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Literature for peptidase C19.022: ubiquitin-specific peptidase 15

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, T Target, P Specificity, I Inhibitor, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Qi,Y., Dong,Q., Luo,P., Meng,J., Guo,B., Zhang,X., Shan,L., Fu,M., Yang,L., Peng,J. and Liu,B.
    USP15 promotes proliferation, migration, and apoptosis resistance of pulmonary arterial smooth muscle cells by targeting MDM2
    Arch Biochem Biophys (2026) 778, 110733-110733. PubMed  Europe PubMed DOI  K
    2. 2025
  2. Ap,A., Jayakumar,H., S,A., Ravindran,S., Arya,R.P. and Lahon,A.
    Silencing of ubiquitin specific protease-15 activates components of innate immune response and inhibits dengue virus infection
    Diagn Microbiol Infect Dis (2025) 113, 117036-117036. PubMed  Europe PubMed DOI
  3. Fang,R., Jia,Z., Xin,Y., Zhao,K., Qin,W., Lu,H., Zhou,Y., Yang,Y. and Fang,H.
    N6-methyladenosine-modification of USP15 regulates chemotherapy resistance by inhibiting LGALS3 ubiquitin-mediated degradation via AKT/mTOR signaling activation pathway in hepatocellular carcinoma
    Cell Death Discov (2025) 11, 3-3. PubMed  Europe PubMed DOI  PMC  EPMC  K
  4. Iwase,R., Maisonet,I.J., Lee,K., Buhrlage,S.J. and Cole,P.A.
    Deubiquitinase processing of a non-natural linkage of ubiquitinated-PTEN
    Bioorg Chem (2025) 157, 108223-108223. PubMed  Europe PubMed DOI
  5. Liang,Q., Ding,Q., Zhao,L., Tan,J. and Niu,W.
    USP15-modified ADMSCs-Exo alleviates chondrocyte damage and effectively relieved osteoarthritis by inducing M2 polarization of macrophages through deubiquitinating FOXC1
    J Orthop Surg Res (2025) 20, 336-336. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Liu,H.R., Wu,L., Wang,K.J., Che,Y.X., Zhu,W.J., Li,X.S., Han,Y., Wei,G.R., Zhang,Y.Y. and Luo,X.J.
    USP15 promotes brain cell disulfidptosis in mouse subjected to ischemic stroke through a mechanism involving deubiquitination of SETD1B
    Biochim Biophys Acta Mol Cell Res (2025) 1872, 120016-120016. PubMed  Europe PubMed DOI  K
  7. Vue,Y., Mullon,P.J., Leehangin,A., Maldonado-Luevano,E., Hasselmann,T.D., Mehta,K.P.M. and Mohni,K.N.
    Ubiquitin-specific protease 15 interacts directly with the HSV-1 alkaline nuclease and facilitates viral recombination and replication fork stability
    J Virol (2025) , e0089325-e0089325. PubMed  Europe PubMed DOI
  8. Yang,H., Sun,T., Sun,Z., Wang,H., Liu,D., Wu,D., Qin,T. and Zhou,M.
    Unravelling the role of ubiquitin-specific proteases in breast carcinoma: insights into tumour progression and immune microenvironment modulation
    World J Surg Oncol (2025) 23, 60-60. PubMed  Europe PubMed DOI  PMC  EPMC  V
  9. Yuan,Z., He,J., Zhao,Z., Chen,G., Li,Y. and Li,X.
    USP15-dependent modulation of TGF-beta/Smad2/3 signaling: implications for chondrocyte matrix degradation and autophagy in osteoarthritis
    Sci Rep (2025) 15, 38142-38142. PubMed  Europe PubMed DOI  PMC  EPMC  K
  10. Zhang,J., Allen,J., Ward,S.J., Dekker,L.V. and Dreveny,I.
    A versatile fluorescence polarization based deubiquitination assay using an isopeptide bond substrate mimetic (IsoMim)
