Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase C11.001: clostripain

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

(Topics flags: A Assay, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Pitel,S., Barnea,A., Diamant,E., Torgeman,A., Noy-Porat,T., Falach,R., Zichel,R., Hayouka,Z. and Ben David,A.<br>Elucidating the activation mechanism of botulinum neurotoxin a: role of alpha-clostripain and NTNH<br>Sci Rep (2025) 15, 37324-37324. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2024
  2. Powell,T., Widdowson,P., Nageli,A., Ebner,M. and Creese,A.<br>GingisREX: A Complementary Enzyme for the Detection of Bacterial Proteins<br>J Am Soc Mass Spectrom (2024) 35, 2790-2794. PubMed  Europe PubMed DOI
  3. Ruma,Y.N., Bu,G. and Gonen,T.<br>MicroED structure of the C11 cysteine protease Clostripain<br>bioRxiv (2024) PubMed  Europe PubMed DOI  PMC  EPMC
  4. Ruma,Y.N., Bu,G., Hattne,J. and Gonen,T.<br>MicroED structure of the C11 cysteine protease clostripain<br>J Struct Biol X (2024) 10, 100107-100107. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2019
  5. Brandhorst,H., Johnson,P.R., Monch,J., Kurfurst,M., Korsgren,O. and Brandhorst,D.<br>Comparison of clostripain and neutral protease as supplementary enzymes for human islet isolation<br>Cell Transplant (2019) 28, 176-184. PubMed  Europe PubMed DOI
    6. 2012
  6. Labrou,N.E.<br>Clostripain<br>[ISSN:978-0-12-407743-0] (2012) 3, 2323-2327. DOI
    7. 2011
  7. Bhattacharya,A.K., Rana,K.C., Raut,D.S., Mhaindarkar,V.P. and Khan,M.I.<br>An efficient synthesis of benzodiazepinyl phosphonates as clostripain inhibitors via FeCl3 catalyzed four-component reaction<br>Org Biomol Chem (2011) 9, 5407-5413. PubMed  Europe PubMed DOI  I
  8. Chakravorty,A., Awad,M.M., Hiscox,T.J., Cheung,J.K., Carter,G.P., Choo,J.M., Lyras,D. and Rood,J.I.<br>The cysteine protease alpha-clostripain is not essential for the pathogenesis of Clostridium perfringens-mediated myonecrosis<br>PLoS ONE (2011) 6, e22762-e22762. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Tanaka,H., Nariya,H., Suzuki,M., Houchi,H., Tamai,E., Miyata,S. and Okabe,A.<br>High-level production and purification of clostripain expressed in a virulence-attenuated strain of Clostridium perfringens<br>Protein Expr Purif (2011) 76, 83-89. PubMed  Europe PubMed DOI  E
    10. 2010
  10. Manabe,S., Nariya,H., Miyata,S., Tanaka,H., Minami,J., Suzuki,M., Taniguchi,Y. and Okabe,A.<br>Purification and characterization of a clostripain-like protease from a recombinant Clostridium perfringens culture<br>Microbiology (Reading) (2010) 156, 561-569. PubMed  Europe PubMed DOI
    11. 2009
  11. Suzuki,T., Yoneyama,T., Miyata,K., Mikami,A., Chikai,T., Inui,K., Kouguchi,H., Niwa,K., Watanabe,T., Miyazaki,S. and Ohyama,T.<br>Molecular characterization of the protease from Clostridium botulinum serotype C responsible for nicking in botulinum neurotoxin complex<br>Biochem Biophys Res Commun (2009) 379, 309-313. PubMed  Europe PubMed DOI  A
    12. 2008
  12. Tanaka,H., Tamai,E., Miyata,S., Taniguchi,Y., Nariya,H., Hatano,N., Houchi,H. and Okabe,A.<br>Construction and characterization of a clostripain-like protease-deficient mutant of Clostridium perfringens as a strain for clostridial gene expression<br>Appl Microbiol Biotechnol (2008) 77, 1063-1071. PubMed  Europe PubMed DOI
    13. 2007
  13. Kim,C.K., Lee,S.Y., Kwon,O.J., Lee,S.M., Nah,S.Y. and Jeong,S.M.<br>Secretory expression of active clostripain in Escherichia coli<br>J Biotechnol (2007) 131, 346-352. PubMed  Europe PubMed DOI  E
