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Literature for peptidase C19.013: ubiquitin-specific peptidase 2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, V Review, M Mutation, I Inhibitor, R Splicing. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Fujimoto,M., Iwasaki,T., Hosotani Saito,M., Takahashi,N., Hashimoto,M., Takahashi,E. and Kitamura,H.<br>Suppression of USP2 in mouse skeletal muscle: a model of oxidative stress in muscle tissue<br>Exp Anim (2025) PubMed  Europe PubMed DOI
  2. Gong,Y., Li,R., Zhang,R. and Jia,L.<br>USP2 reversed cisplatin resistance through p53-mediated ferroptosis in NSCLC<br>BMC Med Genomics (2025) 18, 39-39. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Li,X., He,N., Lv,Y., Wang,H., Zhang,M., Zhai,H., Yang,Z., Yang,Y., Guo,D., Cao,Z. and Chen,Y.<br>Broad-spectrum ubiquitin-specific protease inhibition as a mechanism for the cytotoxicity of YM155 in cancers<br>Sci Rep (2025) 15, 11054-11054. PubMed  Europe PubMed DOI  PMC  EPMC  I
  4. Srikanta,S.B., Brown,T.W., Malescot,A., Cloutier,M.E., Zhu,L., Coutanson,C., Malki,M., Storch,K.F., Rungta,R., Cayouette,M., Dkhissi-Benyahya,O. and Cermakian,N.<br>The Deubiquitinase USP2 Modulates Photic Entrainment of the Circadian Clock at the Level of the Suprachiasmatic Nucleus<br>J Neurochem (2025) 169, e70018-e70018. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Yang,S., Xiong,L., Liao,T., Li,L., Li,Y., Kang,L., Yang,G. and Liang,Z.<br>Deubiquitinating enzyme USP2 alleviates muscle atrophy by stabilizing PPARgamma<br>Diabetes (2025) PubMed  Europe PubMed DOI
  6. Zhang,J., Allen,J., Ward,S.J., Dekker,L.V. and Dreveny,I.<br>A versatile fluorescence polarization based deubiquitination assay using an isopeptide bond substrate mimetic (IsoMim)<br>J Biol Chem (2025) , 110342-110342. PubMed  Europe PubMed DOI  I
  7. Zhang,Z., Cao,J., Xing,H., Liu,J., Li,L. and Zhang,Y.<br>USP2-induced upregulation of LEF1 through deubiquitination relieves osteoporosis development by promoting the osteogenic differentiation of bone marrow mesenchymal stem cells<br>J Orthop Surg Res (2025) 20, 430-430. PubMed  Europe PubMed DOI  PMC  EPMC
    8. 2024
  8. Alhasan,B.A., Morozov,A.V., Guzhova,I.V. and Margulis,B.A.<br>The ubiquitin-proteasome system in the regulation of tumor dormancy and recurrence<br>Biochim Biophys Acta Rev Cancer (2024) 1879, 189119-189119. PubMed  Europe PubMed DOI  V
  9. Gao,W., Guo,N., Yan,H., Zhao,S., Sun,Y. and Chen,Z.<br>Mycn ameliorates cardiac hypertrophy-induced heart failure in mice by mediating the USP2/JUP/Akt/beta-catenin cascade<br>BMC Cardiovasc Disord (2024) 24, 82-82. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Keijzer,N., Priyanka,A., Stijf-Bultsma,Y., Fish,A., Gersch,M. and Sixma,T.K.<br>Variety in the USP deubiquitinase catalytic mechanism<br>Life Sci Alliance (2024) 7 PubMed  Europe PubMed DOI  PMC  EPMC
  11. Kitamura,H., Fujimoto,M., Hashimoto,M., Yasui,H. and Inanami,O.<br>USP2 Mitigates Reactive Oxygen Species-Induced Mitochondrial Damage via UCP2 Expression in Myoblasts<br>Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
