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Literature for peptidase C01.084: bleomycin hydrolase (animal)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, M Mutation, K Knockout, I Inhibitor, P Specificity, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Witucki,L., Borowczyk,K., Suszynska-Zajczyk,J., Warzych,E., Pawlak,P. and Jakubowski,H.<br>Deletion of the Homocysteine Thiolactone Detoxifying Enzyme Bleomycin Hydrolase, in Mice, Causes Memory and Neurological Deficits and Worsens Alzheimer's Disease-Related Behavioral and Biochemical Traits in the 5xFAD Model of Alzheimer's Disease<br>J Alzheimers Dis (2023) 95, 1735-1755. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2022
  2. Zheng,Y.Z., Cui,J., Wang,Y.L., Huang,S.J., Lin,E.C., Huang,S.C., Rudolf,J.D., Yan,X. and Chang,C.Y.<br>The Structure-Function Relationship of Human Bleomycin Hydrolase: Mutation of a Cysteine Protease into a Serine Protease<br>Chembiochem (2022) 23, e202200186-e202200186. PubMed  Europe PubMed DOI
    3. 2019
  3. Riise,R., Odqvist,L., Mattsson,J., Monkley,S., Abdillahi,S.M., Tyrchan,C., Muthas,D. and Yrlid,L.F.<br>Bleomycin hydrolase regulates the release of chemokines important for inflammation and wound healing by keratinocytes<br>Sci Rep (2019) 9, 20407-20407. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2018
  4. Crnovcic,I., Gan,F., Yang,D., Dong,L.B., Schultz,P.G. and Shen,B.<br>Activities of recombinant human bleomycin hydrolase on bleomycins and engineered analogues revealing new opportunities to overcome bleomycin-induced pulmonary toxicity<br>Bioorg Med Chem Lett (2018) 28, 2670-2674. PubMed  Europe PubMed DOI  P
    5. 2016
  5. Jona,A., Miltenyi,Z., Poliska,S., Balint,B.L. and Illes,A.<br>Effect of bleomycin hydrolase gene polymorphism on late pulmonary complications of treatment for Hodgkin lymphoma<br>PLoS ONE (2016) 11, e0157651-e0157651. PubMed  Europe PubMed DOI  M
    6. 2015
  6. van der Linden,W.A., Segal,E., Child,M.A., Byzia,A., Drag,M. and Bogyo,M.<br>Design and synthesis of activity-based probes and inhibitors for bleomycin hydrolase<br>Chem Biol (2015) 22, 995-1001. PubMed  Europe PubMed DOI  A  P  I
    7. 2014
  7. Suszynska-Zajczyk,J., Wroblewski,J., Utyro,O., Luczak,M., Marczak,L. and Jakubowski,H.<br>Bleomycin hydrolase and hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis<br>Amino Acids (2014) 46, 1471-1480. PubMed  Europe PubMed DOI  K
    8. 2013
  8. Chen,Y., Xu,R., Chen,J., Li,X. and He,Q.<br>Cleavage of bleomycin hydrolase by caspase-3 during apoptosis<br>Oncol Rep (2013) 30, 939-944. PubMed  Europe PubMed DOI
    9. 2012
  9. Borowczyk,K., Tisonczyk,J. and Jakubowski,H.<br>Metabolism and neurotoxicity of homocysteine thiolactone in mice: protective role of bleomycin hydrolase<br>Amino Acids (2012) 43, 1339-1348. PubMed  Europe PubMed DOI
  10. Hibino,T., Kamata,Y. and Takeda,A.<br>Bleomycin hydrolase<br>[ISSN:978-0-12-407743-0] (2012) 3, 1974-1980. DOI
    11. 2011
  11. Kamata,Y., Yamamoto,M., Kawakami,F., Tsuboi,R., Takeda,A., Ishihara,K. and Hibino,T.<br>Bleomycin hydrolase is regulated biphasically in a differentiation- and cytokine-dependent manner: relevance to atopic dermatitis<br>J Biol Chem (2011) 286, 8204-8212. PubMed  Europe PubMed DOI
  12. Ratovitski,T., Chighladze,E., Waldron,E., Hirschhorn,R.R. and Ross,C.A.<br>Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin<br>J Biol Chem (2011) 286, 12578-12589. PubMed  Europe PubMed DOI
    13. 2009
