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Literature for peptidase C14.026: paracaspase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Lan,Y., Ma,J., Chen,H., Lan,C. and Zhao,N.
    MALT1 inhibition by MIƒ_'2 suppresses epithelialƒ_'toƒ_'mesenchymal transition and fibrosis by inactivating the NFƒ_'kappaB pathway in high glucoseƒ_'treated HKƒ_'2 cells
    Mol Med Rep (2026) 33 PubMed  Europe PubMed DOI  PMC  EPMC
  2. Li,Y., Hong,Y., Zhang,J. and Xu,S.
    Targeting paracaspase1 (MALT1) for cancer therapy: Updated progress and study on structure-activity relationships (SARs)
    Eur J Med Chem (2026) 302, 118372-118372. PubMed  Europe PubMed DOI
    3. 2025
  3. Grass,C., Ober,F., Sixt,C., Moud,B.N., Antoshkina,I., Eberstadt,F., Puhach,A., Avar,G., Kessler,A., O'Neill,T.J., Seeholzer,T., Kranich,J., Brocker,T., Lammens,K., Menden,M.P., Zielinski,C.E. and Krappmann,D.
    LUBAC modulates CBM complex functions downstream of TRAF6 in T cells
    Nat Commun (2025) 16, 9899-9899. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Kamel,E.M., Khadrawy,S.M., Allam,A.A., Ahmed,N.A., Alkhayl,F.F.A. and Lamsabhi,A.M.
    Breaking the oncogenic link: BCL10-MALT1 disruption as a precision strike against NF-kappaB-driven lymphomas
    Med Oncol (2025) 42, 350-350. PubMed  Europe PubMed DOI
  5. Nie,Z., Trzoss,M., Placzek,A.T., Trzoss,L., Krilov,G., Feng,S., Lawrenz,M., Ye,M., Marshall,N., Dingley,K.H., Pelletier,R.D., Lai,W.G., Bell,J.A., Tang,H., Devine,P., Liu,Z., Skrdla,P., Shimanovich,R., Liu,M., Wang,R., Xu,X., Abel,R., Akinsanya,K. and Yin,W.
    Accelerated In Silico Discovery of SGR-1505: A Potent MALT1 Allosteric Inhibitor for the Treatment of Mature B-Cell Malignancies
    J Med Chem (2025) PubMed  Europe PubMed DOI  I
  6. Tao,Y., Tian,C., Qi,S., Jia,Z., Xu,Z., Meng,J., Xu,G., Hu,H., Wang,X., Zhang,T., You,H., Lan,X., Lin,X., Yu,G., Zhou,H., Liu,J. and Zheng,H.
    Targeting both death and paracaspase domains of MALT1 with antisense oligonucleotides overcomes resistance to immune-checkpoint inhibitors
    Nat Cancer (2025) PubMed  Europe PubMed DOI
  7. Wang,J., Liao,L., Miao,B., Yang,B., Li,B., Ma,X., Fitz,A., Wu,S., He,J., Zhang,Q., Ji,S., Jin,G., Zhang,J., Cao,Y., Wang,H., Qin,W., Sun,C., Bernards,R. and Wang,C.
    Deciphering the role of the MALT1-RC3H1 axis in regulating GPX4 protein stability
    Proc Natl Acad Sci U S A (2025) 122, e2419625121-e2419625121. PubMed  Europe PubMed DOI
  8. Wang,J., Liao,L., Yang,B., Miao,B., Bernards,R., Qin,W., Sun,C. and Wang,C.
    Reply to Mishima et al.: MALT1 modulates GPX4 expression by regulating its stability
    Proc Natl Acad Sci U S A (2025) 122, e2508813122-e2508813122. PubMed  Europe PubMed DOI
  9. Zerillo,L., Zotti,T., Tutela,A., Madera,J.R., Grasso,G., Vito,P. and Stilo,R.
    The CARD14sh-BCL10-MALT1 complex regulates MAVS-mediated antiviral response in keratinocytes
    Proc Natl Acad Sci U S A (2025) 122, e2500711122-e2500711122. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2024
  10. Abdel-Magid,A.F.
    The Inhibitors of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 (MALT-1) Protease as Potential Treatment of ABC-DLBCL and Similar Diseases
    ACS Med Chem Lett (2024) 15, 763-765. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Isay,S.E., Vornholz,L., Schnalzger,T., Groll,T., Magg,T., Loll,P., Weirich,G., Steiger,K., Hauck,F. and Ruland,J.
    Enforced CARD11/MALT1 signaling in dendritic cells triggers hemophagocytic lymphohistiocytosis
    Proc Natl Acad Sci U S A (2024) 121, e2413162121-e2413162121. PubMed  Europe PubMed DOI
  12. Kuo,B.J., Lin,S.C., Tu,Y.F., Huang,P.H. and Lo,Y.C.
    Study of individual domains contributing to MALT1 dimerization in BCL10-independent and dependent assembly
    Biochem Biophys Res Commun (2024) 717, 150029-150029. PubMed  Europe PubMed DOI
  13. Moud,B.N., Ober,F., O'Neill,T.J. and Krappmann,D.
    MALT1 substrate cleavage: what is it good for?
    Front Immunol (2024) 15, 1412347-1412347. PubMed  Europe PubMed DOI  PMC  EPMC
  14. O'Sullivan,P.A., Aidarova,A., Afonina,I., Manils,J., Thurston,T.L.M., Instrell,R., Howell,M., Boeing,S., Ranawana,S., Herpels,M., Chetien,R., Bassa,M., Flynn,H.R., Frith,D., Snijders,A., Howes,A., Beyaert,R., Bowcock,A. and Ley,S.C.
    CARD14 SIGNALOSOME FORMATION IS ASSOCIATED WITH ITS ENDOSOMAL RELOCATION AND mTORC1-INDUCED KERATINOCYTE PROLIFERATION
    Biochem J (2024) PubMed  Europe PubMed DOI
  15. Tsubokawa,A., Chihara,K., Chihara,Y., Takeuchi,K., Fujieda,S. and Sada,K.
    Adaptor protein 3BP2 regulates gene expression in addition to the ubiquitination and proteolytic activity of MALT1 in dectin-1-stimulated cells
    J Biol Chem (2024) , 107980-107980. PubMed  Europe PubMed DOI
  16. Wallerstein,J., Han,X., Levkovets,M., Lesovoy,D., Malmodin,D., Mirabello,C., Wallner,B., Sun,R., Sandalova,T., Agback,P., Karlsson,G., Achour,A., Agback,T. and Orekhov,V.
    Insights into mechanisms of MALT1 allostery from NMR and AlphaFold dynamic analyses
    Commun Biol (2024) 7, 868-868. PubMed  Europe PubMed DOI  PMC  EPMC
    17. 2023
  17. Kowluru,A.
    Regulatory roles of CARD9-BCL10-Rac1 (CBR) signalome in islet beta-cell function in health and metabolic stress: Is there room for MALT1?
    Biochem Pharmacol (2023) 218, 115889-115889. PubMed  Europe PubMed DOI  PMC  EPMC  V
  18. Minderman,M., Lantermans,H.C., Gruneberg,L.J., Cillessen,S.A.G.M., Bende,R.J., van Noesel,C.J.M., Kersten,M.J., Pals,S.T. and Spaargaren,M.
    MALT1-dependent cleavage of CYLD promotes NF-kappaB signaling and growth of aggressive B-cell receptor-dependent lymphomas
    Blood Cancer J (2023) 13, 37-37. PubMed  Europe PubMed DOI  PMC  EPMC
  19. O'Neill,T.J., Tofaute,M.J. and Krappmann,D.
    Function and targeting of MALT1 paracaspase in cancer
    Cancer Treat Rev (2023) 117, 102568-102568. PubMed  Europe PubMed DOI
  20. Peng,Z.M., Zhang,Y.Y., Wei,D., Zhang,X.J., Liu,B., Peng,J. and Luo,X.J.
    MALT1 promotes necroptosis in stroke rat brain via targeting the A20/RIPK3 pathway
    Arch Biochem Biophys (2023) 735, 109502-109502. PubMed  Europe PubMed DOI  K
  21. Schmidt,H., Raj,T., O'Neill,T.J., Muschaweckh,A., Giesert,F., Negraschus,A., Hoefig,K.P., Behrens,G., Esser,L., Baumann,C., Feederle,R., Plaza-Sirvent,C., Geerlof,A., Gewies,A., Isay,S.E., Ruland,J., Schmitz,I., Wurst,W., Korn,T., Krappmann,D. and Heissmeyer,V.
    Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity
    Proc Natl Acad Sci U S A (2023) 120, e2309205120-e2309205120. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Verhelst,S.H.L. and Prothiwa,M.
    Chemical Probes for Profiling of MALT1 Protease Activity
    Chembiochem (2023) 24, e202300444-e202300444. PubMed  Europe PubMed DOI  V
    23. 2022
  23. Bell,P.A., Scheuermann,S., Renner,F., Pan,C.L., Lu,H.Y., Turvey,S.E., Bornancin,F., Regnier,C.H. and Overall,C.M.
    Integrating knowledge of protein sequence with protein function for the prediction and validation of new MALT1 substrates
    Comput Struct Biotechnol J (2022) 20, 4717-4732. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Biswas,S., Chalishazar,A., Helou,Y., DiSpirito,J., DeChristopher,B., Chatterjee,D., Merselis,L., Vincent,B., Monroe,J.G., Rabah,D. and Long,A.J.
