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Literature for peptidase C14.026: paracaspase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Lan,Y., Ma,J., Chen,H., Lan,C. and Zhao,N.<br>MALT1 inhibition by MIƒ_'2 suppresses epithelialƒ_'toƒ_'mesenchymal transition and fibrosis by inactivating the NFƒ_'kappaB pathway in high glucoseƒ_'treated HKƒ_'2 cells<br>Mol Med Rep (2026) 33 PubMed  Europe PubMed DOI  PMC  EPMC
  2. Li,Y., Hong,Y., Zhang,J. and Xu,S.<br>Targeting paracaspase1 (MALT1) for cancer therapy: Updated progress and study on structure-activity relationships (SARs)<br>Eur J Med Chem (2026) 302, 118372-118372. PubMed  Europe PubMed DOI
    3. 2025
  3. Grass,C., Ober,F., Sixt,C., Moud,B.N., Antoshkina,I., Eberstadt,F., Puhach,A., Avar,G., Kessler,A., O'Neill,T.J., Seeholzer,T., Kranich,J., Brocker,T., Lammens,K., Menden,M.P., Zielinski,C.E. and Krappmann,D.<br>LUBAC modulates CBM complex functions downstream of TRAF6 in T cells<br>Nat Commun (2025) 16, 9899-9899. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Kamel,E.M., Khadrawy,S.M., Allam,A.A., Ahmed,N.A., Alkhayl,F.F.A. and Lamsabhi,A.M.<br>Breaking the oncogenic link: BCL10-MALT1 disruption as a precision strike against NF-kappaB-driven lymphomas<br>Med Oncol (2025) 42, 350-350. PubMed  Europe PubMed DOI
  5. Nie,Z., Trzoss,M., Placzek,A.T., Trzoss,L., Krilov,G., Feng,S., Lawrenz,M., Ye,M., Marshall,N., Dingley,K.H., Pelletier,R.D., Lai,W.G., Bell,J.A., Tang,H., Devine,P., Liu,Z., Skrdla,P., Shimanovich,R., Liu,M., Wang,R., Xu,X., Abel,R., Akinsanya,K. and Yin,W.<br>Accelerated In Silico Discovery of SGR-1505: A Potent MALT1 Allosteric Inhibitor for the Treatment of Mature B-Cell Malignancies<br>J Med Chem (2025) PubMed  Europe PubMed DOI  I
  6. Tao,Y., Tian,C., Qi,S., Jia,Z., Xu,Z., Meng,J., Xu,G., Hu,H., Wang,X., Zhang,T., You,H., Lan,X., Lin,X., Yu,G., Zhou,H., Liu,J. and Zheng,H.<br>Targeting both death and paracaspase domains of MALT1 with antisense oligonucleotides overcomes resistance to immune-checkpoint inhibitors<br>Nat Cancer (2025) PubMed  Europe PubMed DOI
  7. Wang,J., Liao,L., Miao,B., Yang,B., Li,B., Ma,X., Fitz,A., Wu,S., He,J., Zhang,Q., Ji,S., Jin,G., Zhang,J., Cao,Y., Wang,H., Qin,W., Sun,C., Bernards,R. and Wang,C.<br>Deciphering the role of the MALT1-RC3H1 axis in regulating GPX4 protein stability<br>Proc Natl Acad Sci U S A (2025) 122, e2419625121-e2419625121. PubMed  Europe PubMed DOI
  8. Wang,J., Liao,L., Yang,B., Miao,B., Bernards,R., Qin,W., Sun,C. and Wang,C.<br>Reply to Mishima et al.: MALT1 modulates GPX4 expression by regulating its stability<br>Proc Natl Acad Sci U S A (2025) 122, e2508813122-e2508813122. PubMed  Europe PubMed DOI
  9. Zerillo,L., Zotti,T., Tutela,A., Madera,J.R., Grasso,G., Vito,P. and Stilo,R.<br>The CARD14sh-BCL10-MALT1 complex regulates MAVS-mediated antiviral response in keratinocytes<br>Proc Natl Acad Sci U S A (2025) 122, e2500711122-e2500711122. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2024
