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Literature for peptidase C01.098: CPC peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, T Target, K Knockout, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Ettari,R.
    Cysteine Proteases as Validated Targets for the Treatment of Neglected and Poverty-Related Parasitic Diseases
    Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2020
  2. Alvarez,V.E., Iribarren,P.A., Niemirowicz,G.T. and Cazzulo,J.J.
    Update on relevant trypanosome peptidases: Validated targets and future challenges
    Biochim Biophys Acta Proteins Proteom (2020) 1869, 140577-140577. PubMed  Europe PubMed DOI
  3. Didwania,N., Ejazi,S.A., Chhajer,R., Sabur,A., Mazumder,S., Kamran,M., Kar,R., Pandey,K., Das,V.N.R., Das,P., Rahaman,M., Goswami,R.P. and Ali,N.
    Evaluation of Cysteine Protease C of Leishmania donovani in comparison with Glycoprotein 63 and Elongation Factor-1alpha for diagnosis of human visceral leishmaniasis and for post-treatment follow-up response
    J Clin Microbiol (2020) PubMed  Europe PubMed DOI
    4. 2016
  4. Ettari,R., Previti,S., Tamborini,L., Cullia,G., Grasso,S. and Zappala,M.
    The inhibition of cysteine proteases rhodesain and TbCatB: a valuable approach to treat human African trypanosomiasis
    Mini Rev Med Chem (2016) 16, 1374-1391. PubMed  Europe PubMed DOI  V  I
  5. Nourrisson,C., Wawrzyniak,I., Cian,A., Livrelli,V., Viscogliosi,E., Delbac,F. and Poirier,P.
    On Blastocystis secreted cysteine proteases: a legumain-activated cathepsin B increases paracellular permeability of intestinal Caco-2 cell monolayers
    Parasitology (2016) 143, 1713-1722. PubMed  Europe PubMed DOI
  6. Schad,C., Baum,U., Frank,B., Dietzel,U., Mattern,F., Gomes,C., Ponte-Sucre,A., Moll,H., Schurigt,U. and Schirmeister,T.
    Development of a new antileishmanial aziridine-2,3-dicarboxylate-based inhibitor with high selectivity for parasite cysteine proteases
    Antimicrob Agents Chemother (2016) 60, 797-805. PubMed  Europe PubMed DOI  I
    7. 2014
  7. Oliveira,L.C., Okamoto,D.N., Oliveira,J.R., Kondo,M.Y., Gouvea,I.E., Biteau,N., Baltz,T., Murakami,M.T., Juliano,L. and Juliano,M.A.
    Analysis of peptidase activities of a cathepsin B-like (TcoCBc1) from Trypanosoma congolense
    Biochim Biophys Acta (2014) 1844, 1260-1267. PubMed  Europe PubMed DOI
    8. 2013
  8. Gerbaba,T.K. and Gedamu,L.
    Cathepsin B gene disruption induced Leishmania donovani proteome remodeling implies cathepsin B role in secretome regulation
    PLoS ONE (2013) 8, e79951-e79951. PubMed  Europe PubMed DOI  PMC  EPMC  K
  9. Redecke,L., Nass,K., Deponte,D.P., White,T.A., Rehders,D., Barty,A., Stellato,F., Liang,M., Barends,T.R., Boutet,S., Williams,G.J., Messerschmidt,M., Seibert,M.M., Aquila,A., Arnlund,D., Bajt,S., Barth,T., Bogan,M.J., Caleman,C., Chao,T.C., Doak,R.B., Fleckenstein,H., Frank,M., Fromme,R., Galli,L., Grotjohann,I., Hunter,M.S., Johansson,L.C., Kassemeyer,S., Katona,G., Kirian,R.A., Koopmann,R., Kupitz,C., Lomb,L., Martin,A.V., Mogk,S., Neutze,R., Shoeman,R.L., Steinbrener,J., Timneanu,N., Wang,D., Weierstall,U., Zatsepin,N.A., Spence,J.C., Fromme,P., Schlichting,I., Duszenko,M., Betzel,C. and Chapman,H.N.
