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Literature for peptidase C19.013: ubiquitin-specific peptidase 2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, V Review, M Mutation, I Inhibitor, R Splicing. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Gong,Y., Li,R., Zhang,R. and Jia,L.
    USP2 reversed cisplatin resistance through p53-mediated ferroptosis in NSCLC
    BMC Med Genomics18, 39-39. PubMed  Europe PubMed DOI
  2. Srikanta,S.B., Brown,T.W., Malescot,A., Cloutier,M.E., Zhu,L., Coutanson,C., Malki,M., Storch,K.F., Rungta,R., Cayouette,M., Dkhissi-Benyahya,O. and Cermakian,N.
    The Deubiquitinase USP2 Modulates Photic Entrainment of the Circadian Clock at the Level of the Suprachiasmatic Nucleus
    J Neurochem169, e70018-e70018. PubMed  Europe PubMed DOI
  3. Yang,S., Xiong,L., Liao,T., Li,L., Li,Y., Kang,L., Yang,G. and Liang,Z.
    Deubiquitinating enzyme USP2 alleviates muscle atrophy by stabilizing PPARgamma
    Diabetes PubMed  Europe PubMed DOI
  4. Zhang,Z., Cao,J., Xing,H., Liu,J., Li,L. and Zhang,Y.
    USP2-induced upregulation of LEF1 through deubiquitination relieves osteoporosis development by promoting the osteogenic differentiation of bone marrow mesenchymal stem cells
    J Orthop Surg Res20, 430-430. PubMed  Europe PubMed DOI
    5. 2024
  5. Alhasan,B.A., Morozov,A.V., Guzhova,I.V. and Margulis,B.A.
    The ubiquitin-proteasome system in the regulation of tumor dormancy and recurrence
    Biochim Biophys Acta Rev Cancer1879, 189119-189119. PubMed  Europe PubMed DOI  V
  6. Gao,W., Guo,N., Yan,H., Zhao,S., Sun,Y. and Chen,Z.
    Mycn ameliorates cardiac hypertrophy-induced heart failure in mice by mediating the USP2/JUP/Akt/beta-catenin cascade
    BMC Cardiovasc Disord24, 82-82. PubMed  Europe PubMed DOI
  7. Keijzer,N., Priyanka,A., Stijf-Bultsma,Y., Fish,A., Gersch,M. and Sixma,T.K.
    Variety in the USP deubiquitinase catalytic mechanism
    Life Sci Alliance7, PubMed  Europe PubMed DOI
  8. Kitamura,H., Fujimoto,M., Hashimoto,M., Yasui,H. and Inanami,O.
    USP2 Mitigates Reactive Oxygen Species-Induced Mitochondrial Damage via UCP2 Expression in Myoblasts
    Int J Mol Sci25, PubMed  Europe PubMed DOI
  9. Liu,X., Zhang,G., Liu,L., Xiong,G., Liu,J. and Wei,W.
    USP2 Promotes the Proliferation and Inflammation of Fibroblast-Like Synovial Cells in Rheumatoid Arthritis Through Deubiquitination of TRAF2
    Biochem Genet PubMed  Europe PubMed DOI
  10. Lu,Y., Sun,Y., Zhang,J., Kong,M., Zhao,Z., Sun,B., Wang,Y., Jiang,Y., Chen,S., Wang,C., Tong,Y., Wen,L., Huang,M., Wu,F. and Zhang,L.
    The deubiquitinase USP2a promotes tumor immunosuppression by stabilizing immune checkpoint B7-H4 in lung adenocarcinoma harboring EGFR-activating mutants
    Cancer Lett596, 217020-217020. PubMed  Europe PubMed DOI
  11. Son,Y., Su Yang,J., Chul Shin,S., Kyoung Park,S., Kim,Y., Park,J. and Yu,J.
    Structural optimization and biological evaluation of ML364 based derivatives as USP2a inhibitors
    Bioorg Chem145, 107222-107222. PubMed  Europe PubMed DOI  I
  12. Song,J., Zhang,J., Shi,Y., Gao,Q., Chen,H., Ding,X., Zhao,M., Zhu,C., Liang,L., Sun,X., Zhu,Y., Wang,W., Li,Q. and Di,X.