  10. Abdel-Magid,A.F.<br>The Inhibitors of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 (MALT-1) Protease as Potential Treatment of ABC-DLBCL and Similar Diseases<br>ACS Med Chem Lett (2024) 15, 763-765. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Isay,S.E., Vornholz,L., Schnalzger,T., Groll,T., Magg,T., Loll,P., Weirich,G., Steiger,K., Hauck,F. and Ruland,J.<br>Enforced CARD11/MALT1 signaling in dendritic cells triggers hemophagocytic lymphohistiocytosis<br>Proc Natl Acad Sci U S A (2024) 121, e2413162121-e2413162121. PubMed  Europe PubMed DOI
  12. Kuo,B.J., Lin,S.C., Tu,Y.F., Huang,P.H. and Lo,Y.C.<br>Study of individual domains contributing to MALT1 dimerization in BCL10-independent and dependent assembly<br>Biochem Biophys Res Commun (2024) 717, 150029-150029. PubMed  Europe PubMed DOI
  13. Moud,B.N., Ober,F., O'Neill,T.J. and Krappmann,D.<br>MALT1 substrate cleavage: what is it good for?<br>Front Immunol (2024) 15, 1412347-1412347. PubMed  Europe PubMed DOI  PMC  EPMC
  14. O'Sullivan,P.A., Aidarova,A., Afonina,I., Manils,J., Thurston,T.L.M., Instrell,R., Howell,M., Boeing,S., Ranawana,S., Herpels,M., Chetien,R., Bassa,M., Flynn,H.R., Frith,D., Snijders,A., Howes,A., Beyaert,R., Bowcock,A. and Ley,S.C.<br>CARD14 SIGNALOSOME FORMATION IS ASSOCIATED WITH ITS ENDOSOMAL RELOCATION AND mTORC1-INDUCED KERATINOCYTE PROLIFERATION<br>Biochem J (2024) PubMed  Europe PubMed DOI
  15. Tsubokawa,A., Chihara,K., Chihara,Y., Takeuchi,K., Fujieda,S. and Sada,K.<br>Adaptor protein 3BP2 regulates gene expression in addition to the ubiquitination and proteolytic activity of MALT1 in dectin-1-stimulated cells<br>J Biol Chem (2024) , 107980-107980. PubMed  Europe PubMed DOI
  16. Wallerstein,J., Han,X., Levkovets,M., Lesovoy,D., Malmodin,D., Mirabello,C., Wallner,B., Sun,R., Sandalova,T., Agback,P., Karlsson,G., Achour,A., Agback,T. and Orekhov,V.<br>Insights into mechanisms of MALT1 allostery from NMR and AlphaFold dynamic analyses<br>Commun Biol (2024) 7, 868-868. PubMed  Europe PubMed DOI  PMC  EPMC
    17. 2023
  17. Kowluru,A.<br>Regulatory roles of CARD9-BCL10-Rac1 (CBR) signalome in islet beta-cell function in health and metabolic stress: Is there room for MALT1?<br>Biochem Pharmacol (2023) 218, 115889-115889. PubMed  Europe PubMed DOI  PMC  EPMC  V
  18. Minderman,M., Lantermans,H.C., Gruneberg,L.J., Cillessen,S.A.G.M., Bende,R.J., van Noesel,C.J.M., Kersten,M.J., Pals,S.T. and Spaargaren,M.<br>MALT1-dependent cleavage of CYLD promotes NF-kappaB signaling and growth of aggressive B-cell receptor-dependent lymphomas<br>Blood Cancer J (2023) 13, 37-37. PubMed  Europe PubMed DOI  PMC  EPMC
  19. O'Neill,T.J., Tofaute,M.J. and Krappmann,D.<br>Function and targeting of MALT1 paracaspase in cancer<br>Cancer Treat Rev (2023) 117, 102568-102568. PubMed  Europe PubMed DOI