    Natively inhibited Trypanosoma brucei cathepsin B structure determined by using an X-ray laser
    Science (2013) 339, 227-230. PubMed  Europe PubMed DOI  S
    10. 2012
  10. Myburgh,E., Coombs,G.H. and Mottram,J.C.
    Leishmania CPA, CPB and CPC cysteine proteases
    [ISSN:978-0-12-407743-0] (2012) 3, 1923-1928. DOI
  11. Rana,S., Dikhit,M.R., Rani,M., Moharana,K.C., Sahoo,G.C. and Das,P.
    CPDB: cysteine protease annotation database in Leishmania species
    Integr Biol (Camb) (2012) 4, 1351-1357. PubMed  Europe PubMed DOI
    12. 2011
  12. Caffrey,C.R., Lima,A.P. and Steverding,D.
    Cysteine peptidases of kinetoplastid parasites
    Adv Exp Med Biol (2011) 712, 84-99. PubMed  Europe PubMed DOI  V
  13. Doroud,D., Zahedifard,F., Vatanara,A., Najafabadi,A.R., Taslimi,Y., Vahabpour,R., Torkashvand,F., Vaziri,B. and Rafati,S.
    Delivery of a cocktail DNA vaccine encoding cysteine proteinases type I, II and III with solid lipid nanoparticles potentiate protective immunity against Leishmania major infection
    J Control Release (2011) 153, 154-162. PubMed  Europe PubMed DOI
    14. 2010
  14. El-Fadili,A.K., Zangger,H., Desponds,C., Gonzalez,I.J., Zalila,H., Schaff,C., Ives,A., Masina,S., Mottram,J.C. and Fasel,N.
    Cathepsin B-like and cell death in the unicellular human pathogen Leishmania
    Cell Death Dis (2010) 1, e71-e71. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Kerr,I.D., Wu,P., Marion-Tsukamaki,R., Mackey,Z.B. and Brinen,L.S.
    Crystal structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei
    PLoS Negl Trop Dis (2010) 4, e701-e701. PubMed  Europe PubMed DOI  PMC  EPMC  S
  16. Mallari,J.P., Zhu,F., Lemoff,A., Kaiser,M., Lu,M., Brun,R. and Guy,R.K.
    Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models
    Bioorg Med Chem (2010) 18, 8302-8309. PubMed  Europe PubMed DOI  I
  17. Mott,B.T., Ferreira,R.S., Simeonov,A., Jadhav,A., Ang,K.K., Leister,W., Shen,M., Silveira,J.T., Doyle,P.S., Arkin,M.R., McKerrow,J.H., Inglese,J., Austin,C.P., Thomas,C.J., Shoichet,B.K. and Maloney,D.J.
    Identification and optimization of inhibitors of trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB
    J Med Chem (2010) 53, 52-60. PubMed  Europe PubMed DOI  S  I
    18. 2009
  18. Caffrey,C.R. and Steverding,D.
    Kinetoplastid papain-like cysteine peptidases
    Mol Biochem Parasitol (2009) 167, 12-19. PubMed  Europe PubMed DOI  I
  19. Laurent,T., Van der Auwera,G., Hide,M., Mertens,P., Quispe-Tintaya,W., Deborggraeve,S., de Doncker,S., Leclipteux,T., Banuls,A.L., Buscher,P. and Dujardin,J.C.
    Identification of Old World Leishmania spp. by specific polymerase chain reaction amplification of cysteine proteinase B genes and rapid dipstick detection
    Diagn Microbiol Infect Dis (2009) 63, 173-181. PubMed  Europe PubMed DOI
  20. Mallari,J.P., Shelat,A.A., Kosinski,A., Caffrey,C.R., Connelly,M., Zhu,F., McKerrow,J.H. and Guy,R.K.
    Structure-guided development of selective TbcatB inhibitors
    J Med Chem (2009) 52, 6489-6493. PubMed  Europe PubMed DOI  PMC  EPMC  I
  21. Oshaghi,M.A., Ravasan,N.M., Hide,M., Javadian,E.A., Rassi,Y., Sedaghat,M.M., Mohebali,M. and Hajjaran,H.
    Development of species-specific PCR and PCR-restriction fragment length polymorphism assays for L.infantum/L.donovani discrimination
    Exp Parasitol (2009) 122, 61-65. PubMed  Europe PubMed DOI
  22. Saffari,B. and Mohabatkar,H.
    Computational analysis of cysteine proteases (Clan CA, Family C1) of Leishmania major to find potential epitopic regions
    Genomics Proteomics Bioinformatics (2009) 7, 87-95. PubMed  Europe PubMed DOI
    23. 2008
  23. Abdulla,M.H., O'Brien,T., Mackey,Z.B., Sajid,M., Grab,D.J. and McKerrow,J.H.
    RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model
    PLoS Negl Trop Dis (2008) 2, e298-e298. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Khoshgoo,N., Zahedifard,F., Azizi,H., Taslimi,Y., Alonso,M.J. and Rafati,S.