  12. Liu,X., Zhang,G., Liu,L., Xiong,G., Liu,J. and Wei,W.<br>USP2 Promotes the Proliferation and Inflammation of Fibroblast-Like Synovial Cells in Rheumatoid Arthritis Through Deubiquitination of TRAF2<br>Biochem Genet (2024) PubMed  Europe PubMed DOI
  13. Lu,Y., Sun,Y., Zhang,J., Kong,M., Zhao,Z., Sun,B., Wang,Y., Jiang,Y., Chen,S., Wang,C., Tong,Y., Wen,L., Huang,M., Wu,F. and Zhang,L.<br>The deubiquitinase USP2a promotes tumor immunosuppression by stabilizing immune checkpoint B7-H4 in lung adenocarcinoma harboring EGFR-activating mutants<br>Cancer Lett (2024) 596, 217020-217020. PubMed  Europe PubMed DOI
  14. Son,Y., Su Yang,J., Chul Shin,S., Kyoung Park,S., Kim,Y., Park,J. and Yu,J.<br>Structural optimization and biological evaluation of ML364 based derivatives as USP2a inhibitors<br>Bioorg Chem (2024) 145, 107222-107222. PubMed  Europe PubMed DOI  I
  15. Song,J., Zhang,J., Shi,Y., Gao,Q., Chen,H., Ding,X., Zhao,M., Zhu,C., Liang,L., Sun,X., Zhu,Y., Wang,W., Li,Q. and Di,X.<br>Hypoxia inhibits ferritinophagy-mediated ferroptosis in esophageal squamous cell carcinoma via the USP2-NCOA4 axis<br>Oncogene (2024) 43, 2000-2014. PubMed  Europe PubMed DOI
  16. Tian,Y., Liu,K., Wu,D., Wu,L., Xu,Q., Wei,W., Li,Z., Du,Q. and Bian,J.<br>The discovery of potent USP2/USP8 dual-target inhibitors for the treatment of breast cancer via structure guided optimization of ML364<br>Eur J Med Chem (2024) 268, 116275-116275. PubMed  Europe PubMed DOI  I
  17. Wang,S., Nie,J., Jiang,H., Li,A., Zhong,N., Tong,W., Yao,G., Jiang,A., Xie,X., Zhong,Y., Shu,Z., Liu,J., Yang,F. and Liu,Z.<br>VCP enhances autophagy-related osteosarcoma progression by recruiting USP2 to inhibit ubiquitination and degradation of FASN<br>Cell Death Dis (2024) 15, 788-788. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Xu,F., Xu,X., Deng,H., Yu,Z., Huang,J., Deng,L. and Chao,H.<br>The role of deubiquitinase USP2 in driving bladder cancer progression by stabilizing EZH2 to epigenetically silence SOX1 expression<br>Transl Oncol (2024) 49, 102104-102104. PubMed  Europe PubMed DOI  K
  19. Yang,D., Liu,X., Yang,Y., Long,Y., Nan,D., Shi,B., Wang,J., Yang,M., Cong,H., Xing,L., Zhou,F., Yuan,Q., Ta,N., Zhang,Y., Ma,R., Liu,F. and Liu,S.<br>Pharmacological USP2 targeting suppresses ovarian cancer growth by potentiating apoptosis and ferroptosis<br>Arch Biochem Biophys (2024) 762, 110193-110193. PubMed  Europe PubMed DOI  I
  20. Zhao,Y., Zheng,G., Yang,S., Liu,S., Wu,Y., Miao,Y., Liang,Z., Hua,Y., Zhang,J., Shi,J., Li,D., Cheng,Y., Zhang,Y., Chen,Y., Fan,G. and Ma,C.<br>The plant extract PNS mitigates atherosclerosis via promoting Nrf2-mediated inhibition of ferroptosis through reducing USP2-mediated Keap1 deubiquitination<br>Br J Pharmacol (2024) 181, 4822-4844. PubMed  Europe PubMed DOI
    21. 2023