    Pharmacological Inhibition of MALT1 Ameliorates Autoimmune Pathogenesis and Can Be Uncoupled From Effects on Regulatory T-Cells
    Front Immunol (2022) 13, 875320-875320. PubMed  Europe PubMed DOI  PMC  EPMC
  25. Chang,K.S., Tsui,K.H., Hsu,S.Y., Sung,H.C., Lin,Y.H., Hou,C.P., Yang,P.S., Chen,C.L., Feng,T.H. and Juang,H.H.
    The Antitumor Effect of Caffeic Acid Phenethyl Ester by Downregulating Mucosa-Associated Lymphoid Tissue 1 via AR/p53/NF-kappaB Signaling in Prostate Carcinoma Cells
    Cancers (Basel) (2022) 14 PubMed  Europe PubMed DOI  PMC  EPMC
  26. Gomez Solsona,B., Schmitt,A., Schulze-Osthoff,K. and Hailfinger,S.
    The Paracaspase MALT1 in Cancer
    Biomedicines (2022) 10 PubMed  Europe PubMed DOI  PMC  EPMC  V
  27. Jones,A.N., Grass,C., Meininger,I., Geerlof,A., Klostermann,M., Zarnack,K., Krappmann,D. and Sattler,M.
    Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of MALT1
    Sci Adv (2022) 8, eabp9153-eabp9153. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Mempel,T.R. and Krappmann,D.
    Combining precision oncology and immunotherapy by targeting the MALT1 protease
    J Immunother Cancer (2022) 10 PubMed  Europe PubMed DOI  PMC  EPMC  V
  29. Sefer,A.P., Abolhassani,H., Ober,F., Kayaoglu,B., Bilgic Eltan,S., Kara,A., Erman,B., Surucu Yilmaz,N., Aydogmus,C., Aydemir,S., Charbonnier,L.M., Kolukisa,B., Azizi,G., Delavari,S., Momen,T., Aliyeva,S., Kendir Demirkol,Y., Tekin,S., Kiykim,A., Baser,O.F., Cokugras,H., Gursel,M., Karakoc-Aydiner,E., Ozen,A., Krappmann,D., Chatila,T.A., Rezaei,N. and Baris,S.
    Expanding the Clinical and Immunological Phenotypes and Natural History of MALT1 Deficiency
    J Clin Immunol (2022) PubMed  Europe PubMed DOI
  30. Zhang,Y.Y., Peng,J. and Luo,X.J.
    Post-translational modification of MALT1 and its role in B cell- and T cell-related diseases
    Biochem Pharmacol (2022) 198, 114977-114977. PubMed  Europe PubMed DOI  V
    31. 2021
  31. Asaba,K.N., Adachi,Y., Tokumaru,K., Watanabe,A., Goto,Y. and Aoki,T.
    Structure-activity relationship studies of 3-substituted pyrazoles as novel allosteric inhibitors of MALT1 protease
    Bioorg Med Chem Lett (2021) 41, 127996-127996. PubMed  Europe PubMed DOI  I
  32. Hailfinger,S. and Schulze-Osthoff,K.
    The paracaspase MALT1 in psoriasis
    Biol Chem (2021) PubMed  Europe PubMed DOI  V
  33. Israel,L., Gluck,A., Berger,M., Coral,M., Ceci,M., Unterreiner,A., Rubert,J., Bardet,M., Ginster,S., Golding-Ochsenbein,A.M., Martin,K., Hoyler,T., Calzascia,T., Wieczorek,G., Hillenbrand,R., Ferretti,S., Ferrero,E. and Bornancin,F.
    CARD10 cleavage by MALT1 restricts lung carcinoma growth in vivo
    Oncogenesis (2021) 10, 32-32. PubMed  Europe PubMed DOI  PMC  EPMC
  34. Liang,X., Cao,Y., Li,C., Yu,H., Yang,C. and Liu,H.
    MALT1 as a promising target to treat lymphoma and other diseases related to MALT1 anomalies
    Med Res Rev (2021) PubMed  Europe PubMed DOI  V
  35. Lu,H.Y. and Turvey,S.E.
    Human MALT1 deficiency and predisposition to infections
    Curr Opin Immunol (2021) 72, 1-12. PubMed  Europe PubMed DOI
    36. 2020
  36. Alfano,D.N., Klei,L.R., Klei,H.B., Trotta,M., Gough,P.J., Foley,K.P., Bertin,J., Sumpter,T.L., Lucas,P.C. and McAllister-Lucas,L.M.
    MALT1 Protease plays a dual role in the allergic response by acting in both mast cells and endothelial cells
    J Immunol (2020) 204, 2337-2348. PubMed  Europe PubMed DOI
  37. Ashcraft,K.A., Johnson-Pais,T.L., Troyer,D.A., Hernandez,J. and Leach,R.J.
    A copy number gain on 18q present in primary prostate tumors is associated with metastatic outcome
    Urol Oncol (2020) PubMed  Europe PubMed DOI
  38. Cheng,J., Klei,L.R., Hubel,N.E., Zhang,M., Schairer,R., Maurer,L.M., Klei,H.B., Kang,H., Concel,V.J., Delekta,P.C., Dang,E.V., Mintz,M.A., Baens,M., Cyster,J.G., Parameswaran,N., Thome,M., Lucas,P.C. and McAllister-Lucas,L.M.
    GRK2 suppresses lymphomagenesis by inhibiting the MALT1 proto-oncoprotein
    J Clin Invest (2020) 130, 1036-1051. PubMed  Europe PubMed DOI  I
  39. Dumont,C., Sivars,U., Andreasson,T., Odqvist,L., Mattsson,J., DeMicco,A., Pardali,K., Johansson,G., Yrlid,L., Cox,R.J., Seeliger,F., Larsson,M., Gehrmann,U., Davis,A.M. and Vaarala,O.
    A MALT1 inhibitor suppresses human myeloid DC, effector T-cell and B-cell responses and retains Th1/regulatory T-cell homeostasis
    PLoS ONE (2020) 15, e0222548-e0222548. PubMed  Europe PubMed DOI  PMC  EPMC
  40. Flynn,S.M., Chen,C., Artan,M., Barratt,S., Crisp,A., Nelson,G.M., Peak-Chew,S.Y., Begum,F., Skehel,M. and de Bono,M.
    MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity
    Nat Commun (2020) 11, 2099-2099. PubMed  Europe PubMed DOI  PMC  EPMC
  41. Hayashi,H., Chiba,T., Mihara-Tomiyama,N., Negishi,T., Kodama,Y., Sakashita,H. and Imai,K.
    Domain structures of mucosa-associated lymphoid tissue lymphoma translocation 1 protein for nuclear localization in oral carcinoma cells and the proliferation inhibition
    Biochem Biophys Res Commun (2020) 522, 799-804. PubMed  Europe PubMed DOI
  42. Liu,X., Yue,C., Shi,L., Liu,G., Cao,Q., Shan,Q., Wang,Y., Chen,X., Li,H., Wang,J., Gao,S., Niu,M. and Yu,R.
    MALT1 is a potential therapeutic target in glioblastoma and plays a crucial role in EGFR-induced NF-kappaB activation
    J Cell Mol Med (2020) PubMed  Europe PubMed DOI  T  I
  43. Martin,K., Touil,R., Cvijetic,G., Israel,L., Kolb,Y., Sarret,S., Valeaux,S., Degl'Innocenti,E., Le Meur,T., Caesar,N., Bardet,M., Beerli,C., Zerwes,H.G., Kovarik,J., Beltz,K., Schlapbach,A., Quancard,J., Regnier,C.H., Bigaud,M., Junt,T., Wieczorek,G., Isnardi,I., Littlewood-Evans,A., Bornancin,F. and Calzascia,T.
    Requirement of mucosa-associated lymphoid tissue lymphoma translocation protein 1 protease activity for fcgamma receptor-induced arthritis but not Fcgamma receptor-mediated platelet elimination in mice
    Arthritis Rheumatol (2020) 72, 919-930. PubMed  Europe PubMed DOI
  44. Nicolau,C.A., Gavard,J. and Bidere,N.
    TAK1 lessens the activity of the paracaspase MALT1 during T cell receptor signaling
    Cell Immunol (2020) 353, 104115-104115. PubMed  Europe PubMed DOI
  45. Schairer,R., Hall,G., Zhang,M., Cowan,R., Baravalle,R., Muskett,F.W., Coombs,P.J., Mpamhanga,C., Hale,L.R., Saxty,B., Iwaszkiewicz,J., Decaillet,C., Perroud,M., Carr,M.D. and Thome,M.
    Allosteric activation of MALT1 by its ubiquitin-binding Ig3 domain
    Proc Natl Acad Sci U S A (2020) 117, 3093-3102. PubMed  Europe PubMed DOI
  46. van de Plassche,M.A.T., O'Neill,T.J., Seeholzer,T., Turk,B., Krappmann,D. and Verhelst,S.H.L.
