$VAR1 = undef;

Summary for peptidase C14.026: paracaspase

Names
MEROPS Name	paracaspase
Other names	mucosa-associated lymphoid tissue protein-1, MALT1 paracaspase, MPC protein

Domain architecture

MEROPS Classification
Classification	Clan CD >> Subclan (none) >> Family C14 >> Subfamily B >> C14.026
Holotype	paracaspase (Homo sapiens), Uniprot accession Q9UDY8 (peptidase unit: 337-523), MERNUM MER0019325
History	Identifier created: MEROPS 5.9 (21 June 2002)

Activity
Catalytic type	Cysteine
NC-IUBMB	Not yet included in IUBMB recommendations.
Activity status	human: putative mouse: putative
Physiology	A human lymphoma translocation fuses the IAP-2 gene to the locus that encodes paracaspase, and this activates NF-kappaB by a mechanism that involves the putative catalytic cysteine of the paracaspase (Uren et al., 2000).
Pathways	KEGG	B cell receptor signaling pathway
	KEGG	NF-kappa B signaling pathway
	KEGG	T cell receptor signaling pathway
	KEGG	Tuberculosis
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Paracaspase
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	Lf/vr/SP/RG/pt/dgs/- (based on 30 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	1	0	0	0	18	1	5	0
Pro	1	0	8	0	0	5	0	2
Ala	0	1	1	0	3	3	3	1
Val	0	7	0	0	0	4	0	0
Leu	18	2	0	0	0	1	2	4
Ile	0	4	0	0	0	0	0	0
Met	2	3	0	0	0	0	0	0
Phe	5	0	0	0	0	0	0	0
Tyr	0	0	0	0	0	0	1	1
Trp	0	0	0	0	0	0	0	0
Ser	0	0	20	0	1	3	5	5
Thr	0	0	0	0	3	5	0	2
Cys	1	3	1	0	0	1	0	0
Asn	0	0	0	0	0	1	0	0
Gln	0	2	0	0	0	0	2	0
Asp	0	1	0	0	0	0	5	4
Glu	0	0	0	0	0	1	0	3
Lys	0	1	0	1	0	0	0	0
Arg	0	6	0	29	0	0	0	2
His	2	0	0	0	0	0	2	1