  21. Dang,F., Bai,L., Dong,J., Hu,X., Wang,J., Paulo,J.A., Xiong,Y., Liang,X., Sun,Y., Chen,Y., Guo,M., Wang,X., Huang,Z., Inuzuka,H., Chen,L., Chu,C., Liu,J., Zhang,T., Rezaeian,A.H., Liu,J., Kaniskan,H.U., Zhong,B., Zhang,J., Letko,M., Jin,J., Lan,K. and Wei,W.<br>USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice<br>Sci Transl Med (2023) 15, eadh7668-eadh7668. PubMed  Europe PubMed DOI  PMC  EPMC  I
  22. Kim,H., Kim,D., Choi,H., Shin,G. and Lee,J.K.<br>Deubiquitinase USP2 stabilizes the MRE11-RAD50-NBS1 complex at DNA double-strand break sites by counteracting the ubiquitination of NBS1<br>J Biol Chem (2023) 299, 102752-102752. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Kuang,Z., Liu,X., Zhang,N., Dong,J., Sun,C., Yin,M., Wang,Y., Liu,L., Xiao,D., Zhou,X., Feng,Y., Song,D. and Deng,H.<br>USP2 promotes tumor immune evasion via deubiquitination and stabilization of PD-L1<br>Cell Death Differ (2023) 30, 2249-2264. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Wei,C., Zhao,X., Zhang,H. and Wang,L.<br>USP2 promotes cell proliferation and metastasis in choroidal melanoma via stabilizing Snail<br>J Cancer Res Clin Oncol (2023) 149, 9263-9276. PubMed  Europe PubMed DOI
  25. Yi,J., Tavana,O., Li,H., Wang,D., Baer,R.J. and Gu,W.<br>Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy<br>Nat Commun (2023) 14, 1941-1941. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Zhang,S., Guo,Y., Zhang,S., Wang,Z., Zhang,Y. and Zuo,S.<br>Targeting the deubiquitinase USP2 for malignant tumor therapy (Review)<br>Oncol Rep (2023) 50 PubMed  Europe PubMed DOI  PMC  EPMC  V
  27. Zhu,H., Zhang,H., Guo,J., Zhang,C., Zhang,Q. and Gao,F.<br>Up-regulated oxidized USP2a can increase Mdm2-p60-p53 to promote cell apoptosis<br>Exp Cell Res (2023) 427, 113597-113597. PubMed  Europe PubMed DOI
    28. 2022
  28. An,R., Wang,P., Guo,H., Liuyu,T., Zhong,B. and Zhang,Z.D.<br>USP2 promotes experimental colitis and bacterial infections by inhibiting the proliferation of myeloid cells and remodeling the extracellular matrix network<br>Cell Insight (2022) 1, 100047-100047. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Hashimoto,M., Fujimoto,M., Konno,K., Lee,M.L., Yamada,Y., Yamashita,K., Toda,C., Tomura,M., Watanabe,M., Inanami,O. and Kitamura,H.<br>Ubiquitin-Specific Protease 2 in the Ventromedial Hypothalamus Modifies Blood Glucose Levels by Controlling Sympathetic Nervous Activation<br>J Neurosci (2022) 42, 4607-4618. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Ke,H.L., Lee,Y.C., Li,W.M., Wang,C.S., Hsu,W.C., Lin,H.H., Lee,Y.A., Jhan,J.H., Li,C.C., Yeh,H.C., Wu,W.J. and Huang,A.M.<br>High Ubiquitin-Specific Protease 2a Expression Level Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma<br>Appl Immunohistochem Mol Morphol (2022) 30, 304-310. PubMed  Europe PubMed DOI
  31. Ullah,S., Junaid,M., Liu,Y., Chen,S., Zhao,Y. and Wadood,A.<br>Validation of catalytic site residues of Ubiquitin Specific Protease 2 (USP2) by molecular dynamic simulation and novel kinetics assay for rational drug design<br>Mol Divers (2022) PubMed  Europe PubMed DOI
