Literature for peptidase S01.131: elastase-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Adamiec-Mroczek,J., Kluz,J., Chwalek,S., Rabczynski,M., Gostomska-Pampuch,K., Lewandowski,L., Misiuk-Hojlo,M., Ponikowska,B., Chourasia,G., Dumas,I., Gamian,A., Fiodorenko-Dumas,Z., Konopska,B., Gola,A., Konikowska,K., Strub,D., Bronowicka-Szydelko,A. and Madziarska,K.
Development of an enzyme-linked immunosorbent assay (ELISA) for determining neutrophil elastase (NE) - a potential useful marker of multi-organ damage observed in COVID-19 and post-Covid-19 (PCS)
Front Mol Biosci12, 1542898-1542898. PubMed Europe PubMed DOI
Ali,A., Gaba,L., Jetley,S., Khan,I.A. and Prakash,P.
Neutrophil elastase binds at the central domain of extracellular Toll-like receptor 4: AI prediction, docking, and validation in disease model
Sci Rep15, 9282-9282. PubMed Europe PubMed DOI
Boyle,L.D., Miguelez-Crespo,A., Paul,M., Villalobos,E., Toews,J.N.C., Ivatt,L., Nagy,B., Magennis,M., Homer,N.Z.M., Andrew,R., Viau,V., Hammond,G.L., Stimson,R.H., Walker,B.R. and Nixon,M.
The NE/AAT/CBG axis regulates adipose tissue glucocorticoid exposure
Nat Commun16, 545-545. PubMed Europe PubMed DOI
Kanoza,M., Folkert,J., Ciaston,I., Aliramezani,A., Potempa,J., Koziel,J. and Kwiecinski,J.M.
Neutrophil elastase limits spread of Staphylococcus aureus during skin infection
J Infect Dis PubMed Europe PubMed DOI
Nie,P., Chen,K., Tian,C., Xu,E., Xue,Q., Song,J. and Wang,P.
Tetrahedral DNA-Enhanced Interparticle Rolling Machine for High-Efficiency Human Neutrophil Elastase SERS Ratiometric Sensing in Serum and Tissue
ACS Sens PubMed Europe PubMed DOI
Tan,Y. and Zuo,W.
Neutrophil Elastase as A Potential Target in Ischemia-Reperfusion Injury
Curr Vasc Pharmacol PubMed Europe PubMed DOI V
Tang,C., Wang,J., Ge,M., Fu,L., Huang,J., Yadav,H., Shi,J., Feng,S. and Wu,F.
DSS-induced colitis exacerbates Alzheimer's pathology via neutrophil elastase and cathepsin B activation
Int Immunopharmacol155, 114666-114666. PubMed Europe PubMed DOI

2024

Barrett,C.D., Moore,P.K., Moore,E.E., Moore,H.B., Chandler,J.G., Siddiqui,H., Maginot,E.R., Sauaia,A., Perez-Calatayud,A.A., Buesing,K., Wang,J., Davila-Chapa,C., Hershberger,D., Douglas,I., Pieracci,F.M. and Yaffe,M.B.
Plasminogen Degradation by Neutrophil Elastase in Pleural Infection, Not High Plasminogen Activator Inhibitor-1 (PAI-1), is the Cause of Intrapleural Lytic Failure
Chest PubMed Europe PubMed DOI
Chernykh,A., Abrahams,J.L., Grant,O.C., Kambanis,L., Sumer-Bayraktar,Z., Ugonotti,J., Kawahara,R., Corcilius,L., Payne,R.J., Woods,R.J. and Thaysen-Andersen,M.
Position-specific N- and O-glycosylation of the reactive center loop impacts neutrophil elastase-mediated proteolysis of corticosteroid-binding globulin
J Biol Chem300, 105519-105519. PubMed Europe PubMed DOI
Hwang,T.L., Lin,J.Y., Kuo,L.M., Kumar Dhandabani,G. and Hsieh,P.W.
Design and synthesis of sirtinol analogs as human neutrophil elastase inhibitors
Bioorg Med Chem Lett97, 129544-129544. PubMed Europe PubMed DOI I
Jia,W., Mao,Y., Luo,Q., Wu,J. and Guan,Q.
Targeting neutrophil elastase is a promising direction for future cancer treatment
Discov Oncol15, 167-167. PubMed Europe PubMed DOI V I
Ma,J., Kummarapurugu,A.B., Zheng,S., Ghio,A.J., Deshpande,L.S. and Voynow,J.A.
Neutrophil Elastase Activates Macrophage Calpain as a Mechanism for Phagocytic Failure
Am J Physiol Lung Cell Mol Physiol PubMed Europe PubMed DOI
Ma,Y., Cao,H., Chen,B., Xu,X., Zhang,Q., Chen,H., Zhang,X.B. and Song,G.
Simultaneous In Vivo Imaging of Neutrophil Elastase and Oxidative Stress in Atherosclerotic Plaques Using a Unimolecular Photoacoustic Probe
Angew Chem Int Ed Engle202411840-e202411840. PubMed Europe PubMed DOI
Ocampo-Gallego,J.S., Pedroza-Escobar,D., Caicedo-Ortega,A.R., Berumen-Murra,M.T., Novelo-Aguirre,A.L., de Sotelo-Leon,R.D. and Delgadillo-Guzman,D.
Human neutrophil elastase inhibitors: Classification, biological-synthetic sources and their relevance in related diseases
Fundam Clin Pharmacol38, 13-32. PubMed Europe PubMed DOI V
Rebstock,A.S., Wiedmann,M., Stelte-Ludwig,B., Wong,H., Johnson,A.J., Izumi,R., Hamdy,A. and Lerchen,H.G.
Neutrophil elastase as a versatile cleavage enzyme for activation of alphavbeta3 integrin-targeted small molecule drug conjugates with different payload classes in the tumor microenvironment
Front Pharmacol15, 1358393-1358393. PubMed Europe PubMed DOI
Ritter,M.U., Nasri,M., Dannenmann,B., Mir,P., Secker,B., Amend,D., Klimiankou,M., Welte,K. and Skokowa,J.
Comparison of Gene-Editing Approaches for Severe Congenital Neutropenia-Causing Mutations in the ELANE Gene
CRISPR J7, 258-271. PubMed Europe PubMed DOI
Torzyk-Jurowska,K., Ciekot,J. and Winiarski,L.
Targeted Library of Phosphonic-Type Inhibitors of Human Neutrophil Elastase
Molecules29, PubMed Europe PubMed DOI
Wakeham,D.J. and New,K.J.
Neutrophil Elastase: A key factor in the development of aortic aneurysm
Am J Hypertens PubMed Europe PubMed DOI
Xu,X., Li,J.D., Green,T.J., Wilson,L., Genschmer,K., Russell,D., Blalock,J.E. and Gaggar,A.
Neutrophil elastase-dependent cleavage of LTA4H alters its aminopeptidase activity in cystic fibrosis
Eur Respir J63, PubMed Europe PubMed DOI
Zheng,S., Bulut,G.B., Kummarapurugu,A.B., Ma,J. and Voynow,J.A.
Neutrophil Elastase Degrades Histone Deacetylases and Sirtuin 1 in Primary Human Monocyte Derived Macrophages
Int J Mol Sci25, PubMed Europe PubMed DOI

2023

Antoni,G., Lubberink,M., Sorensen,J., Lindstrom,E., Elgland,M., Eriksson,O., Hultstrom,M., Frithiof,R., Wanhainen,A., Sigfridsson,J., Skorup,P. and Lipcsey,M.
In Vivo Visualization and Quantification of Neutrophil Elastase in Lungs of COVID-19 Patients - A First-In-Human Positron Emission Tomography Study with (11)C-GW457427
J Nucl Med64, 145-148. PubMed Europe PubMed DOI
Cambier,S., Beretta,F., Portner,N., Metzemaekers,M., de Carvalho,A.C., Martens,E., Kaes,J., Aelbrecht,C., Jacobs,C., Van Mol,P., Wauters,E., Meersseman,P., Hermans,G., Marques,R.E., Vanaudenaerde,B., Vos,R., Wauters,J., Gouwy,M. and Proost,P.
Proteolytic inactivation of CXCL12 in the lungs and circulation of COVID-19 patients
Cell Mol Life Sci80, 234-234. PubMed Europe PubMed DOI I
Huang,L., Su,W., Zhu,L., Li,J., Quan,W., Yoon,J. and Lin,W.
A Biocompatible Probe for the Detection of Neutrophil Elastase Free from the Interference of Structural Changes and Its Application to Ratiometric Photoacoustic Imaging In Vivo
Angew Chem Int Ed Engl62, e202217508-e202217508. PubMed Europe PubMed DOI
Islam,M.M., Salma,U., Irahara,T., Watanabe,E. and Takeyama,N.
Quantifying Myeloperoxidase-DNA and Neutrophil Elastase-DNA Complexes from Neutrophil Extracellular Traps by Using a Modified Sandwich ELISA
J Vis Exp PubMed Europe PubMed DOI
Isono,T., Hirayama,S., Domon,H., Maekawa,T., Tamura,H., Hiyoshi,T., Sirisereephap,K., Takenaka,S., Noiri,Y. and Terao,Y.
Degradation of EGFR on lung epithelial cells by neutrophil elastase contributes to the aggravation of pneumococcal pneumonia
J Biol Chem299, 104760-104760. PubMed Europe PubMed DOI
Kummarapurugu,A.B., Hawkridge,A.M., Ma,J., Osei,S., Martin,R.K., Zheng,S. and Voynow,J.A.
Neutrophil elastase decreases SARS-CoV-2 spike protein binding to human bronchial epithelia by clipping ACE-2 ectodomain from the epithelial surface
J Biol Chem299, 104820-104820. PubMed Europe PubMed DOI
Lee,I.S., Lee,Y.R., Sim,J.H., Kim,K.M. and Kim,Y.S.
The Effects of 1-O-Acetylbritannilactone Isolated from Inula britannica Flowers on Human Neutrophil Elastase and Inflammation of RAW 264.7 Cells and Zebrafish Larvae
Molecules28, PubMed Europe PubMed DOI I
Lulla,A.R., Akli,S., Karakas,C., Caruso,J.A., Warma,L.D., Fowlkes,N.W., Rao,X., Wang,J., Hunt,K.K., Watowich,S.S. and Keyomarsi,K.
Neutrophil elastase remodels mammary tumors to facilitate lung metastasis
Mol Cancer Ther PubMed Europe PubMed DOI
Malicki,S., Ksiazek,M., Sochaj Gregorczyk,A., Kaminska,M., Golda,A., Chruscicka,B., Mizgalska,D., Potempa,J., Marti,H.P., Koziel,J., Wieczorek,M., Pieczykolan,J., Mydel,P. and Dubin,G.
Identification and characterization of aptameric inhibitors of human neutrophil elastase
J Biol Chem299, 104889-104889. PubMed Europe PubMed DOI
Mishra,N., Herdendorf,T.J., Prakash,O. and Geisbrecht,B.V.
Simultaneous inhibition of two neutrophil serine proteases by the S. aureus innate immune evasion protein EapH2
J Biol Chem299, 104878-104878. PubMed Europe PubMed DOI
Tousif,M.I., Nazir,M., Riaz,N., Saleem,M., Tauseef,S., Azam,S.M., Arfan Yawer,M. and Zengin,G.
Terpenoids as Human Neutrophil Elastase (HNE) Inhibitors: A Comprehensive Review of Natural Anti-inflammatory Isoprenoids
Chembiochem24, e202300346-e202300346. PubMed Europe PubMed DOI V
Wang,K., Liao,Y., Li,X., Wang,R., Zeng,Z., Cheng,M., Gao,L., Xu,D., Wen,F., Wang,T. and Chen,J.
Inhibition of neutrophil elastase prevents cigarette smoke exposure-induced formation of neutrophil extracellular traps and improves lung function in a mouse model of chronic obstructive pulmonary disease
Int Immunopharmacol114, 109537-109537. PubMed Europe PubMed DOI I
Zeng,W., Song,Y., Wang,R., He,R. and Wang,T.
Neutrophil elastase: From mechanisms to therapeutic potential
J Pharm Anal13, 355-366. PubMed Europe PubMed DOI V I
Zheng,S., Kummarapurugu,A.B., Bulut,G.B., Syed,A., Kang,L. and Voynow,J.A.
Neutrophil elastase activates the release of extracellular traps from COPD blood monocyte-derived macrophages
Clin Transl Sci16, 2765-2778. PubMed Europe PubMed DOI

2022

Bagga,T., Sn,L., Sivaraman,J. and Shankar,S.
Sequence preference and scaffolding requirement for the inhibition of human neutrophil elastase by ecotin peptide
Protein Sci31, 933-941. PubMed Europe PubMed DOI
Basso,J., Zhang,J., Lasala,D., Rose,S.J., Chen,K.J. and Cipolla,D.
An optimized method of extracting and quantifying active Neutrophil serine proteases from human whole blood cells
PLoS ONE17, e0272575-e0272575. PubMed Europe PubMed DOI
Cheng,Y., Li,G., Smedley,C.J., Giel,M.C., Kitamura,S., Woehl,J.L., Bianco,G., Forli,S., Homer,J.A., Cappiello,J.R., Wolan,D.W., Moses,J.E. and Sharpless,K.B.
Diversity oriented clicking delivers beta-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
Proc Natl Acad Sci U S A119, e2208540119-e2208540119. PubMed Europe PubMed DOI
D'Amato,M., Vertui,V., Pandolfi,L., Bozzini,S., Fossali,T., Colombo,R., Aliberti,A., Fumagalli,M., Iadarola,P., Dido,C., Viglio,S. and Meloni,F.
Investigating the Link between Alpha-1 Antitrypsin and Human Neutrophil Elastase in Bronchoalveolar Lavage Fluid of COVID-19 Patients
Curr Issues Mol Biol44, 2122-2138. PubMed Europe PubMed DOI
Herrmann,L., Schelletter,L., Hoffrogge,R., Niehaus,K., Rudolph,V. and Farr,M.
Human Coxsackie- and adenovirus receptor is a putative target of neutrophil elastase-mediated shedding
Mol Biol Rep49, 3213-3223. PubMed Europe PubMed DOI
Hiyoshi,T., Domon,H., Maekawa,T., Tamura,H., Isono,T., Hirayama,S., Sasagawa,K., Takizawa,F., Tabeta,K. and Terao,Y.
Neutrophil elastase aggravates periodontitis by disrupting gingival epithelial barrier via cleaving cell adhesion molecules
Sci Rep12, 8159-8159. PubMed Europe PubMed DOI
Mackin,R.T., Fontenot,K.R., Edwards,J.V., Prevost,N.T., Jordan,J.H., Easson,M.W., Condon,B.D. and French,A.D.
Detection of Human Neutrophil Elastase by Fluorescent Peptide Sensors Conjugated to TEMPO-Oxidized Nanofibrillated Cellulose
Int J Mol Sci23, PubMed Europe PubMed DOI
Seren,S., Joly,J.P., Voisin,P., Bouchaud,V., Audran,G., Marque,S.R.A. and Mellet,P.
Neutrophil Elastase-Activatable Prodrugs Based on an Alkoxyamine Platform to Deliver Alkyl Radicals Cytotoxic to Tumor Cells
J Med Chem65, 9253-9266. PubMed Europe PubMed DOI
Shinwari,K., Bolkov,M.A., Yasir Akbar,M., Guojun,L., Deryabina,S.S., Tuzankina,I.A. and Chereshnev,V.A.
In Silico Analysis Revealed Five Novel High-Risk Single-Nucleotide Polymorphisms (rs200384291, rs201163886, rs193141883, rs201139487, and rs201723157) in ELANE Gene Causing Autosomal Dominant Severe Congenital Neutropenia 1 and Cyclic Hematopoiesis
ScientificWorldJournal2022, 3356835-3356835. PubMed Europe PubMed DOI
Sullivan,G.P., Davidovich,P., Munoz-Wolf,N., Ward,R.W., Hernandez Santana,Y.E., Clancy,D.M., Gorman,A., Najda,Z., Turk,B., Walsh,P.T., Lavelle,E.C. and Martin,S.J.
Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement
Sci Immunol7, eade5728-eade5728. PubMed Europe PubMed DOI
Wang,X., Mayorga-Flores,M., Bien,K.G., Bailey,A.O. and Iwahara,J.
DNA-mediated proteolysis by neutrophil elastase enhances binding activities of the HMGB1 protein
J Biol Chem298, 102577-102577. PubMed Europe PubMed DOI
Wilkinson,D.J., Falconer,A.M.D., Wright,H.L., Lin,H., Yamamoto,K., Cheung,K., Charlton,S.H., Arques,M.D.C., Janciauskiene,S., Refaie,R., Rankin,K.S., Young,D.A. and Rowan,A.D.
Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis
FEBS J289, 121-139. PubMed Europe PubMed
Yao,L., Xu,J., Yang,X. and Shang,Y.
[Research progress of effect of neutrophil elastase and its inhibitors in sepsis]
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue34, 1209-1212. PubMed Europe PubMed DOI V
Ying,Y., Ye,J., Chen,Y., Chen,Q., Chen,Y., Lu,X., Xi,H., Gu,F., Pan,D. and Zhao,J.
A patient with severe congenital neutropenia harbors a missense ELANE mutation due to paternal germline mosaicism
Clin Chim Acta526, 14-20. PubMed Europe PubMed DOI
Zhang,X., Jiang,C., He,T., Zhao,F., Qu,J., Huang,P. and Lin,J.
Engineering Molecular Probes for In Vivo Near-Infrared Fluorescence/Photoacoustic Duplex Imaging of Human Neutrophil Elastase
Anal Chem94, 3227-3234. PubMed Europe PubMed DOI

2021

Bhattacharyya,C., Das,C., Ghosh,A., Singh,A.K., Mukherjee,S., Majumder,P.P., Basu,A. and Biswas,N.K.
SARS-CoV-2 mutation 614G creates an elastase cleavage site enhancing its spread in high AAT-deficient regions
Infect Genet Evol90, 104760-104760. PubMed Europe PubMed DOI
Chen,K.J., Chen,Y.L., Ueng,S.H., Hwang,T.L., Kuo,L.M. and Hsieh,P.W.
Neutrophil elastase inhibitor (MPH-966) improves intestinal mucosal damage and gut microbiota in a mouse model of 5-fluorouracil-induced intestinal mucositis
Biomed Pharmacother134, 111152-111152. PubMed Europe PubMed DOI I
Cheung,P., Schaffert,S., Chang,S.E., Dvorak,M., Donato,M., Macaubas,C., Foecke,M.H., Li,T.M., Zhang,L., Coan,J.P., Schulert,G.S., Grom,A.A., Henderson,L.A., Nigrovic,P.A., Elias,J.E., Gozani,O., Mellins,E.D., Khatri,P., Utz,P.J. and Kuo,A.J.
Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation
Nat Immunol22, 711-722. PubMed Europe PubMed DOI
Cui,C., Chakraborty,K., Tang,X.A., Zhou,G., Schoenfelt,K.Q., Becker,K.M., Hoffman,A., Chang,Y.F., Blank,A., Reardon,C.A., Kenny,H.A., Vaisar,T., Lengyel,E., Greene,G. and Becker,L.
Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis
Cell184, 3163-3177. PubMed Europe PubMed DOI
Domon,H. and Terao,Y.
The Role of Neutrophils and Neutrophil Elastase in Pneumococcal Pneumonia
Front Cell Infect Microbiol11, 615959-615959. PubMed Europe PubMed DOI V
Domon,H., Maekawa,T., Isono,T., Furuta,K., Kaito,C. and Terao,Y.
Proteolytic cleavage of HLA class II by human neutrophil elastase in pneumococcal pneumonia
Sci Rep11, 2432-2432. PubMed Europe PubMed DOI
Fazleen,A. and Wilkinson,T.
The emerging role of proteases in alpha1-antitrypsin deficiency and beyond
ERJ Open Res7, PubMed Europe PubMed DOI
Frey,D.L., Guerra,M., Mall,M.A. and Schultz,C.
Monitoring Neutrophil Elastase and Cathepsin G Activity in Human Sputum Samples
J Vis Exp PubMed Europe PubMed DOI
Gueant,J.L., Gueant-Rodriguez,R.M., Fromonot,J., Oussalah,A., Louis,H., Chery,C., Gette,M., Gleye,S., Callet,J., Raso,J., Blanchecotte,F., Lacolley,P., Guieu,R. and Regnault,V.
Elastase and Exacerbation of Neutrophil Innate Immunity are Involved in Multi-Visceral Manifestations of COVID-19
Allergy PubMed Europe PubMed DOI
Kang,H., Seo,J., Yang,E.J. and Choi,I.H.
Silver Nanoparticles Induce Neutrophil Extracellular Traps Via Activation of PAD and Neutrophil Elastase
Biomolecules11, PubMed Europe PubMed DOI
Kim,E., Attia,Z., Woodfint,R.M., Zeng,C., Kim,S.H., Steiner,H.E., Shukla,R.K., Liyanage,N.P.M., Ghimire,S., Li,J., Renukaradhya,G.J., Satoskar,A.R., Amer,A.O., Liu,S.L., Cormet-Boyaka,E. and Boyaka,P.N.
Inhibition of elastase enhances the adjuvanticity of alum and promotes anti-SARS-CoV-2 systemic and mucosal immunity
Proc Natl Acad Sci U S A118, PubMed Europe PubMed DOI
Kummarapurugu,A.B., Zheng,S., Ma,J., Ghosh,S., Hawkridge,A. and Voynow,J.A.
Neutrophil Elastase Triggers the Release of Macrophage Extracellular Traps: Relevance to CF
Am J Respir Cell Mol Biol PubMed Europe PubMed DOI
Leahy,D., Grant,C., Jackson,A., Duff,A., Tardiota,N., Van Haeften,J., Chen,X., Peake,J.M., Kruppa,M.D., Smith,E.T., Johnson,D.A., Lott,W.B. and Harris,J.M.
Discrimination of Methionine Sulfoxide and Sulfone by Human Neutrophil Elastase
Molecules26, PubMed Europe PubMed DOI
Leinweber,J., Mizurini,D.M., Francischetti,I.M.B., Fleischer,M., Hermann,D.M., Kleinschnitz,C. and Langhauser,F.
Elastase inhibitor agaphelin protects from acute ischemic stroke in mice by reducing thrombosis, blood-brain barrier damage, and inflammation
Brain Behav Immun PubMed Europe PubMed DOI
Mota,F.A.R., Pereira,S.A.P., Araujo,A.R.T.S. and Saraiva,M.L.M.F.
Evaluation of Ionic Liquids and Ionic Liquids Active Pharmaceutical Ingredients Inhibition in Elastase Enzyme Activity
Molecules26, PubMed Europe PubMed DOI
Mustafa,Z., Zhanapiya,A., Kalbacher,H. and Burster,T.
Neutrophil Elastase and Proteinase 3 Cleavage Sites Are Adjacent to the Polybasic Sequence within the Proteolytic Sensitive Activation Loop of the SARS-CoV-2 Spike Protein
ACS Omega6, 7181-7185. PubMed Europe PubMed DOI
Rydzynska,Z., Pawlik,B., Krzyzanowski,D., Mlynarski,W. and Madzio,J.
Neutrophil Elastase Defects in Congenital Neutropenia
Front Immunol12, 653932-653932. PubMed Europe PubMed DOI V
Valois,M.V., de Oliveira,C., Lapa,A.J., Souccar,C. and Oliva,M.L.V.
Bauhinia Protease Inhibitors Attenuate Gastric Ulcer by Blocking Neutrophil Enzymes
Planta Med87, 169-176. PubMed Europe PubMed DOI
Weiss,S.A.I., Rehm,S.R.T., Perera,N.C., Biniossek,M.L., Schilling,O. and Jenne,D.E.
Origin and Expansion of the Serine Protease Repertoire in the Myelomonocyte Lineage
Int J Mol Sci22, PubMed Europe PubMed DOI
Zhang,W., Zhou,Y., Li,D. and Ma,T.
Near-infrared fluorescent probe with large stokes shift for detecting Human Neutrophil elastase in living cells
Spectrochim Acta A Mol Biomol Spectrosc252, 119533-119533. PubMed Europe PubMed DOI

