Structure for peptidase S01.119: trypsin-2 type C

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Pharma

PDB	Organism	Resolution	Comment
1DPO	Rattus norvegicus	1.59 Å	mature
Catalytic residues are shown in ball-and-stick representation: His63 in purple, Asp107 in pink and Ser200 in orange. The structural calcium ion is shown as a yellow CPK sphere.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Rattus norvegicus
Asp189Ser mutant	2.50 Å	1AMH	1AMH	1AMH	1AMH	1AMH	1AMH	Perona & Craik, 1995
Ser214Glu mutant	2.80 Å	1ANB	1ANB	1ANB	1ANB	1ANB	1ANB	McGrath et al., 1992
Ser214Lys mutant	2.20 Å	1ANC	1ANC	1ANC	1ANC	1ANC	1ANC	McGrath et al., 1992
Arg96His mutant	2.30 Å	1AND	1AND	1AND	1AND	1AND	1AND	McGrath et al., 1993
mature peptidase	2.20 Å	1ANE	1ANE	1ANE	1ANE	1ANE	1ANE	McGrath et al., 1993
mature peptidase	2.20 Å	1BRA	1BRA	1BRA	1BRA	1BRA	1BRA	Perona et al., 1993
mature peptidase	2.10 Å	1BRB	1BRB	1BRB	1BRB	1BRB	1BRB	Perona et al., 1993
mature peptidase	2.50 Å	1BRC	1BRC	1BRC	1BRC	1BRC	1BRC	Perona et al., 1993
complex with bovine pancreatic trypsin inhibitor	1.90 Å	1CO7	1CO7	1CO7	1CO7	1CO7	1CO7
mature peptidase	1.59 Å	1DPO	1DPO	1DPO	1DPO	1DPO	1DPO	Earnest et al., 1991
complex with ecotin inhibitor mutant	2.30 Å	1EZS	1EZS	1EZS	1EZS	1EZS	1EZS	Gillmor et al., 2000
complex with ecotin inhibitor	2.40 Å	1EZU	1EZU	1EZU	1EZU	1EZU	1EZU	Gillmor et al., 2000
engineered precursor; complex with bovine pancreatic trypsin inhibitor	1.65 Å	1F5R	1F5R	1F5R	1F5R	1F5R	1F5R	Pasternak et al., 2001
engineered precursor; complex with bovine pancreatic trypsin inhibitor	1.55 Å	1F7Z	1F7Z	1F7Z	1F7Z	1F7Z	1F7Z	Pasternak et al., 2001
delta Ile16/Val17 precursor; complex with bovine pancreatic trypsin inhibitor 1	1.70 Å	1FY8	1FY8	1FY8	1FY8	1FY8	1FY8	Pasternak et al., 2001
mutant X99RT; complex with benzamidine	2.40 Å	1J14	1J14	1J14	1J14	1J14	1J14	Reyda et al., 2003
mutant X99/175/190RT; complex with benzamidine	2.00 Å	1J15	1J15	1J15	1J15	1J15	1J15	Reyda et al., 2003
mutant X99/175/190RT; complex with benzamidine	1.60 Å	1J16	1J16	1J16	1J16	1J16	1J16	Reyda et al., 2003
mutant X99/175/190RT; complex with factor Xa specific inhibitor	2.00 Å	1J17	1J17	1J17	1J17	1J17	1J17	Reyda et al., 2003
complex with alaserpin	2.30 Å	1K9O	1K9O	1K9O	1K9O	1K9O	1K9O	Ye et al., 2001
Glu97Lys, Tyr99Leu mutant; complex with factor Xa inhibitor	2.30 Å	1QL9	1QL9	1QL9	1QL9	1QL9	1QL9	Reyda et al., 2003
mature peptidase	1.80 Å	1SLU	1SLU	1SLU	1SLU	1SLU	1SLU	Brinen et al., 1996
mature peptidase	2.30 Å	1SLV	1SLV	1SLV	1SLV	1SLV	1SLV	Brinen et al., 1996
mature peptidase	2.00 Å	1SLW	1SLW	1SLW	1SLW	1SLW	1SLW	Brinen et al., 1996
mature peptidase	2.20 Å	1SLX	1SLX	1SLX	1SLX	1SLX	1SLX	Brinen et al., 1996
mature peptidase	2.30 Å	1TRM	1TRM	1TRM	1TRM	1TRM	1TRM	Sprang et al., 1987
complex with aprotinin mutant	1.70 Å	1YKT	1YKT	1YKT	1YKT	1YKT	1YKT	Getun et al., 2008
complex with aprotinin mutant	1.70 Å	1YLC	1YLC	1YLC	1YLC	1YLC	1YLC	Getun et al., 2008
complex with aprotinin mutant	1.70 Å	1YLD	1YLD	1YLD	1YLD	1YLD	1YLD	Getun et al., 2008
mature peptidase	2.80 Å	2TRM	2TRM	2TRM	2TRM	2TRM	2TRM	Sprang et al., 1987
complex with bovine pancreatic trypsin inhibitor	1.49 Å	3FP6	3FP6	3FP6	3FP6	3FP6	3FP6	Zakharova et al., 2009
Ser195Ala mutant; complex with bovine pancreatic trypsin inhibitor (bpti) cleaved at the scissile bond (lys15-ala16)	1.46 Å	3FP7	3FP7	3FP7	3FP7	3FP7	3FP7	Zakharova et al., 2009
Ser195Ala mutant; complex with bovine pancreatic trypsin inhibitor	1.46 Å	3FP8	3FP8	3FP8	3FP8	3FP8	3FP8	Zakharova et al., 2009
complex with bovine pancreatic trypsin inhibitor	1.80 Å	3TGI	3TGI	3TGI	3TGI	3TGI	3TGI	Pasternak et al., 1999
Ser195Ala mutant; complex with bovine pancreatic trypsin inhibitor	2.20 Å	3TGJ	3TGJ	3TGJ	3TGJ	3TGJ	3TGJ	Pasternak et al., 1999
Asp194Asn and Ile16-Val17 deletion mutant; complex with bovine pancreatic trypsin inhibitor	1.70 Å	3TGK	3TGK	3TGK	3TGK	3TGK	3TGK	Pasternak et al., 2001