  14. Sebaihia,M., Peck,M.W., Minton,N.P., Thomson,N.R., Holden,M.T., Mitchell,W.J., Carter,A.T., Bentley,S.D., Mason,D.R., Crossman,L., Paul,C.J., Ivens,A., Wells-Bennik,M.H., Davis,I.J., Cerdeno-Tarraga,A.M., Churcher,C., Quail,M.A., Chillingworth,T., Feltwell,T., Fraser,A., Goodhead,I., Hance,Z., Jagels,K., Larke,N., Maddison,M., Moule,S., Mungall,K., Norbertczak,H., Rabbinowitsch,E., Sanders,M., Simmonds,M., White,B., Whithead,S. and Parkhill,J.<br>Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes<br>Genome Res (2007) 17, 1082-1092. PubMed  Europe PubMed DOI  PMC  EPMC
    15. 2004
  15. Labrou,N.E. and Rigden,D.J.<br>The structure-function relationship in the clostripain family of peptidases<br>Eur J Biochem (2004) 271, 983-992. PubMed  Europe PubMed DOI
  16. Ullmann,D. and Bordusa,F.<br>Clostripain<br>[ISSN:0-12-079610-4] (2004) 2, 1317-1319.  V
    17. 2001
  17. [YEAR:26-1-2001]Gusman,H., Grogan,J., Kagan,H.M., Troxler,R.F. and Oppenheim,F.G.<br>Salivary histatin 5 is a potent competitive inhibitor of the cysteine proteinase clostripain<br>FEBS Lett (26-1-2001) 489, 97-100. PubMed  Europe PubMed DOI
    18. 2000
  18. [YEAR:24-3-2000]Gunther,R., Stein,A. and Bordusa,F.<br>Investigations on the enzyme specificity of clostripain: a new efficient biocatalyst for the synthesis of peptide isosteres<br>J Org Chem (24-3-2000) 65, 1672-1679. PubMed  Europe PubMed DOI
    19. 1997
  19. Bordusa,F., Ullmann,D. and Jakubke,H.D.<br>Subsite specificity studies on the unusual cysteine protease clostripain: charged residues in the P3 position indicate a narrow subsite region<br>Biol Chem (1997) 378, 1193-1198. PubMed  Europe PubMed  P
    20. 1996
  20. Witte,V., Wolf,N. and Dargatz,H.<br>Clostripain linker deletion variants yield active enzyme in Escherichia coli: a possible function of the linker peptide as intramolecular inhibitor of clostripain automaturation<br>Curr Microbiol (1996) 33, 281-286. PubMed  Europe PubMed DOI
    21. 1995
  21. Hansler,M., Ullmann,G. and Jakubke,H.D.<br>The application of papain, ficin and clostripain in kinetically controlled peptide synthesis in frozen aqueous solutions<br>J Pept Sci (1995) 1, 283-287. PubMed  Europe PubMed DOI
    22. 1994
  22. Ullmann,D. and Jakubke,H.D.<br>Kinetic characterization of affinity chromatography purified clostripain<br>Biol Chem Hoppe Seyler (1994) 375, 89-92. PubMed  Europe PubMed
  23. Ullmann,D. and Jakubke,H.D.<br>The specificity of clostripain from Clostridium histolyticum. Mapping the S' subsites via acyl transfer to amino acid amides and peptides<br>Eur J Biochem (1994) 223, 865-872. PubMed  Europe PubMed DOI
    24. 1993
  24. Dargatz,H., Diefenthal,T., Witte,V., Reipen,G. and Von Wettstein,D.<br>The heterodimeric protease clostripain from Clostridium histolyticum is encoded by a single gene<br>Mol Gen Genet (1993) 240, 140-145. PubMed  Europe PubMed
    25. 1991
  25. Kembhavi,A.A., Buttle,D.J., Rauber,P. and Barrett,A.J.<br>Clostripain: characterization of the active site<br>FEBS Lett (1991) 283, 277-280. PubMed  Europe PubMed DOI  I
  26. Meiwes,J., Muller,W., Grabley,S. and Schudok,M.<br>Clostripain: production and use for peptide synthesis<br>Biomed Biochim Acta (1991) 50, S80-S83. PubMed  Europe PubMed
    27. 1990
  27. Fortier,G. and Gagnon,J.<br>Kinetic study of nucleophile specificity in dipeptide synthesis catalyzed by clostridiopeptidase B<br>Arch Biochem Biophys (1990) 276, 317-321. PubMed  Europe PubMed DOI
    28. 1988
  28. Zumbrunn,A., Stone,S. and Shaw,E.<br>Synthesis and properties of Cbz-Phe-Arg-CHN2 (benzyloxycarbonylphenylalanylarginyldiazomethane) as a proteinase inhibitor<br>Biochem J (1988) 250, 621-623. PubMed  Europe PubMed  PMC  EPMC  I
    29. 1986
  29. Fortier,G. and MacKenzie,S.L.<br>Peptide bond synthesis by clostridiopeptidase B<br>Biotechnol Lett (1986) 8, 777-782.
