Substrates for peptidase C01.098: CPC peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Ac-Lys-Gln-Lys-Leu-Arg-NHMec			Ac-Lys-Gln-Lys-Leu-Arg+NHMec	S		Gln	Lys	Leu	Arg	AMC	-	-	-	O'Brien et al., 2008
Bz-Phe-Val-Arg-NHMec			Bz-Phe-Val-Arg+NHMec	S		Bz	Phe	Val	Arg	AMC	-	-	-	Mottram & Coombs, 2004
H-Arg-Gln-Arg-Arg-NHMec			H-Arg-Gln-Arg-Arg+NHMec	S		Arg	Gln	Arg	Arg	AMC	-	-	-	O'Brien et al., 2008
Serotransferrin	Q29443	25-351	Peptide-Ser203+Asn-Peptide	N	NT	Cys	Ala	Cys	Ser	Asn	His	Glu	Pro	O'Brien et al., 2008
Serotransferrin	Q29443	25-351	Peptide-Ala345+Leu-Peptide	N	NT	Tyr	Val	Thr	Ala	Leu	Gln	Asn	Leu	O'Brien et al., 2008
Z-Arg-Arg-Leu-Arg-NHMec			Z-Arg-Arg-Leu-Arg+NHMec	S		Arg	Arg	Leu	Arg	AMC	-	-	-	O'Brien et al., 2008
Z-Arg-Arg-NHMec			Z-Arg-Arg+NHMec	S		-	Z	Arg	Arg	AMC	-	-	-	O'Brien et al., 2008
Z-Arg-Glu-Lys-Arg-NHMec			Z-Arg-Glu-Lys-Arg+NHMec	S		Arg	Glu	Lys	Arg	AMC	-	-	-	O'Brien et al., 2008
Z-Phe-Arg-NHMec			Z-Phe-Arg+NHMec	S		-	Z	Phe	Arg	AMC	-	-	-	O'Brien et al., 2008