2020

Adini,A., Wu,H., Dao,D.T., Ko,V.H., Yu,L.J., Pan,A., Puder,M., Mitiku,S.Z., Potla,R., Chen,H., Rice,J.M. and Matthews,B.D.
PR1P Stabilizes VEGF and Upregulates its Signaling to Reduce Elastase Induced Murine Emphysema
Am J Respir Cell Mol Biol63, 452-463. PubMed Europe PubMed DOI
Akgun,E., Tuzuner,M.B., Sahin,B., Kilercik,M., Kulah,C., Cakiroglu,H.N., Serteser,M., Unsal,I. and Baykal,A.T.
Proteins associated with neutrophil degranulation are upregulated in nasopharyngeal swabs from SARS-CoV-2 patients
PLoS ONE15, e0240012-e0240012. PubMed Europe PubMed DOI
Bano,S., Fatima,S., Ahamad,S., Ansari,S., Gupta,D., Tabish,M., Rehman,S.U. and Jairajpuri,M.A.
Identification and characterization of a novel isoform of heparin cofactor II in human liver
IUBMB Life PubMed Europe PubMed DOI
Barth,P., Bruijnzeel,P., Wach,A., Sellier Kessler,O., Hooftman,L., Zimmermann,J., Naue,N., Huber,B., Heimbeck,I., Kappeler,D., Timmer,W. and Chevalier,E.
Single dose escalation studies with inhaled POL6014, a potent novel selective reversible inhibitor of human neutrophil elastase, in healthy volunteers and subjects with cystic fibrosis
J Cyst Fibros19, 299-304. PubMed Europe PubMed DOI I
Chalmers,J.D., Haworth,C.S., Metersky,M.L., Loebinger,M.R., Blasi,F., Sibila,O., O'Donnell,A.E., Sullivan,E.J., Mange,K.C., Fernandez,C., Zou,J. and Daley,C.L.
Phase 2 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis
N Engl J Med PubMed Europe PubMed DOI I
Chuang,H.C., Chen,Y.Y., Hsiao,T.C., Chou,H.C., Kuo,H.P., Feng,P.H., Ho,S.C., Chen,J.K., Chuang,K.J. and Lee,K.Y.
Alteration in angiotensin-converting enzyme 2 by PM1 during the development of emphysema in rats
ERJ Open Res6, PubMed Europe PubMed DOI
Curciarello,R., Sobande,T., Jones,S., Giuffrida,P., Di Sabatino,A., Docena,G.H., Macdonald,T.T. and Kok,K.
Human Neutrophil Elastase Proteolytic Activity in Ulcerative Colitis Favors the Loss of Function of Therapeutic Monoclonal Antibodies
J Inflamm Res13, 233-243. PubMed Europe PubMed DOI
Deryugina,E., Carre,A., Ardi,V., Muramatsu,T., Schmidt,J., Pham,C. and Quigley,J.P.
Neutrophil Elastase Facilitates Tumor Cell Intravasation and Early Metastatic Events
iScience23, 101799-101799. PubMed Europe PubMed DOI
Fu,Z., Akula,S., Thorpe,M. and Hellman,L.
Potent and broad but not unselective cleavage of cytokines and chemokines by human neutrophil elastase and proteinase 3
Int J Mol Sci21, PubMed Europe PubMed DOI
Giovannoni,M.P., Crocetti,L., Cantini,N., Guerrini,G., Vergelli,C., Iacovone,A., Teodori,E., Schepetkin,I.A., Quinn,M.T., Ciattini,S., Rossi,P. and Paoli,P.
New 3-unsubstituted isoxazolones as potent human neutrophil elastase inhibitors: synthesis and molecular dynamic simulation
Drug Dev Res81, 338-349. PubMed Europe PubMed DOI I
Guerra,M., Halls,V.S., Schatterny,J., Hagner,M., Mall,M.A. and Schultz,C.
Protease FRET Reporters Targeting Neutrophil Extracellular Traps
J Am Chem Soc PubMed Europe PubMed DOI
Jobichen,C., Prabhakar,M.T., Loh,S.N. and Sivaraman,J.
Structural Basis for the Inhibition Mechanism of Ecotin against Neutrophil Elastase by Targeting the Active Site and Secondary Binding Site
Biochemistry59, 2788-2795. PubMed Europe PubMed DOI
Kasperkiewicz,P., Hempel,A., Janiszewski,T., Kolt,S., Snipas,S.J., Drag,M. and Salvesen,G.S.
NETosis Occurs Independently of Neutrophil Serine Proteases
J Biol Chem PubMed Europe PubMed DOI
Liu,S.Y., Yan,A.M., Guo,W.Y., Fang,Y.Y., Dong,Q.J., Li,R.R., Ni,S.N., Sun,Y., Yang,W.C. and Yang,G.F.
Human neutrophil elastase activated fluorescent probe for pulmonary diseases based on fluorescence resonance energy transfer using CdSe/ZnS quantum dots
ACS Nano14, 4244-4254. PubMed Europe PubMed DOI A L
Luo,D. and Luesch,H.
Ahp-Cyclodepsipeptide inhibitors of elastase: lyngbyastatin 7 stability, scalable synthesis, and focused library analysis
ACS Med Chem Lett11, 419-425. PubMed Europe PubMed DOI I
Luo,L., Zhou,X., Kolosov,V.P. and Perelman,J.M.
The Cosmc-mediated effects of neutrophil elastase on T antigen expression in BEAS-2B cells
Respir Physiol Neurobiol281, 103496-103496. PubMed Europe PubMed DOI
Moore,R.M., Katri,R., Kumar,D., Mansour,J.M., Mercer,B. and Moore,J.J.
alpha-Lipoic acid blocks the GMCSF induced protease/protease inhibitor spectrum associated with fetal membrane weakening in-vitro
Placenta97, 79-88. PubMed Europe PubMed DOI
Okeke,E.B., Louttit,C., Fry,C., Najafabadi,A.H., Han,K., Nemzek,J. and Moon,J.J.
Inhibition of neutrophil elastase prevents neutrophil extracellular trap formation and rescues mice from endotoxic shock
Biomaterials238, 119836-119836. PubMed Europe PubMed DOI I
Rios,M.R., Garoffolo,G., Rinaldi,G., Megia-Fernandez,A., Ferrari,S., Robb,C.T., Rossi,A.G., Pesce,M. and Bradley,M.
A fluorogenic peptide-based smartprobe for the detection of neutrophil extracellular traps and inflammation
Chem Commun (Camb) PubMed Europe PubMed DOI
Shu,L., Zhong,L., Xiao,Y., Wu,X., Liu,Y., Jiang,X., Tang,T., Hoo,R., Zhou,Z. and Xu,A.
Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice
Clin Sci (Lond)134, 1679-1696. PubMed Europe PubMed DOI
Sowinska,A., Rensing,M., Klevenvall,L., Neog,M., Lundback,P. and Harris,H.E.
Cleavage of HMGB1 by Proteolytic Enzymes Associated with Inflammatory Conditions
Front Immunol11, 448262-448262. PubMed Europe PubMed DOI
Sugisaki,R., Miyamoto,Y., Yoshimura,K., Sasa,K., Kaneko,K., Tanaka,M., Itose,M., Inoue,S., Baba,K., Shirota,T., Chikazu,D. and Kamijo,R.
Possible involvement of elastase in enhanced osteoclast differentiation by neutrophils through degradation of osteoprotegerin
Bone132, 115216-115216. PubMed Europe PubMed DOI I
Thierry,A.R.
Anti-protease Treatments Targeting Plasmin(ogen) and Neutrophil Elastase May Be Beneficial in Fighting COVID-19
Physiol Rev100, 1597-1598. PubMed Europe PubMed DOI
Vargas-Alarcon,G., Posadas-Sanchez,R. and Ramirez-Bello,J.
Variability in genes related to SARS-CoV-2 entry into host cells (ACE2, TMPRSS2, TMPRSS11A, ELANE, and CTSL) and its potential use in association studies
Life Sci260, 118313-118313. PubMed Europe PubMed DOI
Vidhya,R. and Anuradha,C.V.
Anti-inflammatory effects of troxerutin are mediated through elastase inhibition
Immunopharmacol Immunotoxicol1-13. PubMed Europe PubMed DOI I
Voynow,J.A., Zheng,S. and Kummarapurugu,A.B.
Glycosaminoglycans as Multifunctional Anti-Elastase and Anti-Inflammatory Drugs in Cystic Fibrosis Lung Disease
Front Pharmacol11, 1011-1011. PubMed Europe PubMed DOI

2019

Anderson,B.M., Poole,D.P., Aurelio,L., Ng,G.Z., Fleischmann,M., Kasperkiewicz,P., Morissette,C., Drag,M., van Driel,I.R., Schmidt,B.L., Vanner,S.J., Bunnett,N.W. and Edgington-Mitchell,L.E.
Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease
Sci Rep9, 13295-13295. PubMed Europe PubMed DOI A I
Barbosa da Cruz,D., Helms,J., Aquino,L.R., Stiel,L., Cougourdan,L., Broussard,C., Chafey,P., Ries-Kautt,M., Meziani,F., Toti,F., Gaussem,P. and Angles-Cano,E.
DNA-bound elastase of neutrophil extracellular traps degrades plasminogen, reduces plasmin formation, and decreases fibrinolysis: proof of concept in septic shock plasma
FASEB J33, 14270-14280. PubMed Europe PubMed DOI
Chen,J., Liang,B., Bian,D., Luo,Y., Yang,J., Li,Z., Zhuang,Z., Zang,S. and Shi,J.
Knockout of neutrophil elastase protects against western diet induced nonalcoholic steatohepatitis in mice by regulating hepatic ceramides metabolism
Biochem Biophys Res Commun518, 691-697. PubMed Europe PubMed DOI
Crocetti,L., Quinn,M.T., Schepetkin,I.A. and Giovannoni,M.P.
A patenting perspective on human neutrophil elastase (HNE) inhibitors (2014-2018) and their therapeutic applications
Expert Opin Ther Pat29, 555-578. PubMed Europe PubMed DOI I
Dias,B.T., Dias-Teixeira,K.L., Godinho,J.P., Faria,M.S., Calegari-Silva,T., Mukhtar,M.M., Lopes,U., Mottram,J.C. and Lima,A.P.C.A.
Neutrophil elastase promotes Leishmania donovani infection via interferon-beta
FASEB J33, 10794-10807. PubMed Europe PubMed DOI K
Ferreira,A.V., Antunes,E., Ribeiro,A., Matama,T., Azoia,N.G., Cunha,J. and Cavaco-Paulo,A.
Design of a chromogenic substrate for elastase based on split GFP system-Proof of concept for colour switch sensors
Biotechnol Rep (Amst)22, e00324-e00324. PubMed Europe PubMed DOI A L
Giovannoni,M.P., Cantini,N., Crocetti,L., Guerrini,G., Iacovone,A., Schepetkin,I.A., Vergelli,C., Khlebnikov,A.I. and Quinn,M.T.
Further modifications of 1H-pyrrolo[2,3-b]pyridine derivatives as inhibitors of human neutrophil elastase
Drug Dev Res80, 617-628. PubMed Europe PubMed DOI I
Krasavin,M.Y., Gureev,M.A., Garabadzhiu,A.V., Pashkin,A.Y., Zhukov,A.S., Khairutdinov,V.R., Samtsov,A.V. and Shvets,V.I.
Inhibition of neutrophil elastase and cathepsin G as a new approach to the treatment of psoriasis: from fundamental biology to development of new target-specific drugs
Dokl Biochem Biophys487, 272-276. PubMed Europe PubMed DOI I
Li,Z.P., Kim,J.Y., Ban,Y.J. and Park,K.H.
Human neutrophil elastase (HNE) inhibitory polyprenylated acylphloroglucinols from the flowers of Hypericum ascyron
Bioorg Chem90, 103075-103075. PubMed Europe PubMed DOI I
Liu,S.Y., Xiong,H., Li,R.R., Yang,W.C. and Yang,G.F.
Activity-based near-infrared fluorogenic probe for enabling in vitro and in vivo profiling of neutrophil elastase
Anal Chem91, 3877-3884. PubMed Europe PubMed DOI A
Nganje,C.N., Haynes,S.A., Qabar,C.M., Lent,R.C., Bou Ghanem,E.N. and Shainheit,M.G.
PepN is a non-essential, cell wall-localized protein that contributes to neutrophil elastase-mediated killing of Streptococcus pneumoniae
PLoS ONE14, e0211632-e0211632. PubMed Europe PubMed DOI
Samy,M.N., Le Goff,G., Lopes,P., Georgousaki,K., Gumeni,S., Almeida,C., Gonzalez,I., Genilloud,O., Trougakos,I., Fokialakis,N. and Ouazzani,J.
Osmanicin, a polyketide alkaloid isolated from Streptomyces osmaniensis CA-244599 inhibits elastase in human fibroblasts
Molecules24, PubMed Europe PubMed DOI I
Voisin,M.B., Leoni,G., Woodfin,A., Loumagne,L., Patel,N.S., Di Paola,R., Cuzzocrea,S., Thiemermann,C., Perretti,M. and Nourshargh,S.
Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post-ischemia/reperfusion injury
J Pathol248, 88-102. PubMed Europe PubMed DOI
Yao,W., Han,X., Guan,Y., Guan,J., Wu,S., Chen,C., Li,H. and Hei,Z.
Neutrophil elastase inhibitors suppress oxidative stress in lung during liver transplantation
Oxid Med Cell Longev2019, 7323986-7323986. PubMed Europe PubMed DOI I
Zheng,Q., Woehl,J.L., Kitamura,S., Santos-Martins,D., Smedley,C.J., Li,G., Forli,S., Moses,J.E., Wolan,D.W. and Sharpless,K.B.
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
Proc Natl Acad Sci U S A116, 18808-18814. PubMed Europe PubMed DOI I

2018

Antonio,J.P.M., Goncalves,L.M., Guedes,R.C., Moreira,R. and Gois,P.M.P.
Diazaborines as new inhibitors of human neutrophil elastase
ACS Omega3, 7418-7423. PubMed Europe PubMed DOI I
Craven,T.H., Avlonitis,N., McDonald,N., Walton,T., Scholefield,E., Akram,A.R., Walsh,T.S., Haslett,C., Bradley,M. and Dhaliwal,K.
Super-silent FRET sensor enables live cell imaging and flow cytometric stratification of intracellular serine protease activity in neutrophils
Sci Rep8, 13490-13490. PubMed Europe PubMed DOI A
Crocetti,L., Giovannoni,M.P., Schepetkin,I.A., Quinn,M.T., Khlebnikov,A.I., Cantini,N., Guerrini,G., Iacovone,A., Teodori,E. and Vergelli,C.
1H-pyrrolo[2,3-b]pyridine: a new scaffold for human neutrophil elastase (HNE) inhibitors
Bioorg Med Chem26, 5583-5595. PubMed Europe PubMed DOI I
Dharwal,V. and Naura,A.S.
PARP-1 inhibition ameliorates elastase induced lung inflammation and emphysema in mice
Biochem Pharmacol150, 24-34. PubMed Europe PubMed DOI
Domon,H., Nagai,K., Maekawa,T., Oda,M., Yonezawa,D., Takeda,W., Hiyoshi,T., Tamura,H., Yamaguchi,M., Kawabata,S. and Terao,Y.
Neutrophil elastase subverts the immune response by cleaving toll-like receptors and cytokines in pneumococcal pneumonia
Front Immunol9, 732-732. PubMed Europe PubMed DOI
Fu,Z., Thorpe,M., Akula,S., Chahal,G. and Hellman,L.T.
Extended cleavage specificity of human neutrophil elastase, human proteinase 3, and their distant ortholog clawed frog PR3-three elastases with similar primary but different extended specificities and stability
Front Immunol9, 2387-2387. PubMed Europe PubMed DOI P
Giovannoni,M.P., Schepetkin,I.A., Quinn,M.T., Cantini,N., Crocetti,L., Guerrini,G., Iacovone,A., Paoli,P., Rossi,P., Bartolucci,G., Menicatti,M. and Vergelli,C.
Synthesis, biological evaluation, and molecular modelling studies of potent human neutrophil elastase (HNE) inhibitors
J Enzyme Inhib Med Chem33, 1108-1124. PubMed Europe PubMed DOI I
Hochscherf,J., Pietsch,M., Tieu,W., Kuan,K., Abell,A.D., Gutschow,M. and Niefind,K.
Crystal structure of highly glycosylated human leukocyte elastase in complex with an S2' site binding inhibitor
Acta Crystallogr F Struct Biol Commun74, 480-489. PubMed Europe PubMed DOI S I
Jugniot,N., Duttagupta,I., Rivot,A., Massot,P., Cardiet,C., Pizzoccaro,A., Jean,M., Vanthuyne,N., Franconi,J.M., Voisin,P., Devouassoux,G., Parzy,E., Thiaudiere,E., Marque,S.R.A., Bentaher,A., Audran,G. and Mellet,P.
An elastase activity reporter for electronic paramagnetic resonance (EPR) and Overhauser-enhanced magnetic resonance imaging (OMRI) as a line-shifting nitroxide
Free Radic Biol Med126, 101-112. PubMed Europe PubMed DOI L
Khatib-Massalha,E., Michelis,R., Trabelcy,B., Gerchman,Y., Kristal,B., Ariel,A. and Sela,S.
Free circulating active elastase contributes to chronic inflammation in patients on hemodialysis
Am J Physiol Renal Physiol314, F203-F203. PubMed Europe PubMed DOI
Kim,J.Y., Wang,Y., Uddin,Z., Song,Y.H., Li,Z.P., Jenis,J. and Park,K.H.
Competitive neutrophil elastase inhibitory isoflavones from the roots of Flemingia philippinensis
Bioorg Chem78, 249-257. PubMed Europe PubMed DOI I
Kim,K.C., Kim,D.J., Lee,M.S., Seo,J.Y., Yoo,I.D. and Lee,I.S.
Inhibition of human neutrophil elastase by sesquiterpene lactone dimers from the flowers of Inula britannica
J Microbiol Biotechnol28, 1806-1813. PubMed Europe PubMed DOI I
Kumar,H., Choi,H., Jo,M.J., Joshi,H.P., Muttigi,M., Bonanomi,D., Kim,S.B., Ban,E., Kim,A., Lee,S.H., Kim,K.T., Sohn,S., Zeng,X. and Han,I.
Neutrophil elastase inhibition effectively rescued angiopoietin-1 decrease and inhibits glial scar after spinal cord injury
Acta Neuropathol Commun6, 73-73. PubMed Europe PubMed DOI I
Lerman,I. and Hammes,S.R.
Neutrophil elastase in the tumor microenvironment
Steroids133, 96-101. PubMed Europe PubMed DOI
Marto,J., Ruivo,E., Lucas,S.D., Goncalves,L.M., Simoes,S., Gouveia,L.F., Felix,R., Moreira,R., Ribeiro,H.M. and Almeida,A.J.
Starch nanocapsules containing a novel neutrophil elastase inhibitor with improved pharmaceutical performance
Eur J Pharm Biopharm127, 1-11. PubMed Europe PubMed DOI I
Schulz-Fincke,A.C., Tikhomirov,A.S., Braune,A., Girbl,T., Gilberg,E., Bajorath,J., Blaut,M., Nourshargh,S. and Gutschow,M.
Design of an activity-based probe for human neutrophil elastase: implementation of the Lossen rearrangement to induce Forster resonance energy transfers
Biochemistry57, 742-752. PubMed Europe PubMed DOI L I
Schulz-Fincke,A.C., Blaut,M., Braune,A. and Gutschow,M.
A BODIPY-tagged phosphono peptide as activity-based probe for human leukocyte elastase
ACS Med Chem Lett9, 345-350. PubMed Europe PubMed DOI L I
Seif,K., Alidzanovic,L., Tischler,B., Ibrahim,N., Zagrapan,B., Rauscher,S., Salzmann,M., Hell,L., Mauracher,L.M., Budde,U., Schmid,J.A., Jilma,B., Pabinger,I., Assinger,A., Starlinger,P. and Brostjan,C.
Neutrophil-mediated proteolysis of thrombospondin-1 promotes platelet adhesion and string formation
Thromb Haemost118, 2074-2085. PubMed Europe PubMed DOI
Souwer,Y., Groot Kormelink,T., Taanman-Kueter,E.W., Muller,F.J., van Capel,T.M.M., Varga,D.V., Bar-Ephraim,Y.E., Teunissen,M.B.M., van Ham,S.M., Kuijpers,T.W., Wouters,D., Meyaard,L. and de Jong,E.C.
Human Th17 cell development requires processing of dendritic cell-derived CXCL8 by neutrophil elastase
J Allergy Clin Immunol141, 2286-2289. PubMed Europe PubMed DOI I
Sullivan,G.P., Davidovich,P.B., Sura-Trueba,S., Belotcerkovskaya,E., Henry,C.M., Clancy,D.M., Zinoveva,A., Mametnabiev,T., Garabadzhiu,A.V. and Martin,S.J.
Identification of small-molecule elastase inhibitors as antagonists of IL-36 cytokine activation
FEBS Open Bio8, 751-763. PubMed Europe PubMed DOI I
Towstyka,N.Y., Shiromizu,C.M., Keitelman,I., Sabbione,F., Salamone,G.V., Geffner,J.R., Trevani,A.S. and Jancic,C.C.
Modulation of gammadelta T-cell activation by neutrophil elastase
Immunology153, 225-237. PubMed Europe PubMed DOI
Wen,G., An,W., Chen,J., Maguire,E.M., Chen,Q., Yang,F., Pearce,S.W.A., Kyriakides,M., Zhang,L., Ye,S., Nourshargh,S. and Xiao,Q.
Genetic and pharmacologic inhibition of the neutrophil elastase inhibits experimental atherosclerosis
J Am Heart Assoc7, PubMed Europe PubMed DOI K T I