    Hypoxia inhibits ferritinophagy-mediated ferroptosis in esophageal squamous cell carcinoma via the USP2-NCOA4 axis
    Oncogene43, 2000-2014. PubMed  Europe PubMed DOI
  13. Tian,Y., Liu,K., Wu,D., Wu,L., Xu,Q., Wei,W., Li,Z., Du,Q. and Bian,J.
    The discovery of potent USP2/USP8 dual-target inhibitors for the treatment of breast cancer via structure guided optimization of ML364
    Eur J Med Chem268, 116275-116275. PubMed  Europe PubMed DOI  I
  14. Wang,S., Nie,J., Jiang,H., Li,A., Zhong,N., Tong,W., Yao,G., Jiang,A., Xie,X., Zhong,Y., Shu,Z., Liu,J., Yang,F. and Liu,Z.
    VCP enhances autophagy-related osteosarcoma progression by recruiting USP2 to inhibit ubiquitination and degradation of FASN
    Cell Death Dis15, 788-788. PubMed  Europe PubMed DOI
  15. Xu,F., Xu,X., Deng,H., Yu,Z., Huang,J., Deng,L. and Chao,H.
    The role of deubiquitinase USP2 in driving bladder cancer progression by stabilizing EZH2 to epigenetically silence SOX1 expression
    Transl Oncol49, 102104-102104. PubMed  Europe PubMed DOI  K
  16. Yang,D., Liu,X., Yang,Y., Long,Y., Nan,D., Shi,B., Wang,J., Yang,M., Cong,H., Xing,L., Zhou,F., Yuan,Q., Ta,N., Zhang,Y., Ma,R., Liu,F. and Liu,S.
    Pharmacological USP2 targeting suppresses ovarian cancer growth by potentiating apoptosis and ferroptosis
    Arch Biochem Biophys762, 110193-110193. PubMed  Europe PubMed DOI  I
  17. Zhao,Y., Zheng,G., Yang,S., Liu,S., Wu,Y., Miao,Y., Liang,Z., Hua,Y., Zhang,J., Shi,J., Li,D., Cheng,Y., Zhang,Y., Chen,Y., Fan,G. and Ma,C.
    The plant extract PNS mitigates atherosclerosis via promoting Nrf2-mediated inhibition of ferroptosis through reducing USP2-mediated Keap1 deubiquitination
    Br J Pharmacol181, 4822-4844. PubMed  Europe PubMed DOI
    18. 2023
  18. Dang,F., Bai,L., Dong,J., Hu,X., Wang,J., Paulo,J.A., Xiong,Y., Liang,X., Sun,Y., Chen,Y., Guo,M., Wang,X., Huang,Z., Inuzuka,H., Chen,L., Chu,C., Liu,J., Zhang,T., Rezaeian,A.H., Liu,J., Kaniskan,H.U., Zhong,B., Zhang,J., Letko,M., Jin,J., Lan,K. and Wei,W.
    USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice
    Sci Transl Med15, eadh7668-eadh7668. PubMed  Europe PubMed DOI  I
  19. Kim,H., Kim,D., Choi,H., Shin,G. and Lee,J.K.
    Deubiquitinase USP2 stabilizes the MRE11-RAD50-NBS1 complex at DNA double-strand break sites by counteracting the ubiquitination of NBS1
    J Biol Chem299, 102752-102752. PubMed  Europe PubMed DOI
  20. Kuang,Z., Liu,X., Zhang,N., Dong,J., Sun,C., Yin,M., Wang,Y., Liu,L., Xiao,D., Zhou,X., Feng,Y., Song,D. and Deng,H.
    USP2 promotes tumor immune evasion via deubiquitination and stabilization of PD-L1
