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Literature for peptidase A01.059: plasmepsin-4

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

(Topics flags: S Structure, T Target, K Knockout, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2019
  1. Zogota,R., Kinena,L., Withers-Martinez,C., Blackman,M.J., Bobrovs,R., Pantelejevs,T., Kanepe-Lapsa,I., Ozola,V., Jaudzems,K., Suna,E. and Jirgensons,A.
    Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D
    Eur J Med Chem (2019) 163, 344-352. PubMed  Europe PubMed DOI
    2. 2018
  2. Kumar Singh,A., Rajendran,V., Singh,S., Kumar,P., Kumar,Y., Singh,A., Miller,W., Potemkin,V., Poonam, Grishina,M., Gupta,N., Kempaiah,P., Durvasula,R., Singh,B.K., Dunn,B.M. and Rathi,B.
    Antiplasmodial activity of hydroxyethylamine analogs: synthesis, biological activity and structure activity relationship of plasmepsin inhibitors
    Bioorg Med Chem (2018) 26, 3837-3844. PubMed  Europe PubMed DOI  I
  3. Onchieku,N.M., Mogire,R., Ndung'u,L., Mwitari,P., Kimani,F., Matoke-Muhia,D., Kiboi,D. and Magoma,G.
    Deciphering the targets of retroviral protease inhibitors in Plasmodium berghei
    PLoS ONE (2018) 13, e0201556-e0201556. PubMed  Europe PubMed DOI  PMC  EPMC  I
  4. Rasina,D., Stakanovs,G., Borysov,O.V., Pantelejevs,T., Bobrovs,R., Kanepe-Lapsa,I., Tars,K., Jaudzems,K. and Jirgensons,A.
    2-Aminoquinazolin-4(3H)-one based plasmepsin inhibitors with improved hydrophilicity and selectivity
    Bioorg Med Chem (2018) 26, 2488-2500. PubMed  Europe PubMed DOI  I
    5. 2016
  5. Pirta,C., Sharma,N.N. and Banyal,H.S.
    A 43 kDa recombinant plasmepsin elicits immune response in mice against Plasmodium berghei malaria
    Acta Parasitol (2016) 61, 102-107. PubMed  Europe PubMed DOI  E
  6. Ponsuwanna,P., Kochakarn,T., Bunditvorapoom,D., Kumpornsin,K., Otto,T.D., Ridenour,C., Chotivanich,K., Wilairat,P., White,N.J., Miotto,O. and Chookajorn,T.
    Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasites
    Malar J (2016) 15, 51-51. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Rasina,D., Otikovs,M., Leitans,J., Recacha,R., Borysov,O.V., Kanepe-Lapsa,I., Domraceva,I., Pantelejevs,T., Tars,K., Blackman,M.J., Jaudzems,K. and Jirgensons,A.
    Fragment-based discovery of 2-aminoquinazolin-4(3h)-ones as novel class nonpeptidomimetic inhibitors of the plasmepsins I, II, and IV
    J Med Chem (2016) 59, 374-387. PubMed  Europe PubMed DOI  I
  8. Recacha,R., Jaudzems,K., Akopjana,I., Jirgensons,A. and Tars,K.
    Crystal structure of Plasmodium falciparum proplasmepsin IV: the plasticity of proplasmepsins
    Acta Crystallogr F Struct Biol Commun (2016) 72, 659-666. PubMed  Europe PubMed DOI  S
    9. 2015
  9. Liu,P., Robbins,A.H., Marzahn,M.R., McClung,S.H., Yowell,C.A., Stevens SM Jr, Dame,J.B. and Dunn,B.M.
    Enzymatic characterization of recombinant food vacuole plasmepsin 4 from the rodent malaria parasite Plasmodium berghei
    PLoS ONE (2015) 10, e0141758-e0141758. PubMed  Europe PubMed DOI  P  I
  10. McGillewie,L. and Soliman,M.E.
    Flap flexibility amongst plasmepsins I, II, III, IV, and V: sequence, structural, and molecular dynamics analyses
    Proteins (2015) 83, 1693-1705. PubMed  Europe PubMed DOI
  11. Singh,A.K., Rathore,S., Tang,Y., Goldfarb,N.E., Dunn,B.M., Rajendran,V., Ghosh,P.C., Singh,N., Latha,N., Singh,B.K., Rawat,M. and Rathi,B.