    Use of non-natural amino acids for the design and synthesis of a selective, cell-permeable MALT1 activity-based probe
    J Med Chem (2020) 63, 3996-4004. PubMed  Europe PubMed DOI  A
  47. Wiegmann,H., Reunert,J., Metze,D., Marquardt,T., Engel,T., Kunde,V., Ehl,S., Foell,D., van den Heuvel,I., Oji,V. and Wittkowski,H.
    Refining the dermatological spectrum in primary immunodeficiency: mucosa-associated lymphoid tissue lymphoma translocation protein 1 deficiency mimicking Netherton/Omenn syndromes
    Br J Dermatol (2020) 182, 202-207. PubMed  Europe PubMed DOI  M
  48. Xia,X., Cao,G., Sun,G., Zhu,L., Tian,Y., Song,Y., Guo,C., Wang,X., Zhong,J., Zhou,W., Li,P., Zhang,H., Hao,J., Li,Z., Deng,L., Yin,Z. and Gao,Y.
    GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis
    J Clin Invest (2020) 130, 5180-5196. PubMed  Europe PubMed DOI
    49. 2019
  49. Cheng,L., Deng,N., Yang,N., Zhao,X. and Lin,X.
    Malt1 protease is critical in maintaining function of regulatory T cells and may be a therapeutic target for antitumor immunity
    J Immunol (2019) 202, 3008-3019. PubMed  Europe PubMed DOI
  50. Demeyer,A., Skordos,I., Driege,Y., Kreike,M., Hochepied,T., Baens,M., Staal,J. and Beyaert,R.
    MALT1 Proteolytic activity suppresses autoimmunity in a T cell intrinsic manner
    Front Immunol (2019) 10, 1898-1898. PubMed  Europe PubMed DOI  PMC  EPMC
  51. Demeyer,A., Van Nuffel,E., Baudelet,G., Driege,Y., Kreike,M., Muyllaert,D., Staal,J. and Beyaert,R.
    MALT1-Deficient mice develop atopic-like dermatitis upon aging
    Front Immunol (2019) 10, 2330-2330. PubMed  Europe PubMed DOI  PMC  EPMC  K
  52. Feng,J., Yang,W., Wang,J., Pu,Z., Han,Y. and Wan,L.
    Z-VRPR-FMK can inhibit the growth and invasiveness of diffuse large B-cell lymphoma by depressing NF-kappaB activation and MMP expression induced by MALT1
    Int J Clin Exp Pathol (2019) 12, 1947-1955. PubMed  Europe PubMed  PMC  EPMC  I
  53. Frizinsky,S., Rechavi,E., Barel,O., Najeeb,R.H., Greenberger,S., Lee,Y.N., Simon,A.J., Lev,A., Ma,C.A., Sun,G., Blackstone,S.A., Milner,J.D., Somech,R. and Stauber,T.
    Novel MALT1 mutation linked to immunodeficiency, immune dysregulation, and an abnormal T cell receptor repertoire
    J Clin Immunol (2019) 39, 401-413. PubMed  Europe PubMed DOI  M
  54. Gehring,T., Erdmann,T., Rahm,M., Grass,C., Flatley,A., O'Neill,T.J., Woods,S., Meininger,I., Karayel,O., Kutzner,K., Grau,M., Shinohara,H., Lammens,K., Feederle,R., Hauck,S.M., Lenz,G. and Krappmann,D.
    MALT1 Phosphorylation controls activation of T lymphocytes and survival of ABC-DLBCL tumor cells
    Cell Rep (2019) 29, 873-888. PubMed  Europe PubMed DOI
  55. Gilis,E., Gaublomme,D., Staal,J., Venken,K., Dhaenens,M., Lambrecht,S., Coudenys,J., Decruy,T., Schryvers,N., Driege,Y., Dumas,E., Demeyer,A., De Muynck,A., van Hengel,J., Van Hoorebeke,L., Deforce,D., Beyaert,R. and Elewaut,D.
    Deletion of mucosa-associated lymphoid tissue lymphoma translocation protein 1 in mouse T cells protects against development of autoimmune arthritis but leads to spontaneous osteoporosis
    Arthritis Rheumatol (2019) 71, 2005-2015. PubMed  Europe PubMed DOI  K
  56. Hatcher,J.M., Du,G., Fontan,L., Us,I., Qiao,Q., Chennamadhavuni,S., Shao,J., Wu,H., Melnick,A., Gray,N.S. and Scott,D.A.
    Peptide-based covalent inhibitors of MALT1 paracaspase
    Bioorg Med Chem Lett (2019) 29, 1336-1339. PubMed  Europe PubMed DOI  A  L  I
  57. Jacobs,K.A., Andre-Gregoire,G., Maghe,C., Thys,A., Li,Y., Harford-Wright,E., Trillet,K., Douanne,T., Alves Nicolau,C., Frenel,J.S., Bidere,N. and Gavard,J.
    Paracaspase MALT1 regulates glioma cell survival by controlling endo-lysosome homeostasis
    EMBO J (2019) , e102030-e102030. PubMed  Europe PubMed DOI
  58. Lu,T., Connolly,P.J., Philippar,U., Sun,W., Cummings,M.D., Barbay,K., Gys,L., Van Nuffel,L., Austin,N., Bekkers,M., Shen,F., Cai,A., Attar,R., Meerpoel,L. and Edwards,J.
    Discovery and optimization of a series of small-molecule allosteric inhibitors of MALT1 protease
    Bioorg Med Chem Lett (2019) 29, 126743-126743. PubMed  Europe PubMed DOI  I
  59. Martin,K., Touil,R., Kolb,Y., Cvijetic,G., Murakami,K., Israel,L., Duraes,F., Buffet,D., Gluck,A., Niwa,S., Bigaud,M., Junt,T., Zamurovic,N., Smith,P., McCoy,K.D., Ohashi,P.S., Bornancin,F. and Calzascia,T.
    Malt1 Protease deficiency in mice disrupts immune homeostasis at environmental barriers and drives systemic T cell-mediated autoimmunity
    J Immunol (2019) 203, 2791-2806. PubMed  Europe PubMed DOI
  60. McAuley,J.R., Bailey,K.M., Ekambaram,P., Klei,L.R., Kang,H., Hu,D., Freeman,T.J., Concel,V.J., Hubel,N.E., Lee,J.L., Klei,H.B., Cheng,J., Sekar,P., Bridwell,R.E., Covic,L., Lucas,P.C. and McAllister-Lucas,L.M.
    MALT1 is a critical mediator of PAR1-driven NF-kappaB activation and metastasis in multiple tumor types
    Oncogene (2019) 38, 7384-7398. PubMed  Europe PubMed DOI
  61. Monajemi,M., Fisk,S., Pang,Y.C.F., Leung,J., Menzies,S.C., Ben-Othman,R., Cai,B., Kollmann,T.R., Rozmus,J. and Sly,L.M.
    Malt1 deficient mice develop osteoporosis independent of osteoclast-intrinsic effects of Malt1 deficiency
    J Leukoc Biol (2019) 106, 863-877. PubMed  Europe PubMed DOI  K
  62. Nakamura,Y., Igaki,K., Komoike,Y., Yokoyama,K. and Tsuchimori,N.
    Malt1 inactivation attenuates experimental colitis through the regulation of Th17 and Th1/17 cells
    Inflamm Res (2019) 68, 223-230. PubMed  Europe PubMed DOI  K
  63. Quancard,J., Klein,T., Fung,S.Y., Renatus,M., Hughes,N., Israel,L., Priatel,J.J., Kang,S., Blank,M.A., Viner,R.I., Blank,J., Schlapbach,A., Erbel,P., Kizhakkedathu,J., Villard,F., Hersperger,R., Turvey,S.E., Eder,J., Bornancin,F. and Overall,C.M.
    An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient
    Nat Chem Biol (2019) 15, 304-313. PubMed  Europe PubMed DOI  S  I
  64. Rosenbaum,M., Gewies,A., Pechloff,K., Heuser,C., Engleitner,T., Gehring,T., Hartjes,L., Krebs,S., Krappmann,D., Kriegsmann,M., Weichert,W., Rad,R., Kurts,C. and Ruland,J.
    Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells
    Nat Commun (2019) 10, 2352-2352. PubMed  Europe PubMed DOI  I
  65. Scott,D.A., Hatcher,J.M., Liu,H., Fu,M., Du,G., Fontan,L., Us,I., Casalena,G., Qiao,Q., Wu,H., Melnick,A. and Gray,N.S.
    Quinoline and thiazolopyridine allosteric inhibitors of MALT1
    Bioorg Med Chem Lett (2019) 29, 1694-1698. PubMed  Europe PubMed DOI  I
  66. Spungin,D., Bidle,K.D. and Berman-Frank,I.
    Metacaspase involvement in programmed cell death of the marine cyanobacterium Trichodesmium
    Environ Microbiol (2019) 21, 667-681. PubMed  Europe PubMed DOI
  67. Unterreiner,A., Touil,R., Anastasi,D., Dubois,N., Niwa,S., Calzascia,T. and Bornancin,F.
    Myeloid innate signaling pathway regulation by MALT1 paracaspase activity
    J Vis Exp (2019) PubMed  Europe PubMed DOI  I
  68. [YEAR:1-9-2019]Yamasoba,D., Sato,K., Ichinose,T., Imamura,T., Koepke,L., Joas,S., Reith,E., Hotter,D., Misawa,N., Akaki,K., Uehata,T., Mino,T., Miyamoto S AUID- ORCID:, Noda,T., Yamashita,A., Standley,D.M., Kirchhoff,F., Sauter,D.A., Koyanagi,Y. and Takeuchi,O.A.
