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Literature for peptidase A01.059: plasmepsin-4

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, T Target, K Knockout, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2019
  1. Zogota,R., Kinena,L., Withers-Martinez,C., Blackman,M.J., Bobrovs,R., Pantelejevs,T., Kanepe-Lapsa,I., Ozola,V., Jaudzems,K., Suna,E. and Jirgensons,A.
    Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D
    Eur J Med Chem163, 344-352. PubMed  Europe PubMed DOI
    2. 2018
  2. Kumar Singh,A., Rajendran,V., Singh,S., Kumar,P., Kumar,Y., Singh,A., Miller,W., Potemkin,V., Poonam, Grishina,M., Gupta,N., Kempaiah,P., Durvasula,R., Singh,B.K., Dunn,B.M. and Rathi,B.
    Antiplasmodial activity of hydroxyethylamine analogs: synthesis, biological activity and structure activity relationship of plasmepsin inhibitors
    Bioorg Med Chem26, 3837-3844. PubMed  Europe PubMed DOI  I
  3. Onchieku,N.M., Mogire,R., Ndung'u,L., Mwitari,P., Kimani,F., Matoke-Muhia,D., Kiboi,D. and Magoma,G.
    Deciphering the targets of retroviral protease inhibitors in Plasmodium berghei
    PLoS ONE13, e0201556-e0201556. PubMed  Europe PubMed DOI  I
  4. Rasina,D., Stakanovs,G., Borysov,O.V., Pantelejevs,T., Bobrovs,R., Kanepe-Lapsa,I., Tars,K., Jaudzems,K. and Jirgensons,A.
    2-Aminoquinazolin-4(3H)-one based plasmepsin inhibitors with improved hydrophilicity and selectivity
    Bioorg Med Chem26, 2488-2500. PubMed  Europe PubMed DOI  I
    5. 2016
  5. Pirta,C., Sharma,N.N. and Banyal,H.S.
    A 43 kDa recombinant plasmepsin elicits immune response in mice against Plasmodium berghei malaria
    Acta Parasitol61, 102-107. PubMed  Europe PubMed DOI  E
  6. Ponsuwanna,P., Kochakarn,T., Bunditvorapoom,D., Kumpornsin,K., Otto,T.D., Ridenour,C., Chotivanich,K., Wilairat,P., White,N.J., Miotto,O. and Chookajorn,T.
    Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasites
    Malar J15, 51-51. PubMed  Europe PubMed DOI
  7. Rasina,D., Otikovs,M., Leitans,J., Recacha,R., Borysov,O.V., Kanepe-Lapsa,I., Domraceva,I., Pantelejevs,T., Tars,K., Blackman,M.J., Jaudzems,K. and Jirgensons,A.
    Fragment-based discovery of 2-aminoquinazolin-4(3h)-ones as novel class nonpeptidomimetic inhibitors of the plasmepsins I, II, and IV
    J Med Chem59, 374-387. PubMed  Europe PubMed DOI  I
  8. Recacha,R., Jaudzems,K., Akopjana,I., Jirgensons,A. and Tars,K.
    Crystal structure of Plasmodium falciparum proplasmepsin IV: the plasticity of proplasmepsins
    Acta Crystallogr F Struct Biol Commun72, 659-666. PubMed  Europe PubMed DOI  S
    9. 2015
  9. Liu,P., Robbins,A.H., Marzahn,M.R., McClung,S.H., Yowell,C.A., Stevens SM Jr, Dame,J.B. and Dunn,B.M.
    Enzymatic characterization of recombinant food vacuole plasmepsin 4 from the rodent malaria parasite Plasmodium berghei
    PLoS ONE10, e0141758-e0141758. PubMed  Europe PubMed DOI  P  I
  10. McGillewie,L. and Soliman,M.E.
    Flap flexibility amongst plasmepsins I, II, III, IV, and V: sequence, structural, and molecular dynamics analyses
    Proteins83, 1693-1705. PubMed  Europe PubMed DOI
  11. Singh,A.K., Rathore,S., Tang,Y., Goldfarb,N.E., Dunn,B.M., Rajendran,V., Ghosh,P.C., Singh,N., Latha,N., Singh,B.K., Rawat,M. and Rathi,B.