2017

Bai,Y., Wang,H. and Zhao,Q.
Detection of human neutrophil elastase by aptamer affinity capillary electrophoresis coupled with laser-induced fluorescence using specified site fluorescently labeled aptamer
Anal Bioanal Chem409, 6843-6849. PubMed Europe PubMed DOI A I
Barrett,C.D., Moore,H.B., Banerjee,A., Silliman,C.C., Moore,E.E. and Yaffe,M.B.
Human neutrophil elastase mediates fibrinolysis shutdown through competitive degradation of plasminogen and generation of angiostatin
J Trauma Acute Care Surg83, 1053-1061. PubMed Europe PubMed DOI
Crocetti,L., Bartolucci,G., Cilibrizzi,A., Giovannoni,M.P., Guerrini,G., Iacovone,A., Menicatti,M., Schepetkin,I.A., Khlebnikov,A.I., Quinn,M.T. and Vergelli,C.
Synthesis and analytical characterization of new thiazol-2-(3H)-ones as human neutrophil elastase (HNE) inhibitors
Chem Cent J11, 127-127. PubMed Europe PubMed DOI I
Glinzer,A., Ma,X., Prakash,J., Kimm,M.A., Lohofer,F., Kosanke,K., Pelisek,J., Thon,M.P., Vorlova,S., Heinze,K.G., Eckstein,H.H., Gee,M.W., Ntziachristos,V., Zernecke,A. and Wildgruber,M.
Targeting elastase for molecular imaging of early atherosclerotic lesions
Arterioscler Thromb Vasc Biol37, 525-533. PubMed Europe PubMed DOI L
Grechowa,I., Horke,S., Wallrath,A., Vahl,C.F. and Dorweiler,B.
Human neutrophil elastase induces endothelial cell apoptosis by activating the PERK-CHOP branch of the unfolded protein response
FASEB J31, 3868-3881. PubMed Europe PubMed DOI
Keir,H.R., Fong,C.J., Dicker,A.J. and Chalmers,J.D.
Profile of the ProAxsis active neutrophil elastase immunoassay for precision medicine in chronic respiratory disease
Expert Rev Mol Diagn17, 875-884. PubMed Europe PubMed DOI A
Kistowski,M., Debski,J., Karczmarski,J., Paziewska,A., Oledzki,J., Mikula,M., Ostrowski,J. and Dadlez,M.
A strong neutrophil elastase proteolytic fingerprint marks the carcinoma tumor proteome
Mol Cell Proteomics16, 213-227. PubMed Europe PubMed DOI
Lerman,I., Garcia-Hernandez,M.L., Rangel-Moreno,J., Chiriboga,L., Pan,C., Nastiuk,K.L., Krolewski,J.J., Sen,A. and Hammes,S.R.
Infiltrating myeloid cells exert pro-tumorigenic actions via neutrophil elastase
Mol Cancer Res15, 1138-1152. PubMed Europe PubMed DOI I
Maiorani,O., Pivetta,E., Capuano,A., Modica,T.M., Wassermann,B., Bucciotti,F., Colombatti,A., Doliana,R. and Spessotto,P.
Neutrophil elastase cleavage of the gC1q domain impairs the EMILIN1-alpha4beta1 integrin interaction, cell adhesion and anti-proliferative activity
Sci Rep7, 39974-39974. PubMed Europe PubMed DOI
Muley,M.M., Krustev,E., Reid,A.R. and McDougall,J.J.
Prophylactic inhibition of neutrophil elastase prevents the development of chronic neuropathic pain in osteoarthritic mice
J Neuroinflammation14, 168-168. PubMed Europe PubMed DOI I
Poreba,M., Szalek,A., Rut,W., Kasperkiewicz,P., Rutkowska-Wlodarczyk,I., Snipas,S.J., Itoh,Y., Turk,D., Turk,B., Overall,C.M., Kaczmarek,L., Salvesen,G.S. and Drag,M.
Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families
Sci Rep7, 43135-43135. PubMed Europe PubMed DOI A
Qiu,Y., Zhang,Y., Hu,N. and Dong,F.
A truncated granulocyte colony-stimulating factor receptor (G-CSFR) inhibits apoptosis induced by neutrophil elastase G185R mutant: implication for understanding CSF3R gene mutations in severe congenital neutropenia
J Biol Chem292, 3496-3505. PubMed Europe PubMed DOI M
Vergelli,C., Schepetkin,I.A., Crocetti,L., Iacovone,A., Giovannoni,M.P., Guerrini,G., Khlebnikov,A.I., Ciattini,S., Ciciani,G. and Quinn,M.T.
Isoxazol-5(2H)-one: a new scaffold for potent human neutrophil elastase (HNE) inhibitors
J Enzyme Inhib Med Chem32, 821-831. PubMed Europe PubMed DOI I

2016

Abdolzade-Bavil,A., VonKerczek,A., Cooksey,B.A., Kaufman,T., Krasney,P.A., Pukac,L., Gorlach,M., Lammerich,A., Scheckermann,C., Allgaier,H., Shen,W.D. and Liu,P.M.
Differential sensitivity of lipegfilgrastim and pegfilgrastim to neutrophil elastase correlates with differences in clinical pharmacokinetic profile
J Clin Pharmacol56, 186-194. PubMed Europe PubMed DOI
Chawla,A., Alatrash,G., Philips,A.V., Qiao,N., Sukhumalchandra,P., Kerros,C., Diaconu,I., Gall,V., Neal,S., Peters,H.L., Clise-Dwyer,K., Molldrem,J.J. and Mittendorf,E.A.
Neutrophil elastase enhances antigen presentation by upregulating human leukocyte antigen class I expression on tumor cells
Cancer Immunol Immunother65, 741-751. PubMed Europe PubMed DOI
Craciun,I., Fenner,A.M. and Kerns,R.J.
N-Arylacyl O-sulfonated aminoglycosides as novel inhibitors of human neutrophil elastase, cathepsin G and proteinase 3
Glycobiology26, 701-709. PubMed Europe PubMed DOI I
Crocetti,L., Schepetkin,I.A., Ciciani,G., Giovannoni,M.P., Guerrini,G., Iacovone,A., Khlebnikov,A.I., Kirpotina,L.N., Quinn,M.T. and Vergelli,C.
Synthesis and pharmacological evaluation of indole derivatives as deaza analogues of potent human neutrophil elastase inhibitors
Drug Dev Res77, 285-299. PubMed Europe PubMed DOI I
Di Cesare Mannelli,L., Micheli,L., Cinci,L., Maresca,M., Vergelli,C., Pacini,A., Quinn,M.T., Paola Giovannoni,M. and Ghelardini,C.
Effects of the neutrophil elastase inhibitor EL-17 in rat adjuvant-induced arthritis
Rheumatology (Oxford)55, 1285-1294. PubMed Europe PubMed DOI I
Edwards,J.V., Fontenot,K.R., Haldane,D., Prevost,N.T., Condon,B.D. and Grimm,C.
Human neutrophil elastase peptide sensors conjugated to cellulosic and nanocellulosic materials: part I, synthesis and characterization of fluorescent analogs
Cellulose23, 1283-1295. DOI A
Fontenot,K.R., Edwards,J.V., Haldane,D., Graves,E., Citron,M.S., Prevost,N.T., French,A.D. and Condon,B.D.
Human neutrophil elastase detection with fluorescent peptide sensors conjugated to cellulosic and nanocellulosic materials: part II, structure/function analysis
Cellulose23, 1297-1309. DOI A
Giovannoni,M.P., Schepetkin,I.A., Crocetti,L., Ciciani,G., Cilibrizzi,A., Guerrini,G., Khlebnikov,A.I., Quinn,M.T. and Vergelli,C.
Cinnoline derivatives as human neutrophil elastase inhibitors
J Enzyme Inhib Med Chem31, 628-639. PubMed Europe PubMed DOI I
Gogol,M., Ostrowska,D., Klaga,K., Bochenska,O., Wolak,N., Aoki,W., Ueda,M., Kozik,A. and Rapala-Kozik,M.
Inactivation of alpha1-proteinase inhibitor by Candida albicans aspartic proteases favors the epithelial and endothelial cell colonization in the presence of neutrophil extracellular traps
Acta Biochim Pol63, 167-175. PubMed Europe PubMed DOI
Lokau,J., Nitz,R., Agthe,M., Monhasery,N., Aparicio-Siegmund,S., Schumacher,N., Wolf,J., Moller-Hackbarth,K., Waetzig,G.H., Grotzinger,J., Muller-Newen,G., Rose-John,S., Scheller,J. and Garbers,C.
Proteolytic cleavage governs interleukin-11 trans-signaling
Cell Rep14, 1761-1773. PubMed Europe PubMed DOI P
Mkaouar,H., Akermi,N., Mariaule,V., Boudebbouze,S., Gaci,N., Szukala,F., Pons,N., Marquez,J., Gargouri,A., Maguin,E. and Rhimi,M.
Siropins, novel serine protease inhibitors from gut microbiota acting on human proteases involved in inflammatory bowel diseases
Microb Cell Fact15, 201-201. PubMed Europe PubMed DOI
Muley,M.M., Reid,A.R., Botz,B., Bolcskei,K., Helyes,Z. and McDougall,J.J.
Neutrophil elastase induces inflammation and pain in mouse knee joints via activation of proteinase-activated receptor-2
Br J Pharmacol173, 766-777. PubMed Europe PubMed DOI
Ruivo,E.F., Goncalves,L.M., Carvalho,L.A., Guedes,R.C., Hofbauer,S., Brito,J.A., Archer,M., Moreira,R. and Lucas,S.D.
Clickable 4-oxo-beta-lactam-based selective probing for human neutrophil elastase related proteomes
ChemMedChem11, 2037-2042. PubMed Europe PubMed DOI L I
Schulenburg,C., Faccio,G., Jankowska,D., Maniura-Weber,K. and Richter,M.
A FRET-based biosensor for the detection of neutrophil elastase
Analyst141, 1645-1648. PubMed Europe PubMed DOI A
Tan,X.F., Kim,D.W., Song,Y.H., Kim,J.Y., Yuk,H.J., Wang,Y., Curtis-Long,M.J. and Park,K.H.
Human neutrophil elastase inhibitory potential of flavonoids from Campylotropis hirtella and their kinetics
J Enzyme Inhib Med Chem31, 16-22. PubMed Europe PubMed DOI I
Thiede,S., Wosniok,P.R., Herkommer,D., Schulz-Fincke,A.C., Gutschow,M. and Menche,D.
Total synthesis of leupyrrin B1: a potent inhibitor of human leukocyte elastase
Org Lett18, 3964-3967. PubMed Europe PubMed DOI I
von Nussbaum,F., Li,V.M., Meibom,D., Anlauf,S., Bechem,M., Delbeck,M., Gerisch,M., Harrenga,A., Karthaus,D., Lang,D., Lustig,K., Mittendorf,J., Schafer,M., Schafer,S. and Schamberger,J.
Potent and selective human neutrophil elastase inhibitors with novel equatorial ring topology: in vivo efficacy of the polar pyrimidopyridazine BAY-8040 in a pulmonary arterial hypertension rat model
ChemMedChem11, 199-206. PubMed Europe PubMed DOI I
Yang,R., Zhong,L., Yang,X.Q., Jiang,K.L., Li,L., Song,H. and Liu,B.Z.
Neutrophil elastase enhances the proliferation and decreases apoptosis of leukemia cells via activation of PI3K/Akt signaling
Mol Med Rep13, 4175-4182. PubMed Europe PubMed DOI

2015

Areias,L.R.P., Ruivo,E.F.P., Goncalves,L.M., Duarte,M.T., Andre,V., Moreira,R., Lucas,S.D. and Guedes,R.C.
A unified approach toward the rational design of selective low nanomolar human neutrophil elastase inhibitors
RSC Adv5, 51717-51721. DOI I
Caruso,J.A., Akli,S., Pageon,L., Hunt,K.K. and Keyomarsi,K.
The serine protease inhibitor elafin maintains normal growth control by opposing the mitogenic effects of neutrophil elastase
Oncogene34, 3556-3567. PubMed Europe PubMed DOI
Dau,T., Sarker,R.S., Yildirim,A.O., Eickelberg,O. and Jenne,D.E.
Autoprocessing of neutrophil elastase near its active site reduces the efficiency of natural and synthetic elastase inhibitors
Nat Commun6, 6722-6722. PubMed Europe PubMed DOI
Edwards,J.V., Prevost,N.T., French,A.D., Concha,M. and Condon,B.D.
Kinetic and structural analysis of fluorescent peptides on cotton cellulose nanocrystals as elastase sensors
Carbohydr Polym116, 278-285. PubMed Europe PubMed DOI A
Fayad,S., Nehme,R., Lafite,P. and Morin,P.
Assaying human neutrophil elastase activity by capillary zone electrophoresis combined with laser-induced fluorescence
J Chromatogr A1419, 116-124. PubMed Europe PubMed DOI A
Gregory,A.D., Kliment,C.R., Metz,H.E., Kim,K.H., Kargl,J., Agostini,B.A., Crum,L.T., Oczypok,E.A., Oury,T.A. and Houghton,A.M.
Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis
J Leukoc Biol98, 143-152. PubMed Europe PubMed DOI K I
Guillaume,D., Huynh,T.N., Clement Denhez, Nguyen,K.P. and Belaaouaj,A.
Triterpenoids as neutrophil elastase inhibitors
Nat Prod Commun10, 167-170. PubMed Europe PubMed I
Han,M., Wang,W., Wang,X., Liu,X., Cao,H., Tao,Y. and Yu,X.
Enhanced expression of recombinant elastase in Pichia pastoris through the substitution of Thr for Ser in Asn-Xaa-Ser sequons
Appl Biochem Biotechnol175, 428-435. PubMed Europe PubMed DOI E
Hernandez Gonzalez,J.E., Garcia-Fernandez,R. and Valiente,P.A.
Polar desolvation and position 226 of pancreatic and neutrophil elastases are crucial to their affinity for the Kunitz-type inhibitors ShPI-1 and ShPI-1/K13L
PLoS ONE10, e0137787-e0137787. PubMed Europe PubMed DOI
Huang,G., Feng,L., Liu,B., He,Y., Li,Y. and Chen,Y.
Synthesis and biological evaluation of nigranoic acid esters as novel human neutrophil elastase inhibitors
Nat Prod Res29, 1650-1656. PubMed Europe PubMed DOI I
Hwang,T.L., Wang,W.H., Wang,T.Y., Yu,H.P. and Hsieh,P.W.
Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase 3
Bioorg Med Chem23, 1123-1134. PubMed Europe PubMed DOI I
Jiang,K., Ma,P., Yang,X., Zhong,L., Wang,H., Zhu,X. and Liu,B.
[Over-expression of neutrophil elastase promotes proliferation and inhibits apoptosis in K562 cells]
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi31, 159-162. PubMed Europe PubMed
Jiang,K.L., Ma,P.P., Yang,X.Q., Zhong,L., Wang,H., Zhu,X.Y. and Liu,B.Z.
Neutrophil elastase and its therapeutic effect on leukemia cells
Mol Med Rep12, 4165-4172. PubMed Europe PubMed DOI I
Kurtagic,E., Rich,C.B., Buczek-Thomas,J.A. and Nugent,M.A.
Neutrophil elastase-generated fragment of vascular endothelial growth factor-A stimulates macrophage and endothelial progenitor cell migration
PLoS ONE10, e0145115-e0145115. PubMed Europe PubMed DOI
Lechtenberg,B.C., Kasperkiewicz,P., Robinson,H., Drag,M. and Riedl,S.J.
The elastase-PK101 structure: mechanism of an ultrasensitive activity-based probe revealed
ACS Chem Biol10, 945-951. PubMed Europe PubMed DOI S I
Lee,I.S., Kim,K.C., Yoo,I.D. and Ha,B.J.
Inhibition of human neutrophil elastase by labdane diterpenes from the fruiting bodies of Ramaria formosa
Biosci Biotechnol Biochem79, 1921-1925. PubMed Europe PubMed DOI I
Liu,T., Fu,G., Luo,X., Liu,Y., Wang,Y., Wang,R.E., Schultz,P.G. and Wang,F.
Rational design of antibody protease inhibitors
J Am Chem Soc137, 4042-4045. PubMed Europe PubMed DOI
Semple,B.D., Trivedi,A., Gimlin,K. and Noble-Haeusslein,L.J.
Neutrophil elastase mediates acute pathogenesis and is a determinant of long-term behavioral recovery after traumatic injury to the immature brain
Neurobiol Dis74C, 263-280. PubMed Europe PubMed DOI
Sun,G., Ota,C., Kitaoka,S., Chiba,Y., Takayanagi,M., Kitamura,T., Yamamoto,K., Fujie,H., Mikami,H., Uematsu,M., Hino-Fukuyo,N., Munakata,M., Kure,S. and Haginoya,K.
Elevated serum levels of neutrophil elastase in patients with influenza virus-associated encephalopathy
J Neurol Sci349, 190-195. PubMed Europe PubMed DOI
Tsai,Y.F. and Hwang,T.L.
Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014)
Expert Opin Ther Pat25, 1145-1158. PubMed Europe PubMed DOI V I
Tsai,Y.F., Yu,H.P., Chang,W.Y., Liu,F.C., Huang,Z.C. and Hwang,T.L.
Sirtinol inhibits neutrophil elastase activity and attenuates lipopolysaccharide-mediated acute lung injury in mice
Sci Rep5, 8347-8347. PubMed Europe PubMed DOI I
Vicuna,L., Strochlic,D.E., Latremoliere,A., Bali,K.K., Simonetti,M., Husainie,D., Prokosch,S., Riva,P., Griffin,R.S., Njoo,C., Gehrig,S., Mall,M.A., Arnold,B., Devor,M., Woolf,C.J., Liberles,S.D., Costigan,M. and Kuner,R.
The serine protease inhibitor serpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase
Nat Med21, 518-523. PubMed Europe PubMed DOI I
von Nussbaum,F., Li,V.M., Allerheiligen,S., Anlauf,S., Barfacker,L., Bechem,M., Delbeck,M., Fitzgerald,M.F., Gerisch,M., Gielen-Haertwig,H., Haning,H., Karthaus,D., Lang,D., Lustig,K., Meibom,D., Mittendorf,J., Rosentreter,U., Schafer,M., Schafer,S., Schamberger,J., Telan,L.A. and Tersteegen,A.
Freezing the bioactive conformation to boost potency: the identification of BAY 85-8501, a selective and potent inhibitor of human neutrophil elastase for pulmonary diseases
ChemMedChem10, 1163-1173. PubMed Europe PubMed DOI I
von Nussbaum,F. and Li,V.M.
Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: into clinical testing with pre-adaptive pharmacophores
Bioorg Med Chem Lett25, 4370-4381. PubMed Europe PubMed DOI V I
Weyer,A.D. and Stucky,C.L.
Repurposing a leukocyte elastase inhibitor for neuropathic pain
Nat Med21, 429-430. PubMed Europe PubMed DOI I
Zhao,P., Lieu,T., Barlow,N., Sostegni,S., Haerteis,S., Korbmacher,C., Liedtke,W., Jimenez-Vargas,N.N., Vanner,S.J. and Bunnett,N.W.
Neutrophil elastase activates protease-activated receptor-2 (PAR2) and transient receptor potential vanilloid 4 (TRPV4) to cause inflammation and pain
J Biol Chem290, 13875-13887. PubMed Europe PubMed DOI

2014

Abdel-Magid,A.F.
Neutrophil elastase inhibitors as potential anti-inflammatory therapies
ACS Med Chem Lett5, 1182-1183. PubMed Europe PubMed DOI I
Dhaenens,M., Glibert,P., Lambrecht,S., Vossaert,L., Van Steendam,K., Elewaut,D. and Deforce,D.
Neutrophil elastase in the capacity of the "H2A-specific protease"
Int J Biochem Cell Biol51, 39-44. PubMed Europe PubMed DOI
Gehrig,S., Duerr,J., Weitnauer,M., Wagner,C.J., Graeber,S.Y., Schatterny,J., Hirtz,S., Belaaouaj,A., Dalpke,A.H., Schultz,C. and Mall,M.A.
Lack of neutrophil elastase reduces inflammation, mucus hypersecretion, and emphysema, but not mucus obstruction, in mice with cystic fibrosis-like lung disease
Am J Respir Crit Care Med189, 1082-1092. PubMed Europe PubMed DOI K
Grzywa,R., Burchacka,E., Lecka,M., Winiarski,L., Walczak,M., Lupicka-Slowik,A., Wysocka,M., Burster,T., Bobrek,K., Csencsits-Smith,K., Lesner,A. and Sienczyk,M.
Synthesis of novel phosphonic-type activity-based probes for neutrophil serine proteases and their application in spleen lysates of different organisms
Chembiochem15, 2605-2612. PubMed Europe PubMed DOI I
Habash,M., Abdelazeem,A.H. and Taha,M.O.
Elaborate ligand-based modeling reveals new human neutrophil elastase inhibitors
Med Chem Res23, 3876-3896. DOI I
Kasperkiewicz,P., Poreba,M., Snipas,S.J., Parker,H., Winterbourn,C.C., Salvesen,G.S. and Drag,M.
Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling
Proc Natl Acad Sci U S A111, 2518-2523. PubMed Europe PubMed DOI A P
Nauseef,W.M.
Proteases, neutrophils, and periodontitis: the NET effect
J Clin Invest124, 4237-4239. PubMed Europe PubMed DOI
Pivetta,E., Danussi,C., Wassermann,B., Modica,T.M., Del Bel Belluz,L., Canzonieri,V., Colombatti,A. and Spessotto,P.
Neutrophil elastase-dependent cleavage compromises the tumor suppressor role of EMILIN1
Matrix Biol34, 22-32. PubMed Europe PubMed DOI
Sahoo,M., Del Barrio,L., Miller,M.A. and Re,F.
Neutrophil elastase causes tissue damage that decreases host tolerance to lung infection with Burkholderia species
PLoS Pathog10, e1004327-e1004327. PubMed Europe PubMed DOI
Schillinger,A.S., Grauffel,C., Khan,H.M., Halskau,O. and Reuter,N.
Two homologous neutrophil serine proteases bind to POPC vesicles with different affinities: when aromatic amino acids matter
Biochim Biophys Acta1838, 3191-3202. PubMed Europe PubMed DOI
Shioya,Y., Katakura,K. and Ohira,H.
Neutrophil elastase inhibitor suppresses IL-17 based inflammation of murine experimental colitis
Fukushima J Med Sci60, 14-21. PubMed Europe PubMed I
Stapels,D.A., Ramyar,K.X., Bischoff,M., von Kockritz-Blickwede,M., Milder,F.J., Ruyken,M., Eisenbeis,J., McWhorter,W.J., Herrmann,M., Van Kessel,K.P., Geisbrecht,B.V. and Rooijakkers,S.H.
Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors
Proc Natl Acad Sci U S A111, 13187-13192. PubMed Europe PubMed DOI S
Waisberg,M., Molina-Cruz,A., Mizurini,D.M., Gera,N., Sousa,B.C., Ma,D., Leal,A.C., Gomes,T., Kotsyfakis,M., Ribeiro,J.M., Lukszo,J., Reiter,K., Porcella,S.F., Oliveira,C.J., Monteiro,R.Q., Barillas-Mury,C., Pierce,S.K. and Francischetti,I.M.
Plasmodium falciparum infection induces expression of a mosquito salivary protein (agaphelin) that targets neutrophil function and inhibits thrombosis without impairing hemostasis
PLoS Pathog10, e1004338-e1004338. PubMed Europe PubMed DOI