    N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation
    Nat Microbiol. (1-9-2019) 4, 1532-1544. PubMed  Europe PubMed
  69. Zhu,L., Tang,F., Lei,Z., Guo,C., Song,Y., Huang,J. and Xia,X.
    Antiapoptotic properties of MALT1 protease are associated with redox homeostasis in ABC-DLBCL cells
    Mol Carcinog (2019) 58, 2340-2352. PubMed  Europe PubMed DOI
    70. 2018
  70. Baens,M., Stirparo,R., Lampi,Y., Verbeke,D., Vandepoel,R., Cools,J., Marynen,P., de Bock,C.E. and Bornschein,S.
    Malt1 self-cleavage is critical for regulatory T cell homeostasis and anti-tumor immunity in mice
    Eur J Immunol (2018) 48, 1728-1738. PubMed  Europe PubMed DOI
  71. Bardet,M., Unterreiner,A., Malinverni,C., Lafossas,F., Vedrine,C., Boesch,D., Kolb,Y., Kaiser,D., Gluck,A., Schneider,M.A., Katopodis,A., Renatus,M., Simic,O., Schlapbach,A., Quancard,J., Regnier,C.H., Bold,G., Pissot-Soldermann,C., Carballido,J.M., Kovarik,J., Calzascia,T. and Bornancin,F.
    The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition
    Immunol Cell Biol (2018) 96, 81-99. PubMed  Europe PubMed DOI  I
  72. Bardet,M., Seeholzer,T., Unterreiner,A., Woods,S., Krappmann,D. and Bornancin,F.
    MALT1 activation by TRAF6 needs neither BCL10 nor CARD11
    Biochem Biophys Res Commun (2018) 506, 48-52. PubMed  Europe PubMed DOI
  73. Fontan,L., Qiao,Q., Hatcher,J.M., Casalena,G., Us,I., Teater,M., Durant,M., Du,G., Xia,M., Bilchuk,N., Chennamadhavuni,S., Palladino,G., Inghirami,G., Philippar,U., Wu,H., Scott,D.A., Gray,N.S. and Melnick,A.
    Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth
    J Clin Invest (2018) 128, 4397-4412. PubMed  Europe PubMed DOI  I
  74. Hyeon,J., Lee,B., Shin,S.H., Yoo,H.Y., Kim,S.J., Kim,W.S., Park,W.Y. and Ko,Y.H.
    Targeted deep sequencing of gastric marginal zone lymphoma identified alterations of TRAF3 and TNFAIP3 that were mutually exclusive for MALT1 rearrangement
    Mod Pathol (2018) 31, 1418-1428. PubMed  Europe PubMed DOI  M
  75. Israel,L. and Bornancin,F.
    Ways and waves of MALT1 paracaspase activation
    Cell Mol Immunol (2018) 15, 8-11. PubMed  Europe PubMed DOI
  76. Juilland,M. and Thome,M.
    Holding all the CARDs: how MALT1 controls CARMA/CARD-dependent signaling
    Front Immunol (2018) 9, 1927-1927. PubMed  Europe PubMed DOI  PMC  EPMC  V
  77. Kasperkiewicz,P., Kolt,S., Janiszewski,T., Groborz,K., Poreba,M., Snipas,S.J., Salvesen,G.S. and Drag,M.
    Determination of extended substrate specificity of the MALT1 as a strategy for the design of potent substrates and activity-based probes
    Sci Rep (2018) 8, 15998-15998. PubMed  Europe PubMed DOI  PMC  EPMC  A  P
  78. Kip,E., Staal,J., Tima,H.G., Verstrepen,L., Romano,M., Lemeire,K., Suin,V., Hamouda,A., Baens,M., Libert,C., Kalai,M., Van Gucht,S. and Beyaert,R.
    Inhibition of MALT1 decreases neuroinflammation and pathogenicity of virulent rabies virus in mice
    J Virol (2018) 92, e00720-18-e00720-18. PubMed  Europe PubMed DOI  I
  79. Li,Y., Huang,S., Huang,X., Li,X., Falcon,A., Soutar,A., Bornancin,F., Jiang,Z., Xin,H.B. and Fu,M.
    Pharmacological inhibition of MALT1 protease activity suppresses endothelial activation via enhancing MCPIP1 expression
    Cell Signal (2018) 50, 1-8. PubMed  Europe PubMed DOI  I
  80. Lork,M., Staal,J. and Beyaert,R.
    Ubiquitination and phosphorylation of the CARD11-BCL10-MALT1 signalosome in T cells
    Cell Immunol (2018) DOI
  81. Nakamura,Y., Yokoyama,K., Igaki,K. and Tsuchimori,N.
    Role of Malt1 protease activity in pathogenesis of inflammatory disorders mediated by FcgammaR signaling
    Int Immunopharmacol (2018) 56, 193-196. PubMed  Europe PubMed DOI
  82. Schlapbach,A., Revesz,L., Pissot Soldermann,C., Zoller,T., Regnier,C.H., Bornancin,F., Radimerski,T., Blank,J., Schuffenhauer,A., Renatus,M., Erbel,P., Melkko,S., Heng,R., Simic,O., Endres,R., Wartmann,M. and Quancard,J.
    N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity
    Bioorg Med Chem Lett (2018) 28, 2153-2158. PubMed  Europe PubMed DOI  I
  83. Schlauderer,F., Seeholzer,T., Desfosses,A., Gehring,T., Strauss,M., Hopfner,K.P., Gutsche,I., Krappmann,D. and Lammens,K.
    Molecular architecture and regulation of BCL10-MALT1 filaments
    Nat Commun (2018) 9, 4041-4041. PubMed  Europe PubMed DOI  PMC  EPMC  S
  84. Staal,J., Driege,Y., Haegman,M., Borghi,A., Hulpiau,P., Lievens,L., Gul,I.S., Sundararaman,S., Goncalves,A., Dhondt,I., Pinzon,J.H., Braeckman,B.P., Technau,U., Saeys,Y., Van Roy,F. and Beyaert,R.
    Ancient origin of the CARD-coiled coil/Bcl10/MALT1-like paracaspase signaling complex indicates unknown critical functions
    Front Immunol (2018) 9, 1136-1136. PubMed  Europe PubMed DOI  PMC  EPMC
  85. Wu,C.H., Yang,Y.H., Chen,M.R., Tsai,C.H., Cheng,A.L. and Doong,S.L.
    Autocleavage of the paracaspase MALT1 at Arg-781 attenuates NF-kappaB signaling and regulates the growth of activated B-cell like diffuse large B-cell lymphoma cells
    PLoS ONE (2018) 13, e0199779-e0199779. PubMed  Europe PubMed DOI
  86. Wu,G., Wang,H., Zhou,W., Zeng,B., Mo,W., Zhu,K., Liu,R., Zhou,J., Chen,C. and Chen,H.
    Synthesis and structure-activity relationship studies of MI-2 analogues as MALT1 inhibitors
    Bioorg Med Chem (2018) 26, 3321-3344. PubMed  Europe PubMed DOI  I
  87. Xia,X., Zhou,W., Guo,C., Fu,Z., Zhu,L., Li,P., Xu,Y., Zheng,L., Zhang,H., Shan,C. and Gao,Y.
    Glutaminolysis mediated by MALT1 protease activity facilitates PD-L1 expression on ABC-DLBCL cells and contributes to their immune evasion
    Front Oncol (2018) 8, 632-632. PubMed  Europe PubMed DOI  PMC  EPMC
    88. 2017
  88. Bonsignore,L., Passelli,K., Pelzer,C., Perroud,M., Konrad,A., Thurau,M., Sturzl,M., Dai,L., Trillo-Tinoco,J., del Valle,L., Qin,Z. and Thome,M.
    A role for MALT1 activity in Kaposi's sarcoma-associated herpes virus latency and growth of primary effusion lymphoma
    Leukemia (2017) 31, 614-624. PubMed  Europe PubMed DOI  I
  89. Brustle,A., Brenner,D., Knobbe-Thomsen,C.B., Cox,M., Lang,P.A., Lang,K.S. and Mak,T.W.
    MALT1 is an intrinsic regulator of regulatory T cells
    Cell Death Differ (2017) 24, 1214-1223. PubMed  Europe PubMed DOI
  90. Charbit-Henrion,F., Jeverica,A.K., Begue,B., Markelj,G., Parlato,M., Avcin,S.L., Callebaut,I., Bras,M., Parisot,M., Jazbec,J., Homan,M., Ihan,A., Rieux-Laucat,F., Stolzenberg,M.C., Ruemmele,F.M., Avcin,T. and Cerf-Bensussan,N.
