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Literature for peptidase C01.084: bleomycin hydrolase (animal)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, M Mutation, K Knockout, I Inhibitor, P Specificity, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Witucki,L., Borowczyk,K., Suszynska-Zajczyk,J., Warzych,E., Pawlak,P. and Jakubowski,H.
    Deletion of the Homocysteine Thiolactone Detoxifying Enzyme Bleomycin Hydrolase, in Mice, Causes Memory and Neurological Deficits and Worsens Alzheimer's Disease-Related Behavioral and Biochemical Traits in the 5xFAD Model of Alzheimer's Disease
    J Alzheimers Dis95, 1735-1755. PubMed  Europe PubMed DOI
    2. 2022
  2. Zheng,Y.Z., Cui,J., Wang,Y.L., Huang,S.J., Lin,E.C., Huang,S.C., Rudolf,J.D., Yan,X. and Chang,C.Y.
    The Structure-Function Relationship of Human Bleomycin Hydrolase: Mutation of a Cysteine Protease into a Serine Protease
    Chembiochem23, e202200186-e202200186. PubMed  Europe PubMed DOI
    3. 2019
  3. Riise,R., Odqvist,L., Mattsson,J., Monkley,S., Abdillahi,S.M., Tyrchan,C., Muthas,D. and Yrlid,L.F.
    Bleomycin hydrolase regulates the release of chemokines important for inflammation and wound healing by keratinocytes
    Sci Rep9, 20407-20407. PubMed  Europe PubMed DOI
    4. 2018
  4. Crnovcic,I., Gan,F., Yang,D., Dong,L.B., Schultz,P.G. and Shen,B.
    Activities of recombinant human bleomycin hydrolase on bleomycins and engineered analogues revealing new opportunities to overcome bleomycin-induced pulmonary toxicity
    Bioorg Med Chem Lett28, 2670-2674. PubMed  Europe PubMed DOI  P
    5. 2016
  5. Jona,A., Miltenyi,Z., Poliska,S., Balint,B.L. and Illes,A.
    Effect of bleomycin hydrolase gene polymorphism on late pulmonary complications of treatment for Hodgkin lymphoma
    PLoS ONE11, e0157651-e0157651. PubMed  Europe PubMed DOI  M
    6. 2015
  6. van der Linden,W.A., Segal,E., Child,M.A., Byzia,A., Drag,M. and Bogyo,M.
    Design and synthesis of activity-based probes and inhibitors for bleomycin hydrolase
    Chem Biol22, 995-1001. PubMed  Europe PubMed DOI  A  P  I
    7. 2014
  7. Suszynska-Zajczyk,J., Wroblewski,J., Utyro,O., Luczak,M., Marczak,L. and Jakubowski,H.
    Bleomycin hydrolase and hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis
    Amino Acids46, 1471-1480. PubMed  Europe PubMed DOI  K
    8. 2013
  8. Chen,Y., Xu,R., Chen,J., Li,X. and He,Q.
    Cleavage of bleomycin hydrolase by caspase-3 during apoptosis
    Oncol Rep30, 939-944. PubMed  Europe PubMed DOI
    9. 2012
  9. Borowczyk,K., Tisonczyk,J. and Jakubowski,H.
    Metabolism and neurotoxicity of homocysteine thiolactone in mice: protective role of bleomycin hydrolase
    Amino Acids43, 1339-1348. PubMed  Europe PubMed DOI
  10. Hibino,T., Kamata,Y. and Takeda,A.
    Bleomycin hydrolase
    [ISSN:978-0-12-407743-0]3, 1974-1980. DOI
    11. 2011
  11. Kamata,Y., Yamamoto,M., Kawakami,F., Tsuboi,R., Takeda,A., Ishihara,K. and Hibino,T.
    Bleomycin hydrolase is regulated biphasically in a differentiation- and cytokine-dependent manner: relevance to atopic dermatitis
