Substrates for peptidase C19.013: ubiquitin-specific peptidase 2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Lys29-linked diubiquitin	P0CG47	1-76	Peptide-Gly76+Lys29-Peptide	P	AB	Leu	Arg	Gly	Gly	Lys	Ile	Gln	Asp	Virdee et al., 2010
Lys6-linked diubiquitin	P0CG47	1-76	Peptide-Gly76+Lys6-Peptide	P	AB	Leu	Arg	Gly	Gly	Lys	Thr	Leu	Thr	Virdee et al., 2010
Lys63-linked diubiquitin	P0CG47	1-76	Peptide-Gly76+Lys63-Peptide	P	AB	Leu	Arg	Gly	Gly	Lys	Glu	Ser	Thr	Virdee et al., 2010
Lys63-linked diubiquitin	P0CG47	1-76	Peptide-Gly76+Lys63-Peptide	P	AB	Leu	Arg	Gly	Gly	Lys	Glu	Ser	Thr	Virdee et al., 2010
polyubiquitinated E3 ubiquitin-protein ligase Mdm2	P0CG47/Q00987	1-76	peptide-Gly76+Lys-peptide	P		Leu	Arg	Gly	Gly	Lys	Xaa	Xaa	Xaa	Yang et al., 2008
polyubiquitinated ETS translocation variant 4	P0CG47/P43268	1-76	peptide-Gly76+Lys-peptide	P		Leu	Arg	Gly	Gly	Lys	Xaa	Xaa	Xaa	Guo & Sharrocks, 2009
polyubiquitinated G1/S-specific cyclin-D1	P0CG47/P24385	1-76	peptide-Gly76+Lys48-peptide	P		Leu	Arg	Gly	Gly	Lys	Gln	Leu	Glu	Shan et al., 2009
ubiquitin-aNH-MHISPPEPESEEEEEHYC (Ub-PESTc)	P0CG47	1-76	peptide-Gly76-Met1-peptide	S		Leu	Arg	Gly	Gly	Met	His	Ile	Ser	Baek et al., 1997
ubiquitin-beta-galactosidase fusion protein	P0CG47	1-76	peptide-Gly76+Met1-peptide	N		Leu	Arg	Gly	Gly	Met	His	Gly	Ser	Baek et al., 1997