    Hydroxyethylamine based phthalimides as new class of plasmepsin hits: design, synthesis and antimalarial evaluation
    PLoS ONE (2015) 10, e0139347-e0139347. PubMed  Europe PubMed DOI  PMC  EPMC  I
    12. 2014
  12. Jaudzems,K., Tars,K., Maurops,G., Ivdra,N., Otikovs,M., Leitans,J., Kanepe-Lapsa,I., Domraceva,I., Mutule,I., Trapencieris,P., Blackman,M.J. and Jirgensons,A.
    Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit
    ACS Med Chem Lett (2014) 5, 373-377. PubMed  Europe PubMed DOI  I
  13. Meyers,M.J., Tortorella,M.D., Xu,J., Qin,L., He,Z., Lang,X., Zeng,W., Xu,W., Qin,L., Prinsen,M.J., Sverdrup,F.M., Eickhoff,C.S., Griggs,D.W., Oliva,J., Ruminski,P.G., Jacobsen,E.J., Campbell,M.A., Wood,D.C., Goldberg,D.E., Liu,X., Lu,Y., Lu,X., Tu,Z., Lu,X., Ding,K. and Chen,X.
    Evaluation of aminohydantoins as a novel class of antimalarial agents
    ACS Med Chem Lett (2014) 5, 89-93. PubMed  Europe PubMed DOI  PMC  EPMC  I
    14. 2013
  14. Aureggi,V., Ehmke,V., Wieland,J., Schweizer,W.B., Bernet,B., Bur,D., Meyer,S., Rottmann,M., Freymond,C., Brun,R., Breit,B. and Diederich,F.
    Potent inhibitors of malarial aspartic proteases, the plasmepsins, by hydroformylation of substituted 7-azanorbornenes
    Chemistry (2013) 19, 155-164. PubMed  Europe PubMed DOI  I
  15. Chugh,M., Sundararaman,V., Kumar,S., Reddy,V.S., Siddiqui,W.A., Stuart,K.D. and Malhotra,P.
    Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum
    Proc Natl Acad Sci U S A (2013) 110, 5392-5397. PubMed  Europe PubMed DOI
    16. 2012
  16. Berry,C. and Goldberg,D.E.
    Food vacuole plasmepsins
    [ISSN:978-0-12-407744-7] (2012) 3, 98-103. DOI
  17. Bhaumik,P., Gustchina,A. and Wlodawer,A.
    Structural studies of vacuolar plasmepsins
    Biochim Biophys Acta (2012) 1824, 207-223. PubMed  Europe PubMed DOI  S
  18. Meyers,M.J. and Goldberg,D.E.
    Recent advances in plasmepsin medicinal chemistry and implications for future antimalarial drug discovery efforts
    Curr Top Med Chem (2012) 12, 445-455. PubMed  Europe PubMed DOI  I
    19. 2011
  19. Gil,L., Valiente,P.A., Pascutti,P.G. and Pons,T.
    Computational perspectives into plasmepsins structure-function relationship: implications to inhibitors design
    J Trop Med (2011) 2011, 657483-657483. PubMed  Europe PubMed DOI  PMC  EPMC  V
  20. McKay,P.B., Peters,M.B., Carta,G., Flood,C.T., Dempsey,E., Bell,A., Berry,C., Lloyd,D.G. and Fayne,D.
    Identification of plasmepsin inhibitors as selective anti-malarial agents using ligand based drug design
    Bioorg Med Chem Lett (2011) 21, 3335-3341. PubMed  Europe PubMed DOI  I
  21. Rawat,M., Vijay,S., Gupta,Y., Dixit,R., Tiwari,P.K. and Sharma,A.
    Sequence homology and structural analysis of plasmepsin 4 isolated from Indian Plasmodium vivax isolates
    Infect Genet Evol (2011) 11, 924-933. PubMed  Europe PubMed DOI
  22. Silva,N., Lameira,J. and Alves,C.N.
    A quantum mechanical/molecular mechanical study of the aspartic protease plasmepsin IV complexed with allophenylnorstatine-based inhibitor
    Chem Phys Lett (2011) 509, 169-174. DOI  I
  23. Spaccapelo,R., Aime,E., Caterbi,S., Arcidiacono,P., Capuccini,B., Di Cristina,M., Dottorini,T., Rende,M., Bistoni,F. and Crisanti,A.