  20. Peng,Z.M., Zhang,Y.Y., Wei,D., Zhang,X.J., Liu,B., Peng,J. and Luo,X.J.<br>MALT1 promotes necroptosis in stroke rat brain via targeting the A20/RIPK3 pathway<br>Arch Biochem Biophys (2023) 735, 109502-109502. PubMed  Europe PubMed DOI  K
  21. Schmidt,H., Raj,T., O'Neill,T.J., Muschaweckh,A., Giesert,F., Negraschus,A., Hoefig,K.P., Behrens,G., Esser,L., Baumann,C., Feederle,R., Plaza-Sirvent,C., Geerlof,A., Gewies,A., Isay,S.E., Ruland,J., Schmitz,I., Wurst,W., Korn,T., Krappmann,D. and Heissmeyer,V.<br>Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity<br>Proc Natl Acad Sci U S A (2023) 120, e2309205120-e2309205120. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Verhelst,S.H.L. and Prothiwa,M.<br>Chemical Probes for Profiling of MALT1 Protease Activity<br>Chembiochem (2023) 24, e202300444-e202300444. PubMed  Europe PubMed DOI  V
    23. 2022
  23. Bell,P.A., Scheuermann,S., Renner,F., Pan,C.L., Lu,H.Y., Turvey,S.E., Bornancin,F., Regnier,C.H. and Overall,C.M.<br>Integrating knowledge of protein sequence with protein function for the prediction and validation of new MALT1 substrates<br>Comput Struct Biotechnol J (2022) 20, 4717-4732. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Biswas,S., Chalishazar,A., Helou,Y., DiSpirito,J., DeChristopher,B., Chatterjee,D., Merselis,L., Vincent,B., Monroe,J.G., Rabah,D. and Long,A.J.<br>Pharmacological Inhibition of MALT1 Ameliorates Autoimmune Pathogenesis and Can Be Uncoupled From Effects on Regulatory T-Cells<br>Front Immunol (2022) 13, 875320-875320. PubMed  Europe PubMed DOI  PMC  EPMC
  25. Chang,K.S., Tsui,K.H., Hsu,S.Y., Sung,H.C., Lin,Y.H., Hou,C.P., Yang,P.S., Chen,C.L., Feng,T.H. and Juang,H.H.<br>The Antitumor Effect of Caffeic Acid Phenethyl Ester by Downregulating Mucosa-Associated Lymphoid Tissue 1 via AR/p53/NF-kappaB Signaling in Prostate Carcinoma Cells<br>Cancers (Basel) (2022) 14 PubMed  Europe PubMed DOI  PMC  EPMC
  26. Gomez Solsona,B., Schmitt,A., Schulze-Osthoff,K. and Hailfinger,S.<br>The Paracaspase MALT1 in Cancer<br>Biomedicines (2022) 10 PubMed  Europe PubMed DOI  PMC  EPMC  V
  27. Jones,A.N., Grass,C., Meininger,I., Geerlof,A., Klostermann,M., Zarnack,K., Krappmann,D. and Sattler,M.<br>Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of MALT1<br>Sci Adv (2022) 8, eabp9153-eabp9153. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Mempel,T.R. and Krappmann,D.<br>Combining precision oncology and immunotherapy by targeting the MALT1 protease<br>J Immunother Cancer (2022) 10 PubMed  Europe PubMed DOI  PMC  EPMC  V
  29. Sefer,A.P., Abolhassani,H., Ober,F., Kayaoglu,B., Bilgic Eltan,S., Kara,A., Erman,B., Surucu Yilmaz,N., Aydogmus,C., Aydemir,S., Charbonnier,L.M., Kolukisa,B., Azizi,G., Delavari,S., Momen,T., Aliyeva,S., Kendir Demirkol,Y., Tekin,S., Kiykim,A., Baser,O.F., Cokugras,H., Gursel,M., Karakoc-Aydiner,E., Ozen,A., Krappmann,D., Chatila,T.A., Rezaei,N. and Baris,S.<br>Expanding the Clinical and Immunological Phenotypes and Natural History of MALT1 Deficiency<br>J Clin Immunol (2022) PubMed  Europe PubMed DOI