    J Biol Chem (2025) , 110342-110342. PubMed  Europe PubMed DOI  I
  11. Zhang,Z.T., Niu,S.X., Yu,C.H., Wan,S.Y., Wang,J., Liu,C.Y., Zheng,L., Huang,K. and Zhang,Y.
    USP15 inhibits hypoxia-induced IL-6 signaling by deubiquitinating and stabilizing MeCP2
    FEBS J (2025) 292, 153-167. PubMed  Europe PubMed DOI
  12. Zhao,L., Zhao,R., Gong,Z., Liang,F., Zhao,N., Zhong,B., Liu,M., Zhang,Y., Zhao,Q., Zhang,L. and Tang,C.
    In-situ cross-linking mass spectrometry reveals compartment-specific proteasomal interactions and structural heterogeneity
    Nat Commun (2025) 16, 10725-10725. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Zheng,W., Luo,Q., Wang,X., Zhou,X., Ye,D., Hua,K. and Fang,L.
    NASP Promotes Triple-negative Breast Cancer Progression and Metastasis by Stabilizing YAP in a USP15-Dependent Way
    Int J Biol Sci (2025) 21, 4172-4186. PubMed  Europe PubMed DOI  PMC  EPMC
    14. 2024
  14. Cui,Z., Sun,H., Gao,Z., Li,C., Xiao,T., Bian,Y., Liu,Z., Gu,T., Zhang,J., Li,T., Zhou,Q., He,Z., Li,B., Li,F., Xu,Z. and Xu,H.
    TRIM21/USP15 balances ACSL4 stability and the imatinib resistance of gastrointestinal stromal tumors
    Br J Cancer (2024) 130, 526-541. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Guo,Z., Bao,S., Shi,Z., Li,X., Li,P., Zhong,B., Zhang,M. and Wu,Q.
    USP15-Mediated Deubiquitination of FKBP 5 and Activation of the alphaIIbbeta3 Signaling Pathway Regulate Thrombosis in Mice
    Front Biosci (Landmark Ed) (2024) 29, 325-325. PubMed  Europe PubMed DOI  K
  16. Haussler,U., Neres,J., Vandenplas,C., Eykens,C., Kadiu,I., Schramm,C., Fleurance,R., Stanley,P., Godard,P., de Mot,L., van Eyll,J., Knobeloch,K.P., Haas,C.A. and Dedeurwaerdere,S.
    Downregulation of Ubiquitin-Specific Protease 15 (USP15) Does Not Provide Therapeutic Benefit in Experimental Mesial Temporal Lobe Epilepsy
    Mol Neurobiol (2024) 61, 2367-2389. PubMed  Europe PubMed DOI  K
  17. Hu,X., Zhang,J., Ma,H., Lian,W., Song,W., Du,C., Chen,S., Wang,D., Wei,J. and Lu,Q.
    The broad-spectrum deubiquitinating enzyme inhibitor PR-619 protects retinal ganglion cell and augments parkin-mediated mitophagy in experimental glaucoma
    Sci Rep (2024) 14, 24654-24654. PubMed  Europe PubMed DOI  PMC  EPMC  K  I
  18. Keijzer,N., Priyanka,A., Stijf-Bultsma,Y., Fish,A., Gersch,M. and Sixma,T.K.
    Variety in the USP deubiquitinase catalytic mechanism
    Life Sci Alliance (2024) 7 PubMed  Europe PubMed DOI  PMC  EPMC
  19. Kim,J., Taketomi,T., Yamada,A., Uematsu,Y., Ueda,K., Chiba,T. and Tsuruta,F.
    USP4 regulates TUT1 ubiquitination status in concert with SART3
    Biochem Biophys Res Commun (2024) 701, 149557-149557. PubMed  Europe PubMed DOI
  20. Li,Y., Jiang,C., Liu,Q., Zhou,P., Tian,D., Zeng,Y. and Xiang,M.
    USP15 facilitates the progression of bladder cancer by amplifying the activation of the NF-kappaB signaling pathway
    Aging (Albany NY) (2024) 16, 6757-6772. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Longevity,O.M.A.C.