    Disruption of plasmepsin-4 and merozoites surface protein-7 genes in Plasmodium berghei induces combined virulence-attenuated phenotype
    Sci Rep (2011) 1, 39-39. PubMed  Europe PubMed DOI  PMC  EPMC  K
    24. 2010
  24. Li,F., Patra,K.P., Yowell,C.A., Dame,J.B., Chin,K. and Vinetz,J.M.
    Apical surface expression of aspartic protease plasmepsin 4, a potential transmission-blocking target of the Plasmodium ookinete
    J Biol Chem (2010) 285, 8076-8083. PubMed  Europe PubMed DOI
  25. Luksch,T., Blum,A., Klee,N., Diederich,W.E., Sotriffer,C.A. and Klebe,G.
    Pyrrolidine derivatives as plasmepsin inhibitors: binding mode analysis assisted by molecular dynamics simulations of a highly flexible protein
    ChemMedChem (2010) 5, 443-454. PubMed  Europe PubMed DOI  I
  26. Spaccapelo,R., Janse,C.J., Caterbi,S., Franke-Fayard,B., Bonilla,J.A., Syphard,L.M., Di Cristina,M., Dottorini,T., Savarino,A., Cassone,A., Bistoni,F., Waters,A.P., Dame,J.B. and Crisanti,A.
    Plasmepsin 4-deficient Plasmodium berghei are virulence attenuated and induce protective immunity against experimental malaria
    Am J Pathol (2010) 176, 205-217. PubMed  Europe PubMed DOI  K
    27. 2009
  27. Fah,C., Hardegger,L.A., Baitsch,L., Schweizer,W.B., Meyer,S., Bur,D. and Diederich,F.
    New organofluorine building blocks: inhibition of the malarial aspartic proteases plasmepsin II and IV by alicyclic alpha,alpha-difluoroketone hydrates
    Org Biomol Chem (2009) 7, 3947-3957. PubMed  Europe PubMed DOI  I
  28. Moura,P.A., Dame,J.B. and Fidock,D.A.
    Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors
    Antimicrobial Agents Chemother (2009) 53, 4968-4978. PubMed  Europe PubMed DOI  I
  29. Orrling,K.M., Marzahn,M.R., Gutierrez-de-Teran,H., Aqvist,J., Dunn,B.M. and Larhed,M.
    alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases
    Bioorg Med Chem (2009) 17, 5933-5949. PubMed  Europe PubMed DOI  I
    30. 2008
  30. Janka,L., Clemente,J., Vaiana,N., Sparatore,A., Romeo,S. and Dunn,B.M.
    Targeting the plasmepsin 4 orthologs of Plasmodium sp. with "double drug" inhibitors
    Protein Pept Lett (2008) 15, 868-873. PubMed  Europe PubMed DOI  T  I
  31. Luksch,T., Chan,N.S., Brass,S., Sotriffer,C.A., Klebe,G. and Diederich,W.E.
    Computer-aided design and synthesis of nonpeptidic plasmepsin II and IV inhibitors
    ChemMedChem (2008) 3, 1323-1336. PubMed  Europe PubMed DOI  I
    32. 2007
  32. Bonilla,J.A., Moura,P.A., Bonilla,T.D., Yowell,C.A., Fidock,D.A. and Dame,J.B.
    Effects on growth, hemoglobin metabolism and paralogous gene expression resulting from disruption of genes encoding the digestive vacuole plasmepsins of Plasmodium falciparum
    Int J Parasitol (2007) 37, 317-327. PubMed  Europe PubMed DOI  K
  33. Bonilla,J.A., Bonilla,T.D., Yowell,C.A., Fujioka,H. and Dame,J.B.
    Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function
    Mol Microbiol (2007) 65, 64-75. PubMed  Europe PubMed DOI  K
  34. Kasam,V., Zimmermann,M., Maass,A., Schwichtenberg,H., Wolf,A., Jacq,N., Breton,V. and Hofmann-Apitius,M.
    Design of new plasmepsin inhibitors: a virtual high throughput screening approach on the EGEE grid
    J Chem Inf Model (2007) 47, 1818-1828. PubMed  Europe PubMed DOI  I
    35. 2006
  35. Andrews,K.T., Fairlie,D.P., Madala,P.K., Ray,J., Wyatt,D.M., Hilton,P.M., Melville,L.A., Beattie,L., Gardiner,D.L., Reid,R.C., Stoermer,M.J., Skinner-Adams,T., Berry,C. and McCarthy,J.S.
    Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria
    Antimicrob Agents Chemother (2006) 50, 639-648. PubMed  Europe PubMed DOI  PMC  EPMC  I
  36. Boss,C., Corminboeuf,O., Grisostomi,C., Meyer,S., Jones,A.F., Prade,L., Binkert,C., Fischli,W., Weller,T. and Bur,D.
    Achiral, cheap, and potent inhibitors of plasmepsins I, II, and IV
    ChemMedChem (2006) 1, 1341-1345. PubMed  Europe PubMed DOI  S  I
  37. Clemente,J.C., Govindasamy,L., Madabushi,A., Fisher,S.Z., Moose,R.E., Yowell,C.A., Hidaka,K., Kimura,T., Hayashi,Y., Kiso,Y., Agbandje-McKenna,M., Dame,J.B., Dunn,B.M. and McKenna,R.
    Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor
    Acta Crystallogr D Biol Crystallogr (2006) 62, 246-252. PubMed  Europe PubMed DOI  S  I
  38. [YEAR:21-11-2006]Ersmark,K., Nervall,M., Gutierrez-de-Teran,H., Hamelink,E., Janka,L.K., Clemente,J.C., Dunn,B.M., Gogoll,A., Samuelsson,B., Qvist,J. and Hallberg,A.
    Macrocyclic inhibitors of the malarial aspartic proteases plasmepsin I, II, and IV
    Bioorg Med Chem (21-11-2006) 14, 2197-2208. PubMed  Europe PubMed DOI  I
  39. [YEAR:5-9-2006]Gutierrez-de-Teran,H., Nervall,M., Ersmark,K., Liu,P., Janka,L.K., Dunn,B., Hallberg,A. and Aqvist,J.
    Inhibitor binding to the plasmepsin IV aspartic protease from Plasmodium falciparum
    Biochemistry (5-9-2006) 45, 10529-10541. PubMed  Europe PubMed DOI  I
  40. [YEAR:30-10-2006]Gutierrez-de-Teran,H., Nervall,M., Dunn,B.M., Clemente,J.C. and Aqvist,J.
    Computational analysis of plasmepsin IV bound to an allophenylnorstatine inhibitor
    FEBS Lett (30-10-2006) 580, 5910-5916. PubMed  Europe PubMed DOI  I
  41. Hof,F., Schutz,A., Fah,C., Meyer,S., Bur,D., Liu,J., Goldberg,D.E. and Diederich,F.
    Starving the malaria parasite: inhibitors active against the aspartic proteases plasmepsins I, II, and IV
    Angew Chem Int Ed Engl (2006) 45, 2138-2141. PubMed  Europe PubMed DOI  I
  42. Kim,Y.M., Lee,M.H., Piao,T.G., Lee,J.W., Kim,J.H., Lee,S., Choi,K.M., Jiang,J.H., Kim,T.U. and Park,H.
    Prodomain processing of recombinant plasmepsin II and IV, the aspartic proteases of Plasmodium falciparum, is auto- and trans-catalytic
    J Biochem (2006) 139, 189-195. PubMed  Europe PubMed DOI
  43. [YEAR:6-6-2006]Liu,J., Istvan,E.S., Gluzman,I.Y., Gross,J. and Goldberg,D.E.
    Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems
    Proc Natl Acad Sci U S A (6-6-2006) 103, 8840-8845. PubMed  Europe PubMed DOI  PMC  EPMC
    44. 2005
  44. [YEAR:15-2-2005]Beyer,B.B., Johnson,J.V., Chung,A.Y., Li,T., Madabushi,A., Agbandje-McKenna,M., McKenna,R., Dame,J.B. and Dunn,B.M.
    Active-site specificity of digestive aspartic peptidases from the four species of Plasmodium that infect humans using chromogenic combinatorial peptide libraries
    Biochemistry (15-2-2005) 44, 1768-1779. PubMed  Europe PubMed DOI  I
  45. [YEAR:22-9-2005]Ersmark,K., Nervall,M., Hamelink,E., Janka,L.K., Clemente,J.C., Dunn,B.M., Blackman,M.J., Samuelsson,B., Aqvist,J. and Hallberg,A.
    Synthesis of malarial plasmepsin inhibitors and prediction of binding modes by molecular dynamics simulations
    J Med Chem (22-9-2005) 48, 6090-6106. PubMed  Europe PubMed DOI  I
  46. [YEAR:28-10-2005]Liu,J., Gluzman,I.Y., Drew,M.E. and Goldberg,D.E.