  30. Zhang,Y.Y., Peng,J. and Luo,X.J.<br>Post-translational modification of MALT1 and its role in B cell- and T cell-related diseases<br>Biochem Pharmacol (2022) 198, 114977-114977. PubMed  Europe PubMed DOI  V
    31. 2021
  31. Asaba,K.N., Adachi,Y., Tokumaru,K., Watanabe,A., Goto,Y. and Aoki,T.<br>Structure-activity relationship studies of 3-substituted pyrazoles as novel allosteric inhibitors of MALT1 protease<br>Bioorg Med Chem Lett (2021) 41, 127996-127996. PubMed  Europe PubMed DOI  I
  32. Hailfinger,S. and Schulze-Osthoff,K.<br>The paracaspase MALT1 in psoriasis<br>Biol Chem (2021) PubMed  Europe PubMed DOI  V
  33. Israel,L., Gluck,A., Berger,M., Coral,M., Ceci,M., Unterreiner,A., Rubert,J., Bardet,M., Ginster,S., Golding-Ochsenbein,A.M., Martin,K., Hoyler,T., Calzascia,T., Wieczorek,G., Hillenbrand,R., Ferretti,S., Ferrero,E. and Bornancin,F.<br>CARD10 cleavage by MALT1 restricts lung carcinoma growth in vivo<br>Oncogenesis (2021) 10, 32-32. PubMed  Europe PubMed DOI  PMC  EPMC
  34. Liang,X., Cao,Y., Li,C., Yu,H., Yang,C. and Liu,H.<br>MALT1 as a promising target to treat lymphoma and other diseases related to MALT1 anomalies<br>Med Res Rev (2021) PubMed  Europe PubMed DOI  V
  35. Lu,H.Y. and Turvey,S.E.<br>Human MALT1 deficiency and predisposition to infections<br>Curr Opin Immunol (2021) 72, 1-12. PubMed  Europe PubMed DOI
    36. 2020
  36. Alfano,D.N., Klei,L.R., Klei,H.B., Trotta,M., Gough,P.J., Foley,K.P., Bertin,J., Sumpter,T.L., Lucas,P.C. and McAllister-Lucas,L.M.<br>MALT1 Protease plays a dual role in the allergic response by acting in both mast cells and endothelial cells<br>J Immunol (2020) 204, 2337-2348. PubMed  Europe PubMed DOI
  37. Ashcraft,K.A., Johnson-Pais,T.L., Troyer,D.A., Hernandez,J. and Leach,R.J.<br>A copy number gain on 18q present in primary prostate tumors is associated with metastatic outcome<br>Urol Oncol (2020) PubMed  Europe PubMed DOI
  38. Cheng,J., Klei,L.R., Hubel,N.E., Zhang,M., Schairer,R., Maurer,L.M., Klei,H.B., Kang,H., Concel,V.J., Delekta,P.C., Dang,E.V., Mintz,M.A., Baens,M., Cyster,J.G., Parameswaran,N., Thome,M., Lucas,P.C. and McAllister-Lucas,L.M.<br>GRK2 suppresses lymphomagenesis by inhibiting the MALT1 proto-oncoprotein<br>J Clin Invest (2020) 130, 1036-1051. PubMed  Europe PubMed DOI  I
  39. Dumont,C., Sivars,U., Andreasson,T., Odqvist,L., Mattsson,J., DeMicco,A., Pardali,K., Johansson,G., Yrlid,L., Cox,R.J., Seeliger,F., Larsson,M., Gehrmann,U., Davis,A.M. and Vaarala,O.<br>A MALT1 inhibitor suppresses human myeloid DC, effector T-cell and B-cell responses and retains Th1/regulatory T-cell homeostasis<br>PLoS ONE (2020) 15, e0222548-e0222548. PubMed  Europe PubMed DOI  PMC  EPMC
