Substrates for peptidase A22.003: impas 1 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Genome polyprotein	P26664	2-191	peptide-Phe177+Leu-peptide	P	MS	Phe	Ser	Ile	Phe	Leu	Leu	Ala	Leu	Okamoto et al., 2008
Genome polyprotein	P19712	1-168	peptide-Ala255+Val-peptide	P		Leu	Ala	Trp	Ala	Val	Ile	Thr	Ile	Heimann et al., 2006
Genome polyprotein	Q69422	1-349	Peptide-Gly156+Ala-Peptide	P	AB	Pro	Cys	Ser	Gly	Ala	Arg	Val	Thr	Targett-Adams et al., 2006
Genome polyprotein	P26663	2-383	Peptide-Ala191+Tyr-Peptide	P	AB	Pro	Ala	Ser	Ala	Tyr	Glu	Val	Arg	Targett-Adams et al., 2006
Genome polyprotein	P21530	169-494	Peptide-Ala267+Glu-Peptide	P	AB	Pro	Val	Ala	Ala	Glu	Asn	Ile	Thr	Targett-Adams et al., 2006
hepacivirus polyprotein	P26664	2-3011	peptide-Ala180+Leu-peptide	P		Phe	Leu	Leu	Ala	Leu	Leu	Ser	Cys	Dev et al., 2006