2013

Avlonitis,N., Debunne,M., Aslam,T., McDonald,N., Haslett,C., Dhaliwal,K. and Bradley,M.
Highly specific, multi-branched fluorescent reporters for analysis of human neutrophil elastase
Org Biomol Chem11, 4414-4418. PubMed Europe PubMed DOI A
Carter,R.I., Ungurs,M.J., Mumford,R.A. and Stockley,R.A.
Aalpha-Val360: a marker of neutrophil elastase and COPD disease activity
Eur Respir J41, 31-38. PubMed Europe PubMed DOI
Cheng,L. and Zhao,Q.
Aptamer-capture based assays for human neutrophil elastase
Talanta106, 315-320. PubMed Europe PubMed DOI I
Crocetti,L., Schepetkin,I.A., Cilibrizzi,A., Graziano,A., Vergelli,C., Giomi,D., Khlebnikov,A.I., Quinn,M.T. and Giovannoni,M.P.
Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase
J Med Chem56, 6259-6272. PubMed Europe PubMed DOI I
Edwards,J.V., Prevost,N., Sethumadhavan,K., Ullah,A. and Condon,B.
Peptide conjugated cellulose nanocrystals with sensitive human neutrophil elastase sensor activity
Cellulose20, 1223-1235. DOI A
Feng,L., Liu,X., Zhu,W., Guo,F., Yingchunwu, Wang,R., Chen,K., Huang,C. and Li,Y.
Inhibition of human neutrophil elastase by pentacyclic triterpenes
PLoS ONE8, e82794-e82794. PubMed Europe PubMed DOI I
Gong,L., Cumpian,A.C., da Silva Caetano,M., Ochoa,C.E., De la Garza,M.M., Lapid,D.J., Mirabolfathinejad,S.G., Dickey,B.F., Zhou,Q. and Moghaddam,S.J.
Promoting effect of neutrophils on lung tumorigenesis is mediated by CXCR2 and neutrophil elastase
Mol Cancer12, 154-154. PubMed Europe PubMed DOI
Jiang,D., Wenzel,S.E., Wu,Q., Bowler,R.P., Schnell,C. and Chu,H.W.
Human neutrophil elastase degrades SPLUNC1 and impairs airway epithelial defense against bacteria
PLoS ONE8, e64689-e64689. PubMed Europe PubMed DOI
Lee,H.H. and Sung,M.H.
The neutrophil elastase mutant affects viability and differentiation of the human monocytic THP-1 cell
Cell Biochem Funct31, 305-311. PubMed Europe PubMed DOI M
Lee,W.I., Chen,S.H., Huang,J.L., Jaing,T.H., Chung,H.T., Yeh,K.W., Chen,L.C., Yao,T.C., Hsieh,M.Y., Lin,S.J. and Kuo,M.L.
Identifying patients with neutrophil elastase (ELANE) mutations from patients with a presumptive diagnosis of autoimmune neutropenia
Immunobiology218, 828-833. PubMed Europe PubMed DOI M
Mansuy-Aubert,V., Zhou,Q.L., Xie,X., Gong,Z., Huang,J.Y., Khan,A.R., Aubert,G., Candelaria,K., Thomas,S., Shin,D.J., Booth,S., Baig,S.M., Bilal,A., Hwang,D., Zhang,H., Lovell-Badge,R., Smith,S.R., Awan,F.R. and Jiang,Z.Y.
Imbalance between neutrophil elastase and its inhibitor alpha1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure
Cell Metab17, 534-548. PubMed Europe PubMed DOI I
Mitra,S., Modi,K.D. and Foster,T.H.
Enzyme-activatable imaging probe reveals enhanced neutrophil elastase activity in tumors following photodynamic therapy
J Biomed Opt18, 101314-101314. PubMed Europe PubMed DOI L
Montalbano,F., Cal,P.M., Carvalho,M.A., Goncalves,L.M., Lucas,S.D., Guedes,R.C., Veiros,L.F., Moreira,R. and Gois,P.M.
Discovery of new heterocycles with activity against human neutrophile elastase based on a boron promoted one-pot assembly reaction
Org Biomol Chem11, 4465-4472. PubMed Europe PubMed DOI I
Narayanaswamy,R., Wai,L.K. and Ismail,I.S.
Molecular docking analysis of natural compounds as human neutrophil elastase (HNE) inhibitors
J Chem Pharm Res5, 337-341. I
O'Donoghue,A.J., Jin,Y., Knudsen,G.M., Perera,N.C., Jenne,D.E., Murphy,J.E., Craik,C.S. and Hermiston,T.W.
Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase
PLoS ONE8, e75141-e75141. PubMed Europe PubMed DOI
Parzy,E., Bouchaud,V., Massot,P., Voisin,P., Koonjoo,N., Moncelet,D., Franconi,J.M., Thiaudiere,E. and Mellet,P.
Overhauser-enhanced MRI of elastase activity from in vitro human neutrophil degranulation
PLoS ONE8, e57946-e57946. PubMed Europe PubMed DOI L
Salvador,L.A., Taori,K., Biggs,J.S., Jakoncic,J., Ostrov,D.A., Paul,V.J. and Luesch,H.
Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells
J Med Chem56, 1276-1290. PubMed Europe PubMed DOI I
Sandhaus,R.A. and Turino,G.
Neutrophil elastase-mediated lung disease
COPD10 Suppl 1, 60-63. PubMed Europe PubMed DOI
Stockley,R., De Soyza,A., Gunawardena,K., Perrett,J., Forsman-Semb,K., Entwistle,N. and Snell,N.
Phase II study of a neutrophil elastase inhibitor (AZD9668) in patients with bronchiectasis
Respir Med107, 524-533. PubMed Europe PubMed DOI I
Sun,Q., Li,J., Liu,W.N., Dong,Q.J., Yang,W.C. and Yang,G.F.
Non-peptide-based fluorogenic small-molecule probe for elastase
Anal Chem85, 11304-11311. PubMed Europe PubMed DOI A
Yoshikawa,N., Inomata,T., Okada,Y., Shimbo,T., Takahashi,M., Akita,K., Uesugi,Y. and Narumi,Y.
Sivelestat sodium hydrate reduces radiation-induced lung injury in mice by inhibiting neutrophil elastase
Mol Med Rep7, 1091-1095. PubMed Europe PubMed DOI I
Zhou,J., Perelman,J.M., Kolosov,V.P. and Zhou,X.
Neutrophil elastase induces MUC5AC secretion via protease-activated receptor 2
Mol Cell Biochem377, 75-85. PubMed Europe PubMed DOI

2012

Aronchik,I., Chen,T., Durkin,K.A., Horwitz,M.S., Preobrazhenskaya,M.N., Bjeldanes,L.F. and Firestone,G.L.
Target protein interactions of indole-3-carbinol and the highly potent derivative 1-benzyl-I3C with the C-terminal domain of human elastase uncouples cell cycle arrest from apoptotic signaling
Mol Carcinog51, 881-894. PubMed Europe PubMed DOI I
Asadollahi-Baboli,M.
Quantitative structure-activity relationship analysis of human neutrophil elastase inhibitors using shuffling classification and regression trees and adaptive neuro-fuzzy inference systems
SAR QSAR Environ Res23, 505-520. PubMed Europe PubMed DOI I
Barros,S.C., Martins,J.A., Marcos,J.C. and Cavaco-Paulo,A.
Influence of secretory leukocyte protease inhibitor-based peptides on elastase activity and their incorporation in hyaluronic acid hydrogels for chronic wound therapy
Biopolymers98, 576-590. PubMed Europe PubMed DOI I
Benabid,R., Wartelle,J., Malleret,L., Guyot,N., Gangloff,S., Lebargy,F. and Belaaouaj,A.
Neutrophil elastase modulates cytokine expression: contribution to host defense against Pseudomonas aeruginosa-induced pneumonia
J Biol Chem287, 34883-34894. PubMed Europe PubMed DOI
Brea,D., Meurens,F., Dubois,A.V., Gaillard,J., Chevaleyre,C., Jourdan,M.L., Winter,N., Arbeille,B., Si-Tahar,M., Gauthier,F. and Attucci,S.
The pig as a model for investigating the role of neutrophil serine proteases in human inflammatory lung diseases
Biochem J447, 363-370. PubMed Europe PubMed DOI
Dubois,A.V., Gauthier,A., Brea,D., Varaigne,F., Diot,P., Gauthier,F. and Attucci,S.
Influence of DNA on the activities and inhibition of neutrophil serine proteases in cystic fibrosis sputum
Am J Respir Cell Mol Biol47, 80-86. PubMed Europe PubMed DOI
Enewold,L., Mechanic,L.E., Bowman,E.D., Platz,E.A. and Alberg,A.J.
SERPINA1 and ELA2 Polymorphisms Are Not Associated with COPD or Lung Cancer
Anticancer Res32, 3923-3928. PubMed Europe PubMed M
Feng,L., Zhu,W., Huang,C. and Li,Y.
Direct interaction of ONO-5046 with human neutrophil elastase through 1H NMR and molecular docking
Int J Biol Macromol51, 196-200. PubMed Europe PubMed DOI I
Gill,N., Ferreira,R.B., Antunes,L.C., Willing,B.P., Sekirov,I., Al-Zahrani,F., Hartmann,M. and Finlay,B.B.
Neutrophil elastase alters the murine gut microbiota resulting in enhanced Salmonella colonization
PLoS ONE7, e49646-e49646. PubMed Europe PubMed DOI
Heinz,A., Jung,M.C., Jahreis,G., Rusciani,A., Duca,L., Debelle,L., Weiss,A.S., Neubert,R.H. and Schmelzer,C.E.
The action of neutrophil serine proteases on elastin and its precursor
Biochimie94, 192-202. PubMed Europe PubMed DOI P
Karmakar,M., Sun,Y., Hise,A.G., Rietsch,A. and Pearlman,E.
Cutting edge: IL-1beta processing during Pseudomonas aeruginosa infection is mediated by neutrophil serine proteases and is independent of NLRC4 and caspase-1
J Immunol189, 4231-4235. PubMed Europe PubMed DOI K
Komissarov,A.A., Stankowska,D., Krupa,A., Fudala,R., Florova,G., Florence,J., Fol,M., Allen,T.C., Idell,S., Matthay,M.A. and Kurdowska,A.K.
Novel aspects of urokinase function in the injured lung: role of alpha2-macroglobulin
Am J Physiol Lung Cell Mol Physiol303, L1037-L1045. PubMed Europe PubMed DOI
Korkmaz,B., Attucci,S., Epinette,C., Pitois,E., Jourdan,M.L., Juliano,L. and Gauthier,F.
Measurement of neutrophil elastase, proteinase 3, and cathepsin G activities using intramolecularly quenched fluorogenic substrates
Methods Mol Biol844, 125-138. PubMed Europe PubMed DOI A
Korkmaz,B. and Gauthier,F.
Elastase-2/Leukocyte elastase
[ISSN:978-0-12-407742-3]3, 2653-2661. DOI
Lefrancais,E., Roga,S., Gautier,V., Gonzalez-de-Peredo,A., Monsarrat,B., Girard,J.P. and Cayrol,C.
IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G
Proc Natl Acad Sci U S A109, 1673-1678. PubMed Europe PubMed DOI P
Lin,L., Betsuyaku,T., Heimbach,L., Li,N., Rubenstein,D., Shapiro,S.D., An,L., Giudice,G.J., Diaz,L.A., Senior,R.M. and Liu,Z.
Neutrophil elastase cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid
Matrix Biol31, 38-44. PubMed Europe PubMed DOI
Monleon,L.M., Diez-Garcia,F., Zamora,H., Anaya,J., Grande,M., De Diego,J.G. and David Rodriguez,F.
In vitro evaluation of the antielastase activity of polycyclic beta-lactams
Bioorg Chem45, 29-35. PubMed Europe PubMed DOI I
Moroy,G., Alix,A.J., Sapi,J., Hornebeck,W. and Bourguet,E.
Neutrophil elastase as a target in lung cancer
Anticancer Agents Med Chem12, 565-579. PubMed Europe PubMed T
Nawa,M., Osada,S., Morimitsu,K., Nonaka,K., Futamura,M., Kawaguchi,Y. and Yoshida,K.
Growth effect of neutrophil elastase on breast cancer: favorable action of sivelestat and application to anti-HER2 therapy
Anticancer Res32, 13-19. PubMed Europe PubMed I
Parlee,S.D., McNeil,J.O., Muruganandan,S., Sinal,C.J. and Goralski,K.B.
Elastase and tryptase govern TNFalpha-mediated production of active chemerin by adipocytes
PLoS ONE7, e51072-e51072. PubMed Europe PubMed DOI
Schmelzer,C.E., Jung,M.C., Wohlrab,J., Neubert,R.H. and Heinz,A.
Does human leukocyte elastase degrade intact skin elastin?
FEBS J279, 4191-4200. PubMed Europe PubMed DOI
Sjo,P.
Neutrophil elastase inhibitors: recent advances in the development of mechanism-based and nonelectrophilic inhibitors
Future Med Chem4, 651-660. PubMed Europe PubMed DOI I
Winiarski,L., Oleksyszyn,J. and Sienczyk,M.
Human neutrophil elastase phosphonic inhibitors with improved potency of action
J Med Chem55, 6541-6553. PubMed Europe PubMed DOI I
Wysocka,M., Lesner,A., Popow,J., Legowska,M. and Rolka,K.
Pegylated fluorescent peptides as substrates of proteolytic enzymes
Protein Pept Lett19, 1237-1244. PubMed Europe PubMed A P
Wysocka,M., Lesner,A., Gruba,N., Korkmaz,B., Gauthier,F., Kitamatsu,M., Legowska,A. and Rolka,K.
Three wavelength substrate system of neutrophil serine proteinases
Anal Chem84, 7241-7248. PubMed Europe PubMed DOI A
Zheng,Z., Zhang,S., Lu,X., Ma,Y., Fan,Y., Shi,Y., Dong,A. and Duan,B.
Trivaric acid, a potent depside human leukocyte elastase inhibitor
Biol Pharm Bull35, 2247-2251. PubMed Europe PubMed DOI I

2011

Carter,R.I., Mumford,R.A., Treonze,K.M., Finke,P.E., Davies,P., Si,Q., Humes,J.L., Dirksen,A., Piitulainen,E., Ahmad,A. and Stockley,R.A.
The fibrinogen cleavage product Aalpha-Val360, a specific marker of neutrophil elastase activity in vivo
Thorax66, 686-691. PubMed Europe PubMed DOI
Crocetti,L., Giovannoni,M.P., Schepetkin,I.A., Quinn,M.T., Khlebnikov,A.I., Cilibrizzi,A., Piaz,V.D., Graziano,A. and Vergelli,C.
Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase
Bioorg Med Chem19, 4460-4472. PubMed Europe PubMed DOI I
Estacio,S.G., Moreira,R. and Guedes,R.C.
Characterizing the dynamics and ligand-specific interactions in the human leukocyte elastase through molecular dynamics simulations
J Chem Inf Model51, 1690-1702. PubMed Europe PubMed DOI
Gu,Y., Lee,H.M., Simon,S.R. and Golub,L.M.
Chemically modified tetracycline-3 (CMT-3): a novel inhibitor of the serine proteinase, elastase
Pharmacol Res64, 595-601. PubMed Europe PubMed DOI I
Hahn,I., Klaus,A., Janze,A.K., Steinwede,K., Ding,N., Bohling,J., Brumshagen,C., Serrano,H., Gauthier,F., Paton,J.C., Welte,T. and Maus,U.A.
Cathepsin G and neutrophil elastase play critical and nonredundant roles in lung-protective immunity against Streptococcus pneumoniae in mice
Infect Immun79, 4893-4901. PubMed Europe PubMed DOI
Hansen,G., Gielen-Haertwig,H., Reinemer,P., Schomburg,D., Harrenga,A. and Niefind,K.
Unexpected active-site flexibility in the structure of human neutrophil elastase in complex with a new dihydropyrimidone inhibitor
J Mol Biol409, 681-691. PubMed Europe PubMed DOI S I
Hoffmann,D.C., Textoris,C., Oehme,F., Klaassen,T., Goppelt,A., Romer,A., Fugmann,B., Davidson,J.M., Werner,S., Krieg,T. and Eming,S.A.
Pivotal role for alpha1-antichymotrypsin in skin repair
J Biol Chem286, 28889-28901. PubMed Europe PubMed DOI
Kessenbrock,K., Dau,T. and Jenne,D.E.
Tailor-made inflammation: how neutrophil serine proteases modulate the inflammatory response
J Mol Med (Berl)89, 23-28. PubMed Europe PubMed DOI
Kossodo,S., Zhang,J., Groves,K., Cuneo,G.J., Handy,E., Morin,J., Delaney,J., Yared,W., Rajopadhye,M. and Peterson,J.D.
Noninvasive in vivo quantification of neutrophil elastase activity in acute experimental mouse lung injury
Int J Mol Imaging2011, 581406-581406. PubMed Europe PubMed DOI A L
Meyer-Hoffert,U. and Wiedow,O.
Neutrophil serine proteases: mediators of innate immune responses
Curr Opin Hematol18, 19-24. PubMed Europe PubMed DOI
Moroy,G., Bourguet,E., Decarme,M., Sapi,J., Alix,A.J., Hornebeck,W. and Lorimier,S.
Inhibition of human leukocyte elastase, plasmin and matrix metalloproteinases by oleic acid and oleoyl-galardin derivative(s)
Biochem Pharmacol81, 626-635. PubMed Europe PubMed DOI I
Mulchande,J., Simoes,S.I., Gaspar,M.M., Eleuterio,C.V., Oliveira,R., Cruz,M.E., Moreira,R. and Iley,J.
Synthesis, stability, biochemical and pharmacokinetic properties of a new potent and selective 4-oxo-beta-lactam inhibitor of human leukocyte elastase
J Enzyme Inhib Med Chem26, 169-175. PubMed Europe PubMed DOI I
Nogami,K., Ogiwara,K., Matsumoto,T., Nishiya,K., Takeyama,M. and Shima,M.
Mechanisms of human neutrophil elastase-catalysed inactivation of factor VIII(a)
Thromb Haemost105, 968-980. PubMed Europe PubMed DOI
Nunes,G.L., Simoes,A., Dyszy,F.H., Shida,C.S., Juliano,M.A., Juliano,L., Gesteira,T.F., Nader,H.B., Murphy,G., Chaffotte,A.F., Goldberg,M.E., Tersariol,I.L. and Almeida,P.C.
Mechanism of heparin acceleration of tissue inhibitor of metalloproteases-1 (TIMP-1) degradation by the human neutrophil elastase
PLoS ONE6, e21525-e21525. PubMed Europe PubMed DOI
Papayannopoulos,V., Staab,D. and Zychlinsky,A.
Neutrophil elastase enhances sputum solubilization in cystic fibrosis patients receiving DNase therapy
PLoS ONE6, e28526-e28526. PubMed Europe PubMed DOI
Ramachandran,R., Mihara,K., Chung,H., Renaux,B., Lau,C.S., Muruve,D.A., Defea,K.A., Bouvier,M. and Hollenberg,M.D.
Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2)
J Biol Chem286, 24638-24648. PubMed Europe PubMed DOI
Sienczyk,M., Winiarski,L., Kasperkiewicz,P., Psurski,M., Wietrzyk,J. and Oleksyszyn,J.
Simple phosphonic inhibitors of human neutrophil elastase
Bioorg Med Chem Lett21, 1310-1314. PubMed Europe PubMed DOI I
Sienczyk,M., Podgorski,D., Blazejewska,A., Kulbacka,J., Saczko,J. and Oleksyszyn,J.
Phosphonic pseudopeptides as human neutrophil elastase inhibitors - a combinatorial approach
Bioorg Med Chem19, 1277-1284. PubMed Europe PubMed DOI I
van de Vosse,E., Verhard,E.M., Tool,A.J., de Visser,A.W., Kuijpers,T.W., Hiemstra,P.S. and van Dissel,J.T.
Severe congenital neutropenia in a multigenerational family with a novel neutrophil elastase (ELANE) mutation
Ann Hematol90, 151-158. PubMed Europe PubMed DOI M
Vasconcelos,A., Azoia,N.G., Carvalho,A.C., Gomes,A.C., Guebitz,G. and Cavaco-Paulo,A.
Tailoring elastase inhibition with synthetic peptides
Eur J Pharmacol666, 53-60. PubMed Europe PubMed DOI I
Wada,H. and Habe,K.
Neutrophil elastase affects not only tissue damage, but it also regulates hematopoiesis
Thromb Res128, 205-206. PubMed Europe PubMed DOI
Zelepuga,E., Tabakmakher,V., Monastyrnaya,M., Lukyanov,P. and Kozlovskaya,E.
In silico investigation of interaction between human neutrophil elastase and sea anemone Heteractis crispa Kunitz polypeptides
Int Conf Bioinformatics Biomedical Eng , iCBBE10-12 May 2011, 1-4. DOI

2010

Aronchik,I., Bjeldanes,L.F. and Firestone,G.L.
Direct inhibition of elastase activity by indole-3-carbinol triggers a CD40-TRAF regulatory cascade that disrupts NF-kappaB transcriptional activity in human breast cancer cells
Cancer Res70, 4961-4971. PubMed Europe PubMed DOI I
Bonnart,C., Deraison,C., Lacroix,M., Uchida,Y., Besson,C., Robin,A., Briot,A., Gonthier,M., Lamant,L., Dubus,P., Monsarrat,B. and Hovnanian,A.
Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing
J Clin Invest120, 871-882. PubMed Europe PubMed DOI
Claesson,R., Kanasi,E., Johansson,A. and Kalfas,S.
A new cleavage site for elastase within the complement component 3
APMIS118, 765-768. PubMed Europe PubMed DOI P
Dou,D., He,G., Kuang,R., Fu,Q., Venkataraman,R. and Groutas,W.C.
Effects of structure on inhibitory activity in a series of mechanism-based inhibitors of human neutrophil elastase
Bioorg Med Chem18, 6646-6650. PubMed Europe PubMed DOI I
Fang,H., Sun,C., Xu,L., Owen,R.J., Auth,R.D., Snoy,P.J. and Frucht,D.M.
Neutrophil elastase mediates pathogenic effects of anthrax lethal toxin in the murine intestinal tract
J Immunol185, 5463-5467. PubMed Europe PubMed DOI
Fingleton,B.
Inflammatory proteinase slips into tumor cells
Nat Med16, 161-163. PubMed Europe PubMed DOI
Fitzgerald,M.F.
Small-molecule neutrophil elastase inhibitors as therapies for respiratory disease
39, 225-230. DOI I
Foong,R.E., Sly,P.D., Larcombe,A.N. and Zosky,G.R.
No role for neutrophil elastase in influenza-induced cellular recruitment, cytokine production or airway hyperresponsiveness in mice
Respir Physiol Neurobiol173, 164-170. PubMed Europe PubMed DOI K
Guarnieri,F., Spencer,J.L., Lucey,E.C., Nugent,M.A. and Stone,P.J.
A human surfactant peptide-elastase inhibitor construct as a treatment for emphysema
Proc Natl Acad Sci U S A107, 10661-10666. PubMed Europe PubMed DOI I
Hajjar,E., Broemstrup,T., Kantari,C., Witko-Sarsat,V. and Reuter,N.
Structures of human proteinase 3 and neutrophil elastase - so similar yet so different
FEBS J277, 2238-2254. PubMed Europe PubMed DOI
He,G., Dou,D., Wei,L., Alliston,K.R. and Groutas,W.C.
Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold
Eur J Med Chem45, 4280-4287. PubMed Europe PubMed DOI I
Houghton,A.M., Rzymkiewicz,D.M., Ji,H., Gregory,A.D., Egea,E.E., Metz,H.E., Stolz,D.B., Land,S.R., Marconcini,L.A., Kliment,C.R., Jenkins,K.M., Beaulieu,K.A., Mouded,M., Frank,S.J., Wong,K.K. and Shapiro,S.D.
Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth
Nat Med16, 219-223. PubMed Europe PubMed DOI
Jackson,P.L., Xu,X., Wilson,L., Weathington,N.M., Clancy,J.P., Blalock,J.E. and Gaggar,A.
Human neutrophil elastase-mediated cleavage sites of MMP-9 and TIMP-1: implications to cystic fibrosis proteolytic dysfunction
Mol Med16, 159-166. PubMed Europe PubMed DOI P
Kawai,M., Harada,N., Takeyama,H. and Okajima,K.
Neutrophil elastase contributes to the development of ischemia/reperfusion-induced liver injury by decreasing the production of insulin-like growth factor-I in rats
Transl Res155, 294-304. PubMed Europe PubMed DOI I
Korkmaz,B., Horwitz,M.S., Jenne,D.E. and Gauthier,F.
Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases
Pharmacol Rev62, 726-759. PubMed Europe PubMed DOI V T
Mulchande,J., Oliveira,R., Carrasco,M., Gouveia,L., Guedes,R.C., Iley,J. and Moreira,R.
4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase
J Med Chem53, 241-253. PubMed Europe PubMed DOI I
Pruliere-Escabasse,V., Clerici,C., Vuagniaux,G., Coste,A., Escudier,E. and Planes,C.
Effect of neutrophil elastase and its inhibitor EPI-hNE4 on transepithelial sodium transport across normal and cystic fibrosis human nasal epithelial cells
Respir Res11, 141-141. PubMed Europe PubMed DOI
Schenker,P. and Baici,A.
Paradoxical interactions between modifiers and elastase-2
FEBS J277, 2486-2495. PubMed Europe PubMed DOI

