Literature for peptidase A01.059: plasmepsin-4

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, T Target, K Knockout, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2019

Zogota,R., Kinena,L., Withers-Martinez,C., Blackman,M.J., Bobrovs,R., Pantelejevs,T., Kanepe-Lapsa,I., Ozola,V., Jaudzems,K., Suna,E. and Jirgensons,A. Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D Eur J Med Chem (2019) 163, 344-352. PubMed Europe PubMed DOI

2018

Kumar Singh,A., Rajendran,V., Singh,S., Kumar,P., Kumar,Y., Singh,A., Miller,W., Potemkin,V., Poonam, Grishina,M., Gupta,N., Kempaiah,P., Durvasula,R., Singh,B.K., Dunn,B.M. and Rathi,B. Antiplasmodial activity of hydroxyethylamine analogs: synthesis, biological activity and structure activity relationship of plasmepsin inhibitors Bioorg Med Chem (2018) 26, 3837-3844. PubMed Europe PubMed DOI I
Onchieku,N.M., Mogire,R., Ndung'u,L., Mwitari,P., Kimani,F., Matoke-Muhia,D., Kiboi,D. and Magoma,G. Deciphering the targets of retroviral protease inhibitors in Plasmodium berghei PLoS ONE (2018) 13, e0201556-e0201556. PubMed Europe PubMed DOI PMC EPMC I
Rasina,D., Stakanovs,G., Borysov,O.V., Pantelejevs,T., Bobrovs,R., Kanepe-Lapsa,I., Tars,K., Jaudzems,K. and Jirgensons,A. 2-Aminoquinazolin-4(3H)-one based plasmepsin inhibitors with improved hydrophilicity and selectivity Bioorg Med Chem (2018) 26, 2488-2500. PubMed Europe PubMed DOI I

2016

Pirta,C., Sharma,N.N. and Banyal,H.S. A 43 kDa recombinant plasmepsin elicits immune response in mice against Plasmodium berghei malaria Acta Parasitol (2016) 61, 102-107. PubMed Europe PubMed DOI E
Ponsuwanna,P., Kochakarn,T., Bunditvorapoom,D., Kumpornsin,K., Otto,T.D., Ridenour,C., Chotivanich,K., Wilairat,P., White,N.J., Miotto,O. and Chookajorn,T. Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasites Malar J (2016) 15, 51-51. PubMed Europe PubMed DOI PMC EPMC
Rasina,D., Otikovs,M., Leitans,J., Recacha,R., Borysov,O.V., Kanepe-Lapsa,I., Domraceva,I., Pantelejevs,T., Tars,K., Blackman,M.J., Jaudzems,K. and Jirgensons,A. Fragment-based discovery of 2-aminoquinazolin-4(3h)-ones as novel class nonpeptidomimetic inhibitors of the plasmepsins I, II, and IV J Med Chem (2016) 59, 374-387. PubMed Europe PubMed DOI I
Recacha,R., Jaudzems,K., Akopjana,I., Jirgensons,A. and Tars,K. Crystal structure of Plasmodium falciparum proplasmepsin IV: the plasticity of proplasmepsins Acta Crystallogr F Struct Biol Commun (2016) 72, 659-666. PubMed Europe PubMed DOI S

2015

Liu,P., Robbins,A.H., Marzahn,M.R., McClung,S.H., Yowell,C.A., Stevens SM Jr, Dame,J.B. and Dunn,B.M. Enzymatic characterization of recombinant food vacuole plasmepsin 4 from the rodent malaria parasite Plasmodium berghei PLoS ONE (2015) 10, e0141758-e0141758. PubMed Europe PubMed DOI P I
McGillewie,L. and Soliman,M.E. Flap flexibility amongst plasmepsins I, II, III, IV, and V: sequence, structural, and molecular dynamics analyses Proteins (2015) 83, 1693-1705. PubMed Europe PubMed DOI
Singh,A.K., Rathore,S., Tang,Y., Goldfarb,N.E., Dunn,B.M., Rajendran,V., Ghosh,P.C., Singh,N., Latha,N., Singh,B.K., Rawat,M. and Rathi,B. Hydroxyethylamine based phthalimides as new class of plasmepsin hits: design, synthesis and antimalarial evaluation PLoS ONE (2015) 10, e0139347-e0139347. PubMed Europe PubMed DOI PMC EPMC I

