Literature for peptidase A22.003: impas 1 peptidase

(Topics flags: A Assay, S Structure, P Specificity, K Knockout, V Review, M Mutation, I Inhibitor, R Splicing. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Cao,Y., Xie,Q., Zheng,Q., Zhang,J., Yao,M., Du,Z., Zhang,L., Hu,T., Zhao,Y., Du,J., Li,Y., Feng,Y., Melgiri,N.D., Zhao,X., Huang,R. and Sun,Y.
   Macrophage HM13/SPP Enhances Foamy Macrophage Formation and Atherogenesis
   Adv Sci (Weinh)e2412498-e2412498. PubMed  Europe PubMed DOI
2. Qiao,W., Xie,X., Shi,P.Y., Ooi,Y.S. and Carette,J.E.
   Druggable genome screens identify SPP as an antiviral host target for multiple flaviviruses
   Proc Natl Acad Sci U S A122, e2421573122-e2421573122. PubMed  Europe PubMed DOI
3. Tever,O.K., Mentrup,T., Chinn,I.K., Ishikuma,H., Fluhrer,R., Schmitz,M., Wehner,R., Behrendt,R., Chinen,J. and Schroder,B.
   The DNase TREX1 is a substrate of the intramembrane protease SPP with implications for disease pathogenesis
   Cell Mol Life Sci82, 107-107. PubMed  Europe PubMed DOI
2024
4. Avci,D., Heidasch,R., Costa,M., Luchtenborg,C., Kale,D., Brugger,B. and Lemberg,M.K.
   Intramembrane protease SPP defines a cholesterol-regulated abundance control of the mevalonate pathway enzyme squalene synthase
   J Biol Chem300, 105644-105644. PubMed  Europe PubMed DOI
5. Feng,Y.T., Yang,C.Y., Wu,L., Wang,Y.C., Shen,G.W. and Lin,P.
   BmSPP is a virus resistance gene in Bombyx mori
   Front Immunol15, 1377270-1377270. PubMed  Europe PubMed DOI
6. Mentrup,T., Leinung,N., Patel,M., Fluhrer,R. and Schroder,B.
   The role of SPP/SPPL intramembrane proteases in membrane protein homeostasis
   FEBS J291, 25-44. PubMed  Europe PubMed DOI  V
7. Voorthuijzen,F., Stroobandt,C., van Criekinge,W., Goovaerts,T. and De Meyer,T.
   Loss-of-Imprinting of HM13 Leads to Poor Prognosis in Clear Cell Renal Cell Carcinoma
   Biomolecules14, PubMed  Europe PubMed DOI
2023
8. Hoppner,S., Schroder,B. and Fluhrer,R.
   Structure and function of SPP/SPPL proteases: insights from biochemical evidence and predictive modeling
   FEBS J290, 5456-5474. PubMed  Europe PubMed DOI
2022
9. Schwake,C., Hyon,M. and Chishti,A.H.
   Signal peptide peptidase: a potential therapeutic target for parasitic and viral infections
   Expert Opin Ther Targets26, 261-273. PubMed  Europe PubMed DOI  V
2021
10. Hirano,J., Yoshio,S., Sakai,Y., Songling,L., Suzuki,T., Itoh,Y., Zhang,H., Chen,D.V., Haga,S., Oomori,H., Kodama,T., Maeda,Y., Ono,Y., Takahashi,Y., Standley,D.M., Yamamoto,M., Moriishi,K., Moriya,K., Kanto,T., Takehara,T., Koike,K., Matsuura,Y. and Okamoto,T.