    Hydroxyethylamine based phthalimides as new class of plasmepsin hits: design, synthesis and antimalarial evaluation
    PLoS ONE10, e0139347-e0139347. PubMed  Europe PubMed DOI  I
    12. 2014
  12. Jaudzems,K., Tars,K., Maurops,G., Ivdra,N., Otikovs,M., Leitans,J., Kanepe-Lapsa,I., Domraceva,I., Mutule,I., Trapencieris,P., Blackman,M.J. and Jirgensons,A.
    Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit
    ACS Med Chem Lett5, 373-377. PubMed  Europe PubMed DOI  I
  13. Meyers,M.J., Tortorella,M.D., Xu,J., Qin,L., He,Z., Lang,X., Zeng,W., Xu,W., Qin,L., Prinsen,M.J., Sverdrup,F.M., Eickhoff,C.S., Griggs,D.W., Oliva,J., Ruminski,P.G., Jacobsen,E.J., Campbell,M.A., Wood,D.C., Goldberg,D.E., Liu,X., Lu,Y., Lu,X., Tu,Z., Lu,X., Ding,K. and Chen,X.
    Evaluation of aminohydantoins as a novel class of antimalarial agents
    ACS Med Chem Lett5, 89-93. PubMed  Europe PubMed DOI  I
    14. 2013
  14. Aureggi,V., Ehmke,V., Wieland,J., Schweizer,W.B., Bernet,B., Bur,D., Meyer,S., Rottmann,M., Freymond,C., Brun,R., Breit,B. and Diederich,F.
    Potent inhibitors of malarial aspartic proteases, the plasmepsins, by hydroformylation of substituted 7-azanorbornenes
    Chemistry19, 155-164. PubMed  Europe PubMed DOI  I
  15. Chugh,M., Sundararaman,V., Kumar,S., Reddy,V.S., Siddiqui,W.A., Stuart,K.D. and Malhotra,P.
    Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum
    Proc Natl Acad Sci U S A110, 5392-5397. PubMed  Europe PubMed DOI
    16. 2012
  16. Berry,C. and Goldberg,D.E.
    Food vacuole plasmepsins
    [ISSN:978-0-12-407744-7]3, 98-103. DOI
  17. Bhaumik,P., Gustchina,A. and Wlodawer,A.
    Structural studies of vacuolar plasmepsins
    Biochim Biophys Acta1824, 207-223. PubMed  Europe PubMed DOI  S
  18. Meyers,M.J. and Goldberg,D.E.
    Recent advances in plasmepsin medicinal chemistry and implications for future antimalarial drug discovery efforts
    Curr Top Med Chem12, 445-455. PubMed  Europe PubMed DOI  I
    19. 2011
  19. Gil,L., Valiente,P.A., Pascutti,P.G. and Pons,T.
    Computational perspectives into plasmepsins structure-function relationship: implications to inhibitors design
    J Trop Med2011, 657483-657483. PubMed  Europe PubMed DOI  V
  20. McKay,P.B., Peters,M.B., Carta,G., Flood,C.T., Dempsey,E., Bell,A., Berry,C., Lloyd,D.G. and Fayne,D.
    Identification of plasmepsin inhibitors as selective anti-malarial agents using ligand based drug design
    Bioorg Med Chem Lett21, 3335-3341. PubMed  Europe PubMed DOI  I
  21. Rawat,M., Vijay,S., Gupta,Y., Dixit,R., Tiwari,P.K. and Sharma,A.
    Sequence homology and structural analysis of plasmepsin 4 isolated from Indian Plasmodium vivax isolates
    Infect Genet Evol11, 924-933. PubMed  Europe PubMed DOI
  22. Silva,N., Lameira,J. and Alves,C.N.
    A quantum mechanical/molecular mechanical study of the aspartic protease plasmepsin IV complexed with allophenylnorstatine-based inhibitor
    Chem Phys Lett509, 169-174. DOI  I
  23. Spaccapelo,R., Aime,E., Caterbi,S., Arcidiacono,P., Capuccini,B., Di Cristina,M., Dottorini,T., Rende,M., Bistoni,F. and Crisanti,A.
