Substrates for peptidase C13.007: legumain, trematode-type

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Bz-Asn-NHPhNO2			Bz-Asn+NHPhNO2	S		-	-	Bz	Asn	NAN	-	-	-	Adisakwattana et al., 2007
Hemoglobin subunit beta	P68871	1-147	Peptide-Asn81+Leu-Peptide	N	CS	His	Leu	Asp	Asn	Leu	Lys	Gly	Thr	Delcroix et al., 2006
Serum albumin	P07724	25-608	Peptide-Asn85+Cys-Peptide	N	CS	Ser	Ala	Ala	Asn	Cys	Asp	Lys	Ser	Delcroix et al., 2006
Serum albumin	P07724	25-608	Peptide-Asn103+Leu-Peptide	N	CS	Ala	Ile	Pro	Asn	Leu	Arg	Glu	Asn	Delcroix et al., 2006
Serum albumin	P07724	25-608	Peptide-Asn598+Leu-Peptide	N	CS	Glu	Gly	Pro	Asn	Leu	Val	Thr	Arg	Delcroix et al., 2006
Serum albumin	P07724	25-608	Peptide-Asn482+Arg-Peptide	N	CS	Ala	Ile	Leu	Asn	Arg	Val	Cys	Leu	Delcroix et al., 2006