    Hepatitis C virus modulates signal peptide peptidase to alter host protein processing
    Proc Natl Acad Sci U S A118, PubMed  Europe PubMed DOI
11. Wang,S., Jaggi,U., Yu,J. and Ghiasi,H.
    Blocking HSV-1 glycoprotein K binding to signal peptide peptidase reduces virus infectivity in vitro and in vivo
    PLoS Pathog17, e1009848-e1009848. PubMed  Europe PubMed DOI
2019
12. Avci,D., Malchus,N.S., Heidasch,R., Lorenz,H., Richter,K., Nessling,M. and Lemberg,M.K.
    The intramembrane protease SPP impacts morphology of the endoplasmic reticulum by triggering degradation of morphogenic proteins
    J Biol Chem294, 2786-2800. PubMed  Europe PubMed DOI
13. Hsu,F.F., Chou,Y.T., Chiang,M.T., Li,F.A., Yeh,C.T., Lee,W.H. and Chau,L.Y.
    Signal peptide peptidase promotes tumor progression via facilitating FKBP8 degradation
    Oncogene38, 1688-1701. PubMed  Europe PubMed DOI
14. Wang,S. and Ghiasi,H.
    Absence of signal peptide peptidase, an essential HSV-1 glycoprotein K (gK) binding partner, reduces virus infectivity in vivo
    J Virol93, e01309-19-e01309-19. PubMed  Europe PubMed DOI  K
2017
15. Grigorenko,A.P., Moliaka,Y.K., Plotnikova,O.V., Smirnov,A., Nikishina,V.A., Goltsov,A.Y., Gusev,F., Andreeva,T.V., Nelson,O., Bezprozvanny,I. and Rogaev,E.I.
    Mutational re-modeling of di-aspartyl intramembrane proteases: uncoupling physiologically-relevant activities from those associated with Alzheimer's disease
    Oncotarget8, 82006-82026. PubMed  Europe PubMed DOI  M
16. Guan,J., Zhang,J., Yuan,S., Yang,B., Clark,K.D., Ling,E. and Huang,W.
    Analysis of the functions of the signal peptidase complex in the midgut of Tribolium castaneum
    Arch Insect Biochem Physiol97, PubMed  Europe PubMed DOI
17. Hirano,J., Okamoto,T., Sugiyama,Y., Suzuki,T., Kusakabe,S., Tokunaga,M., Fukuhara,T., Sasai,M., Tougan,T., Matsunaga,Y., Yamashita,K., Sakai,Y., Yamamoto,M., Horii,T., Standley,D.M., Moriishi,K., Moriya,K., Koike,K. and Matsuura,Y.
    Characterization of SPP inhibitors suppressing propagation of HCV and protozoa
    Proc Natl Acad Sci U S A114, E10782-E10782. PubMed  Europe PubMed DOI  I
18. Schaefer,B., Moriishi,K. and Behrends,S.
    Insights into the mechanism of isoenzyme-specific signal peptide peptidase-mediated translocation of heme oxygenase
    PLoS ONE12, e0188344-e0188344. PubMed  Europe PubMed DOI
19. Wei,J.W., Cai,J.Q., Fang,C., Tan,Y.L., Huang,K., Yang,C., Chen,Q., Jiang,C.L. and Kang,C.S.
    Signal peptide peptidase, encoded by HM13, contributes to tumor progression by affecting EGFRvIII secretion profiles in glioblastoma
    CNS Neurosci Ther23, 257-265. PubMed  Europe PubMed DOI
2014
20. Allen,S.J., Mott,K.R. and Ghiasi,H.
    Inhibitors of signal peptide peptidase (SPP) affect HSV-1 infectivity in vitro and in vivo
    Exp Eye Res123, 8-15. PubMed  Europe PubMed DOI  I
21. Boname,J.M., Bloor,S., Wandel,M.P., Nathan,J.A., Antrobus,R., Dingwell,K.S., Thurston,T.L., Smith,D.L., Smith,J.C., Randow,F. and Lehner,P.J.
    Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins
    J Cell Biol205, 847-862. PubMed  Europe PubMed DOI  K
22. Chen,C.Y., Malchus,N.S., Hehn,B., Stelzer,W., Avci,D., Langosch,D. and Lemberg,M.K.
    Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u
    EMBO J33, 2492-2506. PubMed  Europe PubMed DOI
2013
23. Oliveira,C.C., Querido,B., Sluijter,M., de Groot,A.F., van der Zee,R., Rabelink,M.J., Hoeben,R.C., Ossendorp,F., van der Burg,S.H. and van Hall,T.