  13. Kamata,Y., Taniguchi,A., Yamamoto,M., Nomura,J., Ishihara,K., Takahara,H., Hibino,T. and Takeda,A.<br>Neutral cysteine protease bleomycin hydrolase is essential for the breakdown of deiminated filaggrin into amino acids<br>J Biol Chem (2009) 284, 12829-12836. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Kim,E., Kwak,H. and Ahn,K.<br>Cytosolic aminopeptidases influence MHC class I-mediated antigen presentation in an allele-dependent manner<br>J Immunol (2009) 183, 7379-7387. PubMed  Europe PubMed DOI  K
    15. 2008
  15. de Haas,E.C., Zwart,N., Meijer,C., Nuver,J., Boezen,H.M., Suurmeijer,A.J., Hoekstra,H.J., van der Steege,G., Sleijfer,D.T. and Gietema,J.A.<br>Variation in bleomycin hydrolase gene is associated with reduced survival after chemotherapy for testicular germ cell cancer<br>J Clin Oncol (2008) 26, 1817-1823. PubMed  Europe PubMed DOI  M
    16. 2007
  16. Kamata,Y., Itoh,Y., Kajiya,A., Karasawa,S., Sakatani,C., Takekoshi,S., Osamura,R.Y. and Takeda,A.<br>Quantification of neutral cysteine protease bleomycin hydrolase and its localization in rat tissues<br>J Biochem (2007) 141, 69-76. PubMed  Europe PubMed DOI
  17. Montoya,S.E., Thiels,E., Card,J.P. and Lazo,J.S.<br>Astrogliosis and behavioral changes in mice lacking the neutral cysteine protease bleomycin hydrolase<br>Neuroscience (2007) 146, 890-900. PubMed  Europe PubMed DOI  PMC  EPMC  K
  18. Towne,C.F., York,I.A., Watkin,L.B., Lazo,J.S. and Rock,K.L.<br>Analysis of the role of bleomycin hydrolase in antigen presentation and the generation of CD8 T cell responses<br>J Immunol (2007) 178, 6923-6930. PubMed  Europe PubMed
    19. 2006
  19. Kajiya,A., Kaji,H., Isobe,T. and Takeda,A.<br>Processing of amyloid beta-peptides by neutral cysteine protease bleomycin hydrolase<br>Protein Pept Lett (2006) 13, 119-123. PubMed  Europe PubMed DOI
  20. [YEAR:12-6-2006]Zimny,J., Sikora,M., Guranowski,A. and Jakubowski,H.<br>Protective mechanisms against homocysteine toxicity: the role of bleomycin hydrolase<br>J Biol Chem (12-6-2006) 281, 22485-22492. PubMed  Europe PubMed DOI
    21. 2005
  21. Nuver,J., Lutke Holzik,M.F., van Zweeden,M., Hoekstra,H.J., Meijer,C., Suurmeijer,A.J., Groen,H.J., Hofstra,R.M., Sluiter,W.J., Groen,H., Sleijfer,D.T. and Gietema,J.A.<br>Genetic variation in the bleomycin hydrolase gene and bleomycin-induced pulmonary toxicity in germ cell cancer patients<br>Pharmacogenet Genomics (2005) 15, 399-405. PubMed  Europe PubMed  M
    22. 2004
  22. Joshua-Tor,L. and Johnston,S.A.<br>Bleomycin hydrolase<br>[ISSN:0-12-079610-4] (2004) 2, 1197-1201.  V
    23. 2002
  23. [YEAR:1-8-2002]Haston,C.K., Wang,M., Dejournett,R.E., Zhou,X., Ni,D., Gu,X., King,T.M., Weil,M.M., Newman,R.A., Amos,C.I. and Travis,E.L.<br>Bleomycin hydrolase and a genetic locus within the MHC affect risk for pulmonary fibrosis in mice<br>Hum Mol Genet (1-8-2002) 11, 1855-1863. PubMed  Europe PubMed
    24. 2001
  24. [YEAR:18-5-2001]Lefterov,I.M., Koldamova,R.P., Lefterova,M.I., Schwartz,D.R. and Lazo,J.S.<br>Cysteine 73 in bleomycin hydrolase is critical for amyloid precursor protein processing<br>Biochem Biophys Res Commun (18-5-2001) 283, 994-999. PubMed  Europe PubMed DOI
    25. 2000
  25. Lefterov,I.M., Koldamova,R.P. and Lazo,J.S.<br>Human bleomycin hydrolase regulates the secretion of amyloid precursor protein<br>FASEB J (2000) 14, 1837-1847. PubMed  Europe PubMed
  26. Stoltze,L., Schirle,M., Schwarz,G., Schroter,C., Thompson,M.W., Hersh,L.B., Kalbacher,H., Stevanovic,S., Rammensee,H.G. and Schild,H.<br>Two new proteases in the MHC class I processing pathway<br>Nat Immunol (2000) 1, 413-418. PubMed  Europe PubMed DOI