  32. Zhu,L., Chen,Z., Guo,T., Chen,W., Zhao,L., Guo,L. and Pan,X.<br>USP2 Inhibits Lung Cancer Pathogenesis by Reducing ARID2 Protein Degradation via Ubiquitination<br>Biomed Res Int (2022) 2022, 1525216-1525216. PubMed  Europe PubMed DOI  PMC  EPMC
    33. 2021
  33. Kitamura,H. and Hashimoto,M.<br>USP2-Related Cellular Signaling and Consequent Pathophysiological Outcomes<br>Int J Mol Sci (2021) 22 PubMed  Europe PubMed DOI  PMC  EPMC  V
  34. Lin,H.C., Kuan,Y., Chu,H.F., Cheng,S.C., Pan,H.C., Chen,W.Y., Sun,C.Y. and Lin,T.H.<br>Disulfiram and 6-Thioguanine synergistically inhibit the enzymatic activities of USP2 and USP21<br>Int J Biol Macromol (2021) 176, 490-497. PubMed  Europe PubMed DOI  I
  35. Nadolny,C., Zhang,X., Chen,Q., Hashmi,S.F., Ali,W., Hemme,C., Ahsan,N., Chen,Y. and Deng,R.<br>Dysregulation and activities of ubiquitin specific peptidase 2b in the pathogenesis of hepatocellular carcinoma<br>Am J Cancer Res (2021) 11, 4746-4767. PubMed  Europe PubMed  PMC  EPMC
  36. Srikanta,S.B., Stojkovic,K. and Cermakian,N.<br>Behavioral phenotyping of mice lacking the deubiquitinase USP2<br>PLoS ONE (2021) 16, e0241403-e0241403. PubMed  Europe PubMed DOI  PMC  EPMC
  37. Xiong,B., Huang,J., Liu,Y., Zou,M., Zhao,Z., Gong,J., Wu,X. and Qiu,C.<br>Ubiquitin-specific protease 2a promotes hepatocellular carcinoma progression via deubiquitination and stabilization of RAB1A<br>Cell Oncol (Dordr) (2021) 44, 329-343. PubMed  Europe PubMed DOI
  38. Xu,D., Wu,J., Chen,J., Jiang,L., Chen,J., Bao,W., Chen,X., Yang,Q., Zhang,X., Yao,L., Su,H. and Liu,J.<br>Cullin 2-RBX1 E3 ligase and USP2 regulate antithrombin ubiquitination and stability<br>FASEB J (2021) 35, e21800-e21800. PubMed  Europe PubMed DOI  K
  39. Xu,Q., Liu,M., Zhang,F., Liu,X., Ling,S., Chen,X., Gu,J., Ou,W., Liu,S. and Liu,N.<br>Ubiquitin-specific protease 2 regulates Ang -induced cardiac fibroblasts activation by up-regulating cyclin D1 and stabilizing beta-catenin in vitro<br>J Cell Mol Med (2021) 25, 1001-1011. PubMed  Europe PubMed DOI
    40. 2020
  40. Gui,W., Shen,S. and Zhuang,Z.<br>Photocaged Cell-Permeable Ubiquitin Probe for Temporal Profiling of Deubiquitinating Enzymes<br>J Am Chem Soc (2020) 142, 19493-19501. PubMed  Europe PubMed DOI
  41. Guo,B., Yu,L., Sun,Y., Yao,N. and Ma,L.<br>Long Non-Coding RNA USP2-AS1 Accelerates Cell Proliferation and Migration in Ovarian Cancer by Sponging miR-520d-3p and Up-Regulating KIAA1522<br>Cancer Manag Res (2020) 12, 10541-10550. PubMed  Europe PubMed DOI  PMC  EPMC  K
  42. Hashimoto,M., Kimura,S., Kanno,C., Yanagawa,Y., Watanabe,T., Okabe,J., Takahashi,E., Nagano,M. and Kitamura,H.<br>Macrophage ubiquitin-specific protease 2 contributes to motility, hyperactivation, capacitation, and in vitro fertilization activity of mouse sperm<br>Cell Mol Life Sci (2020) PubMed  Europe PubMed DOI
  43. Hulse,M., Johnson,S.M., Boyle,S., Caruso,L.B. and Tempera,I.<br>Epstein-Barr virus-encoded latent membrane protein 1 and B-cell growth transformation induces lipogenesis through fatty acid synthase<br>J Virol (2020) PubMed  Europe PubMed DOI