2014

Jaudzems,K., Tars,K., Maurops,G., Ivdra,N., Otikovs,M., Leitans,J., Kanepe-Lapsa,I., Domraceva,I., Mutule,I., Trapencieris,P., Blackman,M.J. and Jirgensons,A. Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit ACS Med Chem Lett (2014) 5, 373-377. PubMed Europe PubMed DOI I
Meyers,M.J., Tortorella,M.D., Xu,J., Qin,L., He,Z., Lang,X., Zeng,W., Xu,W., Qin,L., Prinsen,M.J., Sverdrup,F.M., Eickhoff,C.S., Griggs,D.W., Oliva,J., Ruminski,P.G., Jacobsen,E.J., Campbell,M.A., Wood,D.C., Goldberg,D.E., Liu,X., Lu,Y., Lu,X., Tu,Z., Lu,X., Ding,K. and Chen,X. Evaluation of aminohydantoins as a novel class of antimalarial agents ACS Med Chem Lett (2014) 5, 89-93. PubMed Europe PubMed DOI PMC EPMC I

2013

Aureggi,V., Ehmke,V., Wieland,J., Schweizer,W.B., Bernet,B., Bur,D., Meyer,S., Rottmann,M., Freymond,C., Brun,R., Breit,B. and Diederich,F. Potent inhibitors of malarial aspartic proteases, the plasmepsins, by hydroformylation of substituted 7-azanorbornenes Chemistry (2013) 19, 155-164. PubMed Europe PubMed DOI I
Chugh,M., Sundararaman,V., Kumar,S., Reddy,V.S., Siddiqui,W.A., Stuart,K.D. and Malhotra,P. Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum Proc Natl Acad Sci U S A (2013) 110, 5392-5397. PubMed Europe PubMed DOI

2012

Berry,C. and Goldberg,D.E. Food vacuole plasmepsins [ISSN:978-0-12-407744-7] (2012) 3, 98-103. DOI
Bhaumik,P., Gustchina,A. and Wlodawer,A. Structural studies of vacuolar plasmepsins Biochim Biophys Acta (2012) 1824, 207-223. PubMed Europe PubMed DOI S
Meyers,M.J. and Goldberg,D.E. Recent advances in plasmepsin medicinal chemistry and implications for future antimalarial drug discovery efforts Curr Top Med Chem (2012) 12, 445-455. PubMed Europe PubMed DOI I

2011

Gil,L., Valiente,P.A., Pascutti,P.G. and Pons,T. Computational perspectives into plasmepsins structure-function relationship: implications to inhibitors design J Trop Med (2011) 2011, 657483-657483. PubMed Europe PubMed DOI PMC EPMC V
McKay,P.B., Peters,M.B., Carta,G., Flood,C.T., Dempsey,E., Bell,A., Berry,C., Lloyd,D.G. and Fayne,D. Identification of plasmepsin inhibitors as selective anti-malarial agents using ligand based drug design Bioorg Med Chem Lett (2011) 21, 3335-3341. PubMed Europe PubMed DOI I
Rawat,M., Vijay,S., Gupta,Y., Dixit,R., Tiwari,P.K. and Sharma,A. Sequence homology and structural analysis of plasmepsin 4 isolated from Indian Plasmodium vivax isolates Infect Genet Evol (2011) 11, 924-933. PubMed Europe PubMed DOI
Silva,N., Lameira,J. and Alves,C.N. A quantum mechanical/molecular mechanical study of the aspartic protease plasmepsin IV complexed with allophenylnorstatine-based inhibitor Chem Phys Lett (2011) 509, 169-174. DOI I
Spaccapelo,R., Aime,E., Caterbi,S., Arcidiacono,P., Capuccini,B., Di Cristina,M., Dottorini,T., Rende,M., Bistoni,F. and Crisanti,A. Disruption of plasmepsin-4 and merozoites surface protein-7 genes in Plasmodium berghei induces combined virulence-attenuated phenotype Sci Rep (2011) 1, 39-39. PubMed Europe PubMed DOI PMC EPMC K