    New role of signal peptide peptidase to liberate C-terminal peptides for MHC class I presentation
    J Immunol191, 4020-4028. PubMed  Europe PubMed DOI
2012
24. Lu,S.H., Jeon,A.H., Schmitt-Ulms,G., Qamar,S., Dodd,R., McDonald,B., Li,Y., Meadows,W., Cox,K., Bohm,C., Chen,F., Fraser,P. and St George-Hyslop,P.
    Vigilin interacts with signal peptide peptidase
    Proteome Sci10, 33-33. PubMed  Europe PubMed DOI
25. Wolfe,M.S.
    Signal peptide peptidase
    [ISSN:978-0-12-407744-7]3, 281-284. DOI
2011
26. Miyashita,H., Maruyama,Y., Isshiki,H., Osawa,S., Ogura,T., Mio,K., Sato,C., Tomita,T. and Iwatsubo,T.
    Three-dimensional structure of the signal peptide peptidase
    J Biol Chem286, 26188-26197. PubMed  Europe PubMed DOI  S
2010
27. Lee,S.O., Cho,K., Cho,S., Kim,I., Oh,C. and Ahn,K.
    Protein disulphide isomerase is required for signal peptide peptidase-mediated protein degradation
    EMBO J29, 363-375. PubMed  Europe PubMed DOI
28. Schroder,B. and Saftig,P.
    Molecular insights into mechanisms of intramembrane proteolysis through signal peptide peptidase (SPP)
    Biochem J427, e1-e3. PubMed  Europe PubMed DOI
29. Schrul,B., Kapp,K., Sinning,I. and Dobberstein,B.
    Signal peptide peptidase (SPP) assembles with substrates and misfolded membrane proteins into distinct oligomeric complexes
    Biochem J427, 523-534. PubMed  Europe PubMed DOI
2009
30. Golde,T.E., Wolfe,M.S. and Greenbaum,D.C.
    Signal peptide peptidases: a family of intramembrane-cleaving proteases that cleave type 2 transmembrane proteins
    Semin Cell Dev Biol20, 225-230. PubMed  Europe PubMed DOI  V
31. Han,S., Green,L. and Schnell,D.J.
    The signal peptide peptidase is required for pollen function in Arabidopsis
    Plant Physiol149, 1289-1301. PubMed  Europe PubMed DOI
32. Tamura,T., Kuroda,M., Oikawa,T., Kyozuka,J., Terauchi,K., Ishimaru,Y., Abe,K. and Asakura,T.
    Signal peptide peptidases are expressed in the shoot apex of rice, localized to the endoplasmic reticulum
    Plant Cell Rep28, 1615-1621. PubMed  Europe PubMed DOI
33. Wolfe,M.S.
    Intramembrane-cleaving proteases
    J Biol Chem284, 13969-13973. PubMed  Europe PubMed DOI
2008
34. El Hage,F., Stroobant,V., Vergnon,I., Baurain,J.F., Echchakir,H., Lazar,V., Chouaib,S., Coulie,P.G. and Mami-Chouaib,F.
    Preprocalcitonin signal peptide generates a cytotoxic T lymphocyte-defined tumor epitope processed by a proteasome-independent pathway
    Proc Natl Acad Sci U S A105, 10119-10124. PubMed  Europe PubMed DOI
35. Okamoto,K., Mori,Y., Komoda,Y., Okamoto,T., Okochi,M., Takeda,M., Suzuki,T., Moriishi,K. and Matsuura,Y.
    Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagation
    J Virol82, 8349-8361. PubMed  Europe PubMed DOI  P  I
36. Robakis,T., Bak,B., Lin,S.H., Bernard,D.J. and Scheiffele,P.
    An internal signal sequence directs intramembrane proteolysis of a cellular immunoglobulin domain protein
    J Biol Chem283, 36369-36376. PubMed  Europe PubMed DOI
37. Sato,T., Ananda,K., Cheng,C.I., Suh,E.J., Narayanan,S. and Wolfe,M.S.
    Distinct pharmacological effects of inhibitors of signal peptide peptidase and gamma-secretase