    The role of Plasmodium falciparum food vacuole plasmepsins
    J Biol Chem (28-10-2005) 280, 1432-1437. PubMed  Europe PubMed DOI
  47. [YEAR:1-2-2005]Madabushi,A., Chakraborty,S., Fisher,S.Z., Clemente,J.C., Yowell,C., Agbandje-McKenna,M., Dame,J.B., Dunn,B.M. and McKenna,R.
    Crystallization and preliminary X-ray analysis of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae
    Acta Crystallograph Sect F Struct Biol Cryst Commun (1-2-2005) 61, 228-231. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
    48. 2004
  48. Berry,C. and Goldberg,D.E.
    Plasmepsins
    [ISSN:0-12-079610-4] (2004) 2, 70-73.  V
  49. Li,T., Yowell,C.A., Beyer,B.B., Hung,S.H., Westling,J., Lam,M.T., Dunn,B.M. and Dame,J.B.
    Recombinant expression and enzymatic subsite characterization of plasmepsin 4 from the four Plasmodium species infecting man
    Mol Biochem Parasitol (2004) 135, 101-109. PubMed  Europe PubMed DOI
  50. [YEAR:24-12-2004]Omara-Opyene,A.L., Moura,P.A., Sulsona,C.R., Bonilla,J.A., Yowell,C.A., Fujioka,H., Fidock,D.A. and Dame,J.B.
    Genetic disruption of the Plasmodium falciparum digestive vacuole plasmepsins demonstrates their functional redundancy
    J Biol Chem (24-12-2004) 279, 54088-54096. PubMed  Europe PubMed DOI
    51. 2003
  51. Banerjee,R., Francis,S.E. and Goldberg,D.E.
    Food vacuole plasmepsins are processed at a conserved site by an acidic convertase activity in Plasmodium falciparum
    Mol Biochem Parasitol (2003) 129, 157-165. PubMed  Europe PubMed DOI
  52. [YEAR:11-8-2003]Dame,J.B., Yowell,C.A., Omara-Opyene,L., Carlton,J.M., Cooper,R.A. and Li,T.
    Plasmepsin 4, the food vacuole aspartic proteinase found in all Plasmodium spp. infecting man
    Mol Biochem Parasitol (11-8-2003) 130, 1-12. PubMed  Europe PubMed DOI
  53. [YEAR:22-7-2003]Nezami,A., Kimura,T., Hidaka,K., Kiso,A., Liu,J., Kiso,Y., Goldberg,D.E. and Freire,E.
    High-affinity inhibition of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor
    Biochemistry (22-7-2003) 42, 8459-8464. PubMed  Europe PubMed DOI  I
    54. 2002
  54. [YEAR:22-1-2002]Banerjee,R., Liu,J., Beatty,W., Pelosof,L., Klemba,M. and Goldberg,D.E.
    Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine
    Proc Natl Acad Sci U S A (22-1-2002) 99, 990-995. PubMed  Europe PubMed DOI  PMC  EPMC
  55. Nezami,A. and Freire,E.
    The integration of genomic and structural information in the development of high affinity plasmepsin inhibitors
    Int J Parasitol (2002) 32, 1669-1676. PubMed  Europe PubMed DOI  I
  56. [YEAR:27-2-2002]Wyatt,D.M. and Berry,C.
    Activity and inhibition of plasmepsin IV, a new aspartic proteinase from the malaria parasite, Plasmodium falciparum
    FEBS Lett (27-2-2002) 513, 159-162. PubMed  Europe PubMed DOI
    57. 2001
  57. Coombs,G.H., Goldberg,D.E., Klemba,M., Berry,C., Kay,J. and Mottram,J.C.
    Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets
    Trends Parasitol (2001) 17, 532-537. PubMed  Europe PubMed DOI
    58. 1999
  58. [YEAR:10-12-1999]Humphreys,M.J., Moon,R.P., Klinder,A., Fowler,S.D., Rupp,K., Bur,D., Ridley,R.G. and Berry,C.
    The aspartic proteinase from the rodent parasite Plasmodium berghei as a potential model for plasmepsins from the human malaria parasite, Plasmodium falciparum
    FEBS Lett (10-12-1999) 463, 43-48. PubMed  Europe PubMed DOI

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