2010

Li,F., Patra,K.P., Yowell,C.A., Dame,J.B., Chin,K. and Vinetz,J.M. Apical surface expression of aspartic protease plasmepsin 4, a potential transmission-blocking target of the Plasmodium ookinete J Biol Chem (2010) 285, 8076-8083. PubMed Europe PubMed DOI
Luksch,T., Blum,A., Klee,N., Diederich,W.E., Sotriffer,C.A. and Klebe,G. Pyrrolidine derivatives as plasmepsin inhibitors: binding mode analysis assisted by molecular dynamics simulations of a highly flexible protein ChemMedChem (2010) 5, 443-454. PubMed Europe PubMed DOI I
Spaccapelo,R., Janse,C.J., Caterbi,S., Franke-Fayard,B., Bonilla,J.A., Syphard,L.M., Di Cristina,M., Dottorini,T., Savarino,A., Cassone,A., Bistoni,F., Waters,A.P., Dame,J.B. and Crisanti,A. Plasmepsin 4-deficient Plasmodium berghei are virulence attenuated and induce protective immunity against experimental malaria Am J Pathol (2010) 176, 205-217. PubMed Europe PubMed DOI K

2009

Fah,C., Hardegger,L.A., Baitsch,L., Schweizer,W.B., Meyer,S., Bur,D. and Diederich,F. New organofluorine building blocks: inhibition of the malarial aspartic proteases plasmepsin II and IV by alicyclic alpha,alpha-difluoroketone hydrates Org Biomol Chem (2009) 7, 3947-3957. PubMed Europe PubMed DOI I
Moura,P.A., Dame,J.B. and Fidock,D.A. Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors Antimicrobial Agents Chemother (2009) 53, 4968-4978. PubMed Europe PubMed DOI I
Orrling,K.M., Marzahn,M.R., Gutierrez-de-Teran,H., Aqvist,J., Dunn,B.M. and Larhed,M. alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases Bioorg Med Chem (2009) 17, 5933-5949. PubMed Europe PubMed DOI I

2008

Janka,L., Clemente,J., Vaiana,N., Sparatore,A., Romeo,S. and Dunn,B.M. Targeting the plasmepsin 4 orthologs of Plasmodium sp. with "double drug" inhibitors Protein Pept Lett (2008) 15, 868-873. PubMed Europe PubMed DOI T I
Luksch,T., Chan,N.S., Brass,S., Sotriffer,C.A., Klebe,G. and Diederich,W.E. Computer-aided design and synthesis of nonpeptidic plasmepsin II and IV inhibitors ChemMedChem (2008) 3, 1323-1336. PubMed Europe PubMed DOI I

2007

Bonilla,J.A., Moura,P.A., Bonilla,T.D., Yowell,C.A., Fidock,D.A. and Dame,J.B. Effects on growth, hemoglobin metabolism and paralogous gene expression resulting from disruption of genes encoding the digestive vacuole plasmepsins of Plasmodium falciparum Int J Parasitol (2007) 37, 317-327. PubMed Europe PubMed DOI K
Bonilla,J.A., Bonilla,T.D., Yowell,C.A., Fujioka,H. and Dame,J.B. Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function Mol Microbiol (2007) 65, 64-75. PubMed Europe PubMed DOI K
Kasam,V., Zimmermann,M., Maass,A., Schwichtenberg,H., Wolf,A., Jacq,N., Breton,V. and Hofmann-Apitius,M. Design of new plasmepsin inhibitors: a virtual high throughput screening approach on the EGEE grid J Chem Inf Model (2007) 47, 1818-1828. PubMed Europe PubMed DOI I