    Cell Death Differ30, 2249-2264. PubMed  Europe PubMed DOI
  21. Wei,C., Zhao,X., Zhang,H. and Wang,L.
    USP2 promotes cell proliferation and metastasis in choroidal melanoma via stabilizing Snail
    J Cancer Res Clin Oncol149, 9263-9276. PubMed  Europe PubMed DOI
  22. Zhang,S., Guo,Y., Zhang,S., Wang,Z., Zhang,Y. and Zuo,S.
    Targeting the deubiquitinase USP2 for malignant tumor therapy (Review)
    Oncol Rep50, PubMed  Europe PubMed DOI  V
  23. Zhu,H., Zhang,H., Guo,J., Zhang,C., Zhang,Q. and Gao,F.
    Up-regulated oxidized USP2a can increase Mdm2-p60-p53 to promote cell apoptosis
    Exp Cell Res427, 113597-113597. PubMed  Europe PubMed DOI
    24. 2022
  24. An,R., Wang,P., Guo,H., Liuyu,T., Zhong,B. and Zhang,Z.D.
    USP2 promotes experimental colitis and bacterial infections by inhibiting the proliferation of myeloid cells and remodeling the extracellular matrix network
    Cell Insight1, 100047-100047. PubMed  Europe PubMed DOI
  25. Hashimoto,M., Fujimoto,M., Konno,K., Lee,M.L., Yamada,Y., Yamashita,K., Toda,C., Tomura,M., Watanabe,M., Inanami,O. and Kitamura,H.
    Ubiquitin-Specific Protease 2 in the Ventromedial Hypothalamus Modifies Blood Glucose Levels by Controlling Sympathetic Nervous Activation
    J Neurosci42, 4607-4618. PubMed  Europe PubMed DOI
  26. Ke,H.L., Lee,Y.C., Li,W.M., Wang,C.S., Hsu,W.C., Lin,H.H., Lee,Y.A., Jhan,J.H., Li,C.C., Yeh,H.C., Wu,W.J. and Huang,A.M.
    High Ubiquitin-Specific Protease 2a Expression Level Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma
    Appl Immunohistochem Mol Morphol30, 304-310. PubMed  Europe PubMed DOI
  27. Ullah,S., Junaid,M., Liu,Y., Chen,S., Zhao,Y. and Wadood,A.
    Validation of catalytic site residues of Ubiquitin Specific Protease 2 (USP2) by molecular dynamic simulation and novel kinetics assay for rational drug design
    Mol Divers PubMed  Europe PubMed DOI
  28. Zhu,L., Chen,Z., Guo,T., Chen,W., Zhao,L., Guo,L. and Pan,X.
    USP2 Inhibits Lung Cancer Pathogenesis by Reducing ARID2 Protein Degradation via Ubiquitination
    Biomed Res Int2022, 1525216-1525216. PubMed  Europe PubMed DOI
    29. 2021
  29. Kitamura,H. and Hashimoto,M.
    USP2-Related Cellular Signaling and Consequent Pathophysiological Outcomes
    Int J Mol Sci22, PubMed  Europe PubMed DOI  V
  30. Lin,H.C., Kuan,Y., Chu,H.F., Cheng,S.C., Pan,H.C., Chen,W.Y., Sun,C.Y. and Lin,T.H.
    Disulfiram and 6-Thioguanine synergistically inhibit the enzymatic activities of USP2 and USP21
    Int J Biol Macromol176, 490-497. PubMed  Europe PubMed DOI  I
  31. Nadolny,C., Zhang,X., Chen,Q., Hashmi,S.F., Ali,W., Hemme,C., Ahsan,N., Chen,Y. and Deng,R.
    Dysregulation and activities of ubiquitin specific peptidase 2b in the pathogenesis of hepatocellular carcinoma
