Literature for peptidase C01.129: cathepsin L3 (Fasciola sp.)

Summary Alignment Sequences Sequence features Distribution Literature Substrates

(Topics flags: P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Chansap,S., Cheukamud,W., Suthisintong,T., Kueakhai,P. and Changklungmoa,N. Development of multi-epitope Cathepsin L driven short peptide vaccine against Fasciola gigantica Front Vet Sci (2025) 12, 1547937-1547937. PubMed Europe PubMed DOI PMC EPMC

2023

Artia,Z., Ferraro,F., Sanchez,C., Cerecetto,H., Gil,J., Pareja,L., Alonzo,M.N., Freire,T., Cabrera,M. and Corvo,I. In vitro and in vivo studies on a group of chalcones find promising results as potential drugs against fascioliasis Exp Parasitol (2023) 255, 108628-108628. PubMed Europe PubMed DOI

2021

Barbour,T., Cwiklinski,K., Lalor,R., Dalton,J.P. and De Marco Verissimo,C. The Zoonotic Helminth Parasite Fasciola hepatica: Virulence-Associated Cathepsin B and Cathepsin L Cysteine Peptidases Secreted by Infective Newly Excysted Juveniles (NEJ) Animals (Basel) (2021) 11 PubMed Europe PubMed DOI PMC EPMC
Cwiklinski,K., Robinson,M.W., Donnelly,S. and Dalton,J.P. Complementary transcriptomic and proteomic analyses reveal the cellular and molecular processes that drive growth and development of Fasciola hepatica in the host liver BMC Genomics (2021) 22, 46-46. PubMed Europe PubMed DOI PMC EPMC

2020

Huang,W., Gu,M., Cheng,W., Zhao,Q.P., Ming,Z. and Dong,H. Characteristics and function of cathepsin L3 from Schistosoma japonicum Parasitol Res (2020) 119, 1619-1628. PubMed Europe PubMed DOI
Pritsch,I.C., Tikhonova,I.G., Jewhurst,H.L., Drysdale,O., Cwiklinski,K., Molento,M.B., Dalton,J.P. and Verissimo,C.M. Regulation of the Fasciola hepatica newly excysted juvenile cathepsin L3 (FhCL3) by its propeptide: a proposed 'clamp-like' mechanism of binding and inhibition BMC Mol Cell Biol (2020) 21, 90-90. PubMed Europe PubMed DOI PMC EPMC

2019

Celias,D.P., Corvo,I., Silvane,L., Tort,J.F., Chiapello,L.S., Fresno,M., Arranz,A., Motran,C.C. and Cervi,L. Cathepsin L3 From Fasciola hepatica induces NLRP3 inflammasome alternative activation in murine dendritic cells Front Immunol (2019) 10, 552-552. PubMed Europe PubMed DOI PMC EPMC

2016

Ferraro,F., Merlino,A., dellOca,N., Gil,J., Tort,J.F., Gonzalez,M., Cerecetto,H., Cabrera,M. and Corvo,I. Identification of chalcones as Fasciola hepatica cathepsin L inhibitors using a comprehensive experimental and computational approach PLoS Negl Trop Dis (2016) 10, e0004834-e0004834. PubMed Europe PubMed DOI I

2015

Hernandez Alvarez,L., Naranjo Feliciano,D., Hernandez Gonzalez,J.E., de Oliveira Soares,R., Barreto Gomes,D.E. and Pascutti,P.G. Insights into the interactions of Fasciola hepatica cathepsin L3 with a substrate and potential novel inhibitors through in silico approaches PLoS Negl Trop Dis (2015) 9, e0003759- PubMed Europe PubMed DOI PMC EPMC I
Meemon,K. and Sobhon,P. Juvenile-specific cathepsin proteases in Fasciola spp.: their characteristics and vaccine efficacies Parasitol Res (2015) 114, 2807-2813. PubMed Europe PubMed DOI