    Deficiency in Mucosa Associated Lymphoid Tissue Lymphoma Translocation 1: a novel cause of IPEX-like syndrome
    J Pediatr Gastroenterol Nutr (2017) 64, 378-384. PubMed  Europe PubMed DOI  M
  91. Du,M.Q.
    MALT lymphoma: genetic abnormalities, immunological stimulation and molecular mechanism
    Best Pract Res Clin Haematol (2017) 30, 13-23. PubMed  Europe PubMed DOI  M
  92. Ginster,S., Bardet,M., Unterreiner,A., Malinverni,C., Renner,F., Lam,S., Freuler,F., Gerrits,B., Voshol,J., Calzascia,T., Regnier,C.H., Renatus,M., Nikolay,R., Israel,L. and Bornancin,F.
    Two antagonistic MALT1 auto-cleavage mechanisms reveal a role for TRAF6 to unleash MALT1 activation
    PLoS ONE (2017) 12, e0169026-e0169026. PubMed  Europe PubMed DOI
  93. Lee,C.H., Bae,S.J. and Kim,M.
    Mucosa-associated lymphoid tissue lymphoma translocation 1 as a novel therapeutic target for rheumatoid arthritis
    Sci Rep (2017) 7, 11889-11889. PubMed  Europe PubMed DOI  PMC  EPMC  T  I
  94. Lee,P., Zhu,Z., Hachmann,J., Nojima,T., Kitamura,D., Salvesen,G. and Rickert,R.C.
    Differing requirements for MALT1 function in peripheral B cell survival and differentiation
    J Immunol (2017) 198, 1066-1080. PubMed  Europe PubMed DOI
  95. Li,Y., Huang,X., Huang,S., He,H., Lei,T., Saaoud,F., Yu,X.Q., Melnick,A., Kumar,A., Papasian,C.J., Fan,D. and Fu,M.
    Central role of myeloid MCPIP1 in protecting against LPS-induced inflammation and lung injury
    Signal Transduct Target Ther (2017) 2, 17066-17066. PubMed  Europe PubMed DOI  PMC  EPMC  U
  96. Saba,N.S., Wong,D.H., Tanios,G., Iyer,J.R., Lobelle-Rich,P., Dadashian,E.L., Liu,D., Fontan,L., Flemington,E.K., Nichols,C.M., Underbayev,C., Safah,H., Melnick,A., Wiestner,A. and Herman,S.E.M.
    MALT1 inhibition is efficacious in both naive and ibrutinib-resistant chronic lymphocytic leukemia
    Cancer Res (2017) 77, 7038-7048. PubMed  Europe PubMed DOI  I
  97. Unterreiner,A., Stoehr,N., Huppertz,C., Calzascia,T., Farady,C.J. and Bornancin,F.
    Selective MALT1 paracaspase inhibition does not block TNF-alpha production downstream of TLR4 in myeloid cells
    Immunol Lett (2017) 192, 48-51. PubMed  Europe PubMed DOI  I
    98. 2016
  98. Abdel-Magid,A.F.
    MALT1 inhibitors may potentially treat lymphomas and autoimmune disorders
    ACS Med Chem Lett (2016) 7, 205-206. PubMed  Europe PubMed DOI  PMC  EPMC  I
  99. Afonina,I.S., Van Nuffel,E., Baudelet,G., Driege,Y., Kreike,M., Staal,J. and Beyaert,R.
    The paracaspase MALT1 mediates CARD14-induced signaling in keratinocytes
    EMBO Rep (2016) 17, 914-927. PubMed  Europe PubMed DOI
  100. Chiba,T., Soeno,Y., Shirako,Y., Sudo,H., Yagishita,H., Taya,Y., Kawashiri,S., Okada,Y. and Imai,K.
    MALT1 inhibition of oral carcinoma cell invasion and ERK/MAPK activation
    J Dent Res (2016) 95, 446-452. PubMed  Europe PubMed DOI
  101. Demeyer,A., Staal,J. and Beyaert,R.
    Targeting MALT1 proteolytic activity in immunity, inflammation and disease: good or bad?
    Trends Mol Med (2016) 22, 135-150. PubMed  Europe PubMed DOI  K
  102. Douanne,T., Gavard,J. and Bidere,N.
    The paracaspase MALT1 cleaves the LUBAC subunit HOIL1 during antigen receptor signaling
    J Cell Sci (2016) 129, 1775-1780. PubMed  Europe PubMed DOI
  103. Elton,L., Carpentier,I., Staal,J., Driege,Y., Haegman,M. and Beyaert,R.
    MALT1 cleaves the E3 ubiquitin ligase HOIL-1 in activated T cells, generating a dominant negative inhibitor of LUBAC-induced NF-kappaB signaling
    FEBS J (2016) 283, 403-412. PubMed  Europe PubMed DOI  P
  104. Hachmann,J. and Salvesen,G.S.
    The paracaspase MALT1
    Biochimie (2016) 122, 324-338. PubMed  Europe PubMed DOI  K  V
  105. Hailfinger,S., Schmitt,A. and Schulze-Osthoff,K.
    The paracaspase MALT1 dampens NF-kappaB signalling by cleaving the LUBAC subunit HOIL-1
    FEBS J (2016) 283, 400-402. PubMed  Europe PubMed DOI
  106. Hulpiau,P., Driege,Y., Staal,J. and Beyaert,R.
    MALT1 is not alone after all: identification of novel paracaspases
    Cell Mol Life Sci (2016) 73, 1103-1116. PubMed  Europe PubMed DOI
  107. Jaworski,M. and Thome,M.
    The paracaspase MALT1: biological function and potential for therapeutic inhibition
    Cell Mol Life Sci (2016) 73, 459-473. PubMed  Europe PubMed DOI  U
  108. Juilland,M. and Thome,M.
    Role of the CARMA1/BCL10/MALT1 complex in lymphoid malignancies
    Curr Opin Hematol (2016) 23, 402-409. PubMed  Europe PubMed DOI  T
  109. Klei,L.R., Hu,D., Panek,R., Alfano,D.N., Bridwell,R.E., Bailey,K.M., Oravecz-Wilson,K.I., Concel,V.J., Hess,E.M., Van Beek,M., Delekta,P.C., Gu,S., Watkins,S.C., Ting,A.T., Gough,P.J., Foley,K.P., Bertin,J., McAllister-Lucas,L.M. and Lucas,P.C.
    MALT1 protease activation triggers acute disruption of endothelial barrier integrity via CYLD cleavage
    Cell Rep (2016) 17, 221-232. PubMed  Europe PubMed DOI
  110. Liu,W., Guo,W., Hang,N., Yang,Y., Wu,X., Shen,Y., Cao,J., Sun,Y. and Xu,Q.
    MALT1 inhibitors prevent the development of DSS-induced experimental colitis in mice via inhibiting NF-kappaB and NLRP3 inflammasome activation
    Oncotarget (2016) 7, 30536-30549. PubMed  Europe PubMed DOI  I
  111. Meininger,I., Griesbach,R.A., Hu,D., Gehring,T., Seeholzer,T., Bertossi,A., Kranich,J., Oeckinghaus,A., Eitelhuber,A.C., Greczmiel,U., Gewies,A., Schmidt-Supprian,M., Ruland,J., Brocker,T., Heissmeyer,V., Heyd,F. and Krappmann,D.
    Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells
    Nat Commun (2016) 7, 11292-11292. PubMed  Europe PubMed DOI  PMC  EPMC  R
  112. Rozmus,J., McDonald,R., Fung,S.Y., Del Bel,K.L., Roden,J., Senger,C., Schultz,K.R., McKinnon,M.L., Davis,J. and Turvey,S.E.
    Successful clinical treatment and functional immunological normalization of human MALT1 deficiency following hematopoietic stem cell transplantation
    Clin Immunol (2016) 168, 1-5. PubMed  Europe PubMed DOI  M
  113. Schmitt,A., Grondona,P., Maier,T., Brandle,M., Schonfeld,C., Jager,G., Kosnopfel,C., Eberle,F.C., Schittek,B., Schulze-Osthoff,K., Yazdi,A.S. and Hailfinger,S.
    MALT1 protease activity controls the expression of inflammatory genes in keratinocytes upon zymosan stimulation
    J Invest Dermatol (2016) 136, 788-797. PubMed  Europe PubMed DOI
  114. Unnerstale,S., Nowakowski,M., Baraznenok,V., Stenberg,G., Lindberg,J., Mayzel,M., Orekhov,V. and Agback,T.
    Backbone assignment of the MALT1 paracaspase by solution NMR
    PLoS ONE (2016) 11, e0146496-e0146496. PubMed  Europe PubMed DOI  S
  115. Xin,B.T., Schimmack,G., Du,Y., Florea,B.I., van der Marel,G.A., Driessen,C., Krappmann,D. and Overkleeft,H.S.
    Development of new Malt1 inhibitors and probes
    Bioorg Med Chem (2016) 24, 3312-3329. PubMed  Europe PubMed DOI  L  I
    116. 2015
  116. Afonina,I.S., Elton,L., Carpentier,I. and Beyaert,R.
    MALT1 - a universal soldier: multiple strategies to ensure NF-kappaB activation and target gene expression
    FEBS J (2015) 282, 3286-3297. PubMed  Europe PubMed DOI
  117. Arora,M., Kaul,D., Varma,N. and Marwaha,R.K.
    Cellular proteolytic modification of tumor-suppressor CYLD is critical for the initiation of human T-cell acute lymphoblastic leukemia
    Blood Cells Mol Dis (2015) 54, 132-138. PubMed  Europe PubMed DOI
  118. Bornancin,F., Renner,F., Touil,R., Sic,H., Kolb,Y., Touil-Allaoui,I., Rush,J.S., Smith,P.A., Bigaud,M., Junker-Walker,U., Burkhart,C., Dawson,J., Niwa,S., Katopodis,A., Nuesslein-Hildesheim,B., Weckbecker,G., Zenke,G., Kinzel,B., Traggiai,E., Brenner,D., Brustle,A., St Paul,M., Zamurovic,N., McCoy,K.D., Rolink,A., Regnier,C.H., Mak,T.W., Ohashi,P.S., Patel,D.D. and Calzascia,T.
    Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation
    J Immunol (2015) 194, 3723-3734. PubMed  Europe PubMed DOI  K
  119. Eitelhuber,A.C., Vosyka,O., Nagel,D., Bognar,M., Lenze,D., Lammens,K., Schlauderer,F., Hlahla,D., Hopfner,K.P., Lenz,G., Hummel,M., Verhelst,S.H. and Krappmann,D.
    Activity-based probes for detection of active MALT1 paracaspase in immune cells and lymphomas
    Chem Biol (2015) 22, 129-138. PubMed  Europe PubMed DOI  A  L
  120. Hachmann,J., Edgington-Mitchell,L.E., Poreba,M., Sanman,L.E., Drag,M., Bogyo,M. and Salvesen,G.S.
    Probes to monitor activity of the paracaspase MALT1
    Chem Biol (2015) 22, 139-147. PubMed  Europe PubMed DOI  L
  121. Kaul,D., Arora,M., Garg,A. and Sharma,S.
    MALT1 induced immune response is governed by miR-2909 RNomics
    Mol Immunol (2015) 64, 210-217. PubMed  Europe PubMed DOI
  122. Klein,T., Fung,S.Y., Renner,F., Blank,M.A., Dufour,A., Kang,S., Bolger-Munro,M., Scurll,J.M., Priatel,J.J., Schweigler,P., Melkko,S., Gold,M.R., Viner,R.I., Regnier,C.H., Turvey,S.E. and Overall,C.M.
    The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-kappaB signalling
    Nat Commun (2015) 6, 8777-8777. PubMed  Europe PubMed DOI
  123. Lim,S.M., Jeong,Y., Lee,S., Im,H., Tae,H.S., Kim,B.G., Park,H.D., Park,J. and Hong,S.
    Identification of beta-lapachone analogs as novel MALT1 inhibitors to treat an aggressive subtype of diffuse large B-cell lymphoma
    J Med Chem (2015) 58, 8491-8502. PubMed  Europe PubMed DOI  I
  124. Nagel,D., Bognar,M., Eitelhuber,A.C., Kutzner,K., Vincendeau,M. and Krappmann,D.
    Combinatorial BTK and MALT1 inhibition augments killing of CD79 mutant diffuse large B cell lymphoma
    Oncotarget (2015) 6, 42232-42242. PubMed  Europe PubMed DOI  I
  125. Nagel,D. and Krappmann,D.
    Detection of recombinant and cellular MALT1 paracaspase activity
    Methods Mol Biol (2015) 1280, 239-246. PubMed  Europe PubMed DOI  A
  126. Nie,Z., Du,M.Q., McAllister-Lucas,L.M., Lucas,P.C., Bailey,N.G., Hogaboam,C.M., Lim,M.S. and Elenitoba-Johnson,K.S.
    Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2-MALT1 in MALT lymphoma
    Nat Commun (2015) 6, 5908-5908. PubMed  Europe PubMed DOI
  127. Punwani,D., Wang,H., Chan,A.Y., Cowan,M.J., Mallott,J., Sunderam,U., Mollenauer,M., Srinivasan,R., Brenner,S.E., Mulder,A., Claas,F.H., Weiss,A. and Puck,J.M.
    Combined immunodeficiency due to MALT1 mutations, treated by hematopoietic cell transplantation
    J Clin Immunol (2015) 35, 135-146. PubMed  Europe PubMed DOI  M
  128. Visan,I.
    MALT1 regulates LUBAC
    Nat Immunol (2015) 16, 1214-1214. DOI
  129. Yu,J.W., Hoffman,S., Beal,A.M., Dykon,A., Ringenberg,M.A., Hughes,A.C., Dare,L., Anderson,A.D., Finger,J., Kasparcova,V., Rickard,D., Berger,S.B., Ramanjulu,J., Emery,J.G., Gough,P.J., Bertin,J. and Foley,K.P.
    MALT1 protease activity is required for innate and adaptive immune responses
    PLoS ONE (2015) 10, e0127083- PubMed  Europe PubMed DOI  PMC  EPMC  K
    130. 2014
  130. Baens,M., Bonsignore,L., Somers,R., Vanderheydt,C., Weeks,S.D., Gunnarsson,J., Nilsson,E., Roth,R.G., Thome,M. and Marynen,P.
    MALT1 auto-proteolysis is essential for NF-kappaB-dependent gene transcription in activated lymphocytes
    PLoS ONE (2014) 9, e103774-e103774. PubMed  Europe PubMed DOI  PMC  EPMC
  131. Bertossi,A. and Krappmann,D.
    MALT1 protease: equilibrating immunity versus tolerance
    EMBO J (2014) 33, 2740-2742. PubMed  Europe PubMed DOI
  132. Gewies,A., Gorka,O., Bergmann,H., Pechloff,K., Petermann,F., Jeltsch,K.M., Rudelius,M., Kriegsmann,M., Weichert,W., Horsch,M., Beckers,J., Wurst,W., Heikenwalder,M., Korn,T., Heissmeyer,V. and Ruland,J.
    Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation
    Cell Rep (2014) 9, 1292-1305. PubMed  Europe PubMed DOI
  133. Hailfinger,S., Pelzer,C. and Thome,M.
    Detection and measurement of paracaspase MALT1 activity
    Methods Mol Biol (2014) 1133, 177-188. PubMed  Europe PubMed DOI  A
  134. Hailfinger,S., Lenz,G. and Thome,M.
    Targeting B-cell lymphomas with inhibitors of the MALT1 paracaspase
    Curr Opin Chem Biol (2014) 23, 47-55. PubMed  Europe PubMed DOI  I
  135. Jaworski,M., Marsland,B.J., Gehrig,J., Held,W., Favre,S., Luther,S.A., Perroud,M., Golshayan,D., Gaide,O. and Thome,M.
    Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity
    EMBO J (2014) 33, 2765-2781. PubMed  Europe PubMed DOI
  136. Jeltsch,K.M., Hu,D., Brenner,S., Zoller,J., Heinz,G.A., Nagel,D., Vogel,K.U., Rehage,N., Warth,S.C., Edelmann,S.L., Gloury,R., Martin,N., Lohs,C., Lech,M., Stehklein,J.E., Geerlof,A., Kremmer,E., Weber,A., Anders,H.J., Schmitz,I., Schmidt-Supprian,M., Fu,M., Holtmann,H., Krappmann,D., Ruland,J., Kallies,A., Heikenwalder,M. and Heissmeyer,V.
    Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation
    Nat Immunol (2014) 15, 1079-1089. PubMed  Europe PubMed DOI
  137. Mc Guire,C., Elton,L., Wieghofer,P., Staal,J., Voet,S., Demeyer,A., Nagel,D., Krappmann,D., Prinz,M., Beyaert,R. and Van Loo,G.
    Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis
    J Neuroinflammation (2014) 11, 124-124. PubMed  Europe PubMed DOI  PMC  EPMC  I
  138. McKinnon,M.L., Rozmus,J., Fung,S.Y., Hirschfeld,A.F., Del Bel,K.L., Thomas,L., Marr,N., Martin,S.D., Marwaha,A.K., Priatel,J.J., Tan,R., Senger,C., Tsang,A., Prendiville,J., Junker,A.K., Seear,M., Schultz,K.R., Sly,L.M., Holt,R.A., Patel,M.S., Friedman,J.M. and Turvey,S.E.
    Combined immunodeficiency associated with homozygous MALT1 mutations
    J Allergy Clin Immunol (2014) 133, 1458-1462. PubMed  Europe PubMed DOI  M
    139. 2013

  139. MALT1 is a therapeutic target in ABC-DLBCL
    Cancer Discov (2013) 3, OF10-OF10. DOI  T
  140. Akira,S.
    Regnase-1, a ribonuclease involved in the regulation of immune responses
    Cold Spring Harb Symp Quant Biol (2013) 78, 51-60. PubMed  Europe PubMed DOI
  141. Burgess,D.J.
    Therapeutics: assault on MALT1
    Nat Rev Cancer (2013) 13, 80-80. PubMed  Europe PubMed DOI  I
  142. Burgess,D.J.
    Anticancer drugs: assault on MALT1
    Nat Rev Drug Discov (2013) 12, 100-100. PubMed  Europe PubMed DOI  I
  143. Cabalzar,K., Pelzer,C., Wolf,A., Lenz,G., Iwaszkiewicz,J., Zoete,V., Hailfinger,S. and Thome,M.
    Monoubiquitination and activity of the paracaspase MALT1 requires glutamate 549 in the dimerization interface
    PLoS ONE (2013) 8, e72051-e72051. PubMed  Europe PubMed DOI  PMC  EPMC
  144. Fontan,L. and Melnick,A.
    Molecular pathways: targeting MALT1 paracaspase activity in lymphoma
    Clin Cancer Res (2013) 19, 6662-6668. PubMed  Europe PubMed DOI  T
  145. Jabara,H.H., Ohsumi,T., Chou,J., Massaad,M.J., Benson,H., Megarbane,A., Chouery,E., Mikhael,R., Gorka,O., Gewies,A., Portales,P., Nakayama,T., Hosokawa,H., Revy,P., Herrod,H., Le Deist,F., Lefranc,G., Ruland,J. and Geha,R.S.