2009

Aimetti,A.A., Tibbitt,M.W. and Anseth,K.S.
Human neutrophil elastase responsive delivery from poly(ethylene glycol) hydrogels
Biomacromolecules10, 1484-1489. PubMed Europe PubMed DOI
Fischer,B.M., Domowicz,D.A., Zheng,S., Carter,J.L., McElvaney,N.G., Taggart,C., Lehmann,J.R., Voynow,J.A. and Ghio,A.J.
Neutrophil elastase increases airway epithelial nonheme iron levels
Clin Transl Sci2, 333-339. PubMed Europe PubMed DOI
Kalupov,T., Brillard-Bourdet,M., Dade,S., Serrano,H., Wartelle,J., Guyot,N., Juliano,L., Moreau,T., Belaaouaj,A. and Gauthier,F.
Structural characterization of mouse neutrophil serine proteases and identification of their substrate specificities: relevance to mouse models of human inflammatory diseases
J Biol Chem284, 34084-34091. PubMed Europe PubMed DOI P
Kim,Y.H., Ryoo,I.J., Choo,S.J., Xu,G.H., Lee,S., Seok,S.J., Bae,K. and Yoo,I.D.
Clitocybin D, a novel human neutrophil elastase inhibitor from the culture broth of Clitocybe aurantiaca
J Microbiol Biotechnol19, 1139-1141. PubMed Europe PubMed DOI I
Kolaczkowska,E., Grzybek,W., van Rooijen,N., Piccard,H., Plytycz,B., Arnold,B. and Opdenakker,G.
Neutrophil elastase activity compensates for a genetic lack of matrix metalloproteinase-9 (MMP-9) in leukocyte infiltration in a model of experimental peritonitis
J Leukoc Biol85, 374-381. PubMed Europe PubMed DOI
Kurtagic,E., Jedrychowski,M.P. and Nugent,M.A.
Neutrophil elastase cleaves VEGF to generate a VEGF fragment with altered activity
Am J Physiol Lung Cell Mol Physiol296, L534-L546. PubMed Europe PubMed DOI
Li,Y., Dou,D., He,G., Lushington,G.H. and Groutas,W.C.
Mechanism-based inhibitors of serine proteases with high selectivity through optimization of S' subsite binding
Bioorg Med Chem17, 3536-3542. PubMed Europe PubMed DOI I
Raife,T.J., Cao,W., Atkinson,B.S., Bedell,B., Montgomery,R.R., Lentz,S.R., Johnson,G.F. and Zheng,X.L.
Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site
Blood114, 1666-1674. PubMed Europe PubMed DOI P
Salipante,S.J., Rojas,M.E., Korkmaz,B., Duan,Z., Wechsler,J., Benson,K.F., Person,R.E., Grimes,H.L. and Horwitz,M.S.
Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase
Mol Cell Biol29, 4394-4405. PubMed Europe PubMed DOI M
Shreder,K.R., Cajica,J., Du,L., Fraser,A., Hu,Y., Kohno,Y., Lin,E.C., Liu,S.J., Okerberg,E., Pham,L., Wu,J. and Kozarich,J.W.
Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase
Bioorg Med Chem Lett19, 4743-4746. PubMed Europe PubMed DOI I
Sisay,M.T., Hautmann,S., Mehner,C., Konig,G.M., Bajorath,J. and Gutschow,M.
Inhibition of human leukocyte elastase by brunsvicamides A-C: cyanobacterial cyclic peptides
ChemMedChem4, 1425-1429. PubMed Europe PubMed DOI I
Suzuki,T., Yamashita,C., Zemans,R.L., Briones,N., Van Linden,A. and Downey,G.P.
Leukocyte elastase induces lung epithelial apoptosis via a PAR-1-, NF-kappaB-, and p53-dependent pathway
Am J Respir Cell Mol Biol41, 742-755. PubMed Europe PubMed DOI
Uchida,Y., Freitas,M.C., Zhao,D., Busuttil,R.W. and Kupiec-Weglinski,J.W.
The inhibition of neutrophil elastase ameliorates mouse liver damage due to ischemia and reperfusion
Liver Transpl15, 939-947. PubMed Europe PubMed DOI I
Weldon,S., McNally,P., McElvaney,N.G., Elborn,J.S., McAuley,D.F., Wartelle,J., Belaaouaj,A., Levine,R.L. and Taggart,C.C.
Decreased levels of secretory leucoprotease inhibitor in the Pseudomonas-infected cystic fibrosis lung are due to neutrophil elastase degradation
J Immunol183, 8148-8156. PubMed Europe PubMed DOI
Xu,G.H., Kim,Y.H., Choo,S.J., Ryoo,I.J., Yoo,J.K., Ahn,J.S. and Yoo,I.D.
Chemical constituents from the leaves of Ilex paraguariensis inhibit human neutrophil elastase
Arch Pharm Res32, 1215-1220. PubMed Europe PubMed DOI I
Xu,G.H., Kim,Y.H., Choo,S.J., Ryoo,I.J., Zheng,C.J., Seok,S.J., Kim,W.G. and Yoo,I.D.
Isodeoxyhelicobasidin, a novel human neutrophil elastase inhibitor from the culture broth of Volvariella bombycina
J Antibiot (Tokyo)62, 333-334. PubMed Europe PubMed DOI I

2008

Averhoff,P., Kolbe,M., Zychlinsky,A. and Weinrauch,Y.
Single residue determines the specificity of neutrophil elastase for Shigella virulence factors
J Mol Biol377, 1053-1066. PubMed Europe PubMed DOI P
Bagoly,Z., Fazakas,F., Komaromi,I., Haramura,G., Toth,E. and Muszbek,L.
Cleavage of factor XIII by human neutrophil elastase results in a novel active truncated form of factor XIII A subunit
Thromb Haemost99, 668-674. PubMed Europe PubMed DOI P
Bergin,D.A., Greene,C.M., Sterchi,E.E., Kenna,C., Geraghty,P., Belaaouaj,A., Taggart,C.C., O'Neill,S.J. and McElvaney,N.G.
Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway
J Biol Chem283, 31736-31744. PubMed Europe PubMed DOI
Bubik,A., Sedmak,B., Novinec,M., Lenarcic,B. and Lah,T.T.
Cytotoxic and peptidase inhibitory activities of selected non-hepatotoxic cyclic peptides from cyanobacteria
Biol Chem389, 1339-1346. PubMed Europe PubMed DOI I
Cooley,J., McDonald,B., Accurso,F.J., Crouch,E.C. and Remold-O'Donnell,E.
Patterns of neutrophil serine protease-dependent cleavage of surfactant protein D in inflammatory lung disease
J Leukoc Biol83, 946-955. PubMed Europe PubMed DOI
Davies,P.L., Maxwell,N.C., Kotecha,S. and Spiller,O.B.
Monoclonal anti-neutrophil elastase antibody characterisation: ability to block function, detect free versus serpin-complexed enzyme and stain intracellular granules
J Immunol Methods336, 175-182. PubMed Europe PubMed DOI
Eilfeld,A., Gonzalez Tanarro,C.M., Frizler,M., Sieler,J., Schulze,B. and Gutschow,M.
Synthesis and elastase-inhibiting activity of 2-pyridinyl-isothiazol-3(2H)-one 1,1-dioxides
Bioorg Med Chem16, 8127-8135. PubMed Europe PubMed DOI I
Hagio,T., Kishikawa,K., Kawabata,K., Tasaka,S., Hashimoto,S., Hasegawa,N. and Ishizaka,A.
Inhibition of neutrophil elastase reduces lung injury and bacterial count in hamsters
Pulm Pharmacol Ther21, 884-891. PubMed Europe PubMed DOI I
Harada,N., Okajima,K. and Isobe,H.
Role of neutrophil elastase in development of pulmonary vascular injury and septic shock in rats
Shock30, 379-387. PubMed Europe PubMed DOI I
Hashimoto,S., Okayama,Y., Shime,N., Kimura,A., Funakoshi,Y., Kawabata,K., Ishizaka,A. and Amaya,F.
Neutrophil elastase activity in acute lung injury and respiratory distress syndrome
Respirology13, 581-584. PubMed Europe PubMed DOI I
Henriksen,P.A. and Sallenave,J.M.
Human neutrophil elastase: mediator and therapeutic target in atherosclerosis
Int J Biochem Cell Biol40, 1095-1100. PubMed Europe PubMed DOI V T
Hirche,T.O., Benabid,R., Deslee,G., Gangloff,S., Achilefu,S., Guenounou,M., Lebargy,F., Hancock,R.E. and Belaaouaj,A.
Neutrophil elastase mediates innate host protection against Pseudomonas aeruginosa
J Immunol181, 4945-4954. PubMed Europe PubMed
Huang,W., Yamamoto,Y., Li,Y., Dou,D., Alliston,K.R., Hanzlik,R.P., Williams,T.D. and Groutas,W.C.
X-Ray snapshot of the mechanism of inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives
J Med Chem51, 2003-2008. PubMed Europe PubMed DOI I
Kaynar,A.M., Houghton,A.M., Lum,E.H., Pitt,B.R. and Shapiro,S.D.
Neutrophil elastase is needed for neutrophil emigration into lungs in ventilator-induced lung injury
Am J Respir Cell Mol Biol39, 53-60. PubMed Europe PubMed DOI
Koizumi,M., Fujino,A., Fukushima,K., Kamimura,T. and Takimoto-Kamimura,M.
Complex of human neutrophil elastase with 1/2SLPI
J Synchrotron Radiat15, 308-311. PubMed Europe PubMed DOI S
Korkmaz,B., Moreau,T. and Gauthier,F.
Neutrophil elastase, proteinase 3 and cathepsin G: physicochemical properties, activity and physiopathological functions
Biochimie90, 227-242. PubMed Europe PubMed DOI V
Li,Y., Yang,Q., Dou,D., Alliston,K.R. and Groutas,W.C.
Inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamides
Bioorg Med Chem16, 692-698. PubMed Europe PubMed DOI I
Lungarella,G., Cavarra,E., Lucattelli,M. and Martorana,P.A.
The dual role of neutrophil elastase in lung destruction and repair
Int J Biochem Cell Biol40, 1287-1296. PubMed Europe PubMed DOI
Mehner,C., Muller,D., Kehraus,S., Hautmann,S., Gutschow,M. and Konig,G.M.
New peptolides from the cyanobacterium Nostoc insulare as selective and potent inhibitors of human leukocyte elastase
Chembiochem9, 2692-2703. PubMed Europe PubMed DOI I
Mulchande,J., Guedes,R.C., Tsang,W.Y., Page,M.I., Moreira,R. and Iley,J.
Azetidine-2,4-diones (4-oxo-beta-lactams) as scaffolds for designing elastase inhibitors
J Med Chem51, 1783-1790. PubMed Europe PubMed DOI I
Mydel,P., Shipley,J.M., Adair-Kirk,T.L., Kelley,D.G., Broekelmann,T.J., Mecham,R.P. and Senior,R.M.
Neutrophil elastase cleaves laminin-332 (laminin-5) generating peptides that are chemotactic for neutrophils
J Biol Chem283, 9513-9522. PubMed Europe PubMed DOI
Nguyen,H.H., Aronchik,I., Brar,G.A., Nguyen,D.H., Bjeldanes,L.F. and Firestone,G.L.
The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing
Proc Natl Acad Sci U S A105, 19750-19755. PubMed Europe PubMed DOI I
Pham,C.T.
Neutrophil serine proteases fine-tune the inflammatory response
Int J Biochem Cell Biol40, 1317-1333. PubMed Europe PubMed DOI
Rosenberg,P.S., Alter,B.P., Link,D.C., Stein,S., Rodger,E., Bolyard,A.A., Aprikyan,A.A., Bonilla,M.A., Dror,Y., Kannourakis,G., Newburger,P.E., Boxer,L.A. and Dale,D.C.
Neutrophil elastase mutations and risk of leukaemia in severe congenital neutropenia
Br J Haematol140, 210-213. PubMed Europe PubMed DOI M
Sato,T., Yoshida,M., Takahashi,S., Fukutomi,T. and Yamashita,J.I.
Neutrophil elastase inhibition: a new cancer therapy
Curr Enzyme Inhib4, 82-85. DOI I
Showell,G.A., Montana,J.G., Chadwick,J.A., Hias,C., Hunt,H.J., MacKenzie,R.E., Price,S. and Wilkinson,T.J.
Silicon in Organic and Bioorganic Chemistry: Silicon Diols, Effective Inhibitors of Human Leucocyte Elastase
569-574. DOI I
Steinbrecher,T., Hrenn,A., Dormann,K.L., Merfort,I. and Labahn,A.
Bornyl (3,4,5-trihydroxy)-cinnamate - an optimized human neutrophil elastase inhibitor designed by free energy calculations
Bioorg Med Chem16, 2385-2390. PubMed Europe PubMed DOI I
Ujiie,Y., Shimada,A., Komatsu,K., Gomi,K., Oida,S., Arai,T. and Fukae,M.
Degradation of noncollagenous components by neutrophil elastase reduces the mechanical strength of rat periodontal ligament
J Periodontal Res43, 22-31. PubMed Europe PubMed DOI
Yang,Q., Li,Y., Dou,D., Gan,X., Mohan,S., Groutas,C.S., Stevenson,L.E., Lai,Z., Alliston,K.R., Zhong,J., Williams,T.D. and Groutas,W.C.
Inhibition of serine proteases by a new class of cyclosulfamide-based carbamylating agents
Arch Biochem Biophys475, 115-120. PubMed Europe PubMed DOI I

2007

Ahangari,G., Chavoshzadeh,Z., Lari,Z., Ramyar,A. and Farhoudi,A.
Novel mutation detection of an inflammatory molecule elastase II gene encoding neutrophil elastase in Kostmann syndrome
Eur J Inflamm5, 65-71. M
Ai,S., Cheng,X.W., Inoue,A., Nakamura,K., Okumura,K., Iguchi,A., Murohara,T. and Kuzuya,M.
Angiogenic activity of bFGF and VEGF suppressed by proteolytic cleavage by neutrophil elastase
Biochem Biophys Res Commun364, 395-401. PubMed Europe PubMed DOI I
Akizuki,M., Fukutomi,T., Takasugi,M., Takahashi,S., Sato,T., Harao,M., Mizumoto,T. and Yamashita,J.
Prognostic significance of immunoreactive neutrophil elastase in human breast cancer: long-term follow-up results in 313 patients
Neoplasia9, 260-264. PubMed Europe PubMed DOI
Brauer,A.B., McBride,J.D., Kelly,G., Matthews,S.J. and Leatherbarrow,R.J.
Resisting degradation by human elastase: commonality of design features shared by 'canonical' plant and bacterial macrocyclic protease inhibitor scaffolds
Bioorg Med Chem15, 4618-4628. PubMed Europe PubMed DOI
Campbell,E.J. and Owen,C.A.
The sulfate groups of chondroitin sulfate- and heparan sulfate-containing proteoglycans in neutrophil plasma membranes are novel binding sites for human leukocyte elastase and cathepsin G
J Biol Chem282, 14645-14654. PubMed Europe PubMed DOI
Carlsson,G., Melin,M., Dahl,N., Ramme,K.G., Nordenskjold,M., Palmblad,J., Henter,J.I. and Fadeel,B.
Kostmann syndrome or infantile genetic agranulocytosis, part two: understanding the underlying genetic defects in severe congenital neutropenia
Acta Paediatr96, 813-819. PubMed Europe PubMed DOI M V
Chua,F., Dunsmore,S.E., Clingen,P.H., Mutsaers,S.E., Shapiro,S.D., Segal,A.W., Roes,J. and Laurent,G.J.
Mice lacking neutrophil elastase are resistant to bleomycin-induced pulmonary fibrosis
Am J Pathol170, 65-74. PubMed Europe PubMed DOI K
Grenda,D.S., Murakami,M., Ghatak,J., Xia,J., Boxer,L.A., Dale,D., Dinauer,M.C. and Link,D.C.
Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis
Blood110, 4179-4187. PubMed Europe PubMed DOI M
Hajjar,E., Korkmaz,B. and Reuter,N.
Differences in the substrate binding sites of murine and human proteinase 3 and neutrophil elastase
FEBS Lett581, 5685-5690. PubMed Europe PubMed DOI P
Kanashiro,A., Souza,J.G., Kabeya,L.M., Azzolini,A.E. and Lucisano-Valim,Y.M.
Elastase release by stimulated neutrophils inhibited by flavonoids: importance of the catechol group
Z Naturforsch [C]62, 357-361. PubMed Europe PubMed I
Kuwahara,I., Lillehoj,E.P., Koga,T., Isohama,Y., Miyata,T. and Kim,K.C.
The signaling pathway involved in neutrophil elastase stimulated MUC1 transcription
Am J Respir Cell Mol Biol37, 691-698. PubMed Europe PubMed DOI
Kuzniar,J., Kuzniar,T.J., Marchewka,Z., Lembas-Bogaczyk,J., Rabczynski,J., Kopec,W. and Klinger,M.
Elastase deposits in the kidney and urinary elastase excretion in patients with glomerulonephritis - evidence for neutrophil involvement in renal injury
Scand J Urol Nephrol41, 527-534. PubMed Europe PubMed DOI
Li,Q. and Zhou,X.D.
[Upstream signaling pathway of neutrophil elastase-induced mucous hypersecretion]
Zhonghua Yi Xue Za Zhi87, 348-352. PubMed Europe PubMed
Maffia,P.C., Zittermann,S.E., Scimone,M.L., Tateosian,N., Amiano,N., Guerrieri,D., Lutzky,V., Rosso,D., Romeo,H.E., Garcia,V.E., Issekutz,A.C. and Chuluyan,H.E.
Neutrophil elastase converts human immature dendritic cells into transforming growth factor-beta1-secreting cells and reduces allostimulatory ability
Am J Pathol171, 928-937. PubMed Europe PubMed DOI
Nakamura,N., Morisaki,H., Suzuki,T., Yajima,S., Katori,N., Kotake,Y., Funakoshi,Y., Kawabata,K., Yamada,S., Ishizaka,A. and Takeda,J.
Inhibition of neutrophil elastase attenuates gut mucosal injury evoked by acute alveolar hypoxia in rabbits
Shock28, 101-105. PubMed Europe PubMed DOI I
Niemann,C.U., Abrink,M., Pejler,G., Fischer,R.L., Christensen,E.I., Knight,S.D. and Borregaard,N.
Neutrophil elastase depends on serglycin proteoglycan for localization in granules
Blood109, 4478-4486. PubMed Europe PubMed DOI
Sakashita,A., Nishimura,Y., Nishiuma,T., Takenaka,K., Kobayashi,K., Kotani,Y. and Yokoyama,M.
Neutrophil elastase inhibitor (sivelestat) attenuates subsequent ventilator-induced lung injury in mice
Eur J Pharmacol571, 62-71. PubMed Europe PubMed DOI I
Salipante,S.J., Benson,K.F., Luty,J., Hadavi,V., Kariminejad,R., Kariminejad,M.H., Rezaei,N. and Horwitz,M.S.
Double de novo mutations of ELA2 in cyclic and severe congenital neutropenia
Hum Mutat28, 874-881. PubMed Europe PubMed DOI M
Samis,J.A., Stewart,K.A., Nesheim,M.E. and Taylor,F.B., Jr.
Factor V cleavage and inactivation are temporally associated with elevated elastase during experimental sepsis
J Thromb Haemost5, 2559-2561. PubMed Europe PubMed DOI
Santagati,N.A., Salerno,L., Di Giacomo,C., Vanella,L. and Ronsisvalle,S.
Inhibition of human leucocyte elastase by novel thieno-1,3-oxazin-4-ones and thieno-1,3-thioxazin-4-ones
Lett Drug Des Discov4, 386-393. DOI I
Schepetkin,I.A., Khlebnikov,A.I. and Quinn,M.T.
N-Benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase
J Med Chem50, 4928-4938. PubMed Europe PubMed DOI I
Scuri,M., Sabater,J.R. and Abraham,W.M.
Hyaluronan blocks porcine pancreatic elastase-induced mucociliary dysfunction in allergic sheep
J Appl Physiol (1985)102, 2324-2331. PubMed Europe PubMed DOI
Stoll,A., Suchodolski,J.S., Ruaux,C.G. and Steiner,J.M.
Purification and partial characterization of canine neutrophil elastase and the development of an immunoassay for the measurement of canine neutrophil elastase in serum obtained from dogs
Am J Vet Res68, 584-591. PubMed Europe PubMed DOI A
Ujiie,Y., Oida,S., Gomi,K., Arai,T. and Fukae,M.
Neutrophil elastase is involved in the initial destruction of human periodontal ligament
J Periodontal Res42, 325-330. PubMed Europe PubMed DOI
Wakayama,F., Fukuda,I., Suzuki,Y. and Kondo,N.
Neutrophil elastase inhibitor, sivelestat, attenuates acute lung injury after cardiopulmonary bypass in the rabbit endotoxemia model
Ann Thorac Surg83, 153-160. PubMed Europe PubMed DOI I
Wysocka,M., Kwiatkowska,B., Rzadkiewicz,M., Lesner,A. and Rolka,K.
Selection of new chromogenic substrates of serine proteinases using combinatorial chemistry methods
Comb Chem High Throughput Screen10, 171-180. PubMed Europe PubMed DOI A