    J Biol Chem286, 8204-8212. PubMed  Europe PubMed DOI
  12. Ratovitski,T., Chighladze,E., Waldron,E., Hirschhorn,R.R. and Ross,C.A.
    Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin
    J Biol Chem286, 12578-12589. PubMed  Europe PubMed DOI
    13. 2009
  13. Kamata,Y., Taniguchi,A., Yamamoto,M., Nomura,J., Ishihara,K., Takahara,H., Hibino,T. and Takeda,A.
    Neutral cysteine protease bleomycin hydrolase is essential for the breakdown of deiminated filaggrin into amino acids
    J Biol Chem284, 12829-12836. PubMed  Europe PubMed DOI
  14. Kim,E., Kwak,H. and Ahn,K.
    Cytosolic aminopeptidases influence MHC class I-mediated antigen presentation in an allele-dependent manner
    J Immunol183, 7379-7387. PubMed  Europe PubMed DOI  K
    15. 2008
  15. de Haas,E.C., Zwart,N., Meijer,C., Nuver,J., Boezen,H.M., Suurmeijer,A.J., Hoekstra,H.J., van der Steege,G., Sleijfer,D.T. and Gietema,J.A.
    Variation in bleomycin hydrolase gene is associated with reduced survival after chemotherapy for testicular germ cell cancer
    J Clin Oncol26, 1817-1823. PubMed  Europe PubMed DOI  M
    16. 2007
  16. Kamata,Y., Itoh,Y., Kajiya,A., Karasawa,S., Sakatani,C., Takekoshi,S., Osamura,R.Y. and Takeda,A.
    Quantification of neutral cysteine protease bleomycin hydrolase and its localization in rat tissues
    J Biochem141, 69-76. PubMed  Europe PubMed DOI
  17. Montoya,S.E., Thiels,E., Card,J.P. and Lazo,J.S.
    Astrogliosis and behavioral changes in mice lacking the neutral cysteine protease bleomycin hydrolase
    Neuroscience146, 890-900. PubMed  Europe PubMed DOI  K
  18. Towne,C.F., York,I.A., Watkin,L.B., Lazo,J.S. and Rock,K.L.
    Analysis of the role of bleomycin hydrolase in antigen presentation and the generation of CD8 T cell responses
    J Immunol178, 6923-6930. PubMed  Europe PubMed
    19. 2006
  19. Kajiya,A., Kaji,H., Isobe,T. and Takeda,A.
    Processing of amyloid beta-peptides by neutral cysteine protease bleomycin hydrolase
    Protein Pept Lett13, 119-123. PubMed  Europe PubMed DOI
  20. [YEAR:12-6-2006]Zimny,J., Sikora,M., Guranowski,A. and Jakubowski,H.
    Protective mechanisms against homocysteine toxicity: the role of bleomycin hydrolase
    J Biol Chem281, 22485-22492. PubMed  Europe PubMed DOI
    21. 2005
  21. Nuver,J., Lutke Holzik,M.F., van Zweeden,M., Hoekstra,H.J., Meijer,C., Suurmeijer,A.J., Groen,H.J., Hofstra,R.M., Sluiter,W.J., Groen,H., Sleijfer,D.T. and Gietema,J.A.
    Genetic variation in the bleomycin hydrolase gene and bleomycin-induced pulmonary toxicity in germ cell cancer patients
    Pharmacogenet Genomics15, 399-405. PubMed  Europe PubMed  M
    22. 2004
  22. Joshua-Tor,L. and Johnston,S.A.
    Bleomycin hydrolase
    [ISSN:0-12-079610-4]2, 1197-1201.  V
    23. 2002
  23. [YEAR:1-8-2002]Haston,C.K., Wang,M., Dejournett,R.E., Zhou,X., Ni,D., Gu,X., King,T.M., Weil,M.M., Newman,R.A., Amos,C.I. and Travis,E.L.
    Bleomycin hydrolase and a genetic locus within the MHC affect risk for pulmonary fibrosis in mice
    Hum Mol Genet11, 1855-1863. PubMed  Europe PubMed
    24. 2001
  24. [YEAR:18-5-2001]Lefterov,I.M., Koldamova,R.P., Lefterova,M.I., Schwartz,D.R. and Lazo,J.S.
    Cysteine 73 in bleomycin hydrolase is critical for amyloid precursor protein processing
    Biochem Biophys Res Commun283, 994-999. PubMed  Europe PubMed DOI
    25. 2000
  25. Lefterov,I.M., Koldamova,R.P. and Lazo,J.S.
    Human bleomycin hydrolase regulates the secretion of amyloid precursor protein
    FASEB J14, 1837-1847. PubMed  Europe PubMed
  26. Stoltze,L., Schirle,M., Schwarz,G., Schroter,C., Thompson,M.W., Hersh,L.B., Kalbacher,H., Stevanovic,S., Rammensee,H.G. and Schild,H.