  44. Rasaei,R., Sarodaya,N., Kim,K.S., Ramakrishna,S. and Hong,S.H.<br>Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation<br>Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC  V
  45. Xing,J., Li,P., Hong,J., Wang,M., Liu,Y., Gao,Y., Dong,J., Gu,H. and Li,L.<br>Overexpression of Ubiquitin-Specific Protease 2 (USP2) in the Heart Suppressed Pressure Overload-Induced Cardiac Remodeling<br>Mediators Inflamm (2020) 2020, 4121750-4121750. PubMed  Europe PubMed DOI  PMC  EPMC
    46. 2019
  46. He,J., Lee,H.J., Saha,S., Ruan,D., Guo,H. and Chan,C.H.<br>Inhibition of USP2 eliminates cancer stem cells and enhances TNBC responsiveness to chemotherapy<br>Cell Death Dis (2019) 10, 285-285. PubMed  Europe PubMed DOI  PMC  EPMC
  47. Pascoe,N., Seetharaman,A., Teyra,J., Manczyk,N., Satori,M.A., Tjandra,D., Makhnevych,T., Schwerdtfeger,C., Brasher,B.B., Moffat,J., Costanzo,M., Boone,C., Sicheri,F. and Sidhu,S.S.<br>Yeast two-hybrid analysis for ubiquitin variant inhibitors of human deubiquitinases<br>J Mol Biol (2019) 431, 1160-1171. PubMed  Europe PubMed DOI
  48. Vamisetti,G.B., Meledin,R., Gopinath,P. and Brik,A.<br>Halogen substituents in the isoquinoline scaffold switches the selectivity of inhibition between USP2 and USP7<br>Chembiochem (2019) 20, 282-286. PubMed  Europe PubMed DOI  I
    49. 2018
  49. Chuang,S.J., Cheng,S.C., Tang,H.C., Sun,C.Y. and Chou,C.Y.<br>6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2<br>Sci Rep (2018) 8, 3102-3102. PubMed  Europe PubMed DOI  PMC  EPMC  I
  50. Kim,J., Alavi Naini,F., Sun,Y. and Ma,L.<br>Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes beta-catenin<br>Am J Cancer Res (2018) 8, 1823-1836. PubMed  Europe PubMed  PMC  EPMC
  51. Tomala,M.D., Magiera-Mularz,K., Kubica,K., Krzanik,S., Zieba,B., Musielak,B., Pustula,M., Popowicz,G.M., Sattler,M., Dubin,G., Skalniak,L. and Holak,T.A.<br>Identification of small-molecule inhibitors of USP2a<br>Eur J Med Chem (2018) 150, 261-267. PubMed  Europe PubMed DOI  I
    52. 2017
  52. Magiera,K., Tomala,M., Kubica,K., De Cesare,V., Trost,M., Zieba,B.J., Kachamakova-Trojanowska,N., Les,M., Dubin,G., Holak,T.A. and Skalniak,L.<br>Lithocholic acid hydroxyamide destabilizes cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a<br>Cell Chem Biol (2017) 24, 458-470. PubMed  Europe PubMed DOI  I
  53. Shin,Y.C., Chen,J.H. and Chang,S.C.<br>The molecular determinants for distinguishing between ubiquitin and NEDD8 by USP2<br>Sci Rep (2017) 7, 2304-2304. PubMed  Europe PubMed DOI  PMC  EPMC
  54. Wang,Z., Xie,W., Zhu,M. and Zhou,H.<br>Development of a highly reliable assay for ubiquitin-specific protease 2 inhibitors<br>Bioorg Med Chem Lett (2017) 27, 4015-4018. PubMed  Europe PubMed DOI  A  I
  55. Wei,T., Folkersen,L., Biskup,E., Xu,N., Manfe,V., Niazi,O. and Gniadecki,R.<br>Ubiquitin-specific peptidase 2 as a potential link between microRNA-125b and psoriasis<br>Br J Dermatol (2017) 176, 723-731. PubMed  Europe PubMed DOI
