$VAR1 = undef;
Summary for peptidase A01.008: renin-2
| Names | |
|---|---|
| MEROPS Name | renin-2 |
| Other names | Ren2 g.p. (Mus musculus), submandibular renin |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan AA >> Subclan (none) >> Family A1 >> Subfamily A >> A01.008 |
| Holotype | renin-2 (Mus musculus), Uniprot accession P00796 (peptidase unit: 70-401), MERNUM MER0000915 |
| History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
| Activity | |||
|---|---|---|---|
| Catalytic type | Aspartic | ||
| Peplist | Included in the Peplist with identifier PL00006 | ||
| NC-IUBMB | Not yet included in IUBMB recommendations. | ||
| Proteolytic events | CutDB database (1 cleavage) | ||
| Knockout | Chen et al. (1999) developed transgenic mice lacking the functional Ren-2 gene, and Peng et al. (2001) studied hypertension in such mice. | ||
| Pathways | KEGG | Renin-angiotensin system | |
| Other databases | PANTHER | http://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR13683:SF77 | |
| Mouse genetics | ||||||
|---|---|---|---|---|---|---|
| Gene symbol | Position | Megabases | Ensembl | Entrez gene | MGI | |
| Ren2 | 1:E4 | ENSMUSG00000026449 | 19702 | MGI:97899 | ||