    27. 1999
  27. [YEAR:15-6-1999]O'Farrell,P.A., Gonzalez,F., Zheng,W., Johnston,S.A. and Joshua-Tor,L.<br>Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease<br>Structure (15-6-1999) 7, 619-627. PubMed  Europe PubMed DOI  S
  28. [YEAR:13-4-1999]Schwartz,D.R., Homanics,G.E., Hoyt,D.G., Klein,E., Abernethy,J. and Lazo,J.S.<br>The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance<br>Proc Natl Acad Sci U S A (13-4-1999) 96, 4680-4685. PubMed  Europe PubMed DOI  PMC  EPMC  K
    29. 1998
  29. [YEAR:24-2-1998]Koldamova,R.P., Lefterov,I.M., Gadjeva,V.G. and Lazo,J.S.<br>Essential binding and functional domains of human bleomycin hydrolase<br>Biochemistry (24-2-1998) 37, 2282-2290. PubMed  Europe PubMed DOI
  30. [YEAR:12-10-1998]Lefterov,I.M., Koldamova,R.P., King,J. and Lazo,J.S.<br>The C-terminus of human bleomycin hydrolase is required for protection against bleomycin-induced chromosomal damage<br>Mutat Res (12-10-1998) 421, 1-7. PubMed  Europe PubMed DOI
    31. 1997
  31. Adachi,H., Tsujimoto,M., Fukasawa,M., Sato,Y., Arai,H., Inoue,K. and Nishimura,T.<br>cDNA cloning and expression of chicken aminopeptidase H, possessing endopeptidase as well as aminopeptidase activity<br>Eur J Biochem (1997) 245, 283-288. PubMed  Europe PubMed
  32. Montoya,S.E., Ferrell,R.E. and Lazo,J.S.<br>Genomic structure and genetic mapping of the human neutral cysteine protease bleomycin hydrolase<br>Cancer Res (1997) 57, 4191-4195. PubMed  Europe PubMed  M
    33. 1996
  33. Bromme,D., Rossi,A.B., Smeekens,S.P., Anderson,D.C. and Payan,D.G.<br>Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization<br>Biochemistry (1996) 35, 6706-6714. PubMed  Europe PubMed DOI  E
  34. Ferrando,A.A., Velasco,G., Campo,E. and Lopez-Otin,C.<br>Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance<br>Cancer Res (1996) 56, 1746-1750. PubMed  Europe PubMed
  35. Takeda,A., Masuda,Y., Yamamoto,T., Hirabayashi,T., Nakamura,Y. and Nakaya,K.<br>Cloning and analysis of cDNA encoding rat bleomycin hydrolase, a DNA-binding cysteine protease<br>J Biochem (1996) 120, 353-359. PubMed  Europe PubMed
  36. Takeda,A., Higuchi,D., Yamamoto,T., Nakamura,Y., Masuda,Y., Hirabayashi,T. and Nakaya,K.<br>Purification and characterization of bleomycin hydrolase, which represents a new family of cysteine proteases, from rat skin<br>J Biochem (1996) 119, 29-36. PubMed  Europe PubMed  I
    37. 1989
  37. Nishimura,C., Suzuki,H., Tanaka,N. and Yamaguchi,H.<br>Bleomycin hydrolase is a unique thiol aminopeptidase<br>Biochem Biophys Res Commun (1989) 163, 788-796. PubMed  Europe PubMed
  38. Sebti,S.M., Mignano,J.E., Jani,J.P., Srimatkandada,S. and Lazo,J.S.<br>Bleomycin hydrolase: molecular cloning, sequencing, and biochemical studies reveal membership in the cysteine proteinase family<br>Biochemistry (1989) 28, 6544-6548. PubMed  Europe PubMed
    39. 1987
  39. [YEAR:24-3-1987]Nishimura,C., Tanaka,N., Suzuki,H. and Tanaka,N.<br>Purification of bleomycin hydrolase with a monoclonal antibody and its characterization<br>Biochemistry (24-3-1987) 26, 1574-1578. PubMed  Europe PubMed
  40. [YEAR:27-1-1987]Sebti,S.M. and Lazo,J.S.<br>Separation of the protective enzyme bleomycin hydrolase from rabbit pulmonary aminopeptidases<br>Biochemistry (27-1-1987) 26, 432-437. PubMed  Europe PubMed
    41. 1974
  41. Umezawa,H., Hori,S., Sawa,T., Yoshioka,T. and Takeuchi,T.<br>A bleomycin-inactivating enzyme in mouse liver<br>J Antibiot (Tokyo) (1974) 27, 419-424. PubMed  Europe PubMed

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