  30. Keil,B. and Gilles,A.M.<br>Multiple forms, structure and specificity of clostripain<br> (1986) , 147-162.
    31. 1984
  31. Gilles,A.M., Lecroisey,A. and Keil,B.<br>Primary structure of alpha-clostripain light chain<br>Eur J Biochem (1984) 145, 469-476. PubMed  Europe PubMed
  32. [YEAR:23-7-1984]Gilles,A.M. and Keil,B.<br>Evidence for an active-center cysteine in the SH-proteinase alpha-clostripain through use of N-tosyl-L-lysine chloromethyl ketone<br>FEBS Lett (23-7-1984) 173, 58-62. PubMed  Europe PubMed  I
    33. 1979
  33. Gilles,A.M., Imhoff,J.M. and Keil,B.<br>alpha-Clostripain. Chemical characterization, activity, and thiol content of the highly active form of clostripain<br>J Biol Chem (1979) 254, 1462-1468. PubMed  Europe PubMed
    34. 1978
  34. Giroux,E. and Vargaftig,B.B.<br>Clostridiopeptidase B inhibition by plasma macroglobulins and microbial antiproteases<br>Biochim Biophys Acta (1978) 525, 429-437. PubMed  Europe PubMed
    35. 1976
  35. Siffert,O., Emod,I. and Keil,B.<br>Interaction of clostripain with natural trypsin inhibitors and its affinity labeling by Nalpha-p-nitrobenzyloxycarbonyl arginine chlormethyl ketone<br>FEBS Lett (1976) 66, 114-119. PubMed  Europe PubMed DOI  I
    36. 1971
  36. Cole,P.W., Murakami,K. and Inagami,T.<br>Specificity and mechanism of clostripain catalysis<br>Biochemistry (1971) 10, 4246-4252. PubMed  Europe PubMed  I
    37. 1970
  37. Mitchell,W.M. and Harrington,W.F.<br>Clostripain<br>Methods Enzymol (1970) 19, 635-642. DOI  I
    38. 1968
  38. [YEAR:18-10-1968]Mitchell,W.M.<br>Hydrolysis at arginylproline in polypeptides by clostridiopeptidase B<br>Science (18-10-1968) 162, 374-375. PubMed  Europe PubMed
    39. 1961
  39. Conklin,D.A., Webster,M.E., Altieri,P.L., Berman,S., Lowenthal,J.P. and Gochenour,R.B.<br>Large scale purification of proteinases from Clostridium histolyticum filtrates<br>J Bacteriol (1961) 82, 589-594. PubMed  Europe PubMed  PMC  EPMC
    40. 1960
  40. Gros,P. and Labouesse,B.<br>[Clostripain, a protease from Clostridium histolyticum. 2. Specificity.]<br>Bull Soc Chim Biol (Paris) (1960) 42, 559-568. PubMed  Europe PubMed  P
  41. Heyns,K. and Legler,G.<br>[On proteins and their decomposition products. 18. The hydrolysis of synthetic and natural substrates by collagenase from Clostridium histolyticum.]<br>Hoppe Seylers Z Physiol Chem (1960) 321, 184-200. PubMed  Europe PubMed  P
  42. Labouesse,B. and Gros,P.<br>[Clostripain, a protease from Clostridium histolyticum. 1. Purification activation by thiols]<br>Bull Soc Chim Biol (Paris) (1960) 42, 543-558. PubMed  Europe PubMed
  43. Labouesse,B.<br>[The hydrolysis of glucagon by Clostripain]<br>Bull Soc Chim Biol (Paris) (1960) 42, 1293-1304. PubMed  Europe PubMed  P
    44. 1953
  44. Ogle,J.D. and Tytell,A.A.<br>The activity of Clostridium histolyticum proteinase on synthetic substrates<br>Arch Biochem Biophys (1953) 42, 327-336. PubMed  Europe PubMed
    45. 1938
  45. Kocholaty,W., Weil,L. and Smith,L.<br>Proteinase secretion and growth of Clostridium histolyticum<br>Biochem J (1938) 32, 1685-1690. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use