  56. Zhu,H.Q. and Gao,F.H.<br>The molecular mechanisms of regulation on USP2's alternative splicing and the significance of its products<br>Int J Biol Sci (2017) 13, 1489-1496. PubMed  Europe PubMed DOI  PMC  EPMC  M
    57. 2016
  57. Davis,M.I., Pragani,R., Fox,J.T., Shen,M., Parmar,K., Gaudiano,E.F., Liu,L., Tanega,C., McGee,L., Hall,M.D., McKnight,C., Shinn,P., Nelson,H., Chattopadhyay,D., D'Andrea,A.D., Auld,D.S., DeLucas,L.J., Li,Z., Boxer,M.B. and Simeonov,A.<br>Small molecule inhibition of the ubiquitin-specific protease USP2 accelerates cyclin D1 degradation and leads to cell cycle arrest in colorectal cancer and mantle cell lymphoma models<br>J Biol Chem (2016) 291, 24628-24640. PubMed  Europe PubMed DOI  I
  58. Leung,I., Dekel,A., Shifman,J.M. and Sidhu,S.S.<br>Saturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21<br>Proc Natl Acad Sci U S A (2016) 113, 8705-8710. PubMed  Europe PubMed DOI
    59. 2015
  59. Nepal,S., Shrestha,A. and Park,P.H.<br>Ubiquitin specific protease 2 acts as a key modulator for the regulation of cell cycle by adiponectin and leptin in cancer cells<br>Mol Cell Endocrinol (2015) 412, 44-55. PubMed  Europe PubMed DOI
  60. Qu,Q., Mao,Y., Xiao,G., Fei,X., Wang,J., Zhang,Y., Liu,J., Cheng,G., Chen,X., Wang,J. and Shen,K.<br>USP2 promotes cell migration and invasion in triple negative breast cancer cell lines<br>Tumour Biol (2015) 36, 5415-5423. PubMed  Europe PubMed DOI
  61. Reglinski,K., Keil,M., Altendorf,S., Waithe,D., Eggeling,C., Schliebs,W. and Erdmann,R.<br>Peroxisomal import reduces the proapoptotic activity of deubiquitinating enzyme USP2<br>PLoS ONE (2015) 10, e0140685-e0140685. PubMed  Europe PubMed DOI  PMC  EPMC  R
  62. Rougier,J.S., Albesa,M., Syam,N., Halet,G., Abriel,H. and Viard,P.<br>Ubiquitin-specific protease USP2-45 acts as a molecular switch to promote alpha2delta-1-induced downregulation of Ca v1.2 channels<br>Pflugers Arch (2015) 467, 1919-1929. PubMed  Europe PubMed DOI
    63. 2014
  63. Wang,C.L., Wang,J.Y., Liu,Z.Y., Ma,X.M., Wang,X.W., Jin,H., Zhang,X.P., Fu,D., Hou,L.J. and Lu,Y.C.<br>Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma<br>Carcinogenesis (2014) 35, 1500-1509. PubMed  Europe PubMed DOI
  64. Yang,Y., Duguay,D., Fahrenkrug,J., Cermakian,N. and Wing,S.S.<br>USP2 regulates the intracellular localization of PER1 and circadian gene expression<br>J Biol Rhythms (2014) 29, 243-256. PubMed  Europe PubMed DOI
  65. Zhang,L., Zhao,X., Zhang,M., Zhao,W. and Gao,C.<br>Ubiquitin-specific protease 2b negatively regulates IFN-beta production and antiviral activity by targeting TANK-binding kinase 1<br>J Immunol (2014) 193, 2230-2237. PubMed  Europe PubMed DOI
    66. 2013
  66. Faresse,N., Debonneville,A. and Staub,O.<br>USP2-45 represses aldosterone mediated responses by decreasing mineralocorticoid receptor availability<br>Cell Physiol Biochem (2013) 31, 462-472. PubMed  Europe PubMed DOI
  67. He,X., Li,Y., Li,C., Liu,L.J., Zhang,X.D., Liu,Y. and Shu,H.B.<br>USP2a negatively regulates IL-1beta- and virus-induced NF-kappaB activation by deubiquitinating TRAF6<br>J Mol Cell Biol (2013) 5, 39-47. PubMed  Europe PubMed DOI