    Cysteine proteinase type III is protective against Leishmania infantum infection in BALB/c mice and highly antigenic in visceral leishmaniasis individuals
    Vaccine (2008) 26, 5822-5829. PubMed  Europe PubMed DOI
  25. Kulkarni,M.M., Jones,E.A., McMaster,W.R. and McGwire,B.S.
    Fibronectin binding and proteolytic degradation by Leishmania and effects on macrophage activation
    Infect Immun (2008) 76, 1738-1747. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Mallari,J.P., Shelat,A.A., Obrien,T., Caffrey,C.R., Kosinski,A., Connelly,M., Harbut,M., Greenbaum,D., McKerrow,J.H. and Guy,R.K.
    Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB
    J Med Chem (2008) 51, 545-552. PubMed  Europe PubMed DOI  I
  27. Mallari,J.P., Shelat,A., Kosinski,A., Caffrey,C.R., Connelly,M., Zhu,F., McKerrow,J.H. and Guy,R.K.
    Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB
    Bioorg Med Chem Lett (2008) 18, 2883-2885. PubMed  Europe PubMed DOI  PMC  EPMC  I
  28. Mendoza-Palomares,C., Biteau,N., Giroud,C., Coustou,V., Coetzer,T., Authie,E., Boulange,A. and Baltz,T.
    Molecular and biochemical characterization of a cathepsin B-like protease family unique to Trypanosoma congolense
    Eukaryot Cell (2008) 7, 684-697. PubMed  Europe PubMed DOI  PMC  EPMC  T
  29. O'Brien,T.C., Mackey,Z.B., Fetter,R.D., Choe,Y., O'Donoghue,A.J., Zhou,M., Craik,C.S., Caffrey,C.R. and McKerrow,J.H.
    A parasite cysteine protease is key to host protein degradation and iron acquisition
    J Biol Chem (2008) 283, 28934-28943. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Rafati,S., Zahedifard,F., Azari,M.K., Taslimi,Y. and Taheri,T.
    Leishmania infantum: prime boost vaccination with C-terminal extension of cysteine proteinase type I displays both type 1 and 2 immune signatures in BALB/c mice
    Exp Parasitol (2008) 118, 393-401. PubMed  Europe PubMed DOI
    31. 2007
  31. Hide,M., Bras-Goncalves,R. and Banuls,A.L.
    Specific cpb copies within the Leishmania donovani complex: evolutionary interpretations and potential clinical implications in humans
    Parasitology (2007) 134, 379-389. PubMed  Europe PubMed DOI
    32. 2006
  32. Hide,M. and Banuls,A.L.
    Species-specific PCR assay for L. infantum/L. donovani discrimination
    Acta Trop (2006) 100, 241-245. PubMed  Europe PubMed DOI
  33. Rafati,S., Zahedifard,F. and Nazgouee,F.
    Prime-boost vaccination using cysteine proteinases type I and II of Leishmania infantum confers protective immunity in murine visceral leishmaniasis
    Vaccine (2006) 24, 2169-2175. PubMed  Europe PubMed DOI
    34. 2004
  34. [YEAR:23-8-2004]Mackey,Z.B., O'Brien,T.C., Greenbaum,D.C., Blank,R.B. and McKerrow,J.H.
    A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei
    J Biol Chem (23-8-2004) 279, 48426-48433. PubMed  Europe PubMed DOI
  35. Mottram,J.C. and Coombs,G.H.
    Leishmania CPA, CPB and CPC cysteine proteases
    [ISSN:0-12-079610-4] (2004) 2, 1166-1169.  V
  36. Mottram,J.C., Coombs,G.H. and Alexander,J.
    Cysteine peptidases as virulence factors of Leishmania
    Curr Opin Microbiol (2004) 7, 375-381. PubMed  Europe PubMed DOI
    37. 2003
  37. Chibale,K. and Musonda,C.C.
    The synthesis of parasitic cysteine protease and trypanothione reductase inhibitors
    Curr Med Chem (2003) 10, 1863-1889. PubMed  Europe PubMed DOI  I
  38. Gantt,K.R., Schultz-Cherry,S., Rodriguez,N., Jeronimo,S.M., Nascimento,E.T., Goldman,T.L., Recker,T.J., Miller,M.A. and Wilson,M.E.
    Activation of TGF-beta by Leishmania chagasi: importance for parasite survival in macrophages
    J Immunol (2003) 170, 2613-2620. PubMed  Europe PubMed  I
    39. 2002
  39. Sajid,M. and McKerrow,J.H.
    Cysteine proteases of parasitic organisms
    Mol Biochem Parasitol (2002) 120, 1-21. PubMed  Europe PubMed
  40. [YEAR:12-7-2002]Somanna,A., Mundodi,V. and Gedamu,L.
