Substrates for peptidase C19.022: ubiquitin-specific peptidase 15

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
polyubiquitin	P0CG47	1-76	peptide-Gly76+Met1-peptide	N	Leu	Arg	Gly	Gly	Met	Gln	Ile	Phe	Baker, 2004
polyubiquitinated TGF-beta receptor type-1	P0CG47/P36897	1-76	peptide-Gly76+Lys-peptide	P	Leu	Arg	Gly	Gly	Lys	Xaa	Xaa	Xaa	Eichhorn et al., 2012
ubiquitiin-CEP80 fusion protein	P0CG47	1-76	peptide-Gly76+Ala-peptide	N	Leu	Arg	Gly	Gly	Ala	-	-	-	Baker, 2004
ubiquitin-beta-galactosidase fusion protein	P0CG47	1-76	peptide-Gly76+Arg1-peptide	N	Leu	Arg	Gly	Gly	Arg	His	Gly	Ser	Baker, 2004
ubiquitin-beta-galactosidase fusion protein	P0CG47	1-76	peptide-Gly76+Met1-peptide	N	Leu	Arg	Gly	Gly	Met	His	Gly	Ser	Baker, 2004
ubiquitin-beta-galactosidase fusion protein	P0CG47	1-76	peptide-Gly76+Met1-peptide	P	Leu	Arg	Gly	Gly	Met	His	Gly	Ser		16277
ubiquitin-dihydrofolate reductase fusion protein	P0CG47	1-76	peptide-Gly76+Met-peptide	N	Leu	Arg	Gly	Gly	Met	Val	Gly	Ser	Baker, 2004
ubiquitin-glutathione S-transferase P fusion protein	P0CG47	1-76	peptide-Gly76+Pro-peptide	N	Leu	Arg	Gly	Gly	Pro	Pro	Tyr	Thr	Baker, 2004
ubiquitin-PESTc fusion protein	P0CG47	1-76	peptide-Gly76+Met-peptide	N	Leu	Arg	Gly	Gly	Met	-	-	-	Baker, 2004
ubiquitinated glutathione S-transferase P	P0CG47	1-76	peptide-Gly76+Met-peptide	N	Leu	Arg	Gly	Gly	Met	Pro	Pro	Tyr	Baker, 2004