2006

[YEAR:20-4-2006]Attucci,S., Gauthier,A., Korkmaz,B., Delepine,P., Martino,M.F., Saudubray,F., Diot,P. and Gauthier,F.
EPI-hNE4, a proteolysis-resistant inhibitor of human neutrophil elastase and potential anti-inflammatory drug for treating cystic fibrosis
J Pharmacol Exp Ther318, 803-809. PubMed Europe PubMed DOI
Chua,F. and Laurent,G.J.
Neutrophil elastase: mediator of extracellular matrix destruction and accumulation
Proc Am Thorac Soc3, 424-427. PubMed Europe PubMed DOI V
[YEAR:25-10-2006]Dell'Aica,I., Sartor,L., Galletti,P., Giacomini,D., Quintavalla,A., Calabrese,F., Giacometti,C., Brunetta,E., Piazza,F., Agostini,C. and Garbisa,S.
Inhibition of leukocyte elastase, polymorphonuclear chemoinvasion, and inflammation-triggered pulmonary fibrosis by a 4-alkyliden-beta-lactam with a galloyl moiety
J Pharmacol Exp Ther316, 539-546. PubMed Europe PubMed DOI I
Hrenn,A., Steinbrecher,T., Labahn,A., Schwager,J., Schempp,C.M. and Merfort,I.
Plant phenolics inhibit neutrophil elastase
Planta Med72, 1127-1131. PubMed Europe PubMed DOI I
Inoue,Y., Tanaka,H., Ogura,H., Ukai,I., Fujita,K., Hosotsubo,H., Shimazu,T. and Sugimoto,H.
A neutrophil elastase inhibitor, sivelestat, improves leukocyte deformability in patients with acute lung injury
J Trauma60, 936-943. PubMed Europe PubMed DOI I
[YEAR:6-10-2006]Ishihara,K., Yamaguchi,Y., Uchino,S., Furuhashi,T., Yamada,S., Kihara,S., Mori,K. and Ogawa,M.
ICAM-1 Signal transduction in cells stimulated with neutrophil elastase
Dig Dis Sci51, 2102-2112. PubMed Europe PubMed DOI I
[YEAR:21-3-2006]Kollner,I., Sodeik,B., Schreek,S., Heyn,H., von Neuhoff,N., Germeshausen,M., Zeidler,C., Kruger,M., Schlegelberger,B., Welte,K. and Beger,C.
Mutations in neutrophil elastase causing congenital neutropenia lead to cytoplasmic protein accumulation and induction of the unfolded protein response
Blood108, 493-500. PubMed Europe PubMed DOI M
Lombard,C., Arzel,L., Bouchu,D., Wallach,J. and Saulnier,J.
Human leukocyte elastase hydrolysis of peptides derived from human elastin exon 24
Biochimie88, 1915-1921. PubMed Europe PubMed DOI P
Martin,S.L., Downey,D., Bilton,D., Keogan,M.T., Edgar,J. and Elborn,J.S.
Safety and efficacy of recombinant alpha(1)-antitrypsin therapy in cystic fibrosis
Pediatr Pulmonol41, 177-183. PubMed Europe PubMed DOI
Morohoshi,Y., Matsuoka,K., Chinen,H., Kamada,N., Sato,T., Hisamatsu,T., Okamoto,S., Inoue,N., Takaishi,H., Ogata,H., Iwao,Y. and Hibi,T.
Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis
J Gastroenterol41, 318-324. PubMed Europe PubMed DOI I
Pham,C.T.
Neutrophil serine proteases: specific regulators of inflammation
Nat Rev Immunol6, 541-550. PubMed Europe PubMed DOI V
[YEAR:1-9-2006]Rescher,U., Goebeler,V., Wilbers,A. and Gerke,V.
Proteolytic cleavage of annexin 1 by human leukocyte elastase
Biochim Biophys Acta1763, 1320-1324. PubMed Europe PubMed DOI
Rykl,J., Thiemann,J., Kurzawski,S., Pohl,T., Gobom,J., Zidek,W. and Schluter,H.
Renal cathepsin G and angiotensin II generation
J Hypertens24, 1797-1807. PubMed Europe PubMed DOI
[YEAR:1-8-2006]Spencer,J.L., Stone,P.J. and Nugent,M.A.
New insights into the inhibition of human neutrophil elastase by heparin
Biochemistry45, 9104-9120. PubMed Europe PubMed DOI
[YEAR:26-7-2006]Tapper,H., Kallquist,L., Johnsson,E., Persson,A.M., Hansson,M. and Olsson,I.
Neutrophil elastase sorting involves plasma membrane trafficking requiring the C-terminal propeptide
Exp Cell Res312, 3471-3484. PubMed Europe PubMed DOI
Thomas,M., Jayandharan,G. and Chandy,M.
Molecular screening of the neutrophil elastase gene in congenital neutropenia
Indian Pediatr43, 1081-1084. PubMed Europe PubMed M
[YEAR:19-9-2006]Thusberg,J. and Vihinen,M.
Bioinformatic analysis of protein structure-function relationships: case study of leukocyte elastase (ELA2) missense mutations
Hum Mutat27, 1230-1243. PubMed Europe PubMed DOI M

2005

[YEAR:31-5-2005]Golden,J.W. and Schiff,L.A.
Neutrophil elastase, an acid-independent serine protease, facilitates reovirus uncoating and infection in U937 promonocyte cells
Virol J2, 48-48. PubMed Europe PubMed DOI
Gutschow,M., Pietsch,M., Themann,A., Fahrig,J. and Schulze,B.
2,4,5-Triphenylisothiazol-3 (2H)-one 1,1-dioxides as inhibitors of human leukocyte elastase
J Enzyme Inhib Med Chem20, 341-347. PubMed Europe PubMed DOI I
Hagio,T., Matsumoto,S., Nakao,S., Matsuoka,S. and Kawabata,K.
Sivelestat, a specific neutrophil elastase inhibitor, prevented phorbol myristate acetate-induced acute lung injury in conscious rabbits
Pulm Pharmacol Ther18, 285-290. PubMed Europe PubMed DOI I
Hoshi,K., Kurosawa,S., Kato,M., Andoh,K., Satoh,D. and Kaise,A.
Sivelestat, a neutrophil elastase inhibitor, reduces mortality rate of critically ill patients
Tohoku J Exp Med207, 143-148. PubMed Europe PubMed DOI I
Kotake,Y., Yamamoto,M., Matsumoto,M., Morisaki,H. and Takeda,J.
Sivelestat, a neutrophil elastase inhibitor, attenuates neutrophil priming after hepatoenteric ischemia in rabbits
Shock23, 156-160. PubMed Europe PubMed DOI I
[YEAR:22-4-2005]Kuwahara,I., Lillehoj,E.P., Hisatsune,A., Lu,W., Isohama,Y., Miyata,T. and Kim,K.C.
Neutrophil elastase stimulates MUC1 gene expression through increased Sp1 binding to the MUC1 promoter
Am J Physiol Lung Cell Mol Physiol289, L355-L362. PubMed Europe PubMed DOI
Lane,A.A. and Ley,T.J.
Neutrophil elastase is important for PML-retinoic acid receptor alpha activities in early myeloid cells
Mol Cell Biol25, 23-33. PubMed Europe PubMed DOI
[YEAR:18-1-2005]Massullo,P., Druhan,L.J., Bunnell,B.A., Hunter,M.G., Robinson,J.M., Marsh,C.B. and Avalos,B.R.
Aberrant subcellular targeting of the G185R neutrophil elastase mutant associated with severe congenital neutropenia induces premature apoptosis of differentiating promyelocytes
Blood105, 3397-3404. PubMed Europe PubMed DOI M
Mayerle,J., Schnekenburger,J., Kruger,B., Kellermann,J., Ruthenburger,M., Weiss,F.U., Nalli,A., Domschke,W. and Lerch,M.M.
Extracellular cleavage of E-cadherin by leukocyte elastase during acute experimental pancreatitis in rats
Gastroenterology129, 1251-1267. PubMed Europe PubMed DOI
[YEAR:28-7-2005]Moreira,R., Santana,A.B., Iley,J., Neres,J., Douglas,K.T., Horton,P.N. and Hursthouse,M.B.
Design, synthesis, and enzymatic evaluation of N1-acyloxyalkyl- and N1-oxazolidin-2,4-dion-5-yl-substituted beta-lactams as novel inhibitors of human leukocyte elastase
J Med Chem48, 4861-4870. PubMed Europe PubMed DOI I
Ohbayashi,H.
Current synthetic inhibitors of human neutrophil elastase in 2005
Expert Opin Ther Pat15, 759-771. V I
[YEAR:22-2-2005]Ryu,O.H., Choi,S.J., Firatli,E., Choi,S.W., Hart,P.S., Shen,R.F., Wang,G., Wu,W.W. and Hart,T.C.
Proteolysis of macrophage inflammatory protein-1alpha isoforms LD78beta and LD78alpha by neutrophil-derived serine proteases
J Biol Chem280, 17415-17421. PubMed Europe PubMed DOI P
Takai,S., Kimura,K., Nagaki,M., Satake,S., Kakimi,K. and Moriwaki,H.
Blockade of neutrophil elastase attenuates severe liver injury in hepatitis B transgenic mice
J Virol79, 15142-15150. PubMed Europe PubMed DOI
[YEAR:1-5-2005]Wang,S., Dangerfield,J.P., Young,R.E. and Nourshargh,S.
PECAM-1, alpha6 integrins and neutrophil elastase cooperate in mediating neutrophil transmigration
J Cell Sci118, 2067-2076. PubMed Europe PubMed DOI
[YEAR:1-7-2005]Wittamer,V., Bondue,B., Guillabert,A., Vassart,G., Parmentier,M. and Communi,D.
Neutrophil-mediated maturation of chemerin: a link between innate and adaptive immunity
J Immunol175, 487-493. PubMed Europe PubMed

2004

[Anon]
Elastase inhibitors
Expert Opin Ther Pat14, 1511-1516. V I
[YEAR:1-1-2004]Beaufort,N., Leduc,D., Rousselle,J.C., Magdolen,V., Luther,T., Namane,A., Chignard,M. and Pidard,D.
Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G
J Immunol172, 540-549. PubMed Europe PubMed
Bieth,J.G.
Leukocyte elastase
[ISSN:0-12-079610-4]2, 1517-1523. V
Chughtai,B. and O'Riordan,T.G.
Potential role of inhibitors of neutrophil elastase in treating diseases of the airway
J Aerosol Med17, 289-298. PubMed Europe PubMed DOI I
Duan,Z., Li,F.Q., Wechsler,J., Meade-White,K., Williams,K., Benson,K.F. and Horwitz,M.
A novel notch protein, N2N, targeted by neutrophil elastase and implicated in hereditary neutropenia
Mol Cell Biol24, 58-70. PubMed Europe PubMed DOI
[YEAR:21-8-2004]Gleeson,M.P., Hillier,I.H. and Burton,N.A.
Theoretical analysis of peptidyl alpha-ketoheterocyclic inhibitors of human neutrophil elastase: insight into the mechanism of inhibition and the application of QM/MM calculations in structure-based drug design
Org Biomol Chem2, 2275-2280. PubMed Europe PubMed DOI I
[YEAR:17-10-2004]Hirche,T.O., Atkinson,J.J., Bahr,S. and Belaaouaj,A.
Deficiency in neutrophil elastase does not impair neutrophil recruitment to inflamed sites
Am J Respir Cell Mol Biol30, 576-584. PubMed Europe PubMed DOI K
Hirota,Y., Suzuki,M., Yamaguchi,K., Fujita,T. and Katsube,N.
Effects of the neutrophil elastase inhibitor (ONO-6818) on acetic acid induced colitis in Syrian hamsters
J Vet Med Sci66, 1223-1228. PubMed Europe PubMed DOI I
Horwitz,M., Benson,K.F., Duan,Z., Li,F.Q. and Person,R.E.
Hereditary neutropenia: dogs explain human neutrophil elastase mutations
Trends Mol Med10, 163-170. PubMed Europe PubMed DOI K
[YEAR:23-12-2004]Korkmaz,B., Attucci,S., Moreau,T., Godat,E., Juliano,L. and Gauthier,F.
Design and use of highly specific substrates of neutrophil elastase and proteinase 3
Am J Respir Cell Mol Biol30, 801-807. PubMed Europe PubMed DOI P
[YEAR:15-9-2004]Lai,Z., Gan,X., Wei,L., Alliston,K.R., Yu,H., Li,Y.H. and Groutas,W.C.
Potent inhibition of human leukocyte elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamide derivatives
Arch Biochem Biophys429, 191-197. PubMed Europe PubMed DOI
[YEAR:1-1-2004]Lopez-Boado,Y.S., Espinola,M., Bahr,S. and Belaaouaj,A.
Neutrophil serine proteinases cleave bacterial flagellin, abrogating its host response-inducing activity
J Immunol172, 509-515. PubMed Europe PubMed
[YEAR:12-2-2004]Maryanoff,B.E.
Inhibitors of serine proteases as potential therapeutic agents: the road from thrombin to tryptase to cathepsin G
J Med Chem47, 769-787. PubMed Europe PubMed DOI I
Pochet,L., Frederick,R. and Masereel,B.
Coumarin and isocoumarin as serine protease inhibitors
Curr Pharm Des10, 3781-3796. PubMed Europe PubMed DOI I
[YEAR:5-1-2004]Sturrock,A., Franklin,K.F., Norman,K. and Hoidal,J.R.
Human leukocyte elastase gene expression is regulated by PU.1 in conjunction with closely associated cytidine-rich and Myb binding sites
Biochim Biophys Acta1676, 104-111. PubMed Europe PubMed DOI
Tamakuma,S., Ogawa,M., Aikawa,N., Kubota,T., Hirasawa,H., Ishizaka,A., Taenaka,N., Hamada,C., Matsuoka,S. and Abiru,T.
Relationship between neutrophil elastase and acute lung injury in humans
Pulm Pharmacol Ther17, 271-279. PubMed Europe PubMed DOI I
Tralau,T., Meyer-Hoffert,U., Schroder,J.M. and Wiedow,O.
Human leukocyte elastase and cathepsin G are specific inhibitors of C5a-dependent neutrophil enzyme release and chemotaxis
Exp Dermatol13, 316-325. PubMed Europe PubMed DOI
[YEAR:23-7-2004]Voynow,J.A., Fischer,B.M., Malarkey,D.E., Burch,L.H., Wong,T., Longphre,M., Ho,S.B. and Foster,W.M.
Neutrophil elastase induces mucus cell metaplasia in mouse lung
Am J Physiol Lung Cell Mol Physiol287, L1293-L1302. PubMed Europe PubMed DOI
[YEAR:1-9-2004]Wei,L., Lai,Z., Gan,X., Alliston,K.R., Zhong,J., Epp,J.B., Tu,J., Perera,A.B., Van Stipdonk,M. and Groutas,W.C.
Mechanism-based inactivation of human leukocyte elastase via an enzyme-induced sulfonamide fragmentation process
Arch Biochem Biophys429, 60-70. PubMed Europe PubMed DOI I
[YEAR:1-4-2004]Young,R.E., Thompson,R.D., Larbi,K.Y., La,M., Roberts,C.E., Shapiro,S.D., Perretti,M. and Nourshargh,S.
Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo
J Immunol172, 4493-4502. PubMed Europe PubMed K
[YEAR:1-2-2004]Zhong,J., Gan,X., Alliston,K.R. and Groutas,W.C.
Design, synthesis, and in vitro evaluation of inhibitors of human leukocyte elastase based on a functionalized cyclic sulfamide scaffold
Bioorg Med Chem12, 589-593. PubMed Europe PubMed DOI I

2003

Becker,M., Franz,G. and Alban,S.
Inhibition of PMN-elastase activity by semisynthetic glucan sulfates
Thromb Haemost89, 915-925. PubMed Europe PubMed DOI
[YEAR:7-2-2003]Bidouard,J.P., Duval,N., Kapui,Z., Herbert,J.M., O'Connor,S.E. and Janiak,P.
SSR69071, an elastase inhibitor, reduces myocardial infarct size following ischemia-reperfusion injury
Eur J Pharmacol461, 49-52. PubMed Europe PubMed DOI I
[YEAR:5-6-2003]Devaney,J.M., Greene,C.M., Taggart,C.C., Carroll,T.P., O'Neill,S.J. and McElvaney,N.G.
Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4
FEBS Lett544, 129-132. PubMed Europe PubMed DOI
Fischer,B.M., Cuellar,J.G., Diehl,M.L., deFreytas,A.M., Zhang,J., Carraway,K.L. and Voynow,J.A.
Neutrophil elastase increases MUC4 expression in normal human bronchial epithelial cells
Am J Physiol Lung Cell Mol Physiol284, L671-L679. PubMed Europe PubMed DOI
[YEAR:23-10-2003]Gasparini,C., Menegazzi,R., Patriarca,P. and Dri,P.
Evidence that elastase is the TNF-R75 shedding enzyme in resting human polymorphonuclear leukocytes
FEBS Lett553, 360-364. PubMed Europe PubMed DOI
[YEAR:18-4-2003]Hermant,B., Bibert,S., Concord,E., Dublet,B., Weidenhaupt,M., Vernet,T. and Gulino-Debrac,D.
Identification of proteases involved in the proteolysis of vascular endothelium cadherin during neutrophil transmigration
J Biol Chem278, 14002-14012. PubMed Europe PubMed DOI
Horwitz,M., Li,F.Q., Albani,D., Duan,Z., Person,R.E., Meade-White,K. and Benson,K.F.
Leukemia in severe congenital neutropenia: defective proteolysis suggests new pathways to malignancy and opportunities for therapy
Cancer Invest21, 579-587. PubMed Europe PubMed DOI
Kapui,Z., Varga,M., Urban-Szabo,K., Mikus,E., Szabo,T., Szeredi,J., Batori,S., Finance,O. and Aranyi,P.
Biochemical and pharmacological characterization of 2-(9-(2-piperidinoethoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yloxymethyl)-4-(1-methylethyl)-6-methoxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide (SSR69071), a novel, orally active elastase inhibitor
J Pharmacol Exp Ther305, 451-459. PubMed Europe PubMed DOI I
[YEAR:31-10-2003]Lane,A.A. and Ley,T.J.
Neutrophil elastase cleaves PML-RARalpha and is important for the development of acute promyelocytic leukemia in mice
Cell115, 305-318. PubMed Europe PubMed DOI
Varga,M., Kapui,Z., Batori,S., Nagy,L.T., Vasvari-Debreczy,L., Mikus,E., Urban-Szabo,K. and Aranyi,P.
A novel orally active inhibitor of HLE
Eur J Med Chem38, 421-425. PubMed Europe PubMed DOI I

2002

Belaaouaj,A.
Neutrophil elastase-mediated killing of bacteria: lessons from targeted mutagenesis
Microbes Infect4, 1259-1264. PubMed Europe PubMed DOI
[YEAR:1-11-2002]Grenda,D.S., Johnson,S.E., Mayer,J.R., McLemore,M.L., Benson,K.F., Horwitz,M. and Link,D.C.
Mice expressing a neutrophil elastase mutation derived from patients with severe congenital neutropenia have normal granulopoiesis
Blood100, 3221-3228. PubMed Europe PubMed DOI
Ishii,K., Ito,Y., Katagiri,H., Matsumoto,Y., Kakita,A. and Majima,M.
Neutrophil elastase inhibitor attenuates lipopolysaccharide-induced hepatic microvascular dysfunction in mice
Shock18, 163-168. PubMed Europe PubMed I
Kawamura,T., Okada,N. and Okada,H.
Elastase from activated human neutrophils activates procarboxypeptidase R
Microbiol Immunol46, 225-230. PubMed Europe PubMed
Kohri,K., Ueki,I.F. and Nadel,J.A.
Neutrophil elastase induces mucin production by ligand-dependent epidermal growth factor receptor activation
Am J Physiol Lung Cell Mol Physiol283, L531-L540. PubMed Europe PubMed DOI
[YEAR:18-10-2002]Korkmaz,B., Attucci,S., Hazouard,E., Ferrandiere,M., Jourdan,M.L., Brillard-Bourdet,M., Juliano,L. and Gauthier,F.
Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates
J Biol Chem277, 39074-39081. PubMed Europe PubMed DOI A
[YEAR:15-8-2002]Kuraki,T., Ishibashi,M., Takayama,M., Shiraishi,M. and Yoshida,M.
A novel oral neutrophil elastase inhibitor (ONO-6818) inhibits human neutrophil elastase-induced emphysema in rats
Am J Respir Crit Care Med166, 496-500. PubMed Europe PubMed DOI I
[YEAR:29-8-2002]Macdonald,S.J., Dowle,M.D., Harrison,L.A., Clarke,G.D., Inglis,G.G., Johnson,M.R., Shah,P., Smith,R.A., Amour,A., Fleetwood,G., Humphreys,D.C., Molloy,C.R., Dixon,M., Godward,R.E., Wonacott,A.J., Singh,O.M., Hodgson,S.T. and Hardy,G.W.
Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151)
J Med Chem45, 3878-3890. PubMed Europe PubMed DOI S I
[YEAR:2-9-2002]Nakayama,Y., Odagaki,Y., Fujita,S., Matsuoka,S., Hamanaka,N., Nakai,H. and Toda,M.
Clarification of mechanism of human sputum elastase inhibition by a new inhibitor, ONO-5046, using electrospray ionization mass spectrometry
Bioorg Med Chem Lett12, 2349-2353. PubMed Europe PubMed DOI I
Nemoto,E., Tada,H. and Shimauchi,H.
Disruption of CD40/CD40 ligand interaction with cleavage of CD40 on human gingival fibroblasts by human leukocyte elastase resulting in down-regulation of chemokine production
J Leukoc Biol72, 538-545. PubMed Europe PubMed
[YEAR:1-1-2002]Ramaha,A. and Patston,P.A.
Release and degradation of angiotensin I and angiotensin II from angiotensinogen by neutrophil serine proteinases
Arch Biochem Biophys397, 77-83. PubMed Europe PubMed DOI
Rogalski,C., Meyer-Hoffert,U., Proksch,E. and Wiedow,O.
Human leukocyte elastase induces keratinocyte proliferation in vitro and in vivo
J Invest Dermatol118, 49-54. PubMed Europe PubMed DOI
[YEAR:25-2-2002]Sato,F., Inoue,Y., Omodani,T., Imano,K., Okazaki,H., Takemura,T. and Komiya,M.
Design and synthesis of peptide-based carboxylic acid-containing transition-state inhibitors of human neutrophil elastase
Bioorg Med Chem Lett12, 551-555. PubMed Europe PubMed DOI I
Shapiro,S.D.
Neutrophil elastase: path clearer, pathogen killer, or just pathologic?
Am J Respir Cell Mol Biol26, 266-268. PubMed Europe PubMed DOI
Tremblay,G.M., Vachon,E., Larouche,C. and Bourbonnais,Y.
Inhibition of human neutrophil elastase-induced acute lung injury in hamsters by recombinant human pre-elafin (trappin-2)
Chest121, 582-588. PubMed Europe PubMed DOI
[YEAR:2-5-2002]Weinrauch,Y., Drujan,D., Shapiro,S.D., Weiss,J. and Zychlinsky,A.
Neutrophil elastase targets virulence factors of enterobacteria
Nature417, 91-94. PubMed Europe PubMed DOI