2006

Andrews,K.T., Fairlie,D.P., Madala,P.K., Ray,J., Wyatt,D.M., Hilton,P.M., Melville,L.A., Beattie,L., Gardiner,D.L., Reid,R.C., Stoermer,M.J., Skinner-Adams,T., Berry,C. and McCarthy,J.S. Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria Antimicrob Agents Chemother (2006) 50, 639-648. PubMed Europe PubMed DOI PMC EPMC I
Boss,C., Corminboeuf,O., Grisostomi,C., Meyer,S., Jones,A.F., Prade,L., Binkert,C., Fischli,W., Weller,T. and Bur,D. Achiral, cheap, and potent inhibitors of plasmepsins I, II, and IV ChemMedChem (2006) 1, 1341-1345. PubMed Europe PubMed DOI S I
Clemente,J.C., Govindasamy,L., Madabushi,A., Fisher,S.Z., Moose,R.E., Yowell,C.A., Hidaka,K., Kimura,T., Hayashi,Y., Kiso,Y., Agbandje-McKenna,M., Dame,J.B., Dunn,B.M. and McKenna,R. Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor Acta Crystallogr D Biol Crystallogr (2006) 62, 246-252. PubMed Europe PubMed DOI S I
[YEAR:21-11-2006]Ersmark,K., Nervall,M., Gutierrez-de-Teran,H., Hamelink,E., Janka,L.K., Clemente,J.C., Dunn,B.M., Gogoll,A., Samuelsson,B., Qvist,J. and Hallberg,A. Macrocyclic inhibitors of the malarial aspartic proteases plasmepsin I, II, and IV Bioorg Med Chem (21-11-2006) 14, 2197-2208. PubMed Europe PubMed DOI I
[YEAR:5-9-2006]Gutierrez-de-Teran,H., Nervall,M., Ersmark,K., Liu,P., Janka,L.K., Dunn,B., Hallberg,A. and Aqvist,J. Inhibitor binding to the plasmepsin IV aspartic protease from Plasmodium falciparum Biochemistry (5-9-2006) 45, 10529-10541. PubMed Europe PubMed DOI I
[YEAR:30-10-2006]Gutierrez-de-Teran,H., Nervall,M., Dunn,B.M., Clemente,J.C. and Aqvist,J. Computational analysis of plasmepsin IV bound to an allophenylnorstatine inhibitor FEBS Lett (30-10-2006) 580, 5910-5916. PubMed Europe PubMed DOI I
Hof,F., Schutz,A., Fah,C., Meyer,S., Bur,D., Liu,J., Goldberg,D.E. and Diederich,F. Starving the malaria parasite: inhibitors active against the aspartic proteases plasmepsins I, II, and IV Angew Chem Int Ed Engl (2006) 45, 2138-2141. PubMed Europe PubMed DOI I
Kim,Y.M., Lee,M.H., Piao,T.G., Lee,J.W., Kim,J.H., Lee,S., Choi,K.M., Jiang,J.H., Kim,T.U. and Park,H. Prodomain processing of recombinant plasmepsin II and IV, the aspartic proteases of Plasmodium falciparum, is auto- and trans-catalytic J Biochem (2006) 139, 189-195. PubMed Europe PubMed DOI
[YEAR:6-6-2006]Liu,J., Istvan,E.S., Gluzman,I.Y., Gross,J. and Goldberg,D.E. Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems Proc Natl Acad Sci U S A (6-6-2006) 103, 8840-8845. PubMed Europe PubMed DOI PMC EPMC

2005

[YEAR:15-2-2005]Beyer,B.B., Johnson,J.V., Chung,A.Y., Li,T., Madabushi,A., Agbandje-McKenna,M., McKenna,R., Dame,J.B. and Dunn,B.M. Active-site specificity of digestive aspartic peptidases from the four species of Plasmodium that infect humans using chromogenic combinatorial peptide libraries Biochemistry (15-2-2005) 44, 1768-1779. PubMed Europe PubMed DOI I
[YEAR:22-9-2005]Ersmark,K., Nervall,M., Hamelink,E., Janka,L.K., Clemente,J.C., Dunn,B.M., Blackman,M.J., Samuelsson,B., Aqvist,J. and Hallberg,A. Synthesis of malarial plasmepsin inhibitors and prediction of binding modes by molecular dynamics simulations J Med Chem (22-9-2005) 48, 6090-6106. PubMed Europe PubMed DOI I
[YEAR:28-10-2005]Liu,J., Gluzman,I.Y., Drew,M.E. and Goldberg,D.E. The role of Plasmodium falciparum food vacuole plasmepsins J Biol Chem (28-10-2005) 280, 1432-1437. PubMed Europe PubMed DOI
[YEAR:1-2-2005]Madabushi,A., Chakraborty,S., Fisher,S.Z., Clemente,J.C., Yowell,C., Agbandje-McKenna,M., Dame,J.B., Dunn,B.M. and McKenna,R. Crystallization and preliminary X-ray analysis of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae Acta Crystallograph Sect F Struct Biol Cryst Commun (1-2-2005) 61, 228-231. PubMed Europe PubMed DOI PMC EPMC S I