    Disruption of plasmepsin-4 and merozoites surface protein-7 genes in Plasmodium berghei induces combined virulence-attenuated phenotype
    Sci Rep1, 39-39. PubMed  Europe PubMed DOI  K
    24. 2010
  24. Li,F., Patra,K.P., Yowell,C.A., Dame,J.B., Chin,K. and Vinetz,J.M.
    Apical surface expression of aspartic protease plasmepsin 4, a potential transmission-blocking target of the Plasmodium ookinete
    J Biol Chem285, 8076-8083. PubMed  Europe PubMed DOI
  25. Luksch,T., Blum,A., Klee,N., Diederich,W.E., Sotriffer,C.A. and Klebe,G.
    Pyrrolidine derivatives as plasmepsin inhibitors: binding mode analysis assisted by molecular dynamics simulations of a highly flexible protein
    ChemMedChem5, 443-454. PubMed  Europe PubMed DOI  I
  26. Spaccapelo,R., Janse,C.J., Caterbi,S., Franke-Fayard,B., Bonilla,J.A., Syphard,L.M., Di Cristina,M., Dottorini,T., Savarino,A., Cassone,A., Bistoni,F., Waters,A.P., Dame,J.B. and Crisanti,A.
    Plasmepsin 4-deficient Plasmodium berghei are virulence attenuated and induce protective immunity against experimental malaria
    Am J Pathol176, 205-217. PubMed  Europe PubMed DOI  K
    27. 2009
  27. Fah,C., Hardegger,L.A., Baitsch,L., Schweizer,W.B., Meyer,S., Bur,D. and Diederich,F.
    New organofluorine building blocks: inhibition of the malarial aspartic proteases plasmepsin II and IV by alicyclic alpha,alpha-difluoroketone hydrates
    Org Biomol Chem7, 3947-3957. PubMed  Europe PubMed DOI  I
  28. Moura,P.A., Dame,J.B. and Fidock,D.A.
    Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors
    Antimicrobial Agents Chemother53, 4968-4978. PubMed  Europe PubMed DOI  I
  29. Orrling,K.M., Marzahn,M.R., Gutierrez-de-Teran,H., Aqvist,J., Dunn,B.M. and Larhed,M.
    alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases
    Bioorg Med Chem17, 5933-5949. PubMed  Europe PubMed DOI  I
    30. 2008
  30. Janka,L., Clemente,J., Vaiana,N., Sparatore,A., Romeo,S. and Dunn,B.M.
    Targeting the plasmepsin 4 orthologs of Plasmodium sp. with "double drug" inhibitors
    Protein Pept Lett15, 868-873. PubMed  Europe PubMed DOI  T  I
  31. Luksch,T., Chan,N.S., Brass,S., Sotriffer,C.A., Klebe,G. and Diederich,W.E.
    Computer-aided design and synthesis of nonpeptidic plasmepsin II and IV inhibitors
    ChemMedChem3, 1323-1336. PubMed  Europe PubMed DOI  I
    32. 2007
  32. Bonilla,J.A., Bonilla,T.D., Yowell,C.A., Fujioka,H. and Dame,J.B.
    Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function
    Mol Microbiol65, 64-75. PubMed  Europe PubMed DOI  K
  33. Bonilla,J.A., Moura,P.A., Bonilla,T.D., Yowell,C.A., Fidock,D.A. and Dame,J.B.
    Effects on growth, hemoglobin metabolism and paralogous gene expression resulting from disruption of genes encoding the digestive vacuole plasmepsins of Plasmodium falciparum
    Int J Parasitol37, 317-327. PubMed  Europe PubMed DOI  K
  34. Kasam,V., Zimmermann,M., Maass,A., Schwichtenberg,H., Wolf,A., Jacq,N., Breton,V. and Hofmann-Apitius,M.
    Design of new plasmepsin inhibitors: a virtual high throughput screening approach on the EGEE grid
    J Chem Inf Model47, 1818-1828. PubMed  Europe PubMed DOI  I
    35. 2006
  35. Andrews,K.T., Fairlie,D.P., Madala,P.K., Ray,J., Wyatt,D.M., Hilton,P.M., Melville,L.A., Beattie,L., Gardiner,D.L., Reid,R.C., Stoermer,M.J., Skinner-Adams,T., Berry,C. and McCarthy,J.S.
    Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria
    Antimicrob Agents Chemother50, 639-648. PubMed  Europe PubMed DOI  I
  36. Boss,C., Corminboeuf,O., Grisostomi,C., Meyer,S., Jones,A.F., Prade,L., Binkert,C., Fischli,W., Weller,T. and Bur,D.
    Achiral, cheap, and potent inhibitors of plasmepsins I, II, and IV
    ChemMedChem1, 1341-1345. PubMed  Europe PubMed DOI  S  I
  37. Clemente,J.C., Govindasamy,L., Madabushi,A., Fisher,S.Z., Moose,R.E., Yowell,C.A., Hidaka,K., Kimura,T., Hayashi,Y., Kiso,Y., Agbandje-McKenna,M., Dame,J.B., Dunn,B.M. and McKenna,R.
    Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor
    Acta Crystallogr D Biol Crystallogr62, 246-252. PubMed  Europe PubMed DOI  S  I
  38. [YEAR:21-11-2006]Ersmark,K., Nervall,M., Gutierrez-de-Teran,H., Hamelink,E., Janka,L.K., Clemente,J.C., Dunn,B.M., Gogoll,A., Samuelsson,B., Qvist,J. and Hallberg,A.
    Macrocyclic inhibitors of the malarial aspartic proteases plasmepsin I, II, and IV
    Bioorg Med Chem14, 2197-2208. PubMed  Europe PubMed DOI  I
  39. [YEAR:30-10-2006]Gutierrez-de-Teran,H., Nervall,M., Dunn,B.M., Clemente,J.C. and Aqvist,J.
    Computational analysis of plasmepsin IV bound to an allophenylnorstatine inhibitor
    FEBS Lett580, 5910-5916. PubMed  Europe PubMed DOI  I
  40. [YEAR:5-9-2006]Gutierrez-de-Teran,H., Nervall,M., Ersmark,K., Liu,P., Janka,L.K., Dunn,B., Hallberg,A. and Aqvist,J.
    Inhibitor binding to the plasmepsin IV aspartic protease from Plasmodium falciparum
    Biochemistry45, 10529-10541. PubMed  Europe PubMed DOI  I
  41. Hof,F., Schutz,A., Fah,C., Meyer,S., Bur,D., Liu,J., Goldberg,D.E. and Diederich,F.
    Starving the malaria parasite: inhibitors active against the aspartic proteases plasmepsins I, II, and IV
    Angew Chem Int Ed Engl45, 2138-2141. PubMed  Europe PubMed DOI  I
  42. Kim,Y.M., Lee,M.H., Piao,T.G., Lee,J.W., Kim,J.H., Lee,S., Choi,K.M., Jiang,J.H., Kim,T.U. and Park,H.
    Prodomain processing of recombinant plasmepsin II and IV, the aspartic proteases of Plasmodium falciparum, is auto- and trans-catalytic
    J Biochem139, 189-195. PubMed  Europe PubMed DOI
  43. [YEAR:6-6-2006]Liu,J., Istvan,E.S., Gluzman,I.Y., Gross,J. and Goldberg,D.E.
    Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems
    Proc Natl Acad Sci U S A103, 8840-8845. PubMed  Europe PubMed DOI
    44. 2005
  44. [YEAR:15-2-2005]Beyer,B.B., Johnson,J.V., Chung,A.Y., Li,T., Madabushi,A., Agbandje-McKenna,M., McKenna,R., Dame,J.B. and Dunn,B.M.
    Active-site specificity of digestive aspartic peptidases from the four species of Plasmodium that infect humans using chromogenic combinatorial peptide libraries
    Biochemistry44, 1768-1779. PubMed  Europe PubMed DOI  I
  45. [YEAR:22-9-2005]Ersmark,K., Nervall,M., Hamelink,E., Janka,L.K., Clemente,J.C., Dunn,B.M., Blackman,M.J., Samuelsson,B., Aqvist,J. and Hallberg,A.