2013

Corvo,I., O'Donoghue,A.J., Pastro,L., Pi-Denis,N., Eroy-Reveles,A., Roche,L., McKerrow,J.H., Dalton,J.P., Craik,C.S., Caffrey,C.R. and Tort,J.F. Dissecting the active site of the collagenolytic cathepsin L3 protease of the invasive stage of Fasciola hepatica PLoS Negl Trop Dis (2013) 7, e2269-e2269. PubMed Europe PubMed DOI PMC EPMC P
Zawistowska-Deniziak,A., Wasyl,K., Norbury,L.J., Wesolowska,A., Bien,J., Grodzik,M., Wisniewski,M., Baska,P. and Wedrychowicz,H. Characterization and differential expression of cathepsin L3 alleles from Fasciola hepatica Mol Biochem Parasitol (2013) 190, 27-37. PubMed Europe PubMed DOI

2012

Caffrey,C.R., Britton,C. and McKerrow,J.H. Helminth cysteine proteases [ISSN:978-0-12-407743-0] (2012) 3, 1949-1957. DOI
McVeigh,P., Maule,A.G., Dalton,J.P. and Robinson,M.W. Fasciola hepatica virulence-associated cysteine peptidases: a systems biology perspective Microbes Infect (2012) 14, 301-310. PubMed Europe PubMed DOI

2011

Morphew,R.M., Wright,H.A., Lacourse,E.J., Porter,J., Barrett,J., Woods,D.J. and Brophy,P.M. Towards delineating functions within the Fasciola secreted cathepsin L protease family by integrating in vivo based sub-proteomics and phylogenetics PLoS Negl Trop Dis (2011) 5, e937-e937. PubMed Europe PubMed DOI PMC EPMC
Norbury,L.J., Beckham,S., Pike,R.N., Grams,R., Spithill,T.W., Fecondo,J.V. and Smooker,P.M. Adult and juvenile Fasciola cathepsin L proteases: different enzymes for different roles Biochimie (2011) 93, 604-611. PubMed Europe PubMed DOI P
Robinson,M.W., Corvo,I., Jones,P.M., George,A.M., Padula,M.P., To,J., Cancela,M., Rinaldi,G., Tort,J.F., Roche,L. and Dalton,J.P. Collagenolytic activities of the major secreted cathepsin L peptidases involved in the virulence of the helminth pathogen, Fasciola hepatica PLoS Negl Trop Dis (2011) 5, e1012-e1012. PubMed Europe PubMed DOI PMC EPMC
Stack,C., Dalton,J.P. and Robinson,M.W. The phylogeny, structure and function of trematode cysteine proteases, with particular emphasis on the Fasciola hepatica cathepsin L family Adv Exp Med Biol (2011) 712, 116-135. PubMed Europe PubMed DOI V

2010

Corvo,I., Cancela,M., Cappetta,M., Pi-Denis,N., Tort,J.F. and Roche,L. 'Corrigendum to "The major cathepsin L secreted by the invasive juvenile Fasciola hepatica prefers proline in the S2 subsite and can cleave collagen" [Mol. Biochem. Parasitol. 176 (1) (2009) 41-47]' (DOI:10.1016/j.molbiopara.2009.04.005) Mol Biochem Parasitol (2010) 176, 68-68. DOI P

2009

Corvo,I., Cancela,M., Cappetta,M., Pi-Denis,N., Tort,J.F. and Roche,L. The major cathepsin L secreted by the invasive juvenile Fasciola hepatica prefers proline in the S2 subsite and can cleave collagen Mol Biochem Parasitol (2009) 167, 41-47. PubMed Europe PubMed DOI P

2005

[YEAR:27-4-2005]Reszka,N., Cornelissen,J.B., Harmsen,M.M., Bienkowska-Szewczyk,K., de Bree,J., Boersma,W.J. and Rijsewijk,F.A. Fasciola hepatica procathepsin L3 protein expressed by a baculovirus recombinant can partly protect rats against fasciolosis Vaccine (27-4-2005) 23, 2987-2993. PubMed Europe PubMed DOI

2004

Harmsen,M.M., Cornelissen,J.B., Buijs,H.E., Boersma,W.J., Jeurissen,S.H. and van Milligen,F.J. Identification of a novel Fasciola hepatica cathepsin L protease containing protective epitopes within the propeptide Int J Parasitol (2004) 34, 675-682. PubMed Europe PubMed DOI