    Am J Cancer Res11, 4746-4767. PubMed  Europe PubMed
  32. Srikanta,S.B., Stojkovic,K. and Cermakian,N.
    Behavioral phenotyping of mice lacking the deubiquitinase USP2
    PLoS ONE16, e0241403-e0241403. PubMed  Europe PubMed DOI
  33. Xiong,B., Huang,J., Liu,Y., Zou,M., Zhao,Z., Gong,J., Wu,X. and Qiu,C.
    Ubiquitin-specific protease 2a promotes hepatocellular carcinoma progression via deubiquitination and stabilization of RAB1A
    Cell Oncol (Dordr)44, 329-343. PubMed  Europe PubMed DOI
  34. Xu,Q., Liu,M., Zhang,F., Liu,X., Ling,S., Chen,X., Gu,J., Ou,W., Liu,S. and Liu,N.
    Ubiquitin-specific protease 2 regulates Ang -induced cardiac fibroblasts activation by up-regulating cyclin D1 and stabilizing beta-catenin in vitro
    J Cell Mol Med25, 1001-1011. PubMed  Europe PubMed DOI
    35. 2020
  35. Gui,W., Shen,S. and Zhuang,Z.
    Photocaged Cell-Permeable Ubiquitin Probe for Temporal Profiling of Deubiquitinating Enzymes
    J Am Chem Soc142, 19493-19501. PubMed  Europe PubMed DOI
  36. Guo,B., Yu,L., Sun,Y., Yao,N. and Ma,L.
    Long Non-Coding RNA USP2-AS1 Accelerates Cell Proliferation and Migration in Ovarian Cancer by Sponging miR-520d-3p and Up-Regulating KIAA1522
    Cancer Manag Res12, 10541-10550. PubMed  Europe PubMed DOI  K
  37. Hashimoto,M., Kimura,S., Kanno,C., Yanagawa,Y., Watanabe,T., Okabe,J., Takahashi,E., Nagano,M. and Kitamura,H.
    Macrophage ubiquitin-specific protease 2 contributes to motility, hyperactivation, capacitation, and in vitro fertilization activity of mouse sperm
    Cell Mol Life Sci PubMed  Europe PubMed DOI
  38. Hulse,M., Johnson,S.M., Boyle,S., Caruso,L.B. and Tempera,I.
    Epstein-Barr virus-encoded latent membrane protein 1 and B-cell growth transformation induces lipogenesis through fatty acid synthase
    J Virol PubMed  Europe PubMed DOI
  39. Rasaei,R., Sarodaya,N., Kim,K.S., Ramakrishna,S. and Hong,S.H.
    Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation
    Int J Mol Sci21, PubMed  Europe PubMed DOI  V
  40. Xing,J., Li,P., Hong,J., Wang,M., Liu,Y., Gao,Y., Dong,J., Gu,H. and Li,L.
    Overexpression of Ubiquitin-Specific Protease 2 (USP2) in the Heart Suppressed Pressure Overload-Induced Cardiac Remodeling
    Mediators Inflamm2020, 4121750-4121750. PubMed  Europe PubMed DOI
    41. 2019
  41. He,J., Lee,H.J., Saha,S., Ruan,D., Guo,H. and Chan,C.H.
    Inhibition of USP2 eliminates cancer stem cells and enhances TNBC responsiveness to chemotherapy
    Cell Death Dis10, 285-285. PubMed  Europe PubMed DOI
  42. Pascoe,N., Seetharaman,A., Teyra,J., Manczyk,N., Satori,M.A., Tjandra,D., Makhnevych,T., Schwerdtfeger,C., Brasher,B.B., Moffat,J., Costanzo,M., Boone,C., Sicheri,F. and Sidhu,S.S.
    Yeast two-hybrid analysis for ubiquitin variant inhibitors of human deubiquitinases
    J Mol Biol431, 1160-1171. PubMed  Europe PubMed DOI
  43. Vamisetti,G.B., Meledin,R., Gopinath,P. and Brik,A.
    Halogen substituents in the isoquinoline scaffold switches the selectivity of inhibition between USP2 and USP7
    Chembiochem20, 282-286. PubMed  Europe PubMed DOI  I
    44. 2018
  44. Chuang,S.J., Cheng,S.C., Tang,H.C., Sun,C.Y. and Chou,C.Y.
    6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2
    Sci Rep8, 3102-3102. PubMed  Europe PubMed DOI  I
  45. Kim,J., Alavi Naini,F., Sun,Y. and Ma,L.
    Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes beta-catenin
    Am J Cancer Res8, 1823-1836. PubMed  Europe PubMed
  46. Tomala,M.D., Magiera-Mularz,K., Kubica,K., Krzanik,S., Zieba,B., Musielak,B., Pustula,M., Popowicz,G.M., Sattler,M., Dubin,G., Skalniak,L. and Holak,T.A.