2001

[YEAR:1-11-2001]Ancliff,P.J., Gale,R.E., Liesner,R., Hann,I.M. and Linch,D.C.
Mutations in the ELA2 gene encoding neutrophil elastase are present in most patients with sporadic severe congenital neutropenia but only in some patients with the familial form of the disease
Blood98, 2645-2650. PubMed Europe PubMed DOI M
Aprikyan,A.A. and Dale,D.C.
Mutations in the neutrophil elastase gene in cyclic and congenital neutropenia
Curr Opin Immunol13, 535-538. PubMed Europe PubMed DOI
[YEAR:23-4-2001]Clemente,A., Domingos,A., Grancho,A.P., Iley,J., Moreira,R., Neres,J., Palma,N., Santana,A.B. and Valente,E.
Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors
Bioorg Med Chem Lett11, 1065-1068. PubMed Europe PubMed DOI I
Cumashi,A., Ansuini,H., Celli,N., De Blasi,A., O'Brien,P.J., Brass,L.F. and Molino,M.
Neutrophil proteases can inactivate human PAR3 and abolish the co-receptor function of PAR3 on murine platelets
Thromb Haemost85, 533-538. PubMed Europe PubMed
Germeshausen,M., Schulze,H., Ballmaier,M., Zeidler,C. and Welte,K.
Mutations in the gene encoding neutrophil elastase (ELA2) are not sufficient to cause the phenotype of congenital neutropenia
Br J Haematol115, 222-224. PubMed Europe PubMed DOI
[YEAR:1-9-2001]Lee,W.L. and Downey,G.P.
Leukocyte elastase: physiological functions and role in acute lung injury
Am J Respir Crit Care Med164, 896-904. PubMed Europe PubMed DOI
[YEAR:27-4-2001]Li,F.Q. and Horwitz,M.
Characterization of mutant neutrophil elastase in severe congenital neutropenia
J Biol Chem276, 14230-14241. PubMed Europe PubMed DOI
[YEAR:9-4-2001]Macdonald,S.J., Dowle,M.D., Harrison,L.A., Shah,P., Johnson,M.R., Inglis,G.G., Clarke,G.D., Smith,R.A., Humphreys,D., Molloy,C.R., Amour,A., Dixon,M., Murkitt,G., Godward,R.E., Padfield,T., Skarzynski,T., Singh,O.M., Kumar,K.A., Fleetwood,G., Hodgson,S.T., Hardy,G.W. and Finch,H.
The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase - GW311616A a development candidate
Bioorg Med Chem Lett11, 895-898. PubMed Europe PubMed DOI I
[YEAR:22-1-2001]Macdonald,S.J.F., Dowle,M.D., Harrison,L.A., Spooner,J.E., Shah,P., Johnson,M.R., Inglis,G.G.A., Clarke,G.D.E., Belton,D.J., Smith,R.A., Molloy,C.R., Dixon,M., Murkitt,G., Godward,R.E., Skarzynski,T., Singh,O.M.P., Kumar,K.A., Hodgson,S.T., McDonald,E., Hardy,G.W., Finch,H., Humphreys,D.C. and Fleetwood,G.
Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine-trans-lactams
Bioorg Med Chem Lett11, 243-246. PubMed Europe PubMed DOI
Odagaki,Y., Ohmoto,K., Matsuoka,S., Hamanaka,N., Nakai,H., Toda,M. and Katsuya,Y.
The crystal structure of the complex of non-peptidic inhibitor of human neutrophil elastase ONO-6818 and porcine pancreatic elastase
Bioorg Med Chem9, 647-651. PubMed Europe PubMed DOI S I
Ohmoto,K., Okuma,M., Yamamoto,T., Kijima,H., Sekioka,T., Kitagawa,K., Yamamoto,S., Tanaka,K., Kawabata,K., Sakata,A., Imawaka,H., Nakai,H. and Toda,M.
Design and synthesis of new orally active inhibitors of human neutrophil elastase
Bioorg Med Chem9, 1307-1323. PubMed Europe PubMed DOI I
Rodis,N.P. and Digenis,G.A.
Synthesis and in-vitro evaluation of novel low molecular weight thiocarbamates as inhibitors of human leukocyte elastase
J Enzyme Inhib16, 95-105. PubMed Europe PubMed I
Yamashita,S., Suzuki,A., Yanagita,T., Hirohata,S. and Toyoshima,S.
Characterization of a protease responsible for truncated actin increase in neutrophils of patients with Behcet's disease
Biol Pharm Bull24, 119-122. PubMed Europe PubMed DOI P

2000

[YEAR:1-10-2000]Dale,D.C., Person,R.E., Bolyard,A.A., Aprikyan,A.G., Bos,C., Bonilla,M.A., Boxer,L.A., Kannourakis,G., Zeidler,C., Welte,K., Benson,K.F. and Horwitz,M.
Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia
Blood96, 2317-2322. PubMed Europe PubMed K
[YEAR:5-7-2000]Harris,J.L., Backes,B.J., Leonetti,F., Mahrus,S., Ellman,J.A. and Craik,C.S.
Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries
Proc Natl Acad Sci U S A97, 7754-7759. PubMed Europe PubMed DOI P
Kawabata,K., Hagio,T., Matsumoto,S., Nakao,S., Orita,S., Aze,Y. and Ohno,H.
Delayed neutrophil elastase inhibition prevents subsequent progression of acute lung injury induced by endotoxin inhalation in hamsters
Am J Respir Crit Care Med161, 2013-2018. PubMed Europe PubMed
Kuang,R., Epp,J.B., Ruan,S., Chong,L.S., Venkataraman,R., Tu,J., He,S., Truong,T.M. and Groutas,W.C.
Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates
Bioorg Med Chem8, 1005-1016. PubMed Europe PubMed DOI I
Liu,Z., Shapiro,S.D., Zhou,X., Twining,S.S., Senior,R.M., Giudice,G.J., Fairley,J.A. and Diaz,L.A.
A critical role for neutrophil elastase in experimental bullous pemphigoid
J Clin Invest105, 113-123. PubMed Europe PubMed DOI
Macchia,B., Gentili,D., Macchia,M., Mamone,F., Martinelli,A., Orlandini,E., Rossello,A., Cercignani,G., Pierotti,R., Allegretti,M., Asti,C. and Caselli,G.
Synthesis, inhibitory activity towards human leukocyte elastase and molecular modelling studies of 1-carbamoyl-4-methyleneaminoxyazetidinones
Eur J Med Chem35, 53-67. PubMed Europe PubMed DOI I
Pochet,L., Doucet,C., Dive,G., Wouters,J., Masereel,B., Reboud-Ravaux,M. and Pirotte,B.
Coumarinic derivatives as mechanism-based inhibitors of alpha-chymotrypsin and human leukocyte elastase
Bioorg Med Chem8, 1489-1501. PubMed Europe PubMed DOI I
Poorafshar,M., Aveskogh,M., Munday,B. and Hellman,L.
Identification and structural analysis of four serine proteases in a monotreme, the platypus, Ornithorhynchus anatinus
Immunogenetics52, 19-28. PubMed Europe PubMed DOI
Tkalcevic,J., Novelli,M., Phylactides,M., Iredale,J.P., Segal,A.W. and Roes,J.
Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G
Immunity12, 201-210. PubMed Europe PubMed K
Valueva,T.A., Revina,T.A., Mosolov,V.V. and Mentele,R.
Primary structure of potato Kunitz-type serine proteinase inhibitor
Biol Chem381, 1215-1221. PubMed Europe PubMed DOI

1999

[YEAR:30-12-1999]Gutschow,M., Kuerschner,L., Neumann,U., Pietsch,M., Loser,R., Koglin,N. and Eger,K.
2-(diethylamino)thieno1,3oxazin-4-ones as stable inhibitors of human leukocyte elastase
J Med Chem42, 5437-5447. PubMed Europe PubMed DOI I
Horwitz,M., Benson,K.F., Person,R.E., Aprikyan,A.G. and Dale,D.C.
Mutations in ELA2, encoding neutrophil elastase, define a 21-day biological clock in cyclic haematopoiesis
Nat Genet23, 433-436. PubMed Europe PubMed DOI K
McBride,J.D., Freeman,H.N. and Leatherbarrow,R.J.
Selection of human elastase inhibitors from a conformationally constrained combinatorial peptide library
Eur J Biochem266, 403-412. PubMed Europe PubMed DOI
Mitsuhashi,H., Nonaka,T., Hamamura,I., Kishimoto,T., Muratani,E. and Fujii,K.
Pharmacological activities of TEI-8362, a novel inhibitor of human neutrophil elastase
Br J Pharmacol126, 1147-1152. PubMed Europe PubMed DOI I
Nakanishi,I., Kinoshita,T., Tada,T., Fujita,T., Hatanaka,H. and Sato,A.
Molecular structure of FR901277, a novel inhibitor of human leukocyte elastase, and its binding mode simulation
Bioorg Med Chem Lett9, 2397-2402. PubMed Europe PubMed DOI I
[YEAR:1-12-1999]Wong,E.T., Jenne,D.E., Zimmer,M., Porter,S.D. and Gilks,C.B.
Changes in chromatin organization at the neutrophil elastase locus associated with myeloid cell differentiation
Blood94, 3730-3736. PubMed Europe PubMed

1998

Belaaouaj,A., McCarthy,R., Baumann,M., Gao,Z., Ley,T.J., Abraham,S.N. and Shapiro,S.D.
Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis
Nat Med4, 615-618. PubMed Europe PubMed DOI K
Cregge,R.J., Durham,S.L., Farr,R.A., Gallion,S.L., Hare,C.M., Hoffman,R.V., Janusz,M.J., Kim,H.O., Koehl,J.R., Mehdi,S., Metz,W.A., Peet,N.P., Pelton,J.T., Schreuder,H.A., Sunder,S. and Tardif,C.
Inhibition of human neutrophil elastase. 4. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of P2-modified, orally active peptidyl pentafluoroethyl ketones
J Med Chem41, 2461-2480. PubMed Europe PubMed DOI I
Garcia,R., Gusmani,L., Murgia,R., Guarnaccia,C., Cinco,M. and Rottini,G.
Elastase is the only human neutrophil granule protein that alone is responsible for in vitro killing of Borrelia burgdorferi
Infect Immun66, 1408-1412. PubMed Europe PubMed
[YEAR:7-5-1998]Gutschow,M. and Neumann,U.
Novel thieno[2,3-d][1,3]oxazin-4-ones as inhibitors of human leukocyte elastase
J Med Chem41, 1729-1740. PubMed Europe PubMed DOI I
[YEAR:1-3-1998]Kafienah,W., Buttle,D.J., Burnett,D. and Hollander,A.P.
Cleavage of native type I collagen by human neutrophil elastase
Biochem J330, 897-902. PubMed Europe PubMed
Samis,J.A., Kam,E., Nesheim,M.E. and Giles,A.R.
Neutrophil elastase cleavage of human factor IX generates an activated factor IX-like product devoid of coagulant function
Blood92, 1287-1296. PubMed Europe PubMed
Sturrock,A., Franklin,K.F., Wu,S. and Hoidal,J.R.
Characterization and localization of the genes for mouse proteinase-3 (Prtn3) and neutrophil elastase (Ela2)
Cytogenet Cell Genet83, 104-108. PubMed Europe PubMed

1997

Andisik,D., Bernstein,P., Brown,F., Bryant,C., Ceccarelli,C., Damewood,J., Edwards,P., Feeney,S., Gomes,B., Green,R., Kosmider,B., Shaw,A., Steelman,G., Thomas,R., Tuthill,P., Vacek,E., Veale,C., Warner,P., Williams,J., Wolanin,D. and Woolson,S.
Computer-aided design of novel inhibitors of human leukocyte elastase
Pharmacochem Libr28, 499-509. DOI I
Cook,L., Knight,K.R., Burdon,J.G.W., Brenton,S. and Hunt,J.M.
Function of a rare variant of alpha-1-antitrypsin, phenotype Pi E(Franklin) S, a poor inhibitor of human neutrophil elastase
Res Exp Med (Berl)196, 355-362. PubMed Europe PubMed DOI M
Edelstein,C., Italia,J.A. and Scanu,A.M.
Polymorphonuclear cells isolated from human peripheral blood cleave lipoprotein(a) and apolipoprotein(a) at multiple interkringle sites via the enzyme elastase. Generation of mini-Lp(a) particles and apo(a) fragments
J Biol Chem272, 11079-11087. PubMed Europe PubMed DOI
Rees,D.D., Brain,J.D., Wohl,M.E., Humes,J.L. and Mumford,R.A.
Inhibition of neutrophil elastase in CF sputum by L-658,758
J Pharmacol Exp Ther283, 1201-1206. PubMed Europe PubMed I
Samis,J.A., Garrett,M., Manuel,R.P., Nesheim,M.E. and Giles,A.R.
Human neutrophil elastase activates human factor V but inactivates thrombin-activated human factor V
Blood90, 1065-1074. PubMed Europe PubMed
Veale,C.A., Bernstein,P.R., Bohnert,C.M., Brown,F.J., Bryant,C., Damewood,J.R., Jr., Earley,R., Feeney,S.W., Edwards,P.D., Gomes,B., Hulsizer,J.M., Kosmider,B.J., Krell,R.D., Moore,G., Salcedo,T.W., Shaw,A., Silberstein,D.S., Steelman,G.B., Stein,M., Strimpler,A., Thomas,R.M., Vacek,E.P., Williams,J.C., Wolanin,D.J. and Woolson,S.
Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase
J Med Chem40, 3173-3181. PubMed Europe PubMed DOI I

1996

Groutas,W.C., Epp,J.B., Venkataraman,R., Kuang,R., Truong,T.M., McClenahan,J.J. and Prakash,O.
Design, synthesis, and in vitro inhibitory activity toward human leukocyte elastase, cathepsin G, and proteinase 3 of saccharin-derived sulfones and congeners
Bioorg Med Chem4, 1393-1400. PubMed Europe PubMed DOI I
Vincent,S.H., Painter,S.K., Krieter,P.A., Colletti,A.E., Lyszack,E., Rosegay,A., Dean,D., Luffer-Atlas,D., Miller,R.R., Cioffe,C. and Chiu,S.H.
Orally active inhibitors of human leukocyte elastase. I. Disposition of L-683,845 in rats and rhesus monkeys
Drug Metab Dispos24, 1369-1377. PubMed Europe PubMed I

1995

[YEAR:20-1-1995]Allen,D.H. and Tracy,P.B.
Human coagulation factor V is activated to the functional cofactor by elastase and cathepsin G expressed at the monocyte surface
J Biol Chem270, 1408-1415. PubMed Europe PubMed DOI
Bernstein,P.R., Gomes,B.C., Kosmider,B.J., Vacek,E.P. and Williams,J.C.
Nonpeptidic inhibitors of human leukocyte elastase. 6. Design of a potent, intratracheally active, pyridone-based trifluoromethyl ketone
J Med Chem38, 212-215. PubMed Europe PubMed I
[YEAR:28-4-1995]Desai,R.C., Court,J.C., Ferguson,E., Gordon,R.J., Hlasta,D.J., Dunlap,R.P. and Franke,C.A.
Phosphonates and phosphinates: novel leaving groups for benzisothiazolone inhibitors of human leukocyte elastase
J Med Chem38, 1571-1574. PubMed Europe PubMed I
Edwards,P.D., Wolanin,D.J., Andisik,D.W. and Davis,M.W.
Peptidyl alpha-ketoheterocyclic inhibitors of human neutrophil elastase. 2. Effect of varying the heterocyclic ring on in vitro potency
J Med Chem38, 76-85. PubMed Europe PubMed DOI I
[YEAR:23-6-1995]Finke,P.E., Shah,S.K., Fletcher,D.S., Ashe,B.M., Brause,K.A., Chandler,G.O., Dellea,P.S., Hand,K.M., Maycock,A.L. and Osinga,D.G.
Orally active beta-lactam inhibitors of human leukocyte elastase. 3. Stereospecific synthesis and structure-activity relationships for 3,3-dialkylazetidin-2-ones
J Med Chem38, 2449-2462. PubMed Europe PubMed DOI I
Groutas,W.C., Brubaker,M.J., Chong,L.S., Venkataraman,R., Huang,H., Epp,J.B., Kuang,R. and Hoidal,J.R.
Design, synthesis and biological evaluation of succinimide derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3
Bioorg Med Chem3, 375-381. PubMed Europe PubMed DOI I
Itoh,Y. and Nagase,H.
Preferential inactivation of tissue inhibitor of metalloproteinases-1 that is bound to the precursor of matrix metalloproteinase 9 (progelatinase B) by human neutrophil elastase
J Biol Chem270, 16518-16521. PubMed Europe PubMed DOI
Kerrigan,J.E., Oleksyszyn,J., Kam,C.M., Selzler,J. and Powers,J.C.
Mechanism-based isocoumarin inhibitors for human leukocyte elastase. Effect of the 7-amino substituent and 3-alkoxy group in 3-alkoxy-7-amino-4-chloroisocoumarins on inhibitory potency
J Med Chem38, 544-552. PubMed Europe PubMed DOI I
Szardenings,M., Vasel,B., Hecht,H.J., Collins,J. and Schomburg,D.
Highly effective protease inhibitors from variants of human pancreatic secretory trypsin inhibitor (hPSTI): an assessment of 3-D structure-based protein design
Protein Eng8, 45-52. PubMed Europe PubMed
[YEAR:7-11-1995]Underwood,D.J., Green,B.G., Chabin,R., Mills,S., Doherty,J.B., Finke,P.E., MacCoss,M., Shah,S.K., Burgey,C.S. and Dickinson,T.A.
Mechanism of inhibition of human leucocyte elastase by beta-lactams. 3. Use of electrospray ionization mass spectrometry and two-dimensional NMR techniques to identify beta-lactam-derived E-I complexes
Biochemistry34, 14344-14355. PubMed Europe PubMed DOI I
Veale,C.A., Bernstein,P.R., Bryant,C., Ceccarelli,C., Damewood,J.R., Jr., Earley,R., Feeney,S.W., Gomes,B., Kosmider,B.J., Steelman,G.B., Thomas,R.M., Vacek,E.P., Williams,J.C., Wolanin,D.J. and Woolson,S.
Nonpeptidic inhibitors of human leukocyte elastase. 5. Design, synthesis, and X-ray crystallography of a series of orally active 5-aminopyrimidin-6-one-containing trifluoromethyl ketones
J Med Chem38, 98-108. PubMed Europe PubMed DOI I
Veale,C.A., Damewood,J.R., Jr., Steelman,G.B., Bryant,C., Gomes,B. and Williams,J.
Non-peptidic inhibitors of human leukocyte elastase. 4. Design, synthesis, and in vitro and in vivo activity of a series of beta-carbolinone-containing trifluoromethyl ketones
J Med Chem38, 86-97. PubMed Europe PubMed DOI I

1994

Pulmonary-allergy, dermatological, gastrointestinal & arthritis: Betalactams as inhibitors of human leukocyte elastase
Expert Opin Ther Pat4, 1519-1522. DOI I
[YEAR:11-11-1994]Alpegiani,M., Bissolino,P., Corigli,R., Del Nero,S., Perrone,E., Rizzo,V., Sacchi,N., Cassinelli,G., Franceschi,G. and Baici,A.
Cephem sulfones as inactivators of human leukocyte elastase. 5. 7 alpha-methoxy- and 7 alpha-chloro-1,1-dioxocephem 4-ketones
J Med Chem37, 4003-4019. PubMed Europe PubMed DOI I
[YEAR:1-6-1994]Dubin,A., Potempa,J. and Travis,J.
Structural and functional characterization of elastases from horse neutrophils
Biochem J300, 401-406. PubMed Europe PubMed
Edwards,P.D. and Bernstein,P.R.
Synthetic inhibitors of elastase
Med Res Rev14, 127-194. PubMed Europe PubMed V I
Srikanth,S. and Rado,T.A.
A 30-base pair element is responsible for the myeloid-specific activity of the human neutrophil elastase promoter
J Biol Chem269, 32626-32633. PubMed Europe PubMed E

1993

[YEAR:1-9-1993]Anderssen,T., Halvorsen,H., Bajaj,S.P. and Osterud,B.
Human leukocyte elastase and cathepsin G inactivate factor VII by limited proteolysis
Thromb Haemost70, 414-417. PubMed Europe PubMed
Balduyck,M., Piva,F., Mizon,C., Maes,P., Malki,N., Gressier,B., Michalski,C. and Mizon,J.
Human leucocyte elastase (HLE) preferentially cleaves the heavy chain H2 of inter-alpha-trypsin inhibitor (ITI)
Biol Chem Hoppe Seyler374, 895-901. PubMed Europe PubMed
Groutas,W.C., Castrisos,J.C., Stanga,M.A., Kuang,R., Venkataraman,R., Epp,J.B., Brubaker,M.J. and Chong,L.S.
Heterocyclic inhibitors of human leukocyte elastase: 3-Hydroxypyridazopyrimidine, 3-hydroxypyridopyrimidine and 3-hydroxyquinazoline-2,4(1H,3H)dione derivatives
Bioorg Med Chem Lett3, 1163-1168. DOI I
[YEAR:19-3-1993]Hagmann,W.K., Kissinger,A.L., Shah,S.K., Finke,P.E., Dorn,C.P., Brause,K.A., Ashe,B.M., Weston,H., Maycock,A.L. and Knight,W.B.
Orally active beta-lactam inhibitors of human leukocyte elastase. 2. Effect of C-4 substitution
J Med Chem36, 771-777. PubMed Europe PubMed I
Uejima,Y., Kokubo,M., Oshida,J., Kawabata,H., Kato,Y. and Fujii,K.
5-Methyl-4H-3,1-benzoxazin-4-one derivatives: specific inhibitors of human leukocyte elastase
J Pharmacol Exp Ther265, 516-523. PubMed Europe PubMed I
[YEAR:23-2-1993]Ying,Q.L. and Simon,S.R.
Kinetics of the inhibition of human leukocyte elastase by elafin, a 6-kilodalton elastase-specific inhibitor from human skin
Biochemistry32, 1866-1874. PubMed Europe PubMed

1992

[YEAR:16-10-1992]Finke,P.E., Shah,S.K., Ashe,B.M., Ball,R.G., Blacklock,T.J., Bonney,R.J., Brause,K.A., Chandler,G.O., Cotton,M. and Davies,P.
Inhibition of human leukocyte elastase. 4. Selection of a substituted cephalosporin (L-658,758) as a topical aerosol
J Med Chem35, 3731-3744. PubMed Europe PubMed DOI I
Hernandez,M.A., Powers,J.C., Glinski,J., Oleksyszyn,J., Vijayalakshmi,J. and Meyer,E.F., Jr.
Effect of the 7-amino substituent on the inhibitory potency of mechanism-based isocoumarin inhibitors for porcine pancreatic and human neutrophil elastases: A 1.85-A X-ray structure of the complex between porcine pancreatic elastase and 7-[(N- tosylphenylalanyl)amino]-4-chloro-3-methoxyisocoumarin
J Med Chem35, 1121-1129. PubMed Europe PubMed S I
[YEAR:1-4-1992]Higuchi,D.A., Wun,T.C., Likert,K.M. and Broze,G.J., Jr.
The effect of leukocyte elastase on tissue factor pathway inhibitor
Blood79, 1712-1719. PubMed Europe PubMed P
[YEAR:8-9-1992]Knight,W.B., Green,B.G., Chabin,R.M., Gale,P., Maycock,A.L., Weston,H., Kuo,D.W., Westler,W.M., Dorn,C.P. and Finke,P.E.
Specificity, stability, and potency of monocyclic beta-lactam inhibitors of human leucocyte elastase
Biochemistry31, 8160-8170. PubMed Europe PubMed I
[YEAR:2-6-1992]Knight,W.B., Maycock,A.L., Green,B.G., Ashe,B.M., Gale,P., Weston,H., Finke,P.E., Hagmann,W.K., Shah,S.K. and Doherty,J.B.
Mechanism of inhibition of human leukocyte elastase by two cephalosporin derivatives
Biochemistry31, 4980-4986. PubMed Europe PubMed I
[YEAR:16-10-1992]Shah,S.K., Dorn,C.P., Jr., Finke,P.E., Hale,J.J., Hagmann,W.K., Brause,K.A., Chandler,G.O., Kissinger,A.L., Ashe,B.M. and Weston,H.
Orally active beta-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones
J Med Chem35, 3745-3754. PubMed Europe PubMed DOI I
Varga,Z., Saulnier,J., Hauck,M., Wallach,J.M. and Fulop,T., Jr.
Age-dependent variations of human PMNL elastase activity as a function of pH, ionic strength and calcium concentration
Arch Gerontol Geriatr14, 273-281. PubMed Europe PubMed