    Functional analysis of cathepsin B-like cysteine proteases from Leishmania donovani complex. Evidence for the activation of latent transforming growth factor beta
    J Biol Chem (12-7-2002) 277, 25305-25312. PubMed  Europe PubMed DOI
    41. 2000
  41. Yong,V., Schmitz,V., Vannier-Santos,M.A., de Lima,A.P., Lalmanach,G., Juliano,L., Gauthier,F. and Scharfstein,J.
    Altered expression of cruzipain and a cathepsin B-like target in a Trypanosoma cruzi cell line displaying resistance to synthetic inhibitors of cysteine-proteinases
    Mol Biochem Parasitol (2000) 109, 47-59. PubMed  Europe PubMed DOI
    42. 1999
  42. [YEAR:15-5-1999]Chan,V.J., Selzer,P.M., McKerrow,J.H. and Sakanari,J.A.
    Expression and alteration of the S2 subsite of the Leishmania major cathepsin B-like cysteine protease
    Biochem J (15-5-1999) 340, 113-117. PubMed  Europe PubMed  PMC  EPMC  I
    43. 1998
  43. [YEAR:15-3-1998]Garcia,M.P., Nobrega,O.T., Teixeira,A.R., Sousa,M.V. and Santana,J.M.
    Characterisation of a Trypanosoma cruzi acidic 30 kDa cysteine protease
    Mol Biochem Parasitol (15-3-1998) 91, 263-272. PubMed  Europe PubMed DOI
  44. Mottram,J.C., Brooks,D.R. and Coombs,G.H.
    Roles of cysteine proteinases of trypanosomes and Leishmania in host-parasite interactions
    Curr Opin Microbiol (1998) 1, 455-460. PubMed  Europe PubMed
  45. [YEAR:30-11-1998]Nobrega,O.T., Santos Silva,M.A., Teixeira,A.R. and Santana,J.M.
    Cloning and sequencing of tccb, a gene encoding a Trypanosoma cruzi cathepsin B-like protease
    Mol Biochem Parasitol (30-11-1998) 97, 235-240. PubMed  Europe PubMed DOI
    46. 1997
  46. Bart,G., Frame,M.J., Carter,R., Coombs,G.H. and Mottram,J.C.
    Cathepsin B-like cysteine proteinase-deficient mutants of Leishmania mexicana
    Mol Biochem Parasitol (1997) 88, 53-61. PubMed  Europe PubMed DOI  K
  47. Sakanari,J.A., Nadler,S.A., Chan,V.J., Engel,J.C., Leptak,C. and Bouvier,J.
    Leishmania major: Comparison of the cathepsin L- and B-like cysteine protease genes with those of other trypanosomatids
    Exp Parasitol (1997) 85, 63-76. PubMed  Europe PubMed DOI
  48. Selzer,P.M., Chen,X., Chan,V.J., Cheng,M., Kenyon,G.L., Kuntz,I.D., Sakanari,J.A., Cohen,F.E. and McKerrow,J.H.
    Leishmania major: molecular modeling of cysteine proteases and prediction of new nonpeptide inhibitors
    Exp Parasitol (1997) 87, 212-221. PubMed  Europe PubMed DOI
    49. 1995
  49. Bart,G., Coombs,G.H. and Mottram,J.C.
    Isolation of lmcpc, a gene encoding a Leishmania mexicana cathepsin-B-like cysteine proteinase
    Mol Biochem Parasitol (1995) 73, 271-274. PubMed  Europe PubMed DOI
    50. 1994
  50. Robertson,C.D. and Coombs,G.H.
    Multiple high activity cysteine proteases of Leishmania mexicana are encoded by the Imcpb gene array
    Microbiology (Reading, Engl.) (1994) 140, 417-424. PubMed  Europe PubMed
    51. 1993
  51. Robertson,C.D. and Coombs,G.H.
    Cathepsin B-like cysteine proteases of Leishmania mexicana
    Mol Biochem Parasitol (1993) 62, 271-279. PubMed  Europe PubMed DOI
    52. 1990
  52. Robertson,C.D. and Coombs,G.H.
    Characterisation of three groups of cysteine proteinases in the amastigotes of Leishmania mexicana mexicana
    Mol Biochem Parasitol (1990) 42, 269-276. PubMed  Europe PubMed DOI

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