    Identification of small-molecule inhibitors of USP2a
    Eur J Med Chem150, 261-267. PubMed  Europe PubMed DOI  I
    47. 2017
  47. Magiera,K., Tomala,M., Kubica,K., De Cesare,V., Trost,M., Zieba,B.J., Kachamakova-Trojanowska,N., Les,M., Dubin,G., Holak,T.A. and Skalniak,L.
    Lithocholic acid hydroxyamide destabilizes cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a
    Cell Chem Biol24, 458-470. PubMed  Europe PubMed DOI  I
  48. Shin,Y.C., Chen,J.H. and Chang,S.C.
    The molecular determinants for distinguishing between ubiquitin and NEDD8 by USP2
    Sci Rep7, 2304-2304. PubMed  Europe PubMed DOI
  49. Wang,Z., Xie,W., Zhu,M. and Zhou,H.
    Development of a highly reliable assay for ubiquitin-specific protease 2 inhibitors
    Bioorg Med Chem Lett27, 4015-4018. PubMed  Europe PubMed DOI  A  I
  50. Wei,T., Folkersen,L., Biskup,E., Xu,N., Manfe,V., Niazi,O. and Gniadecki,R.
    Ubiquitin-specific peptidase 2 as a potential link between microRNA-125b and psoriasis
    Br J Dermatol176, 723-731. PubMed  Europe PubMed DOI
  51. Zhu,H.Q. and Gao,F.H.
    The molecular mechanisms of regulation on USP2's alternative splicing and the significance of its products
    Int J Biol Sci13, 1489-1496. PubMed  Europe PubMed DOI  M
    52. 2016
  52. Davis,M.I., Pragani,R., Fox,J.T., Shen,M., Parmar,K., Gaudiano,E.F., Liu,L., Tanega,C., McGee,L., Hall,M.D., McKnight,C., Shinn,P., Nelson,H., Chattopadhyay,D., D'Andrea,A.D., Auld,D.S., DeLucas,L.J., Li,Z., Boxer,M.B. and Simeonov,A.
    Small molecule inhibition of the ubiquitin-specific protease USP2 accelerates cyclin D1 degradation and leads to cell cycle arrest in colorectal cancer and mantle cell lymphoma models
    J Biol Chem291, 24628-24640. PubMed  Europe PubMed DOI  I
  53. Leung,I., Dekel,A., Shifman,J.M. and Sidhu,S.S.
    Saturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21
    Proc Natl Acad Sci U S A113, 8705-8710. PubMed  Europe PubMed DOI
    54. 2015
  54. Nepal,S., Shrestha,A. and Park,P.H.
    Ubiquitin specific protease 2 acts as a key modulator for the regulation of cell cycle by adiponectin and leptin in cancer cells
    Mol Cell Endocrinol412, 44-55. PubMed  Europe PubMed DOI
  55. Qu,Q., Mao,Y., Xiao,G., Fei,X., Wang,J., Zhang,Y., Liu,J., Cheng,G., Chen,X., Wang,J. and Shen,K.
    USP2 promotes cell migration and invasion in triple negative breast cancer cell lines
    Tumour Biol36, 5415-5423. PubMed  Europe PubMed DOI
  56. Reglinski,K., Keil,M., Altendorf,S., Waithe,D., Eggeling,C., Schliebs,W. and Erdmann,R.
    Peroxisomal import reduces the proapoptotic activity of deubiquitinating enzyme USP2
    PLoS ONE10, e0140685-e0140685. PubMed  Europe PubMed DOI  R
  57. Rougier,J.S., Albesa,M., Syam,N., Halet,G., Abriel,H. and Viard,P.
    Ubiquitin-specific protease USP2-45 acts as a molecular switch to promote alpha2delta-1-induced downregulation of Ca v1.2 channels