1991

Abrahamson,M., Buttle,D.J., Mason,R.W., Hansson,H., Grubb,A., Lilja,H. and Ohlsson,K.
Regulation of cystatin C activity by serine proteinases
Biomed Biochim Acta50, 587-593. PubMed Europe PubMed
Davies,P., Ashe,B.M., Bonney,R.J., Dorn,C., Finke,P., Fletcher,D., Hanlon,W.A., Humes,J.L., Maycock,A. and Mumford,R.A.
The discovery and biologic properties of cephalosporin-based inhibitors of PMN elastase
Ann N Y Acad Sci624, 219-229. PubMed Europe PubMed I
Eckle,I., Seitz,R., Egbring,R., Kolb,G. and Havemann,K.
Protein C degradation in vitro by neutrophil elastase
Biol Chem Hoppe Seyler372, 1007-1013. PubMed Europe PubMed
Frommherz,K.J., Faller,B. and Bieth,J.G.
Heparin strongly decreases the rate of inhibition of neutrophil elastase by alpha1-proteinase inhibitor
J Biol Chem266, 15356-15362. PubMed Europe PubMed
Green,B.G., Weston,H., Ashe,B.M., Doherty,J., Finke,P., Hagmann,W., Lark,M., Mao,J., Maycock,A., Moore,V., Mumford,R., Shah,S., Walakovits,L. and Knight,W.B.
PMN elastases: a comparison of the specificity of human isozymes and the enzyme from other species toward substrates and inhibitors
Arch Biochem Biophys286, 284-292. PubMed Europe PubMed P
Janusz,M.J. and Doherty,N.S.
Degradation of cartilage matrix proteoglycan by human neutrophils involves both elastase and cathepsin G
J Immunol146, 3922-3928. PubMed Europe PubMed
[YEAR:14-6-1991]Kawabata,K., Suzuki,M., Sugitani,M., Imaki,K., Toda,M. and Miyamoto,T.
ONO-5046, a novel inhibitor of human neutrophil elastase
Biochem Biophys Res Commun177, 814-820. PubMed Europe PubMed I
Salvesen,G. and Enghild,J.J.
Zymogen activation specificity and genomic structures of human neutrophil elastase and cathepsin G reveal a new branch of the chymotrypsinogen superfamily of serine proteinases
Biomed Biochim Acta50, 665-671. PubMed Europe PubMed
Wakselman,M., Joyeau,R., Kobaiter,R., Boggetto,N., Vergely,I., Maillard,J., Okochi,V., Montagne,J.J. and Reboud-Ravaux,M.
Functionalized N-aryl azetidinones as novel mechanism- based inhibitors of neutrophil elastase
FEBS Lett282, 377-381. PubMed Europe PubMed DOI I
Williams,J.C., Stein,R.L., Strimpler,A.M., Reaves,B. and Krell,R.D.
Biochemical and pharmacological characterization of ICI 186,756: a novel, potent, and selective inhibitor of human neutrophil elastase
Exp Lung Res17, 725-741. PubMed Europe PubMed I
Ying,Q.L., Rinehart,A.R., Simon,S.R. and Cheronis,J.C.
Inhibition of human leucocyte elastase by ursolic acid. Evidence for a binding site for pentacyclic triterpenes
Biochem J277, 521-526. PubMed Europe PubMed I

1990

Baici,A., Pelloso,R. and Horler,D.
The kinetic mechanism of inhibition of human leukocyte elastase by MR889, a new cyclic thiolic compound
Biochem Pharmacol39, 919-924. PubMed Europe PubMed DOI I
Okada,Y., Tsuboi,S., Tsuda,Y., Nagamatsu,Y. and Yamamoto,J.
Synthesis of a trihexacontapeptide corresponding to the sequence 8-70 of eglin c and studies on the relationship between the structure and the inhibitory activity against human leukocyte elastase, cathepsin G and alpha-chymotrypsin
FEBS Lett272, 113-116. PubMed Europe PubMed DOI
Okano,K., Aoki,Y., Shimizu,H. and Naruto,M.
Functional expression of human leukocyte elastase (HLE)/medullasin in eukaryotic cells
Biochem Biophys Res Commun167, 1326-1332. PubMed Europe PubMed DOI E
[YEAR:15-4-1990]Pratt,C.W., Tobin,R.B. and Church,F.C.
Interaction of heparin cofactor II with neutrophil elastase and cathepsin G
J Biol Chem265, 6092-6097. PubMed Europe PubMed
[YEAR:5-9-1990]Wiedow,O., Schroder,J.M., Gregory,H., Young,J.A. and Christophers,E.
Elafin: an elastase-specific inhibitor of human skin. Purification, characterization, and complete amino acid sequence
J Biol Chem265, 14791-14795. PubMed Europe PubMed
Wilde,C.G., Snable,J.L., Griffith,J.E. and Scott,R.W.
Characterization of two azurophil granule proteases with active-site homology to neutrophil elastase
J Biol Chem265, 2038-2041. PubMed Europe PubMed

1989

Bieth,J.G., Dirrig,S., Jung,M.L., Boudier,C., Papamichael,E., Sakarellos,C. and Dimicoli,J.L.
Investigation of the active center of rat pancreatic elastase
Biochim Biophys Acta994, 64-74. PubMed Europe PubMed I
Bode,W., Meyer,E., Jr. and Powers,J.C.
Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors
Biochemistry28, 1951-1963. PubMed Europe PubMed S I
Bonney,R.J., Ashe,B., Maycock,A., Dellea,P., Hand,K., Osinga,D., Fletcher,D., Mumford,R., Davies,P. and Frankenfield,D.
Pharmacological profile of the substituted beta-lactam L-659,286: a member of a new class of human PMN elastase inhibitors
J Cell Biochem39, 47-53. PubMed Europe PubMed DOI I
Cook,L. and Ternai,B.
Effect of Cu2+ and Zn2+ on the inhibition of human leucocyte elastase by 6-alkyl-3-(omega-carboxyalkyl)-2-pyrone, oleic acid and sulindac sulfide
Biol Chem Hoppe Seyler370, 11-19. PubMed Europe PubMed I
Farley,D., Travis,J. and Salvesen,G.
The human neutrophil elastase gene. Analysis of the nucleotide sequence reveals three distinct classes of repetitive DNA
Biol Chem Hoppe Seyler370, 737-744. PubMed Europe PubMed
Gadher,S.J., Schmid,T.M., Heck,L.W. and Woolley,D.E.
Cleavage of collagen type X by human synovial collagenase and neutrophil elastase
Matrix9, 109-115. PubMed Europe PubMed
Heinz,D.W., Liersch,M. and Grutter,M.G.
Crystallization of human leukocyte elastase with its inhibitor Pro44-eglin c
J Mol Biol207, 641-642. PubMed Europe PubMed S
Ikai,A., Nakashima,M. and Aoki,Y.
Inhibition of inflammatory proteinase, medullasin, by alpha2-macroglobulin and ovomacroglobulin
Biochem Biophys Res Commun158, 831-836. PubMed Europe PubMed
[YEAR:25-6-1989]Jordan,R.E., Nelson,R.M., Kilpatrick,J., Newgren,J.O., Esmon,P.C. and Fournel,M.A.
Inactivation of human antithrombin by neutrophil elastase. Kinetics of the heparin-dependent reaction
J Biol Chem264, 10493-10500. PubMed Europe PubMed
Navia,M.A., McKeever,B.M., Springer,J.P., Lin,T.Y., Williams,H.R., Fluder,E.M., Dorn,C.P. and Hoogsteen,K.
Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution
Proc Natl Acad Sci U S A86, 7-11. PubMed Europe PubMed S I
Remold-O'Donnell,E., Nixon,J.C. and Rose,R.M.
Elastase inhibitor. Characterization of the human elastase inhibitor molecule associated with monocytes, macrophages, and neutrophils
J Exp Med169, 1071-1086. PubMed Europe PubMed

1988

Farley,D., Salvesen,G. and Travis,J.
Molecular cloning of human neutrophil elastase
Biol Chem Hoppe Seyler369 Suppl, 3-7. PubMed Europe PubMed
Godeau,G. and Hornebeck,W.
Morphometric analysis of the degradation of human skin elastic fibres by human leukocyte elastase (EC 3-4-21-37) and human skin fibroblast elastase (EC 3-4-24)
Pathol Biol (Paris)36, 1133-1138. PubMed Europe PubMed
Miyano,M., Deason,J.R., Nakao,A., Stealey,M.A., Villamil,C.I., Sohn,D.D. and Mueller,R.A.
(Acyloxy)benzophenones and (acyloxy)-4-pyrones. A new class of inhibitors of human neutrophil elastase
J Med Chem31, 1052-1061. PubMed Europe PubMed I
Takahashi,H., Nukiwa,T., Yoshimura,K., Quick,C.D., States,D.J., Holmes,M.D., Whang-Peng,J., Knutsen,T. and Crystal,R.G.
Structure of the human neutrophil elastase gene
J Biol Chem263, 14739-14747. PubMed Europe PubMed
Wei,A.Z., Mayr,I. and Bode,W.
The refined 2.3 A crystal structure of human leukocyte elastase in a complex with a valine chloromethyl ketone inhibitor
FEBS Lett234, 367-373. PubMed Europe PubMed DOI S I

1987

Braun,N.J., Bodmer,J.L., Virca,G.D., Metz-Virca,G., Maschler,R., Bieth,J.G. and Schnebli,H.P.
Kinetic studies on the interaction of eglin c with human leukocyte elastase and cathepsin G
Biol Chem Hoppe Seyler368, 299-308. PubMed Europe PubMed
Brower,M.S., Walz,D.A., Garry,K.E. and Fenton,J.W.
Human neutrophil elastase alters human alpha-thrombin function: limited proteolysis near the gamma-cleavage site results in decreased fibrinogen clotting and platelet-stimulatory activity
Blood69, 813-819. PubMed Europe PubMed
[YEAR:13-1-1987]Copp,L.J., Krantz,A. and Spencer,R.W.
Kinetics and mechanism of human leukocyte elastase inactivation by ynenol lactones
Biochemistry26, 169-178. PubMed Europe PubMed I
Dunlap,R.P., Stone,P.J. and Abeles,R.H.
Reversible, slow, tight-binding inhibition of human leukocyte elastase
Biochem Biophys Res Commun145, 509-513. PubMed Europe PubMed I
Nakamura,H., Okano,K., Aoki,Y., Shimizu,H. and Naruto,M.
Nucleotide sequence of human bone marrow serine protease (medullasin) gene
Nucleic Acids Res15, 9601-9602. PubMed Europe PubMed
Okano,K., Aoki,Y., Sakurai,T., Kajitani,M., Kanai,S., Shimazu,T., Shimizu,H. and Naruto,M.
Molecular cloning of complementary DNA for human medullasin: an inflammatory serine protease in bone marrow cells
J Biochem102, 13-16. PubMed Europe PubMed
Sinha,S., Watorek,W., Karr,S., Giles,J., Bode,W. and Travis,J.
Primary structure of human neutrophil elastase
Proc Natl Acad Sci U S A84, 2228-2232. PubMed Europe PubMed
Stein,R.L. and Strimpler,A.M.
Catalysis by human leukocyte elastase. 9. pH-dependent change in the rate-limiting step
J Am Chem Soc109, 6538-6540.
Stein,R.L. and Strimpler,A.M.
P1 residue determines the operation of the catalytic triad of serine proteases during hydrolyses of acyl-enzymes
J Am Chem Soc109, 4387-4390.
Stein,R.L., Strimpler,A.M., Hori,H. and Powers,J.C.
Catalysis by human leukocyte elastase: mechanistic insights into specificity requirements
Biochemistry26, 1301-1305. PubMed Europe PubMed
Stein,R.L., Strimpler,A.M., Hori,H. and Powers,J.C.
Catalysis by human leukocyte elastase: proton inventory as a mechanistic probe
Biochemistry26, 1305-1314. PubMed Europe PubMed
Stein,R.L. and Strimpler,A.M.
Catalysis by human leukocyte elastase. Aminolysis of acyl-enzymes by amino acid amides and peptides
Biochemistry26, 2238-2242. PubMed Europe PubMed
Stein,R.L., Strimpler,A.M., Viscarello,B.R., Wildonger,R.A., Mauger,R.C. and Trainor,D.A.
Mechanism for slow-binding inhibition of human leukocyte elastase by valine-derived benzoxazinones
Biochemistry26, 4126-4130. PubMed Europe PubMed I
Stein,R.L., Strimpler,A.M., Edwards,P.D., Lewis,J.J., Mauger,R.C., Schwartz,J.A., Stein,M.M., Trainor,D.A., Wildonger,R.A. and Zottola,M.A.
Mechanism of slow-binding inhibition of human leukocyte elastase by trifluoromethyl ketones
Biochemistry26, 2682-2689. PubMed Europe PubMed I
Takada,Y., Maruta,H., Wagner,B., FA,X.G., James,H.L. and Erdos,E.G.
Activation of human prorenin by neutrophil elastase
J Clin Endocrinol Metab65, 1225-1230. PubMed Europe PubMed DOI
Williams,H.R., Lin,T.Y., Navia,M.A., Springer,J.P., McKeever,B.M., Hoogsteen,K. and Dorn,C.P., Jr.
Crystallization of human neutrophil elastase
J Biol Chem262, 17178-17181. PubMed Europe PubMed I

1986

Bode,W., Wei,A.Z., Huber,R., Meyer,E., Travis,J. and Neumann,S.
X-ray crystal structure of the complex of human leukocyte elastase (PMN elastase) and the third domain of the turkey ovomucoid inhibitor
EMBO J5, 2453-2458. PubMed Europe PubMed S
Cs-Szabo,G., Szell,E. and Elodi,P.
Specific inhibition of human granulocyte elastase with peptide aldehydes
FEBS Lett195, 265-268. PubMed Europe PubMed I
[YEAR:10-7-1986]Doherty,J.B., Ashe,B.M., Argenbright,L.W., Barker,P.L., Bonney,R.J., Chandler,G.O., Dahlgren,M.E., Dorn,C.P., Jr., Finke,P.E. and Firestone,R.A.
Cephalosporin antibiotics can be modified to inhibit human leukocyte elastase
Nature322, 192-194. PubMed Europe PubMed DOI I
Groutas,W.C., Brubaker,M.J., Zandler,M.E., Mazo-Gray,V., Rude,S.A., Crowley,J.P., Castrisos,J.C., Dunshee,D.A. and Giri,P.K.
Inactivation of leukocyte elastase by aryl azolides and sulfonate salts. Structure-activity relationship studies
J Med Chem29, 1302-1305. PubMed Europe PubMed I
Groutas,W.C., Giri,P.K., Crowley,J.P., Castrisos,J.C. and Brubaker,M.J.
The Lossen rearrangement in biological systems. Inactivation of leukocyte elastase and alpha-chymotrypsin by (dl)-3-benzyl-N- (methanesulfonyloxy) succinimide
Biochem Biophys Res Commun141, 741-748. PubMed Europe PubMed I
[YEAR:23-9-1986]Stein,R.L. and Trainor,D.A.
Mechanism of inactivation of human leukocyte elastase by a chloromethyl ketone: kinetic and solvent isotope effect studies
Biochemistry25, 5414-5419. PubMed Europe PubMed I

1985

[YEAR:9-4-1985]Hemmi,K., Harper,J.W. and Powers,J.C.
Inhibition of human leukocyte elastase, cathepsin G, chymotrypsin A alpha, and porcine pancreatic elastase with substituted isobenzofuranones and benzopyrandiones
Biochemistry24, 1841-1848. PubMed Europe PubMed I
Kasafirek,E., Fric,P. and Slaby,J.
Anionic inhibitors of pancreatic and leukocyte elastase. Alkylamides of 3-carboxypropionyl- and 4-carboxybutyrylalanine peptides
Biol Chem Hoppe Seyler366, 333-343. PubMed Europe PubMed I
Stein,R.L.
Catalysis by human leukocyte elastase. 5. Structural features of the virtual transition state for acylation
J Am Chem Soc107, 7768-7769.
Stein,R.L.
Catalysis by human leukocyte elastase. 4. Role of secondary-subsite interactions
J Am Chem Soc107, 5767-5775.

1984

[YEAR:10-12-1984]Byrne,R.E., Polacek,D., Gordon,J.I. and Scanu,A.M.
The enzyme that cleaves apolipoprotein A-II upon in vitro incubation of human plasma high-density lipoprotein-3 with blood polymorphonuclear cells is an elastase
J Biol Chem259, 14537-14543. PubMed Europe PubMed
Harper,J.W., Cook,R.R., Roberts,C.J., McLaughlin,B.J. and Powers,J.C.
Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II, bovine chymotrypsin Aalpha, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates
Biochemistry23, 2995-3002. PubMed Europe PubMed
Neumann,S., Gunzer,G., Hennrich,N. and Lang,H.
"PMN-elastase assay": enzyme immunoassay for human polymorphonuclear elastase complexed with alpha 1-proteinase inhibitor
J Clin Chem Clin Biochem22, 693-697. PubMed Europe PubMed
Stein,R.L., Viscarello,B.R. and Wildonger,R.A.
Catalysis by human leukocyte elastase. 2. Rate-limiting deacylation for specific p-nitroanilides and amides
J Am Chem Soc106, 796-798.
[YEAR:23-6-1984]Virca,G.D. and Schnebli,H.P.
The elastase/alpha 1-proteinase inhibitor balance in the lung. A review
Schweiz Med Wochenschr114, 895-898. PubMed Europe PubMed
[YEAR:1-10-1984]Virca,G.D., Metz,G. and Schnebli,H.P.
Similarities between human and rat leukocyte elastase and cathepsin G
Eur J Biochem144, 1-9. PubMed Europe PubMed

1983

Harper,J.W., Hemmi,K. and Powers,J.C.
New mechanism-based serine protease inhibitors: inhibition of human leukocyte elastase, porcine pancreatic elastase, human leukocyte cathepsin G, and chymotrypsin by 3-chloroisocoumarin and 3,3-dichlorophthatide
J Am Chem Soc105, 6518-6520. I
[YEAR:19-7-1983]Lonky,S.A. and Wohl,H.
Regulation of elastolysis of insoluble elastin by human leukocyte elastase: stimulation by lysine-rich ligands, anionic detergents, and ionic strength
Biochemistry22, 3714-3720. PubMed Europe PubMed

1982

[YEAR:10-5-1982]Teshima,T., Griffin,J.C. and Powers,J.C.
A new class of heterocyclic serine protease inhibitors. Inhibition of human leukocyte elastase, porcine pancreatic elastase, cathepsin G, and bovine chymotrypsin A alpha with substituted benzoxazinones, quinazolines, and anthranilates
J Biol Chem257, 5085-5091. PubMed Europe PubMed I
[YEAR:10-5-1982]Yoshimura,T., Barker,L.N. and Powers,J.C.
Specificity and reactivity of human leukocyte elastase, porcine pancreatic elastase, human granulocyte cathepsin G, and bovine pancreatic chymotrypsin with arylsulfonyl fluorides. Discovery of a new series of potent and specific irreversible elastase inhibitors
J Biol Chem257, 5077-5084. PubMed Europe PubMed I

1981

Barrett,A.J.
Leukocyte elastase
Methods Enzymol80, 581-588. PubMed Europe PubMed DOI V
Jochum,M., Lander,S., Heimburger,N. and Fritz,H.
Effect of human granulocytic elastase on isolated human antithrombin III
Hoppe Seylers Z Physiol Chem362, 103-112. PubMed Europe PubMed
Wenzel,H.R. and Tschesche,H.
Cleavage of peptide-4-nitroanilide substrates with varying chain length by human leukocyte elastase
Hoppe Seylers Z Physiol Chem362, 829-831. PubMed Europe PubMed

1980

[YEAR:19-8-1980]McRae,B., Nakajima,K., Travis,J. and Powers,J.C.
Studies on reactivity of human leukocyte elastase, cathepsin G, and porcine pancreatic elastase toward peptides including sequences related to the reactive site of alpha 1-protease inhibitor (alpha 1-antitrypsin)
Biochemistry19, 3973-3978. PubMed Europe PubMed P
Menninger,H., Putzier,R., Mohr,W., Wessinghage,D. and Tillmann,K.
Granulocyte elastase at the site of cartilage erosion by rheumatoid synovial tissue
Z Rheumatol39, 145-156. PubMed Europe PubMed
[YEAR:24-1-1980]Reilly,C.F. and Travis,J.
The degradation of human lung elastin by neutrophil proteinases
Biochim Biophys Acta621, 147-157. PubMed Europe PubMed
Wenzel,H.R., Engelbrecht,S., Reich,H., Mondry,W. and Tschesche,H.
Synthesis and analytical use of 3-carboxypropionyl-alanyl-alanyl-valine-4-nitroanilide: a specific substrate for human leukocyte elastase
Hoppe Seylers Z Physiol Chem361, 1413-1416. PubMed Europe PubMed

1979

[YEAR:25-6-1979]Lestienne,P., Dimicoli,J.L., Renaud,A. and Bieth,J.G.
Inhibition of human leukocyte elastase by acetyl and trifluoroacetyl oligopeptide chloromethyl ketones
J Biol Chem254, 5219-5221. PubMed Europe PubMed I
[YEAR:25-5-1979]Nakajima,K., Powers,J.C., Ashe,B.M. and Zimmerman,M.
Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. Studies with peptide substrates related to the alpha 1-protease inhibitor reactive site
J Biol Chem254, 4027-4032. PubMed Europe PubMed P

1978

Lestienne,P., Dimicoli,J.L. and Bieth,J.
On the inhibition of human leukocyte elastase by trifluoroacetyl tripeptides
J Biol Chem253, 3459-3460. PubMed Europe PubMed I
Lively,M.O. and Powers,J.C.
Specificity and reactivity of human granulocyte elastase and cathepsin G, porcine pancreatic elastase, bovine chymotrypsin and trypsin toward inhibition with sulfonyl fluorides
Biochim Biophys Acta525, 171-179. PubMed Europe PubMed I

1977

Blow,A.M.J.
Action of human lysosomal elastase on the oxidized B chain of insulin
Biochem J161, 13-16. PubMed Europe PubMed
Powers,J.C., Gupton,B.F., Harley,A.D., Nishino,N. and Whitley,R.J.
Specificity of porcine pancreatic elastase, human leukocyte elastase and cathepsin G. Inhibition with peptide chloromethyl ketones
Biochim Biophys Acta485, 156-166. PubMed Europe PubMed I

1976

[YEAR:24-2-1976]Baugh,R.J. and Travis,J.
Human leukocyte granule elastase: rapid isolation and characterization
Biochemistry15, 836-841. PubMed Europe PubMed
[YEAR:13-5-1976]Feinstein,G., Malemud,C.J. and Janoff,A.
The inhibition of human leucocyte elastase and chymotrypsin-like protease by elastatinal and chymostatin
Biochim Biophys Acta429, 925-932. PubMed Europe PubMed I
[YEAR:1-5-1976]Starkey,P.M. and Barrett,A.J.
Neutral proteinases of human spleen. Purification and criteria for homogeneity of elastase and cathepsin G
Biochem J155, 255-263. PubMed Europe PubMed
[YEAR:1-5-1976]Starkey,P.M. and Barrett,A.J.
Human lysosomal elastase. Catalytic and immunological properties
Biochem J155, 265-271. PubMed Europe PubMed

1972

Janoff,A.
Human granulocyte elastase. Further delineation of its role in connective tissue damage
Am J Pathol68, 579-592. PubMed Europe PubMed
Janoff,A.
Inhibition of human granulocyte elastase by serum alpha-1-antitrypsin
Am Rev Respir Dis105, 121-122. PubMed Europe PubMed

1931

Husfeldt,E.
Proteolytic Enzyme in den Leucocyten des Menschen
Hoppe Seylers Z Physiol Chem194, 137-165.