  68. Li,Y., He,X., Wang,S., Shu,H.B. and Liu,Y.<br>USP2a positively regulates TCR-induced NF-kappaB activation by bridging MALT1-TRAF6<br>Protein Cell (2013) 4, 62-70. PubMed  Europe PubMed DOI
  69. Liu,Z., Zanata,S.M., Kim,J., Peterson,M.A., Di Vizio,D., Chirieac,L.R., Pyne,S., Agostini,M., Freeman,M.R. and Loda,M.<br>The ubiquitin-specific protease USP2a prevents endocytosis-mediated EGFR degradation<br>Oncogene (2013) 32, 1660-1669. PubMed  Europe PubMed DOI
  70. Pouly,D., Debonneville,A., Ruffieux-Daidie,D., Maillard,M., Abriel,H., Loffing,J. and Staub,O.<br>Mice carrying ubiquitin-specific protease 2 (Usp2) gene inactivation maintain normal sodium balance and blood pressure<br>Am J Physiol Renal Physiol (2013) 305, F21-F30. PubMed  Europe PubMed DOI  K
    71. 2012
  71. Bozza,W.P., Liang,Q., Gong,P. and Zhuang,Z.<br>Transient kinetic analysis of USP2-catalyzed deubiquitination reveals a conformational rearrangement in the K48-linked diubiquitin substrate<br>Biochemistry (2012) 51, 10075-10086. PubMed  Europe PubMed DOI
  72. Finck,B.N.<br>A sweet new role for ubiquitin-specific protease 2 in controlling hepatic gluconeogenesis<br>Diabetes (2012) 61, 993-994. PubMed  Europe PubMed DOI
  73. Issaenko,O.A. and Amerik,A.Y.<br>Chalcone-based small-molecule inhibitors attenuate malignant phenotype via targeting deubiquitinating enzymes<br>Cell Cycle (2012) 11, 1804-1817. PubMed  Europe PubMed DOI  I
  74. Kim,J., Kim,W.J., Liu,Z., Loda,M.F. and Freeman,M.R.<br>The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer<br>Cell Cycle (2012) 11, 1123-1130. PubMed  Europe PubMed DOI
  75. Mahul-Mellier,A.L., Pazarentzos,E., Datler,C., Iwasawa,R., Abuali,G., Lin,B. and Grimm,S.<br>De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF<br>Cell Death Differ (2012) 19, 891-899. PubMed  Europe PubMed DOI
  76. Mahul-Mellier,A.L., Datler,C., Pazarentzos,E., Lin,B., Chaisaklert,W., Abuali,G. and Grimm,S.<br>De-ubiquitinating proteases USP2a and USP2c cause apoptosis by stabilising RIP1<br>Biochim Biophys Acta (2012) 1823, 1353-1365. PubMed  Europe PubMed DOI
  77. Molusky,M.M., Li,S., Ma,D., Yu,L. and Lin,J.D.<br>Ubiquitin-specific protease 2 regulates hepatic gluconeogenesis and diurnal glucose metabolism through 11beta-hydroxysteroid dehydrogenase 1<br>Diabetes (2012) 61, 1025-1035. PubMed  Europe PubMed DOI
  78. Molusky,M.M., Ma,D., Buelow,K., Yin,L. and Lin,J.D.<br>Peroxisomal localization and circadian regulation of ubiquitin-specific protease 2<br>PLoS ONE (2012) 7, e47970-e47970. PubMed  Europe PubMed DOI  PMC  EPMC
  79. Renatus,M. and Hassiepen,U.<br>Ubiquitin specific protease 2<br>[ISSN:978-0-12-407743-0] (2012) 3, 2066-2069. DOI
  80. Tong,X., Buelow,K., Guha,A., Rausch,R. and Yin,L.<br>USP2a protein deubiquitinates and stabilizes the circadian protein CRY1 in response to inflammatory signals<br>J Biol Chem (2012) 287, 25280-25291. PubMed  Europe PubMed DOI
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