    J Biol Chem283, 33287-33295. PubMed  Europe PubMed DOI  I
38. Targett-Adams,P., Hope,G., Boulant,S. and McLauchlan,J.
    Maturation of hepatitis C virus core protein by signal peptide peptidase is required for virus production
    J Biol Chem283, 16850-16859. PubMed  Europe PubMed DOI
2007
39. Chang,H.T., Kao,Y.L., Wu,C.M., Fan,T.C., Lai,Y.K., Huang,K.L., Chang,Y.S., Tsai,J.J. and Chang,M.D.
    Signal peptide of eosinophil cationic protein upregulates transforming growth factor-alpha expression in human cells
    J Cell Biochem100, 1266-1275. PubMed  Europe PubMed DOI
40. Narayanan,S., Sato,T. and Wolfe,M.S.
    A C-terminal region of signal peptide peptidase defines a functional domain for intramembrane aspartic protease catalysis
    J Biol Chem282, 20172-20179. PubMed  Europe PubMed DOI
2006
41. Ait-Goughoulte,M., Hourioux,C., Patient,R., Trassard,S., Brand,D. and Roingeard,P.
    Core protein cleavage by signal peptide peptidase is required for hepatitis C virus-like particle assembly
    J Gen Virol87, 855-860. PubMed  Europe PubMed DOI
42. [YEAR:15-4-2006]Dev,K.K., Chatterjee,S., Osinde,M., Stauffer,D., Morgan,H., Kobialko,M., Dengler,U., Rueeger,H., Martoglio,B. and Rovelli,G.
    Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals
    Eur J Pharmacol540, 10-17. PubMed  Europe PubMed DOI  I
43. Heimann,M., Roman-Sosa,G., Martoglio,B., Thiel,H.J. and Rumenapf,T.
    Core protein of pestiviruses is processed at the C terminus by signal peptide peptidase
    J Virol80, 1915-1921. PubMed  Europe PubMed DOI  I
44. Hope,R.G., McElwee,M.J. and McLauchlan,J.
    Efficient cleavage by signal peptide peptidase requires residues within the signal peptide between the core and E1 proteins of hepatitis C virus strain J1
    J Gen Virol87, 623-627. PubMed  Europe PubMed DOI  P
45. Nyborg,A.C., Herl,L., Berezovska,O., Thomas,A.V., Ladd,T.B., Jansen,K., Hyman,B.T. and Golde,T.E.
    Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells
    Mol Neurodegener1, 16-16. PubMed  Europe PubMed DOI
46. [YEAR:18-7-2006]Sato,T., Nyborg,A.C., Iwata,N., Diehl,T.S., Saido,T.C., Golde,T.E. and Wolfe,M.S.
    Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs
    Biochemistry45, 8649-8656. PubMed  Europe PubMed DOI
47. [YEAR:1-8-2006]Targett-Adams,P., Schaller,T., Hope,G., Lanford,R.E., Lemon,S.M., Martin,A. and McLauchlan,J.
    Signal peptide peptidase cleavage of GB virus B core protein is required for productive infection in vivo
    J Biol Chem281, 29221-29227. PubMed  Europe PubMed DOI
48. Urny,J., Hermans-Borgmeyer,I. and Schaller,H.C.
    Cell-surface expression of a new splice variant of the mouse signal peptide peptidase
    Biochim Biophys Acta1759, 159-165. PubMed  Europe PubMed DOI  R
49. [YEAR:18-7-2006]Vauloup-Fellous,C., Pene,V., Garaud-Aunis,J., Harper,F., Bardin,S., Suire,Y., Pichard,E., Schmitt,A., Sogni,P., Pierron,G., Briand,P. and Rosenberg,A.R.
    Signal peptide peptidase-catalyzed cleavage of hepatitis C virus core protein is dispensable for virus budding but destabilizes the viral capsid
    J Biol Chem281, 27679-27692. PubMed  Europe PubMed DOI
2005
50. [YEAR:16-2-2005]Casso,D.J., Tanda,S., Biehs,B., Martoglio,B. and Kornberg,T.B.
    Drosophila signal peptide peptidase is an essential protease for larval development
    Genetics170, 139-148. PubMed  Europe PubMed DOI
51. Majeau,N., Gagne,V., Bolduc,M. and Leclerc,D.
    Signal peptide peptidase promotes the formation of hepatitis C virus non-enveloped particles and is captured on the viral membrane during assembly
    J Gen Virol86, 3055-3064. PubMed  Europe PubMed DOI
2004
52. [YEAR:21-9-2004]Friedmann,E., Lemberg,M.K., Weihofen,A., Dev,K.K., Dengler,U., Rovelli,G. and Martoglio,B.
    Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins
    J Biol Chem279, 50790-50798. PubMed  Europe PubMed DOI
53. [YEAR:30-4-2004]Lemberg,M.K. and Martoglio,B.
    On the mechanism of SPP-catalysed intramembrane proteolysis; conformational control of peptide bond hydrolysis in the plane of the membrane
    FEBS Lett564, 213-218. PubMed  Europe PubMed DOI
54. [YEAR:16-1-2004]Moliaka,Y.K., Grigorenko,A., Madera,D. and Rogaev,E.I.
    Impas 1 possesses endoproteolytic activity against multipass membrane protein substrate cleaving the presenilin 1 holoprotein
    FEBS Lett557, 185-192. PubMed  Europe PubMed DOI
55. [YEAR:5-1-2004]Nyborg,A.C., Kornilova,A.Y., Jansen,K., Ladd,T.B., Wolfe,M.S. and Golde,T.E.
    Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor
    J Biol Chem279, 15153-15160. PubMed  Europe PubMed DOI  I
56. [YEAR:12-7-2004]Nyborg,A.C., Jansen,K., Ladd,T.B., Fauq,A. and Golde,T.E.
    A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin
    J Biol Chem279, 43148-43156. PubMed  Europe PubMed DOI  A
57. Okamoto,K., Moriishi,K., Miyamura,T. and Matsuura,Y.
    Intramembrane proteolysis and endoplasmic reticulum retention of hepatitis C virus core protein
    J Virol78, 6370-6380. PubMed  Europe PubMed DOI
58. [YEAR:17-9-2004]Wu,C.M. and Chang,M.D.
    Signal peptide of eosinophil cationic protein is toxic to cells lacking signal peptide peptidase
    Biochem Biophys Res Commun322, 585-592. PubMed  Europe PubMed DOI
2003
59. Urny,J., Hermans-Borgmeyer,I., Gercken,G. and Schaller,H.C.
    Expression of the presenilin-like signal peptide peptidase (SPP) in mouse adult brain and during development
    Gene Expr Patterns3, 685-691. PubMed  Europe PubMed DOI
60. [YEAR:9-5-2003]Weihofen,A., Lemberg,M.K., Friedmann,E., Rueeger,H., Schmitz,A., Paganetti,P., Rovelli,G. and Martoglio,B.
    Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors
    J Biol Chem278, 16528-16533. PubMed  Europe PubMed DOI  I
2002
61. Grigorenko,A.P., Moliaka,Y.K., Korovaitseva,G.I. and Rogaev,E.I.
    Novel class of polytopic proteins with domains associated with putative protease activity
    Biochemistry (Mosc)67, 826-835. PubMed  Europe PubMed DOI
62. Lemberg,M.K. and Martoglio,B.
    Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis
    Mol Cell10, 735-744. PubMed  Europe PubMed DOI
63. [YEAR:1-8-2002]McLauchlan,J., Lemberg,M.K., Hope,G. and Martoglio,B.
    Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets
    EMBO J21, 3980-3988. PubMed  Europe PubMed DOI  I
64. [YEAR:21-6-2002]Weihofen,A., Binns,K., Lemberg,M.K., Ashman,K. and Martoglio,B.
    Identification of signal peptide peptidase, a presenilin-type aspartic protease
    Science296, 2215-2218. PubMed  Europe PubMed DOI  I
2001
65. [YEAR:1-12-2001]Lemberg,M.K., Bland,F.A., Weihofen,A., Braud,V.M. and Martoglio,B.
    Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E epitopes
    J Immunol167, 6441-6446. PubMed  Europe PubMed  I
1995
66. [YEAR:25-8-1995]Lyko,F., Martoglio,B., Jungnickel,B., Rapoport,T.A. and Dobberstein,B.
    Signal sequence processing in rough microsomes
    J Biol Chem270, 19873-19878. PubMed  Europe PubMed DOI