    Retracted: Platelet-Rich Plasma-Derived Exosomal USP15 Promotes Cutaneous Wound Healing via Deubiquitinating EIF4A1
    Oxid Med Cell Longev (2024) 2024, 9808072-9808072. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Ma,J., Li,Z., Xu,J., Lai,J., Zhao,J., Ma,L. and Sun,X.
    PRDM1 promotes the ferroptosis and immune escape of thyroid cancer by regulating USP15-mediated SELENBP1 deubiquitination
    J Endocrinol Invest (2024) 47, 2981-2997. PubMed  Europe PubMed DOI  K
  23. Rezaei,S., Timani,K.A., Liu,Y. and He,J.J.
    Ectopic USP15 expression inhibits HIV-1 transcription involving changes in YY1 deubiquitination and stability
    Front Cell Infect Microbiol (2024) 14, 1371655-1371655. PubMed  Europe PubMed DOI  PMC  EPMC  K
  24. Shi,Y., Zhang,J., Li,J., He,J., Wu,S., Yu,M., Yang,D. and Ju,L.
    USP15, activated by TFAP4 transcriptionally, stabilizes SHC1 via deubiquitination and deteriorates renal cell carcinoma
    Cancer Sci (2024) 115, 2617-2629. PubMed  Europe PubMed DOI
  25. Wang,P.S., Liu,Z., Sweef,O., Xie,J., Chen,J., Zhu,H., Zeidler-Erdely,P.C., Yang,C. and Wang,Z.
    Long noncoding RNA ABHD11-AS1 interacts with SART3 and regulates CD44 RNA alternative splicing to promote lung carcinogenesis
    Environ Int (2024) 185, 108494-108494. PubMed  Europe PubMed DOI  K
  26. Wang,S.S., Ye,D.X., Wang,B., Li,M.Y. and Zhao,W.X.
    USP15 promotes the progression of papillary thyroid cancer by regulating HMGB1 stability through its deubiquitination
    J Cancer (2024) 15, 2561-2572. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Wang,X., Deng,X., Hu,J., Zheng,W., Ye,D., Zhou,X. and Fang,L.
    K48-linked deubiquitination of VGLL4 by USP15 enhances the efficacy of tumor immunotherapy in triple-negative breast cancer
    Cancer Lett (2024) 588, 216764-216764. PubMed  Europe PubMed DOI
  28. Xu,C., Wang,B., Li,M., Dong,Z., Chen,N., Duan,J., Zhou,Y., Jin,M., Chen,R. and Yuan,W.
    FUNDC1/USP15/Drp1 ameliorated TNF-alpha-induced pulmonary artery endothelial cell proliferation by regulating mitochondrial dynamics
    Cell Signal (2024) 113, 110939-110939. PubMed  Europe PubMed DOI
  29. Yi,H., Xiao,X., Lei,F. and Zhang,F.
    USP15 as a Potential Therapeutic Target in Cerebral Ischemia: Modulation of Ferroptosis and Cognitive Dysfunction via the Nrf2/GPX4 Axis in Mice
    Neuromolecular Med (2024) 26, 44-44. PubMed  Europe PubMed DOI  K
  30. Zhu,R., Li,M., Wang,D., Liu,C., Xie,L., Yang,Y., Gu,X., Zhao,K., Tian,Y. and Cai,S.
    USP15 regulates radiation-induced DNA damage and intestinal injury through K48-linked deubiquitination and stabilisation of ATM
    Mol Med (2024) 30, 205-205. PubMed  Europe PubMed DOI  PMC  EPMC
    31. 2023
  31. Baek,J.H., Kim,M.S., Jung,H.R., Hwang,M.S., Lee,C.H., Han,D.H., Lee,Y.H., Yi,E.C., Im,S.S., Hwang,I., Kim,K., Chung,J.Y. and Chun,K.H.