    Pflugers Arch467, 1919-1929. PubMed  Europe PubMed DOI
    58. 2014
  58. Wang,C.L., Wang,J.Y., Liu,Z.Y., Ma,X.M., Wang,X.W., Jin,H., Zhang,X.P., Fu,D., Hou,L.J. and Lu,Y.C.
    Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma
    Carcinogenesis35, 1500-1509. PubMed  Europe PubMed DOI
  59. Yang,Y., Duguay,D., Fahrenkrug,J., Cermakian,N. and Wing,S.S.
    USP2 regulates the intracellular localization of PER1 and circadian gene expression
    J Biol Rhythms29, 243-256. PubMed  Europe PubMed DOI
  60. Zhang,L., Zhao,X., Zhang,M., Zhao,W. and Gao,C.
    Ubiquitin-specific protease 2b negatively regulates IFN-beta production and antiviral activity by targeting TANK-binding kinase 1
    J Immunol193, 2230-2237. PubMed  Europe PubMed DOI
    61. 2013
  61. Faresse,N., Debonneville,A. and Staub,O.
    USP2-45 represses aldosterone mediated responses by decreasing mineralocorticoid receptor availability
    Cell Physiol Biochem31, 462-472. PubMed  Europe PubMed DOI
  62. He,X., Li,Y., Li,C., Liu,L.J., Zhang,X.D., Liu,Y. and Shu,H.B.
    USP2a negatively regulates IL-1beta- and virus-induced NF-kappaB activation by deubiquitinating TRAF6
    J Mol Cell Biol5, 39-47. PubMed  Europe PubMed DOI
  63. Li,Y., He,X., Wang,S., Shu,H.B. and Liu,Y.
    USP2a positively regulates TCR-induced NF-kappaB activation by bridging MALT1-TRAF6
    Protein Cell4, 62-70. PubMed  Europe PubMed DOI
  64. Liu,Z., Zanata,S.M., Kim,J., Peterson,M.A., Di Vizio,D., Chirieac,L.R., Pyne,S., Agostini,M., Freeman,M.R. and Loda,M.
    The ubiquitin-specific protease USP2a prevents endocytosis-mediated EGFR degradation
    Oncogene32, 1660-1669. PubMed  Europe PubMed DOI
  65. Pouly,D., Debonneville,A., Ruffieux-Daidie,D., Maillard,M., Abriel,H., Loffing,J. and Staub,O.
    Mice carrying ubiquitin-specific protease 2 (Usp2) gene inactivation maintain normal sodium balance and blood pressure
    Am J Physiol Renal Physiol305, F21-F30. PubMed  Europe PubMed DOI  K
    66. 2012
  66. Bozza,W.P., Liang,Q., Gong,P. and Zhuang,Z.
    Transient kinetic analysis of USP2-catalyzed deubiquitination reveals a conformational rearrangement in the K48-linked diubiquitin substrate
    Biochemistry51, 10075-10086. PubMed  Europe PubMed DOI
  67. Finck,B.N.
    A sweet new role for ubiquitin-specific protease 2 in controlling hepatic gluconeogenesis
    Diabetes61, 993-994. PubMed  Europe PubMed DOI
  68. Issaenko,O.A. and Amerik,A.Y.
    Chalcone-based small-molecule inhibitors attenuate malignant phenotype via targeting deubiquitinating enzymes
