Substrates for peptidase C14.026: paracaspase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Ac-Ala-Leu-Val-Ser-Arg-ACC			Ac-Ala-Leu-Val-Ser-Arg+ACC	S		Leu	Arg	Ser	Arg	ACC	-	-	-	Hachmann et al., 2012
Ac-Leu-Arg-Ser-Arg-ACC			Ac-Leu-Arg-Ser-Arg+ACC	S		Leu	Arg	Ser	Arg	ACC	-	-	-	Hachmann et al., 2012
Ac-Leu-Arg-Ser-Arg-AFC			Ac-Leu-Arg-Ser-Arg+AFC	S		Leu	Arg	Ser	Arg	AFC	-	-	-	Hachmann et al., 2012
Ac-Leu-Val-Ser-Arg-ACC			Ac-Leu-Val-Ser-Arg+ACC	S		Leu	Val	Ser	Arg	ACC	-	-	-	Hachmann et al., 2012
B-cell lymphoma/leukemia 10	Q9Z0H7	1-233	peptide-Arg228+Ala-peptide	P	NT	Leu	Arg	Ser	Arg	Ala	Leu	Ser	Arg	Jaworski et al., 2014
B-cell lymphoma/leukemia 10 (Bcl-10)	O95999	1-233	peptide-Arg228+Thr-peptide	P		Leu	Arg	Ser	Arg	Thr	Val	Ser	Arg	Rebeaud et al., 2008
caspase recruitment domain-containing protein 10	Q9BWT7	1-1032	peptide-Arg587+Gly-peptide	P	NT	Leu	Leu	Ala	Arg	Gly	Cys	Gly	Leu	Israel et al., 2021
Leu-Arg-Ser-Arg-AMC			Leu-Arg-Ser-Arg+AMC	S		Leu	Arg	Ser	Arg	AMC	-	-	-	Rebeaud et al., 2008
lIM domain and actin-binding protein 1	Q9UHB6	1-759	peptide-Lys449+Gly-peptide	P	NT	Phe	Lys	Ser	Lys	Gly	Asn	Tyr	Asp	Nie et al., 2015
lIM domain and actin-binding protein 1	Q9UHB6	1-759	peptide-Arg366+Ala-peptide	P	NT	Pro	Asp	Ser	Arg	Ala	Ser	Ser	Leu	Nie et al., 2015
Mitogen-activated protein kinase kinase kinase 14 (NIK)	Q99558	1-947	Peptide-Arg325+Gly-Peptide	P		Cys	Leu	Ser	Arg	Gly	Ala	His	Glu	Hachmann et al., 2012
mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9UDY8	1-824	peptide-Arg149+Ala-peptide	P	MU	Leu	Cys	Cys	Arg	Ala	Thr	Gly	His	Baens et al., 2014
mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9UDY8	2-824	peptide-Arg781+Thr-peptide	P	NT	His	Cys	Ser	Arg	Thr	Pro	Asp	Ala	Ginster et al., 2017
mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog	Q2TBA3	2-832	peptide-Arg789+Thr-peptide	P	NT	His	Cys	Ser	Arg	Thr	Pro	His	Thr	Ginster et al., 2017
nEDD4-binding protein 1	O75113	1-896	peptide-Arg509+Gly-peptide	P	NT	Phe	Val	Ser	Arg	Gly	Ala	Ser	Ser	Yamasoba et al., 2019
ranBP-type and C3HC4-type zinc finger-containing protein 1	Q9BYM8	1-510	peptide-Arg165+Gly-peptide	P	MS	Leu	Gln	Pro	Arg	Gly	Pro	Leu	Glu	Klein et al., 2015
ranBP-type and C3HC4-type zinc finger-containing protein 1	Q9WUB0	1-508	peptide-Arg165+Gly-peptide	P	MS	Leu	Gln	Ser	Arg	Gly	Pro	Leu	Glu	Elton et al., 2016
ribonuclease ZC3H12A (regnase-1)	Q5D1E7	1-596	peptide-Arg111+Gly-peptide	P	NT	Leu	Val	Pro	Arg	Gly	Gly	Ser	Thr	Jeltsch et al., 2014
roquin-1	Q5TC82	1-1133	peptide-Arg510+Gly-peptide	N	MU	Leu	Ile	Pro	Arg	Gly	Thr	Asp	Pro	Jeltsch et al., 2014
roquin-1	Q5TC82	1-1133	peptide-Arg579+Gly-peptide	N	AB	Met	Val	Pro	Arg	Gly	Ser	Gln	Leu	Jeltsch et al., 2014
roquin-1	Q4VGL6	1-1130	peptide-Arg510+Gly-peptide	P	MU	Leu	Ile	Pro	Arg	Gly	Thr	Asp	Pro	Jeltsch et al., 2014
roquin-1	Q4VGL6	1-1130	peptide-Arg579+Gly-peptide	P	MU	Met	Val	Pro	Arg	Gly	Ser	Gln	Leu	Jeltsch et al., 2014
roquin-2	P0C090	1-1187	peptide-Arg509+Gly-peptide	N	NT	Leu	Ile	Pro	Arg	Gly	Thr	Asp	Ser	Jeltsch et al., 2014
roquin-2	Q9HBD1	1-1191	peptide-Arg509+Ser-peptide	P	NT	Leu	Ile	Ser	Arg	Ser	Thr	Asp	Ser	Jeltsch et al., 2014
transcription factor RelB	Q01201	1-579	peptide-Arg85+Gly-peptide	P	MU	Leu	Val	Ser	Arg	Gly	Ala	Ala	Ser	Hailfinger et al., 2011
transcription factor RelB	Q04863	1-558	peptide-Arg64+Gly-peptide	P	NT	Leu	Val	Pro	Arg	Gly	Pro	Ala	Ser	Hailfinger et al., 2011
tumor necrosis factor alpha-induced protein 3 (A20)	P21580	1-790	peptide-Arg439+Gly-peptide	P		Gly	Ala	Ser	Arg	Gly	Glu	Ala	Tyr	Coornaert et al., 2008
Ubiquitin carboxyl-terminal hydrolase CYLD	Q9NQC7	1-956	Peptide-Arg324+Gly-Peptide	P	NT	Phe	Met	Ser	Arg	Gly	Val	Gly	Asp	Hachmann et al., 2012
ubiquitin carboxyl-terminal hydrolase CYLD	Q80TQ2	1-952	peptide-Arg321+Gly-peptide	P	MS	Phe	Met	Ser	Arg	Gly	Val	Gly	Asp	Klei et al., 2016
ubiquitin carboxyl-terminal hydrolase CYLD	Q9NQC7	1-956	peptide-Arg324+Gly-peptide	P	MS	Phe	Met	Ser	Arg	Gly	Val	Gly	Asp	Staal et al., 2011