    Ablation of the deubiquitinase USP15 ameliorates nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
    Exp Mol Med (2023) 55, 1520-1530. PubMed  Europe PubMed DOI  PMC  EPMC
  32. Chan,S.C., Tung,C.W., Lin,C.W., Tung,Y.S., Wu,P.M., Cheng,P.H., Chen,C.M. and Yang,S.H.
    miR-196a provides antioxidative neuroprotection via USP15/Nrf2 regulation in Huntington's disease
    Free Radic Biol Med (2023) 209, 292-300. PubMed  Europe PubMed DOI
  33. Ghoreshi,Z.A., Molaei,H.R. and Arefinia,N.
    The Role of DNA Viruses in Human Cancer
    Cancer Inform (2023) 22, 11769351231154186-11769351231154186. PubMed  Europe PubMed DOI  PMC  EPMC  V
  34. Nishi,H., Ono,M., Ohno,S., Yamanaka,Z., Sasaki,T., Ohyashiki,K., Ohyashiki,J.H. and Kuroda,M.
    Hypoxia-induced paclitaxel resistance in cervical cancer modulated by miR-100 targeting of USP15
    Gynecol Oncol Rep (2023) 45, 101138-101138. PubMed  Europe PubMed DOI  PMC  EPMC
  35. Park,H.M., Le,L., Nguyen,T.T., Nam,K.H., Ordureau,A., Lee,J.E. and Nguyen,T.V.
    The CRL3(gigaxonin) ubiquitin ligase-USP15 pathway governs the destruction of neurofilament proteins
    Proc Natl Acad Sci U S A (2023) 120, e2306395120-e2306395120. PubMed  Europe PubMed DOI  PMC  EPMC
  36. Ren,Y., Song,Z., Rieser,J., Ackermann,J., Koch,I., Lv,X., Ji,T. and Cai,X.
    USP15 Represses Hepatocellular Carcinoma Progression by Regulation of Pathways of Cell Proliferation and Cell Migration: A System Biology Analysis
    Cancers (Basel) (2023) 15 PubMed  Europe PubMed DOI  PMC  EPMC
  37. Taniue,K., Oda,T., Hayashi,T., Kamoshida,Y., Takeda,Y., Sugawara,A., Shimoura,Y., Negishi,L., Nagashima,T., Okada-Hatakeyama,M., Kawamura,Y., Goshima,N., Akimitsu,N. and Akiyama,T.
    LncRNA ZNNT1 induces p53 degradation by interfering with the interaction between p53 and the SART3-USP15 complex
    PNAS Nexus (2023) 2, ad220-ad220. PubMed  Europe PubMed DOI  PMC  EPMC  K
  38. Zheng,H., Liu,X. and Song,B.
    Circular RNA circADAM9 Promotes Inflammation, Oxidative Stress, and Fibrosis of Human Mesangial Cells via the Keap1-Nrf2 Pathway in Diabetic Nephropathy
    Exp Clin Endocrinol Diabetes (2023) 131, 491-499. PubMed  Europe PubMed DOI  K
    39. 2022
  39. Das,T., Lee,E.Y., You,H.J., Kim,E.E. and Song,E.J.
    USP15 and USP4 facilitate lung cancer cell proliferation by regulating the alternative splicing of SRSF1
    Cell Death Discov (2022) 8, 24-24. PubMed  Europe PubMed DOI  PMC  EPMC
  40. Kim,M.J., Min,Y., Jeong,S.K., Son,J., Kim,J.Y., Lee,J.S., Kim,D.H., Lee,J.S., Chun,E. and Lee,K.Y.
    USP15 negatively regulates lung cancer progression through the TRAF6-BECN1 signaling axis for autophagy induction
    Cell Death Dis (2022) 13, 348-348. PubMed  Europe PubMed DOI  PMC  EPMC
  41. Priyanka,A., Tisi,D. and Sixma,T.K.
    Mitoxantrone stacking does not define the active or inactive state of USP15 catalytic domain
    J Struct Biol (2022) 214, 107862-107862. PubMed  Europe PubMed DOI  I
  42. Tian,X., Zhao,Y., Yang,Z., Lu,Q., Zhou,L. and Zheng,S.
    USP15 regulates p66Shc stability associated with Drp1 activation in liver ischemia/reperfusion
