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Literature for peptidase C01.098: CPC peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, T Target, K Knockout, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Ettari,R.<br>Cysteine Proteases as Validated Targets for the Treatment of Neglected and Poverty-Related Parasitic Diseases<br>Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2020
  2. Alvarez,V.E., Iribarren,P.A., Niemirowicz,G.T. and Cazzulo,J.J.<br>Update on relevant trypanosome peptidases: Validated targets and future challenges<br>Biochim Biophys Acta Proteins Proteom (2020) 1869, 140577-140577. PubMed  Europe PubMed DOI
  3. Didwania,N., Ejazi,S.A., Chhajer,R., Sabur,A., Mazumder,S., Kamran,M., Kar,R., Pandey,K., Das,V.N.R., Das,P., Rahaman,M., Goswami,R.P. and Ali,N.<br>Evaluation of Cysteine Protease C of Leishmania donovani in comparison with Glycoprotein 63 and Elongation Factor-1alpha for diagnosis of human visceral leishmaniasis and for post-treatment follow-up response<br>J Clin Microbiol (2020) PubMed  Europe PubMed DOI
    4. 2016
  4. Ettari,R., Previti,S., Tamborini,L., Cullia,G., Grasso,S. and Zappala,M.<br>The inhibition of cysteine proteases rhodesain and TbCatB: a valuable approach to treat human African trypanosomiasis<br>Mini Rev Med Chem (2016) 16, 1374-1391. PubMed  Europe PubMed DOI  V  I
  5. Nourrisson,C., Wawrzyniak,I., Cian,A., Livrelli,V., Viscogliosi,E., Delbac,F. and Poirier,P.<br>On Blastocystis secreted cysteine proteases: a legumain-activated cathepsin B increases paracellular permeability of intestinal Caco-2 cell monolayers<br>Parasitology (2016) 143, 1713-1722. PubMed  Europe PubMed DOI
  6. Schad,C., Baum,U., Frank,B., Dietzel,U., Mattern,F., Gomes,C., Ponte-Sucre,A., Moll,H., Schurigt,U. and Schirmeister,T.<br>Development of a new antileishmanial aziridine-2,3-dicarboxylate-based inhibitor with high selectivity for parasite cysteine proteases<br>Antimicrob Agents Chemother (2016) 60, 797-805. PubMed  Europe PubMed DOI  I
    7. 2014
  7. Oliveira,L.C., Okamoto,D.N., Oliveira,J.R., Kondo,M.Y., Gouvea,I.E., Biteau,N., Baltz,T., Murakami,M.T., Juliano,L. and Juliano,M.A.<br>Analysis of peptidase activities of a cathepsin B-like (TcoCBc1) from Trypanosoma congolense<br>Biochim Biophys Acta (2014) 1844, 1260-1267. PubMed  Europe PubMed DOI
    8. 2013
  8. Gerbaba,T.K. and Gedamu,L.<br>Cathepsin B gene disruption induced Leishmania donovani proteome remodeling implies cathepsin B role in secretome regulation<br>PLoS ONE (2013) 8, e79951-e79951. PubMed  Europe PubMed DOI  PMC  EPMC  K
  9. Redecke,L., Nass,K., Deponte,D.P., White,T.A., Rehders,D., Barty,A., Stellato,F., Liang,M., Barends,T.R., Boutet,S., Williams,G.J., Messerschmidt,M., Seibert,M.M., Aquila,A., Arnlund,D., Bajt,S., Barth,T., Bogan,M.J., Caleman,C., Chao,T.C., Doak,R.B., Fleckenstein,H., Frank,M., Fromme,R., Galli,L., Grotjohann,I., Hunter,M.S., Johansson,L.C., Kassemeyer,S., Katona,G., Kirian,R.A., Koopmann,R., Kupitz,C., Lomb,L., Martin,A.V., Mogk,S., Neutze,R., Shoeman,R.L., Steinbrener,J., Timneanu,N., Wang,D., Weierstall,U., Zatsepin,N.A., Spence,J.C., Fromme,P., Schlichting,I., Duszenko,M., Betzel,C. and Chapman,H.N.<br>Natively inhibited Trypanosoma brucei cathepsin B structure determined by using an X-ray laser<br>Science (2013) 339, 227-230. PubMed  Europe PubMed DOI  S
    10. 2012
  10. Myburgh,E., Coombs,G.H. and Mottram,J.C.<br>Leishmania CPA, CPB and CPC cysteine proteases<br>[ISSN:978-0-12-407743-0] (2012) 3, 1923-1928. DOI