    Two new proteases in the MHC class I processing pathway
    Nat Immunol1, 413-418. PubMed  Europe PubMed DOI
    27. 1999
  27. [YEAR:15-6-1999]O'Farrell,P.A., Gonzalez,F., Zheng,W., Johnston,S.A. and Joshua-Tor,L.
    Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease
    Structure7, 619-627. PubMed  Europe PubMed DOI  S
  28. [YEAR:13-4-1999]Schwartz,D.R., Homanics,G.E., Hoyt,D.G., Klein,E., Abernethy,J. and Lazo,J.S.
    The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance
    Proc Natl Acad Sci U S A96, 4680-4685. PubMed  Europe PubMed DOI  K
    29. 1998
  29. [YEAR:24-2-1998]Koldamova,R.P., Lefterov,I.M., Gadjeva,V.G. and Lazo,J.S.
    Essential binding and functional domains of human bleomycin hydrolase
    Biochemistry37, 2282-2290. PubMed  Europe PubMed DOI
  30. [YEAR:12-10-1998]Lefterov,I.M., Koldamova,R.P., King,J. and Lazo,J.S.
    The C-terminus of human bleomycin hydrolase is required for protection against bleomycin-induced chromosomal damage
    Mutat Res421, 1-7. PubMed  Europe PubMed DOI
    31. 1997
  31. Adachi,H., Tsujimoto,M., Fukasawa,M., Sato,Y., Arai,H., Inoue,K. and Nishimura,T.
    cDNA cloning and expression of chicken aminopeptidase H, possessing endopeptidase as well as aminopeptidase activity
    Eur J Biochem245, 283-288. PubMed  Europe PubMed
  32. Montoya,S.E., Ferrell,R.E. and Lazo,J.S.
    Genomic structure and genetic mapping of the human neutral cysteine protease bleomycin hydrolase
    Cancer Res57, 4191-4195. PubMed  Europe PubMed  M
    33. 1996
  33. Bromme,D., Rossi,A.B., Smeekens,S.P., Anderson,D.C. and Payan,D.G.
    Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization
    Biochemistry35, 6706-6714. PubMed  Europe PubMed DOI  E
  34. Ferrando,A.A., Velasco,G., Campo,E. and Lopez-Otin,C.
    Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance
    Cancer Res56, 1746-1750. PubMed  Europe PubMed
  35. Takeda,A., Masuda,Y., Yamamoto,T., Hirabayashi,T., Nakamura,Y. and Nakaya,K.
    Cloning and analysis of cDNA encoding rat bleomycin hydrolase, a DNA-binding cysteine protease
    J Biochem120, 353-359. PubMed  Europe PubMed
  36. Takeda,A., Higuchi,D., Yamamoto,T., Nakamura,Y., Masuda,Y., Hirabayashi,T. and Nakaya,K.
    Purification and characterization of bleomycin hydrolase, which represents a new family of cysteine proteases, from rat skin
    J Biochem119, 29-36. PubMed  Europe PubMed  I
    37. 1989
  37. Nishimura,C., Suzuki,H., Tanaka,N. and Yamaguchi,H.
    Bleomycin hydrolase is a unique thiol aminopeptidase
    Biochem Biophys Res Commun163, 788-796. PubMed  Europe PubMed
  38. Sebti,S.M., Mignano,J.E., Jani,J.P., Srimatkandada,S. and Lazo,J.S.
    Bleomycin hydrolase: molecular cloning, sequencing, and biochemical studies reveal membership in the cysteine proteinase family
    Biochemistry28, 6544-6548. PubMed  Europe PubMed
    39. 1987
  39. [YEAR:24-3-1987]Nishimura,C., Tanaka,N., Suzuki,H. and Tanaka,N.
    Purification of bleomycin hydrolase with a monoclonal antibody and its characterization
    Biochemistry26, 1574-1578. PubMed  Europe PubMed
  40. [YEAR:27-1-1987]Sebti,S.M. and Lazo,J.S.
    Separation of the protective enzyme bleomycin hydrolase from rabbit pulmonary aminopeptidases
    Biochemistry26, 432-437. PubMed  Europe PubMed
    41. 1974
  41. Umezawa,H., Hori,S., Sawa,T., Yoshioka,T. and Takeuchi,T.
    A bleomycin-inactivating enzyme in mouse liver
    J Antibiot (Tokyo)27, 419-424. PubMed  Europe PubMed

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