Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase C11.001: clostripain

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors Pharma

(Topics flags: A Assay, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Pitel,S., Barnea,A., Diamant,E., Torgeman,A., Noy-Porat,T., Falach,R., Zichel,R., Hayouka,Z. and Ben David,A.
    Elucidating the activation mechanism of botulinum neurotoxin a: role of alpha-clostripain and NTNH
    Sci Rep (2025) 15, 37324-37324. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2024
  2. Powell,T., Widdowson,P., Nageli,A., Ebner,M. and Creese,A.
    GingisREX: A Complementary Enzyme for the Detection of Bacterial Proteins
    J Am Soc Mass Spectrom (2024) 35, 2790-2794. PubMed  Europe PubMed DOI
  3. Ruma,Y.N., Bu,G. and Gonen,T.
    MicroED structure of the C11 cysteine protease Clostripain
    bioRxiv (2024) PubMed  Europe PubMed DOI  PMC  EPMC
  4. Ruma,Y.N., Bu,G., Hattne,J. and Gonen,T.
    MicroED structure of the C11 cysteine protease clostripain
    J Struct Biol X (2024) 10, 100107-100107. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2019
  5. Brandhorst,H., Johnson,P.R., Monch,J., Kurfurst,M., Korsgren,O. and Brandhorst,D.
    Comparison of clostripain and neutral protease as supplementary enzymes for human islet isolation
    Cell Transplant (2019) 28, 176-184. PubMed  Europe PubMed DOI
    6. 2012
  6. Labrou,N.E.
    Clostripain
    [ISSN:978-0-12-407743-0] (2012) 3, 2323-2327. DOI
    7. 2011
  7. Bhattacharya,A.K., Rana,K.C., Raut,D.S., Mhaindarkar,V.P. and Khan,M.I.
    An efficient synthesis of benzodiazepinyl phosphonates as clostripain inhibitors via FeCl3 catalyzed four-component reaction
    Org Biomol Chem (2011) 9, 5407-5413. PubMed  Europe PubMed DOI  I
  8. Chakravorty,A., Awad,M.M., Hiscox,T.J., Cheung,J.K., Carter,G.P., Choo,J.M., Lyras,D. and Rood,J.I.
    The cysteine protease alpha-clostripain is not essential for the pathogenesis of Clostridium perfringens-mediated myonecrosis
    PLoS ONE (2011) 6, e22762-e22762. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Tanaka,H., Nariya,H., Suzuki,M., Houchi,H., Tamai,E., Miyata,S. and Okabe,A.
    High-level production and purification of clostripain expressed in a virulence-attenuated strain of Clostridium perfringens
    Protein Expr Purif (2011) 76, 83-89. PubMed  Europe PubMed DOI  E
    10. 2010
  10. Manabe,S., Nariya,H., Miyata,S., Tanaka,H., Minami,J., Suzuki,M., Taniguchi,Y. and Okabe,A.
    Purification and characterization of a clostripain-like protease from a recombinant Clostridium perfringens culture
    Microbiology (Reading) (2010) 156, 561-569. PubMed  Europe PubMed DOI
    11. 2009
  11. Suzuki,T., Yoneyama,T., Miyata,K., Mikami,A., Chikai,T., Inui,K., Kouguchi,H., Niwa,K., Watanabe,T., Miyazaki,S. and Ohyama,T.
    Molecular characterization of the protease from Clostridium botulinum serotype C responsible for nicking in botulinum neurotoxin complex
    Biochem Biophys Res Commun (2009) 379, 309-313. PubMed  Europe PubMed DOI  A
    12. 2008
  12. Tanaka,H., Tamai,E., Miyata,S., Taniguchi,Y., Nariya,H., Hatano,N., Houchi,H. and Okabe,A.
    Construction and characterization of a clostripain-like protease-deficient mutant of Clostridium perfringens as a strain for clostridial gene expression
    Appl Microbiol Biotechnol (2008) 77, 1063-1071. PubMed  Europe PubMed DOI
    13. 2007
  13. Kim,C.K., Lee,S.Y., Kwon,O.J., Lee,S.M., Nah,S.Y. and Jeong,S.M.
    Secretory expression of active clostripain in Escherichia coli
    J Biotechnol (2007) 131, 346-352. PubMed  Europe PubMed DOI  E
  14. Sebaihia,M., Peck,M.W., Minton,N.P., Thomson,N.R., Holden,M.T., Mitchell,W.J., Carter,A.T., Bentley,S.D., Mason,D.R., Crossman,L., Paul,C.J., Ivens,A., Wells-Bennik,M.H., Davis,I.J., Cerdeno-Tarraga,A.M., Churcher,C., Quail,M.A., Chillingworth,T., Feltwell,T., Fraser,A., Goodhead,I., Hance,Z., Jagels,K., Larke,N., Maddison,M., Moule,S., Mungall,K., Norbertczak,H., Rabbinowitsch,E., Sanders,M., Simmonds,M., White,B., Whithead,S. and Parkhill,J.
    Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes
    Genome Res (2007) 17, 1082-1092. PubMed  Europe PubMed DOI  PMC  EPMC
    15. 2004
  15. Labrou,N.E. and Rigden,D.J.
    The structure-function relationship in the clostripain family of peptidases
    Eur J Biochem (2004) 271, 983-992. PubMed  Europe PubMed DOI
  16. Ullmann,D. and Bordusa,F.
    Clostripain
    [ISSN:0-12-079610-4] (2004) 2, 1317-1319.  V
    17. 2001
  17. [YEAR:26-1-2001]Gusman,H., Grogan,J., Kagan,H.M., Troxler,R.F. and Oppenheim,F.G.
    Salivary histatin 5 is a potent competitive inhibitor of the cysteine proteinase clostripain
    FEBS Lett (26-1-2001) 489, 97-100. PubMed  Europe PubMed DOI
    18. 2000
  18. [YEAR:24-3-2000]Gunther,R., Stein,A. and Bordusa,F.
    Investigations on the enzyme specificity of clostripain: a new efficient biocatalyst for the synthesis of peptide isosteres
    J Org Chem (24-3-2000) 65, 1672-1679. PubMed  Europe PubMed DOI
    19. 1997
  19. Bordusa,F., Ullmann,D. and Jakubke,H.D.
    Subsite specificity studies on the unusual cysteine protease clostripain: charged residues in the P3 position indicate a narrow subsite region
    Biol Chem (1997) 378, 1193-1198. PubMed  Europe PubMed  P
    20. 1996
  20. Witte,V., Wolf,N. and Dargatz,H.
    Clostripain linker deletion variants yield active enzyme in Escherichia coli: a possible function of the linker peptide as intramolecular inhibitor of clostripain automaturation
    Curr Microbiol (1996) 33, 281-286. PubMed  Europe PubMed DOI
    21. 1995
  21. Hansler,M., Ullmann,G. and Jakubke,H.D.
    The application of papain, ficin and clostripain in kinetically controlled peptide synthesis in frozen aqueous solutions
    J Pept Sci (1995) 1, 283-287. PubMed  Europe PubMed DOI
    22. 1994
  22. Ullmann,D. and Jakubke,H.D.
    Kinetic characterization of affinity chromatography purified clostripain
    Biol Chem Hoppe Seyler (1994) 375, 89-92. PubMed  Europe PubMed
  23. Ullmann,D. and Jakubke,H.D.
    The specificity of clostripain from Clostridium histolyticum. Mapping the S' subsites via acyl transfer to amino acid amides and peptides
    Eur J Biochem (1994) 223, 865-872. PubMed  Europe PubMed DOI
    24. 1993
  24. Dargatz,H., Diefenthal,T., Witte,V., Reipen,G. and Von Wettstein,D.
    The heterodimeric protease clostripain from Clostridium histolyticum is encoded by a single gene
    Mol Gen Genet (1993) 240, 140-145. PubMed  Europe PubMed
    25. 1991
  25. Kembhavi,A.A., Buttle,D.J., Rauber,P. and Barrett,A.J.
    Clostripain: characterization of the active site
    FEBS Lett (1991) 283, 277-280. PubMed  Europe PubMed DOI  I
  26. Meiwes,J., Muller,W., Grabley,S. and Schudok,M.
    Clostripain: production and use for peptide synthesis
    Biomed Biochim Acta (1991) 50, S80-S83. PubMed  Europe PubMed
    27. 1990
  27. Fortier,G. and Gagnon,J.
    Kinetic study of nucleophile specificity in dipeptide synthesis catalyzed by clostridiopeptidase B
    Arch Biochem Biophys (1990) 276, 317-321. PubMed  Europe PubMed DOI
    28. 1988
  28. Zumbrunn,A., Stone,S. and Shaw,E.
    Synthesis and properties of Cbz-Phe-Arg-CHN2 (benzyloxycarbonylphenylalanylarginyldiazomethane) as a proteinase inhibitor
    Biochem J (1988) 250, 621-623. PubMed  Europe PubMed  PMC  EPMC  I
    29. 1986
  29. Fortier,G. and MacKenzie,S.L.
    Peptide bond synthesis by clostridiopeptidase B
    Biotechnol Lett (1986) 8, 777-782.