    A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency
    J Allergy Clin Immunol (2013) 132, 151-158. PubMed  Europe PubMed DOI  M
  146. Li,Y., He,X., Wang,S., Shu,H.B. and Liu,Y.
    USP2a positively regulates TCR-induced NF-kappaB activation by bridging MALT1-TRAF6
    Protein Cell (2013) 4, 62-70. PubMed  Europe PubMed DOI
  147. Li,Y., Chen,X., Wang,Z., Zhao,D., Chen,H., Chen,W., Zhou,Z., Zhang,J., Zhang,J., Li,H. and Chen,C.
    The HECTD3 E3 ubiquitin ligase suppresses cisplatin-induced apoptosis via stabilizing MALT1
    Neoplasia (2013) 15, 39-48. PubMed  Europe PubMed  PMC  EPMC
  148. Mc Guire,C., Wieghofer,P., Elton,L., Muylaert,D., Prinz,M., Beyaert,R. and Van Loo,G.
    Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination
    J Immunol (2013) 190, 2896-2903. PubMed  Europe PubMed DOI  K
  149. Pelzer,C., Cabalzar,K., Wolf,A., Gonzalez,M., Lenz,G. and Thome,M.
    The protease activity of the paracaspase MALT1 is controlled by monoubiquitination
    Nat Immunol (2013) 14, 337-345. PubMed  Europe PubMed DOI
  150. Schlauderer,F., Lammens,K., Nagel,D., Vincendeau,M., Eitelhuber,A.C., Verhelst,S.H., Kling,D., Chrusciel,A., Ruland,J., Krappmann,D. and Hopfner,K.P.
    Structural analysis of phenothiazine derivatives as allosteric inhibitors of the MALT1 paracaspase
    Angew Chem Int Ed Engl (2013) 52, 10384-10387. PubMed  Europe PubMed DOI  S  I
  151. Uehata,T., Iwasaki,H., Vandenbon,A., Matsushita,K., Hernandez-Cuellar,E., Kuniyoshi,K., Satoh,T., Mino,T., Suzuki,Y., Standley,D.M., Tsujimura,T., Rakugi,H., Isaka,Y., Takeuchi,O. and Akira,S.
    MALT1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation
    Cell (2013) 153, 1036-1049. PubMed  Europe PubMed DOI
    152. 2012
  152. Brustle,A., Brenner,D., Knobbe,C.B., Lang,P.A., Virtanen,C., Hershenfield,B.M., Reardon,C., Lacher,S.M., Ruland,J., Ohashi,P.S. and Mak,T.W.
    The NF-kappaB regulator MALT1 determines the encephalitogenic potential of Th17 cells
    J Clin Invest (2012) 122, 4698-4709. PubMed  Europe PubMed DOI  K
  153. Fontan,L., Yang,C., Kabaleeswaran,V., Volpon,L., Osborne,M.J., Beltran,E., Garcia,M., Cerchietti,L., Shaknovich,R., Yang,S.N., Fang,F., Gascoyne,R.D., Martinez-Climent,J.A., Glickman,J.F., Borden,K., Wu,H. and Melnick,A.
    MALT1 small molecule inhibitors specifically suppress ABC-DLBCL invitro and invivo
    Cancer Cell (2012) 22, 812-824. PubMed  Europe PubMed DOI  A  I
  154. Fontan,L. and Melnick,A.
    Targeting lymphomas through MALT1 inhibition
    Oncotarget (2012) 3, 1493-1494. PubMed  Europe PubMed  T  I
  155. Hachmann,J., Snipas,S.J., van Raam,B.J., Cancino,E.M., Houlihan,E.J., Poreba,M., Kasperkiewicz,P., Drag,M. and Salvesen,G.S.
    Mechanism and specificity of the human paracaspase MALT1
    Biochem J (2012) 443, 287-295. PubMed  Europe PubMed DOI  E
  156. Jou,S.Y., Chang,C.C., Wu,C.H., Chen,M.R., Tsai,C.H., Chuang,W.H., Chen,Y.H., Cheng,A.L. and Doong,S.L.
    BCL10GFP fusion protein as a substrate for analysis of determinants required for Mucosa-Associated Lymphoid Tissue 1 (MALT1)-mediated cleavage
    J Biomed Sci (2012) 19, 85-85. PubMed  Europe PubMed DOI  P
  157. Kirchhofer,D. and Vucic,D.
    Protease activity of MALT1: a mystery unravelled
    Biochem J (2012) 444, e3-e5. PubMed  Europe PubMed DOI
  158. Krappmann,D.
    Attacking MALT1 for ABC-DLBCL therapy
    Oncotarget (2012) 3, 1489-1490. PubMed  Europe PubMed  I
  159. Nagel,D., Spranger,S., Vincendeau,M., Grau,M., Raffegerst,S., Kloo,B., Hlahla,D., Neuenschwander,M., Peter von Kries,J., Hadian,K., Dorken,B., Lenz,P., Lenz,G., Schendel,D.J. and Krappmann,D.
    Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL
    Cancer Cell (2012) 22, 825-837. PubMed  Europe PubMed DOI  I
  160. Papatriantafyllou,M.
    T cells: the MALT1 switch in autoimmunity
    Nat Rev Immunol (2012) 12, 807-807. DOI
  161. Staal,J. and Beyaert,R.
    A two-step activation mechanism of MALT1 paracaspase
    J Mol Biol (2012) 419, 1-3. PubMed  Europe PubMed DOI
  162. Thome,M. and Hailfinger,S.
    Paracaspase
    [ISSN:978-0-12-407743-0] (2012) 3, 2295-2300. DOI
  163. Vicente-Duenas,C., Fontan,L., Gonzalez-Herrero,I., Romero-Camarero,I., Segura,V., Aznar,M.A., Alonso-Escudero,E., Campos-Sanchez,E., Ruiz-Roca,L., Barajas-Diego,M., Sagardoy,A., Martinez-Ferrandis,J.I., Abollo-Jimenez,F., Bertolo,C., Penuelas,I., Garcia-Criado,F.J., Garcia-Cenador,M.B., Tousseyn,T., Agirre,X., Prosper,F., Garcia-Bragado,F., McPhail,E.D., Lossos,I.S., Du,M.Q., Flores,T., Hernandez-Rivas,J.M., Gonzalez,M., Salar,A., Bellosillo,B., Conde,E., Siebert,R., Sagaert,X., Cobaleda,C., Sanchez-Garcia,I. and Martinez-Climent,J.A.
    Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice
    Proc Natl Acad Sci U S A (2012) 109, 10534-10539. PubMed  Europe PubMed DOI  I
  164. Wiesmann,C., Leder,L., Blank,J., Bernardi,A., Melkko,S., Decock,A., D'arcy,A., Villard,F., Erbel,P., Hughes,N., Freuler,F., Nikolay,R., Alves,J., Bornancin,F. and Renatus,M.
    Structural determinants of MALT1 protease activity
    J Mol Biol (2012) 419, 4-21. PubMed  Europe PubMed DOI  S
  165. Young,R.M. and Staudt,L.M.
    A new "brew" of MALT1 Inhibitors
    Cancer Cell (2012) 22, 706-707. PubMed  Europe PubMed DOI  I
    166. 2011
  166. Hailfinger,S., Nogai,H., Pelzer,C., Jaworski,M., Cabalzar,K., Charton,J.E., Guzzardi,M., Decaillet,C., Grau,M., Dorken,B., Lenz,P., Lenz,G. and Thome,M.
    Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines
    Proc Natl Acad Sci U S A (2011) 108, 14596-14601. PubMed  Europe PubMed DOI  P
  167. Kloo,B., Nagel,D., Pfeifer,M., Grau,M., Duwel,M., Vincendeau,M., Dorken,B., Lenz,P., Lenz,G. and Krappmann,D.
    Critical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells
    Proc Natl Acad Sci U S A (2011) 108, 272-277. PubMed  Europe PubMed DOI
  168. McAllister-Lucas,L.M., Baens,M. and Lucas,P.C.
    MALT1 protease: a new therapeutic target in B lymphoma and beyond?
    Clin Cancer Res (2011) 17, 6623-6631. PubMed  Europe PubMed DOI  T
  169. Rosebeck,S., Lucas,P.C. and McAllister-Lucas,L.M.
    Protease activity of the API2-MALT1 fusion oncoprotein in MALT lymphoma development and treatment
    Future Oncol (2011) 7, 613-617. PubMed  Europe PubMed DOI
  170. Rosebeck,S., Madden,L., Jin,X., Gu,S., Apel,I.J., Appert,A., Hamoudi,R.A., Noels,H., Sagaert,X., Van Loo,P., Baens,M., Du,M.Q., Lucas,P.C. and McAllister-Lucas,L.M.
    Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation
    Science (2011) 331, 468-472. PubMed  Europe PubMed DOI  PMC  EPMC  P
  171. Staal,J., Bekaert,T. and Beyaert,R.
    Regulation of NF-kappaB signaling by caspases and MALT1 paracaspase
    Cell Res (2011) 21, 40-54. PubMed  Europe PubMed DOI
  172. Staal,J., Driege,Y., Bekaert,T., Demeyer,A., Muyllaert,D., Van Damme,P., Gevaert,K. and Beyaert,R.
    T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1
    EMBO J (2011) 30, 1742-1752. PubMed  Europe PubMed DOI
  173. Yu,J.W., Jeffrey,P.D., Ha,J.Y., Yang,X. and Shi,Y.
    Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region
    Proc Natl Acad Sci U S A (2011) 108, 21004-21009. PubMed  Europe PubMed DOI  S
    174. 2010
  174. Malinverni,C., Unterreiner,A., Staal,J., Demeyer,A., Galaup,M., Luyten,M., Beyaert,R. and Bornancin,F.
    Cleavage by MALT1 induces cytosolic release of A20
    Biochem Biophys Res Commun (2010) 400, 543-547. PubMed  Europe PubMed DOI  P
    175. 2009
  175. Duwel,M., Welteke,V., Oeckinghaus,A., Baens,M., Kloo,B., Ferch,U., Darnay,B.G., Ruland,J., Marynen,P. and Krappmann,D.
    A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains
    J Immunol (2009) 182, 7718-7728. PubMed  Europe PubMed DOI
  176. Ferch,U., Kloo,B., Gewies,A., Pfander,V., Duwel,M., Peschel,C., Krappmann,D. and Ruland,J.
    Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cells
    J Exp Med (2009) 206, 2313-2320. PubMed  Europe PubMed DOI  PMC  EPMC  I
  177. Hailfinger,S., Rebeaud,F. and Thome,M.
    Adapter and enzymatic functions of proteases in T-cell activation
    Immunol Rev (2009) 232, 334-347. PubMed  Europe PubMed DOI
  178. Hailfinger,S., Lenz,G., Ngo,V., Posvitz-Fejfar,A., Rebeaud,F., Guzzardi,M., Penas,E.M., Dierlamm,J., Chan,W.C., Staudt,L.M. and Thome,M.
    Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma
    Proc Natl Acad Sci U S A (2009) 106, 19946-19951. PubMed  Europe PubMed DOI
  179. Vucic,D. and Dixit,V.M.
    Masking MALT1: the paracaspase's potential for cancer therapy
    J Exp Med (2009) 206, 2309-2312. PubMed  Europe PubMed DOI  PMC  EPMC
    180. 2008
  180. Coornaert,B., Baens,M., Heyninck,K., Bekaert,T., Haegman,M., Staal,J., Sun,L., Chen,Z.J., Marynen,P. and Beyaert,R.
    T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20
    Nat Immunol (2008) 9, 263-271. PubMed  Europe PubMed DOI
  181. Kawadler,H., Gantz,M.A., Riley,J.L. and Yang,X.
    The paracaspase MALT1 controls caspase-8 activation during lymphocyte proliferation
    Mol Cell (2008) 31, 415-421. PubMed  Europe PubMed DOI  PMC  EPMC
  182. McAllister-Lucas,L.M. and Lucas,P.C.
    Finally, MALT1 is a protease!
    Nat Immunol (2008) 9, 231-233. PubMed  Europe PubMed DOI  V  P
  183. Ray,L.B.
    Looks like a protease, walks like a protease
    Sci Signal (2008) 1, ec69-ec69. DOI
  184. Rebeaud,F., Hailfinger,S., Posevitz-Fejfar,A., Tapernoux,M., Moser,R., Rueda,D., Gaide,O., Guzzardi,M., Iancu,E.M., Rufer,N., Fasel,N. and Thome,M.
    The proteolytic activity of the paracaspase MALT1 is key in T cell activation
    Nat Immunol (2008) 9, 272-281. PubMed  Europe PubMed DOI  P  I
  185. Thome,M.
    Multifunctional roles for MALT1 in T-cell activation
    Nat Rev Immunol (2008) 8, 495-500. PubMed  Europe PubMed DOI
    186. 2007
  186. Inagaki,H.
    Mucosa-associated lymphoid tissue lymphoma: molecular pathogenesis and clinicopathological significance
    Pathol Int (2007) 57, 474-484. PubMed  Europe PubMed DOI
  187. Murga Penas,E.M., Callet-Bauchu,E., Ye,H., Hinz,K., Albert,N., Copie-Bergman,C., Gazzo,S., Berger,F., Salles,G., Bokemeyer,C., Du,M.Q. and Dierlamm,J.
    The translocations t(6;18;11)(q24;q21;q21) and t(11;14;18)(q21;q32;q21) lead to a fusion of the API2 and MALT1 genes and occur in MALT lymphomas
    Haematologica (2007) 92, 405-409. PubMed  Europe PubMed DOI
  188. Oeckinghaus,A., Wegener,E., Welteke,V., Ferch,U., Arslan,S.C., Ruland,J., Scheidereit,C. and Krappmann,D.
    Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation
    EMBO J (2007) 26, 4634-4645. PubMed  Europe PubMed DOI  PMC  EPMC
  189. Wegener,E. and Krappmann,D.
    CARD-Bcl10-Malt1 signalosomes: missing link to NF-kappaB
    Sci STKE (2007) 2007, e21-e21. PubMed  Europe PubMed DOI
    190. 2004
  190. [YEAR:19-3-2004]Roisin-Bouffay,C., Luciani,M.F., Klein,G., Levraud,J.P., Adam,M. and Golstein,P.
    Developmental cell death in Dictyostelium does not require paracaspase
    J Biol Chem (19-3-2004) 279, 11489-11494. PubMed  Europe PubMed DOI
  191. Snipas,S.J., Wildfang,E., Nazif,T., Christensen,L., Boatright,K.M., Bogyo,M., Stennicke,H.R. and Salvesen,G.S.
    Characteristics of the caspase-like catalytic domain of human paracaspase
    Biol Chem (2004) 385, 1093-1098. PubMed  Europe PubMed DOI
    192. 2003
  192. [YEAR:28-11-2003]Ruefli-Brasse,A.A., French,D.M. and Dixit,V.M.
    Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase
    Science (28-11-2003) 302, 1581-1584. PubMed  Europe PubMed DOI
  193. Ruland,J., Duncan,G.S., Wakeham,A. and Mak,T.W.
    Differential requirement for Malt1 in T and B cell antigen receptor signaling
    Immunity (2003) 19, 749-758. PubMed  Europe PubMed DOI
  194. Sanchez-Izquierdo,D., Buchonnet,G., Siebert,R., Gascoyne,R.D., Climent,J., Karran,L., Marin,M., Blesa,D., Horsman,D., Rosenwald,A., Staudt,L.M., Albertson,D.G., Du,M.Q., Ye,H., Marynen,P., Garcia-Conde,J., Pinkel,D., Dyer,M.J. and Martinez-Climent,J.A.
    MALT1 is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma
    Blood (2003) 101, 4539-4546. PubMed  Europe PubMed DOI
  195. [YEAR:28-11-2003]Yu,L. and Lenardo,M.J.
    Immunology. The paracaspase connection
    Science (28-11-2003) 302, 1515-1516. PubMed  Europe PubMed DOI
    196. 2002
  196. Koonin,E.V. and Aravind,L.
    Origin and evolution of eukaryotic apoptosis: the bacterial connection
    Cell Death Differ (2002) 9, 394-404. PubMed  Europe PubMed DOI
    197. 2000
  197. Uren,A.G., O'Rourke,K., Aravind,L.A., Pisabarro,M.T., Seshagiri,S., Koonin,E.V. and Dixit,V.M.
    Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma
    Mol Cell (2000) 6, 961-967. PubMed  Europe PubMed
    198. 1999
  198. Akagi,T., Motegi,M., Tamura,A., Suzuki,R., Hosokawa,Y., Suzuki,H., Ota,H., Nakamura,S., Morishima,Y., Taniwaki,M. and Seto,M.
    A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue
    Oncogene (1999) 18, 5785-5794. PubMed  Europe PubMed DOI
  199. Dierlamm,J., Baens,M., Wlodarska,I., Stefanova-Ouzounova,M., Hernandez,J.M., Hossfeld,D.K., De Wolf-Peeters,C., Hagemeijer,A., Van Den Berghe,H. and Marynen,P.
    The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas
    Blood (1999) 93, 3601-3609. PubMed  Europe PubMed
  200. Morgan,J.A., Yin,Y., Borowsky,A.D., Kuo,F., Nourmand,N., Koontz,J.I., Reynolds,C., Soreng,L., Griffin,C.A., Graeme-Cook,F., Harris,N.L., Weisenburger,D., Pinkus,G.S., Fletcher,J.A. and Sklar,J.
    Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18
    Cancer Res (1999) 59, 6205-6213. PubMed  Europe PubMed

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