  40. Flynn,S.M., Chen,C., Artan,M., Barratt,S., Crisp,A., Nelson,G.M., Peak-Chew,S.Y., Begum,F., Skehel,M. and de Bono,M.<br>MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity<br>Nat Commun (2020) 11, 2099-2099. PubMed  Europe PubMed DOI  PMC  EPMC
  41. Hayashi,H., Chiba,T., Mihara-Tomiyama,N., Negishi,T., Kodama,Y., Sakashita,H. and Imai,K.<br>Domain structures of mucosa-associated lymphoid tissue lymphoma translocation 1 protein for nuclear localization in oral carcinoma cells and the proliferation inhibition<br>Biochem Biophys Res Commun (2020) 522, 799-804. PubMed  Europe PubMed DOI
  42. Liu,X., Yue,C., Shi,L., Liu,G., Cao,Q., Shan,Q., Wang,Y., Chen,X., Li,H., Wang,J., Gao,S., Niu,M. and Yu,R.<br>MALT1 is a potential therapeutic target in glioblastoma and plays a crucial role in EGFR-induced NF-kappaB activation<br>J Cell Mol Med (2020) PubMed  Europe PubMed DOI  T  I
  43. Martin,K., Touil,R., Cvijetic,G., Israel,L., Kolb,Y., Sarret,S., Valeaux,S., Degl'Innocenti,E., Le Meur,T., Caesar,N., Bardet,M., Beerli,C., Zerwes,H.G., Kovarik,J., Beltz,K., Schlapbach,A., Quancard,J., Regnier,C.H., Bigaud,M., Junt,T., Wieczorek,G., Isnardi,I., Littlewood-Evans,A., Bornancin,F. and Calzascia,T.<br>Requirement of mucosa-associated lymphoid tissue lymphoma translocation protein 1 protease activity for fcgamma receptor-induced arthritis but not Fcgamma receptor-mediated platelet elimination in mice<br>Arthritis Rheumatol (2020) 72, 919-930. PubMed  Europe PubMed DOI
  44. Nicolau,C.A., Gavard,J. and Bidere,N.<br>TAK1 lessens the activity of the paracaspase MALT1 during T cell receptor signaling<br>Cell Immunol (2020) 353, 104115-104115. PubMed  Europe PubMed DOI
  45. Schairer,R., Hall,G., Zhang,M., Cowan,R., Baravalle,R., Muskett,F.W., Coombs,P.J., Mpamhanga,C., Hale,L.R., Saxty,B., Iwaszkiewicz,J., Decaillet,C., Perroud,M., Carr,M.D. and Thome,M.<br>Allosteric activation of MALT1 by its ubiquitin-binding Ig3 domain<br>Proc Natl Acad Sci U S A (2020) 117, 3093-3102. PubMed  Europe PubMed DOI
  46. van de Plassche,M.A.T., O'Neill,T.J., Seeholzer,T., Turk,B., Krappmann,D. and Verhelst,S.H.L.<br>Use of non-natural amino acids for the design and synthesis of a selective, cell-permeable MALT1 activity-based probe<br>J Med Chem (2020) 63, 3996-4004. PubMed  Europe PubMed DOI  A
  47. Wiegmann,H., Reunert,J., Metze,D., Marquardt,T., Engel,T., Kunde,V., Ehl,S., Foell,D., van den Heuvel,I., Oji,V. and Wittkowski,H.<br>Refining the dermatological spectrum in primary immunodeficiency: mucosa-associated lymphoid tissue lymphoma translocation protein 1 deficiency mimicking Netherton/Omenn syndromes<br>Br J Dermatol (2020) 182, 202-207. PubMed  Europe PubMed DOI  M
  48. Xia,X., Cao,G., Sun,G., Zhu,L., Tian,Y., Song,Y., Guo,C., Wang,X., Zhong,J., Zhou,W., Li,P., Zhang,H., Hao,J., Li,Z., Deng,L., Yin,Z. and Gao,Y.<br>GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis<br>J Clin Invest (2020) 130, 5180-5196. PubMed  Europe PubMed DOI
