Summary for peptidase A22.003: impas 1 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors


MEROPS Nameimpas 1 peptidase
Other namesAtSPP (Arabidopsis thaliana), HM13 g.p. (Homo sapiens), IMP1, intramembrane protease 1, minor histocompatibility antigen H13, CG11840 g. p. (Drosophila melanogaster), Shanti protein (Drosophila melanogaster), signal peptide peptidase, SPP peptidase, PSH3, presenilin homologue-3
Domain architecture
MEROPS Classification
Classification Clan AD >> Subclan (none) >> Family A22 >> Subfamily B >> A22.003
Holotypeimpas 1 peptidase (Homo sapiens), Uniprot accession Q8TCT9 (peptidase unit: 1-377), MERNUM MER0019701
History Identifier created: MEROPS 6.0 (30 August 2002)
Catalytic typeAspartic
NC-IUBMBNot yet included in IUBMB recommendations.
Activity statushuman: active (Lemberg & Martoglio, 2002)
mouse: active (Lemberg & Martoglio, 2002)
PhysiologyImpas 1 endopeptidase is one of the signal peptide peptidases. It can cleave signal peptides within their transmembrane region. It is essential for the generation of signal peptide-derived HLA-E epitopes in humans and is exploited by hepatitis C virus for processing of the viral polyprotein (Lemberg et al., 2002). Impas 1 endopeptidase (termed signal peptide peptidase) is essential for embryonic development in Drosophila (Casso et al., 2005).
Pharmaceutical relevanceImpas 1 endopeptidase is of pharmaceutical interest because it may be affected by inhibitors of gamma-secretase, and the consequences of this would need to be considered if such inhibitors were developed as drugs (Weihofen et al., 2003).
Other databases WIKIPEDIA
Relevant inhibitors 1,3-di-(N-benzyloxycarbonyl-L-leucyl-L-leucyl)aminoacetone, LY411575
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
HM13 20q11.21 ENSG00000101294 81502 HM13 607106
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
H13 2:H2 ENSMUSG00000019188 14950 MGI:95886