirus leader proteinases based on papain and bleomycin hydrolase
    J Gen Virol79, 301-307. PubMed  Europe PubMed  S
    53. 1996
  53. Brown,C.C., Piccone,M.E., Mason,P.W., McKenna,T.S. and Grubman,M.J.
    Pathogenesis of wild-type and leaderless foot-and-mouth disease virus in cattle
    J Virol70, 5638-5641. PubMed  Europe PubMed
  54. Guarne,A., Kirchweger,R., Verdaguer,N., Liebig,H.D., Blaas,D., Skern,T. and Fita,I.
    Crystallization and preliminary X-ray diffraction studies of the Lb proteinase from foot-and-mouth disease virus
    Protein Sci5, 1931-1933. PubMed  Europe PubMed DOI  S
    55. 1995
  55. Piccone,M.E., Sira,S., Zellner,M. and Grubman,M.J.
    Expression in Escherichia coli and purification of biologically active L proteinase of foot-and-mouth disease virus
    Virus Res35, 263-275. PubMed  Europe PubMed DOI  E
  56. Piccone,M.E., Zellner,M., Kumosinski,T.F., Mason,P.W. and Grubman,M.J.
    Identification of the active-site residues of the L proteinase of foot-and-mouth disease virus
    J Virol69, 4950-4956. PubMed  Europe PubMed
  57. Piccone,M.E., Rieder,E., Mason,P.W. and Grubman,M.J.
    The foot-and-mouth disease virus leader proteinase gene is not required for viral replication
    J Virol69, 5376-5382. PubMed  Europe PubMed
  58. Roberts,P.J. and Belsham,G.J.
    Identification of critical amino acids within the foot-and- mouth disease virus leader protein, a cysteine protease
    Virology213, 140-146. PubMed  Europe PubMed DOI
  59. Ziegler,E., Borman,A.M., Kirchweger,R., Skern,T. and Kean,K.M.
    Foot-and-mouth disease virus Lb proteinase can stimulate rhinovirus and enterovirus IRES-driven translation and cleave several proteins of cellular and viral origin
    J Virol69, 3465-3474. PubMed  Europe PubMed
    60. 1994
  60. Kirchweger,R., Ziegler,E., Lamphear,B.J., Waters,D., Liebig,H.D., Sommergruber,W., Sobrino,F., Hohenadl,C., Blaas,D., Rhoads,R.E. and Skern,T.
    Foot-and-mouth disease virus leader proteinase: purification of the Lb form and determination of its cleavage site on eIF-4 gamma
    J Virol68, 5677-5684. PubMed  Europe PubMed
    61. 1993
  61. Medina,M., Domingo,E., Brangwyn,J.K. and Belsham,G.J.
    The two species of the foot-and-mouth disease virus leader protein, expressed individually, exhibit the same activities
    Virology194, 355-359. PubMed  Europe PubMed DOI
    62. 1992
  62. Kleina,L.G. and Grubman,M.J.
    Antiviral effects of a thiol protease inhibitor on foot-and-mouth disease virus
    J Virol66, 7168-7175. PubMed  Europe PubMed  I
    63. 1991
  63. Gorbalenya,A.E., Koonin,E.V. and Lai,M.M.C.
    Putative papain-related thiol proteases of positive-strand RNA viruses. Identification of rubi- and aphthovirus proteases and delineation of a novel conserved domain associated with proteases of rubi-, alpha- and coronaviruses
    FEBS Lett288, 201-205. PubMed  Europe PubMed DOI
    64. 1989
  64. Ryan,M.D., Belsham,G.J. and King,A.M.
    Specificity of enzyme-substrate interactions in foot-and-mouth disease virus polyprotein processing
    Virology173, 35-45. PubMed  Europe PubMed
    65. 1988
  65. Devaney,M.A., Vakharia,V.N., Lloyd,R.E., Ehrenfeld,E. and Grubman,M.J.
    Leader protein of foot-and-mouth disease virus is required for cleavage of the p220 component of the cap-binding protein complex
    J Virol62, 4407-4409. PubMed  Europe PubMed
    66. 1986
  66. Strebel,K. and Beck,E.
    A second protease of foot-and-mouth disease virus
    J Virol58, 893-899. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use