    Cell Death Dis (2022) 13, 823-823. PubMed  Europe PubMed DOI  PMC  EPMC  K
  43. Timani,K.A., Rezaei,S., Whitmill,A., Liu,Y. and He,J.J.
    Tip110/SART3-Mediated Regulation of NF-kappaB Activity by Targeting IkappaBalpha Stability Through USP15
    Front Oncol (2022) 12, 843157-843157. PubMed  Europe PubMed DOI  PMC  EPMC
    44. 2021
  44. Das,T., Song,E.J. and Kim,E.E.
    The Multifaceted Roles of USP15 in Signal Transduction
    Int J Mol Sci (2021) 22 PubMed  Europe PubMed DOI  PMC  EPMC
  45. Georges,A., Gros,P. and Fodil,N.
    USP15: a review of its implication in immune and inflammatory processes and tumor progression
    Genes Immun (2021) 22, 12-23. PubMed  Europe PubMed DOI
  46. Niederkorn,M., Ishikawa,C., Hueneman,M., Bartram,J., Stepanchick,E., Bennett,R., Culver-Cochran,E., Bolanos,L.C., Uible,E., Choi,K., Wunderlich,M., Perentesis,J.P., Chlon,M., Filippi,M.D. and Starczynowski,D.T.
    The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia
    Leukemia (2021) PubMed  Europe PubMed DOI
  47. Tu,L., Lin,Z., Huang,Q. and Liu,D.
    USP15 Enhances the Proliferation, Migration, and Collagen Deposition of Hypertrophic Scar-Derived Fibroblasts by Deubiquitinating TGF-betaR1 In Vitro
    Plast Reconstr Surg (2021) PubMed  Europe PubMed DOI  K
  48. Xia,X., Huang,C., Liao,Y., Liu,Y., He,J., Shao,Z., Hu,T., Yu,C., Jiang,L., Liu,J. and Huang,H.
    The deubiquitinating enzyme USP15 stabilizes ERalpha and promotes breast cancer progression
    Cell Death Dis (2021) 12, 329-329. PubMed  Europe PubMed DOI  PMC  EPMC  K
  49. Xu,Y., Lin,Z., He,L., Qu,Y., Ouyang,L., Han,Y., Xu,C. and Duan,D.
    Platelet-Rich Plasma-Derived Exosomal USP15 Promotes Cutaneous Wound Healing via Deubiquitinating EIF4A1
    Oxid Med Cell Longev (2021) 2021, 9674809-9674809. PubMed  Europe PubMed DOI  PMC  EPMC
  50. Zhang,L., Gao,X., Qin,Z., Shi,X., Xu,K., Wang,S., Tang,M., Wang,W., Gao,S., Zuo,L., Zhang,L. and Zhang,W.
    USP15 participates in DBP-induced testicular oxidative stress injury through regulating the Keap1/Nrf2 signaling pathway
    Sci Total Environ (2021) 783, 146898-146898. PubMed  Europe PubMed DOI
  51. Zhong,M., Zhou,L., Fang,Z., Yao,Y.Y., Zou,J.P., Xiong,J.P., Xiang,X.J. and Deng,J.
    Ubiquitin-specific protease 15 contributes to gastric cancer progression by regulating the Wnt/beta-catenin signaling pathway
    World J Gastroenterol (2021) 27, 4221-4235. PubMed  Europe PubMed DOI  PMC  EPMC  K
    52. 2020
  52. Dubiel,W., Chaithongyot,S., Dubiel,D. and Naumann,M.
    The COP9 Signalosome: A Multi-DUB Complex
    Biomolecules (2020) 10, 1082-1082. PubMed  Europe PubMed DOI
  53. Jiang,B., Zhou,L., Lu,J., Wang,Y., Liu,C., Liang,Z., Zhou,W., You,L. and Guo,J.
    Clinicopathological and prognostic significance of ubiquitin-specific peptidase 15 and its relationship with transforming growth factor-beta receptors in patients with pancreatic ductal adenocarcinoma
    J Gastroenterol Hepatol (2020) PubMed  Europe PubMed DOI
  54. Kim,J., Nakamura,J., Hamada,C., Taketomi,T., Yano,S., Okajima,T., Kashiwabara,S.I., Baba,T., Sato,B., Chiba,T. and Tsuruta,F.