  11. Rana,S., Dikhit,M.R., Rani,M., Moharana,K.C., Sahoo,G.C. and Das,P.<br>CPDB: cysteine protease annotation database in Leishmania species<br>Integr Biol (Camb) (2012) 4, 1351-1357. PubMed  Europe PubMed DOI
    12. 2011
  12. Caffrey,C.R., Lima,A.P. and Steverding,D.<br>Cysteine peptidases of kinetoplastid parasites<br>Adv Exp Med Biol (2011) 712, 84-99. PubMed  Europe PubMed DOI  V
  13. Doroud,D., Zahedifard,F., Vatanara,A., Najafabadi,A.R., Taslimi,Y., Vahabpour,R., Torkashvand,F., Vaziri,B. and Rafati,S.<br>Delivery of a cocktail DNA vaccine encoding cysteine proteinases type I, II and III with solid lipid nanoparticles potentiate protective immunity against Leishmania major infection<br>J Control Release (2011) 153, 154-162. PubMed  Europe PubMed DOI
    14. 2010
  14. El-Fadili,A.K., Zangger,H., Desponds,C., Gonzalez,I.J., Zalila,H., Schaff,C., Ives,A., Masina,S., Mottram,J.C. and Fasel,N.<br>Cathepsin B-like and cell death in the unicellular human pathogen Leishmania<br>Cell Death Dis (2010) 1, e71-e71. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Kerr,I.D., Wu,P., Marion-Tsukamaki,R., Mackey,Z.B. and Brinen,L.S.<br>Crystal structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei<br>PLoS Negl Trop Dis (2010) 4, e701-e701. PubMed  Europe PubMed DOI  PMC  EPMC  S
  16. Mallari,J.P., Zhu,F., Lemoff,A., Kaiser,M., Lu,M., Brun,R. and Guy,R.K.<br>Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models<br>Bioorg Med Chem (2010) 18, 8302-8309. PubMed  Europe PubMed DOI  I
  17. Mott,B.T., Ferreira,R.S., Simeonov,A., Jadhav,A., Ang,K.K., Leister,W., Shen,M., Silveira,J.T., Doyle,P.S., Arkin,M.R., McKerrow,J.H., Inglese,J., Austin,C.P., Thomas,C.J., Shoichet,B.K. and Maloney,D.J.<br>Identification and optimization of inhibitors of trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB<br>J Med Chem (2010) 53, 52-60. PubMed  Europe PubMed DOI  S  I
    18. 2009
  18. Caffrey,C.R. and Steverding,D.<br>Kinetoplastid papain-like cysteine peptidases<br>Mol Biochem Parasitol (2009) 167, 12-19. PubMed  Europe PubMed DOI  I
  19. Laurent,T., Van der Auwera,G., Hide,M., Mertens,P., Quispe-Tintaya,W., Deborggraeve,S., de Doncker,S., Leclipteux,T., Banuls,A.L., Buscher,P. and Dujardin,J.C.<br>Identification of Old World Leishmania spp. by specific polymerase chain reaction amplification of cysteine proteinase B genes and rapid dipstick detection<br>Diagn Microbiol Infect Dis (2009) 63, 173-181. PubMed  Europe PubMed DOI
  20. Mallari,J.P., Shelat,A.A., Kosinski,A., Caffrey,C.R., Connelly,M., Zhu,F., McKerrow,J.H. and Guy,R.K.<br>Structure-guided development of selective TbcatB inhibitors<br>J Med Chem (2009) 52, 6489-6493. PubMed  Europe PubMed DOI  PMC  EPMC  I
  21. Oshaghi,M.A., Ravasan,N.M., Hide,M., Javadian,E.A., Rassi,Y., Sedaghat,M.M., Mohebali,M. and Hajjaran,H.<br>Development of species-specific PCR and PCR-restriction fragment length polymorphism assays for L.infantum/L.donovani discrimination<br>Exp Parasitol (2009) 122, 61-65. PubMed  Europe PubMed DOI
  22. Saffari,B. and Mohabatkar,H.<br>Computational analysis of cysteine proteases (Clan CA, Family C1) of Leishmania major to find potential epitopic regions<br>Genomics Proteomics Bioinformatics (2009) 7, 87-95. PubMed  Europe PubMed DOI
    23. 2008
  23. Abdulla,M.H., O'Brien,T., Mackey,Z.B., Sajid,M., Grab,D.J. and McKerrow,J.H.<br>RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model<br>PLoS Negl Trop Dis (2008) 2, e298-e298. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Khoshgoo,N., Zahedifard,F., Azizi,H., Taslimi,Y., Alonso,M.J. and Rafati,S.<br>Cysteine proteinase type III is protective against Leishmania infantum infection in BALB/c mice and highly antigenic in visceral leishmaniasis individuals<br>Vaccine (2008) 26, 5822-5829. PubMed  Europe PubMed DOI