  30. Keil,B. and Gilles,A.M.
    Multiple forms, structure and specificity of clostripain
     (1986) , 147-162.
    31. 1984
  31. Gilles,A.M., Lecroisey,A. and Keil,B.
    Primary structure of alpha-clostripain light chain
    Eur J Biochem (1984) 145, 469-476. PubMed  Europe PubMed
  32. [YEAR:23-7-1984]Gilles,A.M. and Keil,B.
    Evidence for an active-center cysteine in the SH-proteinase alpha-clostripain through use of N-tosyl-L-lysine chloromethyl ketone
    FEBS Lett (23-7-1984) 173, 58-62. PubMed  Europe PubMed  I
    33. 1979
  33. Gilles,A.M., Imhoff,J.M. and Keil,B.
    alpha-Clostripain. Chemical characterization, activity, and thiol content of the highly active form of clostripain
    J Biol Chem (1979) 254, 1462-1468. PubMed  Europe PubMed
    34. 1978
  34. Giroux,E. and Vargaftig,B.B.
    Clostridiopeptidase B inhibition by plasma macroglobulins and microbial antiproteases
    Biochim Biophys Acta (1978) 525, 429-437. PubMed  Europe PubMed
    35. 1976
  35. Siffert,O., Emod,I. and Keil,B.
    Interaction of clostripain with natural trypsin inhibitors and its affinity labeling by Nalpha-p-nitrobenzyloxycarbonyl arginine chlormethyl ketone
    FEBS Lett (1976) 66, 114-119. PubMed  Europe PubMed DOI  I
    36. 1971
  36. Cole,P.W., Murakami,K. and Inagami,T.
    Specificity and mechanism of clostripain catalysis
    Biochemistry (1971) 10, 4246-4252. PubMed  Europe PubMed  I
    37. 1970
  37. Mitchell,W.M. and Harrington,W.F.
    Clostripain
    Methods Enzymol (1970) 19, 635-642. DOI  I
    38. 1968
  38. [YEAR:18-10-1968]Mitchell,W.M.
    Hydrolysis at arginylproline in polypeptides by clostridiopeptidase B
    Science (18-10-1968) 162, 374-375. PubMed  Europe PubMed
    39. 1961
  39. Conklin,D.A., Webster,M.E., Altieri,P.L., Berman,S., Lowenthal,J.P. and Gochenour,R.B.
    Large scale purification of proteinases from Clostridium histolyticum filtrates
    J Bacteriol (1961) 82, 589-594. PubMed  Europe PubMed  PMC  EPMC
    40. 1960
  40. Gros,P. and Labouesse,B.
    [Clostripain, a protease from Clostridium histolyticum. 2. Specificity.]
    Bull Soc Chim Biol (Paris) (1960) 42, 559-568. PubMed  Europe PubMed  P
  41. Heyns,K. and Legler,G.
    [On proteins and their decomposition products. 18. The hydrolysis of synthetic and natural substrates by collagenase from Clostridium histolyticum.]
    Hoppe Seylers Z Physiol Chem (1960) 321, 184-200. PubMed  Europe PubMed  P
  42. Labouesse,B. and Gros,P.
    [Clostripain, a protease from Clostridium histolyticum. 1. Purification activation by thiols]
    Bull Soc Chim Biol (Paris) (1960) 42, 543-558. PubMed  Europe PubMed
  43. Labouesse,B.
    [The hydrolysis of glucagon by Clostripain]
    Bull Soc Chim Biol (Paris) (1960) 42, 1293-1304. PubMed  Europe PubMed  P
    44. 1953
  44. Ogle,J.D. and Tytell,A.A.
    The activity of Clostridium histolyticum proteinase on synthetic substrates
    Arch Biochem Biophys (1953) 42, 327-336. PubMed  Europe PubMed
    45. 1938
  45. Kocholaty,W., Weil,L. and Smith,L.
    Proteinase secretion and growth of Clostridium histolyticum
    Biochem J (1938) 32, 1685-1690. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use