    USP15 deubiquitinates TUT1 associated with RNA metabolism and maintains cerebellar homeostasis
    Mol Cell Biol (2020) PubMed  Europe PubMed DOI
  55. Rasaei,R., Sarodaya,N., Kim,K.S., Ramakrishna,S. and Hong,S.H.
    Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation
    Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC  V
  56. Yao,X.Q., Li,L., Piao,L.Z., Zhang,G.J., Huang,X.Z., Wang,Y. and Liang,Z.L.
    Overexpression of Ubiquitin-Specific Protease15 (USP15) Promotes Tumor Growth and Inhibits Apoptosis and Correlated With Poor Disease-Free Survival in Hepatocellular Carcinoma
    Technol Cancer Res Treat (2020) 19, 1533033820967455-1533033820967455. PubMed  Europe PubMed DOI  PMC  EPMC
  57. Yu,B., Shen,B., Ba,Z., Liu,Z., Yuan,J., Zhao,W. and Wu,D.
    USP15 promotes the apoptosis of degenerative nucleus pulposus cells by suppressing the PI3K/AKT signalling pathway
    J Cell Mol Med (2020) 24, 13813-13823. PubMed  Europe PubMed DOI
  58. Zhao,Y., Huang,X., Zhang,Z., Zhang,Y., Zhang,G., Zan,T. and Li,Q.
    USP15 Enhances Re-epithelialization Through Deubiquitinating EIF4A1 During Cutaneous Wound Repair
    Front Cell Dev Biol (2020) 8, 529-529. PubMed  Europe PubMed DOI  PMC  EPMC
  59. Zhou,Q., Cheng,C., Wei,Y., Yang,J., Zhou,W., Song,Q., Ke,M., Yan,W., Zheng,L., Zhang,Y. and Huang,K.
    USP15 potentiates NF-kappaB activation by differentially stabilizing TAB2 and TAB3
    FEBS J (2020) 287, 3165-3183. PubMed  Europe PubMed DOI
    60. 2019
  60. Kusakabe,S., Suzuki,T., Sugiyama,Y., Haga,S., Horike,K., Tokunaga,M., Hirano,J., He,Z., Chen,D.V., Ishiga,H., Komoda,Y., Ono,C., Fukuhara,T., Yamamoto,M., Ikawa,M., Satoh,T., Akira,S., Tanaka,T., Moriishi,K., Fukai,M., Taketomi,A., Yoshio,S., Kanto,T., Suzuki,T., Okamoto,T. and Matsuura,Y.
    USP15 participates in hepatitis C virus propagation through the regulation of viral RNA translation and lipid droplet formation
    J Virol (2019) 93, e01708-18-e01708-18. PubMed  Europe PubMed DOI  K
  61. Middleton,A.J. and Day,C.L.
    Ubiquitin variant inhibitors meet the deubiquitinase USP15
    Structure (2019) 27, 564-565. PubMed  Europe PubMed DOI  I
  62. Nune,M., Morgan,M.T., Connell,Z., McCullough,L., Jbara,M., Sun,H., Brik,A., Formosa,T. and Wolberger,C.
    FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics
    elife (2019) 8 PubMed  Europe PubMed DOI
  63. Peng,Y., Liao,Q., Tan,W., Peng,C., Hu,Z., Chen,Y., Li,Z., Li,J., Zhen,B., Zhu,W., Li,X., Yao,Y., Song,Q., Liu,C., Qi,X., He,F. and Pei,H.
    The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors
    Nat Commun (2019) 10, 1224-1224. PubMed  Europe PubMed DOI  PMC  EPMC
  64. Teyra,J., Singer,A.U., Schmitges,F.W., Jaynes,P., Kit Leng Lui,S., Polyak,M.J., Fodil,N., Krieger,J.R., Tong,J., Schwerdtfeger,C., Brasher,B.B., Ceccarelli,D.F.J., Moffat,J., Sicheri,F., Moran,M.F., Gros,P., Eichhorn,P.J.A., Lenter,M., Boehmelt,G. and Sidhu,S.S.