    49. 2019
  49. Cheng,L., Deng,N., Yang,N., Zhao,X. and Lin,X.<br>Malt1 protease is critical in maintaining function of regulatory T cells and may be a therapeutic target for antitumor immunity<br>J Immunol (2019) 202, 3008-3019. PubMed  Europe PubMed DOI
  50. Demeyer,A., Skordos,I., Driege,Y., Kreike,M., Hochepied,T., Baens,M., Staal,J. and Beyaert,R.<br>MALT1 Proteolytic activity suppresses autoimmunity in a T cell intrinsic manner<br>Front Immunol (2019) 10, 1898-1898. PubMed  Europe PubMed DOI  PMC  EPMC
  51. Demeyer,A., Van Nuffel,E., Baudelet,G., Driege,Y., Kreike,M., Muyllaert,D., Staal,J. and Beyaert,R.<br>MALT1-Deficient mice develop atopic-like dermatitis upon aging<br>Front Immunol (2019) 10, 2330-2330. PubMed  Europe PubMed DOI  PMC  EPMC  K
  52. Feng,J., Yang,W., Wang,J., Pu,Z., Han,Y. and Wan,L.<br>Z-VRPR-FMK can inhibit the growth and invasiveness of diffuse large B-cell lymphoma by depressing NF-kappaB activation and MMP expression induced by MALT1<br>Int J Clin Exp Pathol (2019) 12, 1947-1955. PubMed  Europe PubMed  PMC  EPMC  I
  53. Frizinsky,S., Rechavi,E., Barel,O., Najeeb,R.H., Greenberger,S., Lee,Y.N., Simon,A.J., Lev,A., Ma,C.A., Sun,G., Blackstone,S.A., Milner,J.D., Somech,R. and Stauber,T.<br>Novel MALT1 mutation linked to immunodeficiency, immune dysregulation, and an abnormal T cell receptor repertoire<br>J Clin Immunol (2019) 39, 401-413. PubMed  Europe PubMed DOI  M
  54. Gehring,T., Erdmann,T., Rahm,M., Grass,C., Flatley,A., O'Neill,T.J., Woods,S., Meininger,I., Karayel,O., Kutzner,K., Grau,M., Shinohara,H., Lammens,K., Feederle,R., Hauck,S.M., Lenz,G. and Krappmann,D.<br>MALT1 Phosphorylation controls activation of T lymphocytes and survival of ABC-DLBCL tumor cells<br>Cell Rep (2019) 29, 873-888. PubMed  Europe PubMed DOI
  55. Gilis,E., Gaublomme,D., Staal,J., Venken,K., Dhaenens,M., Lambrecht,S., Coudenys,J., Decruy,T., Schryvers,N., Driege,Y., Dumas,E., Demeyer,A., De Muynck,A., van Hengel,J., Van Hoorebeke,L., Deforce,D., Beyaert,R. and Elewaut,D.<br>Deletion of mucosa-associated lymphoid tissue lymphoma translocation protein 1 in mouse T cells protects against development of autoimmune arthritis but leads to spontaneous osteoporosis<br>Arthritis Rheumatol (2019) 71, 2005-2015. PubMed  Europe PubMed DOI  K
  56. Hatcher,J.M., Du,G., Fontan,L., Us,I., Qiao,Q., Chennamadhavuni,S., Shao,J., Wu,H., Melnick,A., Gray,N.S. and Scott,D.A.<br>Peptide-based covalent inhibitors of MALT1 paracaspase<br>Bioorg Med Chem Lett (2019) 29, 1336-1339. PubMed  Europe PubMed DOI  A  L  I
  57. Jacobs,K.A., Andre-Gregoire,G., Maghe,C., Thys,A., Li,Y., Harford-Wright,E., Trillet,K., Douanne,T., Alves Nicolau,C., Frenel,J.S., Bidere,N. and Gavard,J.<br>Paracaspase MALT1 regulates glioma cell survival by controlling endo-lysosome homeostasis<br>EMBO J (2019) , e102030-e102030. PubMed  Europe PubMed DOI