    Cell Cycle11, 1804-1817. PubMed  Europe PubMed DOI  I
  69. Kim,J., Kim,W.J., Liu,Z., Loda,M.F. and Freeman,M.R.
    The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer
    Cell Cycle11, 1123-1130. PubMed  Europe PubMed DOI
  70. Mahul-Mellier,A.L., Pazarentzos,E., Datler,C., Iwasawa,R., Abuali,G., Lin,B. and Grimm,S.
    De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF
    Cell Death Differ19, 891-899. PubMed  Europe PubMed DOI
  71. Mahul-Mellier,A.L., Datler,C., Pazarentzos,E., Lin,B., Chaisaklert,W., Abuali,G. and Grimm,S.
    De-ubiquitinating proteases USP2a and USP2c cause apoptosis by stabilising RIP1
    Biochim Biophys Acta1823, 1353-1365. PubMed  Europe PubMed DOI
  72. Molusky,M.M., Li,S., Ma,D., Yu,L. and Lin,J.D.
    Ubiquitin-specific protease 2 regulates hepatic gluconeogenesis and diurnal glucose metabolism through 11beta-hydroxysteroid dehydrogenase 1
    Diabetes61, 1025-1035. PubMed  Europe PubMed DOI
  73. Molusky,M.M., Ma,D., Buelow,K., Yin,L. and Lin,J.D.
    Peroxisomal localization and circadian regulation of ubiquitin-specific protease 2
    PLoS ONE7, e47970-e47970. PubMed  Europe PubMed DOI
  74. Renatus,M. and Hassiepen,U.
    Ubiquitin specific protease 2
    [ISSN:978-0-12-407743-0]3, 2066-2069. DOI
  75. Tong,X., Buelow,K., Guha,A., Rausch,R. and Yin,L.
    USP2a protein deubiquitinates and stabilizes the circadian protein CRY1 in response to inflammatory signals
    J Biol Chem287, 25280-25291. PubMed  Europe PubMed DOI
  76. Yang,Y., Duguay,D., Bedard,N., Rachalski,A., Baquiran,G., Na,C.H., Fahrenkrug,J., Storch,K.F., Peng,J., Wing,S.S. and Cermakian,N.
    Regulation of behavioral circadian rhythms and clock protein PER1 by the deubiquitinating enzyme USP2
    Biol Open1, 789-801. PubMed  Europe PubMed DOI
    77. 2011
  77. Bedard,N., Yang,Y., Gregory,M., Cyr,D.G., Suzuki,J., Yu,X., Chian,R.C., Hermo,L., O'Flaherty,C., Smith,C.E., Clarke,H.J. and Wing,S.S.
    Mice lacking the USP2 deubiquitinating enzyme have severe male subfertility associated with defects in fertilization and sperm motility
    Biol Reprod85, 594-604. PubMed  Europe PubMed DOI  K
  78. Metzig,M., Nickles,D., Falschlehner,C., Lehmann-Koch,J., Straub,B.K., Roth,W. and Boutros,M.
    An RNAi screen identifies USP2 as a factor required for TNF-alpha-induced NF-kappaB signaling
    Int J Cancer129, 607-618. PubMed  Europe PubMed DOI
  79. Oberfeld,B., Ruffieux-Daidie,D., Vitagliano,J.J., Pos,K.M., Verrey,F. and Staub,O.
    Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2
    Am J Physiol Renal Physiol301, F189-F196. PubMed  Europe PubMed DOI
  80. Oh,K.H., Yang,S.W., Park,J.M., Seol,J.H., Iemura,S., Natsume,T., Murata,S., Tanaka,K., Jeon,Y.J. and Chung,C.H.
    Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme
    Cell Death Differ18, 1326-1336. PubMed  Europe PubMed DOI
  81. Ruffieux-Daidie,D. and Staub,O.
    Intracellular ubiquitylation of the epithelial Na+ channel controls extracellular proteolytic channel activation via conformational change
    J Biol Chem286, 2416-2424. PubMed  Europe PubMed DOI
  82. Scoma,H.D., Humby,M., Yadav,G., Zhang,Q., Fogerty,J. and Besharse,J.C.
    The de-ubiquitinylating enzyme, USP2, is associated with the circadian clockwork and regulates its sensitivity to light
    PLoS ONE6, e25382-e25382. PubMed  Europe PubMed DOI  K
  83. Shi,Y., Solomon,L.R., Pereda-Lopez,A., Giranda,V.L., Luo,Y., Johnson,E.F., Shoemaker,A.R., Leverson,J. and Liu,X.
    Ubiquitin-specific cysteine protease 2a (USP2a) regulates the stability of Aurora-A
    J Biol Chem286, 38960-38968. PubMed  Europe PubMed DOI
  84. Zhang,W., Sulea,T., Tao,L., Cui,Q., Purisima,E.O., Vongsamphanh,R., Lachance,P., Lytvyn,V., Qi,H., Li,Y. and Menard,R.
    Contribution of active site residues to substrate hydrolysis by USP2: insights into catalysis by ubiquitin specific proteases
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