2004

Berry,C. and Goldberg,D.E. Plasmepsins [ISSN:0-12-079610-4] (2004) 2, 70-73. V
Li,T., Yowell,C.A., Beyer,B.B., Hung,S.H., Westling,J., Lam,M.T., Dunn,B.M. and Dame,J.B. Recombinant expression and enzymatic subsite characterization of plasmepsin 4 from the four Plasmodium species infecting man Mol Biochem Parasitol (2004) 135, 101-109. PubMed Europe PubMed DOI
[YEAR:24-12-2004]Omara-Opyene,A.L., Moura,P.A., Sulsona,C.R., Bonilla,J.A., Yowell,C.A., Fujioka,H., Fidock,D.A. and Dame,J.B. Genetic disruption of the Plasmodium falciparum digestive vacuole plasmepsins demonstrates their functional redundancy J Biol Chem (24-12-2004) 279, 54088-54096. PubMed Europe PubMed DOI

2003

Banerjee,R., Francis,S.E. and Goldberg,D.E. Food vacuole plasmepsins are processed at a conserved site by an acidic convertase activity in Plasmodium falciparum Mol Biochem Parasitol (2003) 129, 157-165. PubMed Europe PubMed DOI
[YEAR:11-8-2003]Dame,J.B., Yowell,C.A., Omara-Opyene,L., Carlton,J.M., Cooper,R.A. and Li,T. Plasmepsin 4, the food vacuole aspartic proteinase found in all Plasmodium spp. infecting man Mol Biochem Parasitol (11-8-2003) 130, 1-12. PubMed Europe PubMed DOI
[YEAR:22-7-2003]Nezami,A., Kimura,T., Hidaka,K., Kiso,A., Liu,J., Kiso,Y., Goldberg,D.E. and Freire,E. High-affinity inhibition of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor Biochemistry (22-7-2003) 42, 8459-8464. PubMed Europe PubMed DOI I

2002

[YEAR:22-1-2002]Banerjee,R., Liu,J., Beatty,W., Pelosof,L., Klemba,M. and Goldberg,D.E. Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine Proc Natl Acad Sci U S A (22-1-2002) 99, 990-995. PubMed Europe PubMed DOI PMC EPMC
Nezami,A. and Freire,E. The integration of genomic and structural information in the development of high affinity plasmepsin inhibitors Int J Parasitol (2002) 32, 1669-1676. PubMed Europe PubMed DOI I
[YEAR:27-2-2002]Wyatt,D.M. and Berry,C. Activity and inhibition of plasmepsin IV, a new aspartic proteinase from the malaria parasite, Plasmodium falciparum FEBS Lett (27-2-2002) 513, 159-162. PubMed Europe PubMed DOI

2001

Coombs,G.H., Goldberg,D.E., Klemba,M., Berry,C., Kay,J. and Mottram,J.C. Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets Trends Parasitol (2001) 17, 532-537. PubMed Europe PubMed DOI

1999

[YEAR:10-12-1999]Humphreys,M.J., Moon,R.P., Klinder,A., Fowler,S.D., Rupp,K., Bur,D., Ridley,R.G. and Berry,C. The aspartic proteinase from the rodent parasite Plasmodium berghei as a potential model for plasmepsins from the human malaria parasite, Plasmodium falciparum FEBS Lett (10-12-1999) 463, 43-48. PubMed Europe PubMed DOI