    Synthesis of malarial plasmepsin inhibitors and prediction of binding modes by molecular dynamics simulations
    J Med Chem48, 6090-6106. PubMed  Europe PubMed DOI  I
  46. [YEAR:28-10-2005]Liu,J., Gluzman,I.Y., Drew,M.E. and Goldberg,D.E.
    The role of Plasmodium falciparum food vacuole plasmepsins
    J Biol Chem280, 1432-1437. PubMed  Europe PubMed DOI
  47. [YEAR:1-2-2005]Madabushi,A., Chakraborty,S., Fisher,S.Z., Clemente,J.C., Yowell,C., Agbandje-McKenna,M., Dame,J.B., Dunn,B.M. and McKenna,R.
    Crystallization and preliminary X-ray analysis of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae
    Acta Crystallograph Sect F Struct Biol Cryst Commun61, 228-231. PubMed  Europe PubMed DOI  S  I
    48. 2004
  48. Berry,C. and Goldberg,D.E.
    Plasmepsins
    [ISSN:0-12-079610-4]2, 70-73.  V
  49. Li,T., Yowell,C.A., Beyer,B.B., Hung,S.H., Westling,J., Lam,M.T., Dunn,B.M. and Dame,J.B.
    Recombinant expression and enzymatic subsite characterization of plasmepsin 4 from the four Plasmodium species infecting man
    Mol Biochem Parasitol135, 101-109. PubMed  Europe PubMed DOI
  50. [YEAR:24-12-2004]Omara-Opyene,A.L., Moura,P.A., Sulsona,C.R., Bonilla,J.A., Yowell,C.A., Fujioka,H., Fidock,D.A. and Dame,J.B.
    Genetic disruption of the Plasmodium falciparum digestive vacuole plasmepsins demonstrates their functional redundancy
    J Biol Chem279, 54088-54096. PubMed  Europe PubMed DOI
    51. 2003
  51. Banerjee,R., Francis,S.E. and Goldberg,D.E.
    Food vacuole plasmepsins are processed at a conserved site by an acidic convertase activity in Plasmodium falciparum
    Mol Biochem Parasitol129, 157-165. PubMed  Europe PubMed DOI
  52. [YEAR:11-8-2003]Dame,J.B., Yowell,C.A., Omara-Opyene,L., Carlton,J.M., Cooper,R.A. and Li,T.
    Plasmepsin 4, the food vacuole aspartic proteinase found in all Plasmodium spp. infecting man
    Mol Biochem Parasitol130, 1-12. PubMed  Europe PubMed DOI
  53. [YEAR:22-7-2003]Nezami,A., Kimura,T., Hidaka,K., Kiso,A., Liu,J., Kiso,Y., Goldberg,D.E. and Freire,E.
    High-affinity inhibition of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor
    Biochemistry42, 8459-8464. PubMed  Europe PubMed DOI  I
    54. 2002
  54. [YEAR:22-1-2002]Banerjee,R., Liu,J., Beatty,W., Pelosof,L., Klemba,M. and Goldberg,D.E.
    Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine
    Proc Natl Acad Sci U S A99, 990-995. PubMed  Europe PubMed DOI
  55. Nezami,A. and Freire,E.
    The integration of genomic and structural information in the development of high affinity plasmepsin inhibitors
    Int J Parasitol32, 1669-1676. PubMed  Europe PubMed DOI  I
  56. [YEAR:27-2-2002]Wyatt,D.M. and Berry,C.
    Activity and inhibition of plasmepsin IV, a new aspartic proteinase from the malaria parasite, Plasmodium falciparum
    FEBS Lett513, 159-162. PubMed  Europe PubMed DOI
    57. 2001
  57. Coombs,G.H., Goldberg,D.E., Klemba,M., Berry,C., Kay,J. and Mottram,J.C.
    Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets
    Trends Parasitol17, 532-537. PubMed  Europe PubMed DOI
    58. 1999
  58. [YEAR:10-12-1999]Humphreys,M.J., Moon,R.P., Klinder,A., Fowler,S.D., Rupp,K., Bur,D., Ridley,R.G. and Berry,C.
    The aspartic proteinase from the rodent parasite Plasmodium berghei as a potential model for plasmepsins from the human malaria parasite, Plasmodium falciparum
    FEBS Lett463, 43-48. PubMed  Europe PubMed DOI

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