  25. Kulkarni,M.M., Jones,E.A., McMaster,W.R. and McGwire,B.S.<br>Fibronectin binding and proteolytic degradation by Leishmania and effects on macrophage activation<br>Infect Immun (2008) 76, 1738-1747. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Mallari,J.P., Shelat,A.A., Obrien,T., Caffrey,C.R., Kosinski,A., Connelly,M., Harbut,M., Greenbaum,D., McKerrow,J.H. and Guy,R.K.<br>Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB<br>J Med Chem (2008) 51, 545-552. PubMed  Europe PubMed DOI  I
  27. Mallari,J.P., Shelat,A., Kosinski,A., Caffrey,C.R., Connelly,M., Zhu,F., McKerrow,J.H. and Guy,R.K.<br>Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB<br>Bioorg Med Chem Lett (2008) 18, 2883-2885. PubMed  Europe PubMed DOI  PMC  EPMC  I
  28. Mendoza-Palomares,C., Biteau,N., Giroud,C., Coustou,V., Coetzer,T., Authie,E., Boulange,A. and Baltz,T.<br>Molecular and biochemical characterization of a cathepsin B-like protease family unique to Trypanosoma congolense<br>Eukaryot Cell (2008) 7, 684-697. PubMed  Europe PubMed DOI  PMC  EPMC  T
  29. O'Brien,T.C., Mackey,Z.B., Fetter,R.D., Choe,Y., O'Donoghue,A.J., Zhou,M., Craik,C.S., Caffrey,C.R. and McKerrow,J.H.<br>A parasite cysteine protease is key to host protein degradation and iron acquisition<br>J Biol Chem (2008) 283, 28934-28943. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Rafati,S., Zahedifard,F., Azari,M.K., Taslimi,Y. and Taheri,T.<br>Leishmania infantum: prime boost vaccination with C-terminal extension of cysteine proteinase type I displays both type 1 and 2 immune signatures in BALB/c mice<br>Exp Parasitol (2008) 118, 393-401. PubMed  Europe PubMed DOI
    31. 2007
  31. Hide,M., Bras-Goncalves,R. and Banuls,A.L.<br>Specific cpb copies within the Leishmania donovani complex: evolutionary interpretations and potential clinical implications in humans<br>Parasitology (2007) 134, 379-389. PubMed  Europe PubMed DOI
    32. 2006
  32. Hide,M. and Banuls,A.L.<br>Species-specific PCR assay for L. infantum/L. donovani discrimination<br>Acta Trop (2006) 100, 241-245. PubMed  Europe PubMed DOI
  33. Rafati,S., Zahedifard,F. and Nazgouee,F.<br>Prime-boost vaccination using cysteine proteinases type I and II of Leishmania infantum confers protective immunity in murine visceral leishmaniasis<br>Vaccine (2006) 24, 2169-2175. PubMed  Europe PubMed DOI
    34. 2004
  34. [YEAR:23-8-2004]Mackey,Z.B., O'Brien,T.C., Greenbaum,D.C., Blank,R.B. and McKerrow,J.H.<br>A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei<br>J Biol Chem (23-8-2004) 279, 48426-48433. PubMed  Europe PubMed DOI
  35. Mottram,J.C. and Coombs,G.H.<br>Leishmania CPA, CPB and CPC cysteine proteases<br>[ISSN:0-12-079610-4] (2004) 2, 1166-1169.  V
  36. Mottram,J.C., Coombs,G.H. and Alexander,J.<br>Cysteine peptidases as virulence factors of Leishmania<br>Curr Opin Microbiol (2004) 7, 375-381. PubMed  Europe PubMed DOI
    37. 2003
  37. Chibale,K. and Musonda,C.C.<br>The synthesis of parasitic cysteine protease and trypanothione reductase inhibitors<br>Curr Med Chem (2003) 10, 1863-1889. PubMed  Europe PubMed DOI  I
  38. Gantt,K.R., Schultz-Cherry,S., Rodriguez,N., Jeronimo,S.M., Nascimento,E.T., Goldman,T.L., Recker,T.J., Miller,M.A. and Wilson,M.E.<br>Activation of TGF-beta by Leishmania chagasi: importance for parasite survival in macrophages<br>J Immunol (2003) 170, 2613-2620. PubMed  Europe PubMed  I