    Structural and functional characterization of ubiquitin variant inhibitors of USP15
    Structure (2019) 27, 590-605. PubMed  Europe PubMed DOI  I
  65. Zhao,Y., Wang,Z., Ho,C., Zhang,G. and Li,Q.
    Ubiquitin-specific protease 15 maintains transforming growth factor-beta pathway activity by deubiquitinating TGF-beta receptor I (TBR1) during wound healing
    Am J Pathol (2019) 189, 1351-1362. PubMed  Europe PubMed DOI
    66. 2018
  66. Fielding,A.B., Concannon,M., Darling,S., Rusilowicz-Jones,E.V., Sacco,J.J., Prior,I.A., Clague,M.J., Urbe,S. and Coulson,J.M.
    The deubiquitylase USP15 regulates topoisomerase II alpha to maintain genome integrity
    Oncogene (2018) 37, 2326-2342. PubMed  Europe PubMed DOI
  67. Padmanabhan,A., Candelaria,N., Wong,K.K., Nikolai,B.C., Lonard,D.M., O'Malley,B.W. and Richards,J.S.
    USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells
    Nat Commun (2018) 9, 1270-1270. PubMed  Europe PubMed DOI  PMC  EPMC
  68. Ward,S.J., Gratton,H.E., Indrayudha,P., Michavila,C., Mukhopadhyay,R., Maurer,S.K., Caulton,S.G., Emsley,J. and Dreveny,I.
    The structure of the deubiquitinase USP15 reveals a misaligned catalytic triad and an open ubiquitin-binding channel
    J Biol Chem (2018) 293, 17362-17374. PubMed  Europe PubMed DOI  S
  69. Xu,K., Pei,H., Zhang,Z., Wang,H., Li,L. and Xia,Q.
    Ubiquitin-specific protease 15 promotes tumor cell invasion and proliferation in glioblastoma
    Oncol Lett (2018) 15, 3846-3851. PubMed  Europe PubMed DOI  PMC  EPMC
  70. Yaginuma,Y., Yoshimoto,M. and Tokuda,A.
    USP15 inhibits HPV16 E6 degradation and catalytically inactive USP15 has reduced inhibitory activity
    Acta Virol (2018) 62, 147-156. PubMed  Europe PubMed DOI
    71. 2017
  71. Chou,C.K., Chang,Y.T., Korinek,M., Chen,Y.T., Yang,Y.T., Leu,S., Lin,I.L., Tang,C.J. and Chiu,C.C.
    The regulations of deubiquitinase USP15 and its pathophysiological mechanisms in diseases
    Int J Mol Sci (2017) 18 PubMed  Europe PubMed DOI
  72. Das,T., Park,J.K., Park,J., Kim,E., Rape,M., Kim,E.E. and Song,E.J.
    USP15 regulates dynamic protein-protein interactions of the spliceosome through deubiquitination of PRP31
    Nucleic Acids Res (2017) 45, 4866-4880. PubMed  Europe PubMed DOI
  73. Das,T., Park,J.K., Park,J., Kim,E., Rape,M., Kim,E.E. and Song,E.J.
    USP15 regulates dynamic protein-protein interactions of the spliceosome through deubiquitination of PRP31
    Nucleic Acids Res (2017) 45, 5010-5011. PubMed  Europe PubMed DOI
  74. Fukushima,T., Yoshihara,H., Furuta,H., Hakuno,F., Iemura,S.I., Natsume,T., Nakatsu,Y., Kamata,H., Asano,T., Komada,M. and Takahashi,S.I.
    USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination
    Biochem Biophys Res Commun (2017) 484, 522-528. PubMed  Europe PubMed DOI
  75. Kotani,Y., Morito,D., Sakata,K., Ainuki,S., Sugihara,M., Hatta,T., Iemura,S.I., Takashima,S., Natsume,T. and Nagata,K.
    Alternative exon skipping biases substrate preference of the deubiquitylase USP15 for mysterin/RNF213, the moyamoya disease susceptibility factor
    Sci Rep (2017) 7, 44293-44293. PubMed  Europe PubMed DOI  PMC  EPMC
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