Structure for peptidase S01.131: elastase-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
1HNE	Homo sapiens	1.84 Å	complex with MeOSuc-Ala-Ala-Pro-Ala chloromethyl ketone
Catalytic residues are shown in ball-and-stick representation: His70 in purple, Asp117 in pink and Ser202 in orange. Bound inhibitor is shown in grey in ball-and-stick representation.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Homo sapiens
complex with peptidyl-pentafluoroethyl ketone MDL 101, 146	3.00 Å	1B0F	1B0F	1B0F	1B0F	1B0F	1B0F	Cregge et al., 1998
complex with MDL 101,146	3.00 Å	1BOF	1BOF	1BOF	1BOF	1BOF	1BOF	Coleman & Sprang, 1998
complex with inhibitor GW475151	2.00 Å	1H1B	1H1B	1H1B	1H1B	1H1B	1H1B	Macdonald et al., 2002
complex with MeOSuc-Ala-Ala-Pro-Ala chloromethyl ketone	1.84 Å	1HNE	1HNE	1HNE	1HNE	1HNE	1HNE	Navia et al., 1989
complex with turkey ovomucoid third domain	1.80 Å	1PPF	1PPF	1PPF	1PPF	1PPF	1PPF	Bode et al., 1986
complex with MeOSuc-Ala-Ala-Pro-Val chloromethylacetone	2.30 Å	1PPG	1PPG	1PPG	1PPG	1PPG	1PPG	Wei et al., 1988
covalent complex structure of elastase	1.80 Å	2RG3	2RG3	2RG3	2RG3	2RG3	2RG3	Huang et al., 2008
complex with antileukoproteinase domain 2	1.70 Å	2Z7F	2Z7F	2Z7F	2Z7F	2Z7F	2Z7F	Koizumi et al., 2008
mature peptidase	1.86 Å	3Q76	3Q76	3Q76	3Q76	3Q76	3Q76	Hansen et al., 2011
mature peptidase	2.00 Å	3Q77	3Q77	3Q77	3Q77	3Q77	3Q77	Hansen et al., 2011
complex with extracellular adherence protein (Staphylococcus aureus)	1.85 Å	4NZL	4NZL	4NZL	4NZL	4NZL	4NZL
mature peptidase	1.63 Å	4WVP	4WVP	4WVP	4WVP	4WVP	4WVP	Lechtenberg et al., 2015
mature peptidase	1.81 Å	5A09	5A09	5A09	5A09	5A09	5A09
mature peptidase	1.78 Å	5A0A	5A0A	5A0A	5A0A	5A0A	5A0A
mature peptidase	2.23 Å	5A0B	5A0B	5A0B	5A0B	5A0B	5A0B
mature peptidase	2.10 Å	5A0C	5A0C	5A0C	5A0C	5A0C	5A0C
complex with a dihydropyrimidone inhibitor	2.23 Å	5A8X	5A8X	5A8X	5A8X	5A8X	5A8X
complex with a dihydropyrimidone inhibitor	1.90 Å	5A8Y	5A8Y	5A8Y	5A8Y	5A8Y	5A8Y
complex with a dihydropyrimidone inhibitor	2.00 Å	5A8Z	5A8Z	5A8Z	5A8Z	5A8Z	5A8Z
mature peptidase	1.60 Å	5ABW	5ABW	5ABW	5ABW	5ABW	5ABW
highly glycosylated form; complex with a thiazolidinedione inhibitor	2.70 Å	6F5M	6F5M	6F5M	6F5M	6F5M	6F5M