    39. 2002
  39. Sajid,M. and McKerrow,J.H.<br>Cysteine proteases of parasitic organisms<br>Mol Biochem Parasitol (2002) 120, 1-21. PubMed  Europe PubMed
  40. [YEAR:12-7-2002]Somanna,A., Mundodi,V. and Gedamu,L.<br>Functional analysis of cathepsin B-like cysteine proteases from Leishmania donovani complex. Evidence for the activation of latent transforming growth factor beta<br>J Biol Chem (12-7-2002) 277, 25305-25312. PubMed  Europe PubMed DOI
    41. 2000
  41. Yong,V., Schmitz,V., Vannier-Santos,M.A., de Lima,A.P., Lalmanach,G., Juliano,L., Gauthier,F. and Scharfstein,J.<br>Altered expression of cruzipain and a cathepsin B-like target in a Trypanosoma cruzi cell line displaying resistance to synthetic inhibitors of cysteine-proteinases<br>Mol Biochem Parasitol (2000) 109, 47-59. PubMed  Europe PubMed DOI
    42. 1999
  42. [YEAR:15-5-1999]Chan,V.J., Selzer,P.M., McKerrow,J.H. and Sakanari,J.A.<br>Expression and alteration of the S2 subsite of the Leishmania major cathepsin B-like cysteine protease<br>Biochem J (15-5-1999) 340, 113-117. PubMed  Europe PubMed  PMC  EPMC  I
    43. 1998
  43. [YEAR:15-3-1998]Garcia,M.P., Nobrega,O.T., Teixeira,A.R., Sousa,M.V. and Santana,J.M.<br>Characterisation of a Trypanosoma cruzi acidic 30 kDa cysteine protease<br>Mol Biochem Parasitol (15-3-1998) 91, 263-272. PubMed  Europe PubMed DOI
  44. Mottram,J.C., Brooks,D.R. and Coombs,G.H.<br>Roles of cysteine proteinases of trypanosomes and Leishmania in host-parasite interactions<br>Curr Opin Microbiol (1998) 1, 455-460. PubMed  Europe PubMed
  45. [YEAR:30-11-1998]Nobrega,O.T., Santos Silva,M.A., Teixeira,A.R. and Santana,J.M.<br>Cloning and sequencing of tccb, a gene encoding a Trypanosoma cruzi cathepsin B-like protease<br>Mol Biochem Parasitol (30-11-1998) 97, 235-240. PubMed  Europe PubMed DOI
    46. 1997
  46. Bart,G., Frame,M.J., Carter,R., Coombs,G.H. and Mottram,J.C.<br>Cathepsin B-like cysteine proteinase-deficient mutants of Leishmania mexicana<br>Mol Biochem Parasitol (1997) 88, 53-61. PubMed  Europe PubMed DOI  K
  47. Sakanari,J.A., Nadler,S.A., Chan,V.J., Engel,J.C., Leptak,C. and Bouvier,J.<br>Leishmania major: Comparison of the cathepsin L- and B-like cysteine protease genes with those of other trypanosomatids<br>Exp Parasitol (1997) 85, 63-76. PubMed  Europe PubMed DOI
  48. Selzer,P.M., Chen,X., Chan,V.J., Cheng,M., Kenyon,G.L., Kuntz,I.D., Sakanari,J.A., Cohen,F.E. and McKerrow,J.H.<br>Leishmania major: molecular modeling of cysteine proteases and prediction of new nonpeptide inhibitors<br>Exp Parasitol (1997) 87, 212-221. PubMed  Europe PubMed DOI
    49. 1995
  49. Bart,G., Coombs,G.H. and Mottram,J.C.<br>Isolation of lmcpc, a gene encoding a Leishmania mexicana cathepsin-B-like cysteine proteinase<br>Mol Biochem Parasitol (1995) 73, 271-274. PubMed  Europe PubMed DOI
    50. 1994
  50. Robertson,C.D. and Coombs,G.H.<br>Multiple high activity cysteine proteases of Leishmania mexicana are encoded by the Imcpb gene array<br>Microbiology (Reading, Engl.) (1994) 140, 417-424. PubMed  Europe PubMed
    51. 1993
  51. Robertson,C.D. and Coombs,G.H.<br>Cathepsin B-like cysteine proteases of Leishmania mexicana<br>Mol Biochem Parasitol (1993) 62, 271-279. PubMed  Europe PubMed DOI
    52. 1990
  52. Robertson,C.D. and Coombs,G.H.<br>Characterisation of three groups of cysteine proteinases in the amastigotes of Leishmania mexicana mexicana<br>Mol Biochem Parasitol (1990) 42, 269-276. PubMed  Europe PubMed DOI

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