  58. Lu,T., Connolly,P.J., Philippar,U., Sun,W., Cummings,M.D., Barbay,K., Gys,L., Van Nuffel,L., Austin,N., Bekkers,M., Shen,F., Cai,A., Attar,R., Meerpoel,L. and Edwards,J.<br>Discovery and optimization of a series of small-molecule allosteric inhibitors of MALT1 protease<br>Bioorg Med Chem Lett (2019) 29, 126743-126743. PubMed  Europe PubMed DOI  I
  59. Martin,K., Touil,R., Kolb,Y., Cvijetic,G., Murakami,K., Israel,L., Duraes,F., Buffet,D., Gluck,A., Niwa,S., Bigaud,M., Junt,T., Zamurovic,N., Smith,P., McCoy,K.D., Ohashi,P.S., Bornancin,F. and Calzascia,T.<br>Malt1 Protease deficiency in mice disrupts immune homeostasis at environmental barriers and drives systemic T cell-mediated autoimmunity<br>J Immunol (2019) 203, 2791-2806. PubMed  Europe PubMed DOI
  60. McAuley,J.R., Bailey,K.M., Ekambaram,P., Klei,L.R., Kang,H., Hu,D., Freeman,T.J., Concel,V.J., Hubel,N.E., Lee,J.L., Klei,H.B., Cheng,J., Sekar,P., Bridwell,R.E., Covic,L., Lucas,P.C. and McAllister-Lucas,L.M.<br>MALT1 is a critical mediator of PAR1-driven NF-kappaB activation and metastasis in multiple tumor types<br>Oncogene (2019) 38, 7384-7398. PubMed  Europe PubMed DOI
  61. Monajemi,M., Fisk,S., Pang,Y.C.F., Leung,J., Menzies,S.C., Ben-Othman,R., Cai,B., Kollmann,T.R., Rozmus,J. and Sly,L.M.<br>Malt1 deficient mice develop osteoporosis independent of osteoclast-intrinsic effects of Malt1 deficiency<br>J Leukoc Biol (2019) 106, 863-877. PubMed  Europe PubMed DOI  K
  62. Nakamura,Y., Igaki,K., Komoike,Y., Yokoyama,K. and Tsuchimori,N.<br>Malt1 inactivation attenuates experimental colitis through the regulation of Th17 and Th1/17 cells<br>Inflamm Res (2019) 68, 223-230. PubMed  Europe PubMed DOI  K
  63. Quancard,J., Klein,T., Fung,S.Y., Renatus,M., Hughes,N., Israel,L., Priatel,J.J., Kang,S., Blank,M.A., Viner,R.I., Blank,J., Schlapbach,A., Erbel,P., Kizhakkedathu,J., Villard,F., Hersperger,R., Turvey,S.E., Eder,J., Bornancin,F. and Overall,C.M.<br>An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient<br>Nat Chem Biol (2019) 15, 304-313. PubMed  Europe PubMed DOI  S  I
  64. Rosenbaum,M., Gewies,A., Pechloff,K., Heuser,C., Engleitner,T., Gehring,T., Hartjes,L., Krebs,S., Krappmann,D., Kriegsmann,M., Weichert,W., Rad,R., Kurts,C. and Ruland,J.<br>Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells<br>Nat Commun (2019) 10, 2352-2352. PubMed  Europe PubMed DOI  I
  65. Scott,D.A., Hatcher,J.M., Liu,H., Fu,M., Du,G., Fontan,L., Us,I., Casalena,G., Qiao,Q., Wu,H., Melnick,A. and Gray,N.S.<br>Quinoline and thiazolopyridine allosteric inhibitors of MALT1<br>Bioorg Med Chem Lett (2019) 29, 1694-1698. PubMed  Europe PubMed DOI  I
  66. Spungin,D., Bidle,K.D. and Berman-Frank,I.<br>Metacaspase involvement in programmed cell death of the marine cyanobacterium Trichodesmium<br>Environ Microbiol (2019) 21, 667-681. PubMed  Europe PubMed DOI
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