Structure for peptidase M27.002: bontoxilysin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
1F82_A	Clostridium botulinum	2.20 Å	catalytic domain
The catalytic zinc is shown as a light grey CPK sphere. The zinc ligands are shown in ball-and-stick representation: His229 and His233 in purple and Glu267 in blue. The catalytic Glu230 is shown in blue.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Clostridium botulinum
type B	1.90 Å	1EPW	1EPW	1EPW	1EPW	1EPW	1EPW	Swaminathan & Eswaramoorthy, 2000
complex with a trisaccharide	2.60 Å	1F31	1F31	1F31	1F31	1F31	1F31	Swaminathan & Eswaramoorthy, 2000
catalytic domain	2.20 Å	1F82	1F82	1F82	1F82	1F82	1F82	Hanson & Stevens, 2000
catalytic domain; complex with cleaved form of synaptobrevin-II: SUPERCEDED BY 3G94	2.00 Å	1F83	1F83	1F83	1F83	1F83	1F83	Hanson & Stevens, 2000
OBSOLETE; catalytic domain; complex with bis(5-amidino-benzimidazolyl)methane inhibitor: OBSOLETE	2.80 Å	1FQH	1FQH	1FQH	1FQH	1FQH	1FQH
complex with bis(5-amidino-benzimidazolyl)methane inhibitor	2.10 Å	1G9A	1G9A	1G9A	1G9A	1G9A	1G9A	Eswaramoorthy et al., 2002
complex with bis(5-amidino-benzimidazolyl)methane inhibitor	2.00 Å	1G9B	1G9B	1G9B	1G9B	1G9B	1G9B	Eswaramoorthy et al., 2002
complex with bis(5-amidino-benzimidazolyl)methane inhibitor	2.35 Å	1G9C	1G9C	1G9C	1G9C	1G9C	1G9C	Eswaramoorthy et al., 2002
complex with bis(5-amidino-benzimidazolyl)methane inhibitor	2.20 Å	1G9D	1G9D	1G9D	1G9D	1G9D	1G9D	Eswaramoorthy et al., 2002
complex with doxorubicin	2.50 Å	1I1E	1I1E	1I1E	1I1E	1I1E	1I1E	Eswaramoorthy et al., 2001
pH 4.0	2.00 Å	1S0B	1S0B	1S0B	1S0B	1S0B	1S0B	Eswaramoorthy et al., 2004
pH 5.0	2.20 Å	1S0C	1S0C	1S0C	1S0C	1S0C	1S0C	Eswaramoorthy et al., 2004
pH 5.5	2.20 Å	1S0D	1S0D	1S0D	1S0D	1S0D	1S0D	Eswaramoorthy et al., 2004
pH 6.0	1.90 Å	1S0E	1S0E	1S0E	1S0E	1S0E	1S0E	Eswaramoorthy et al., 2004
pH 7.0	2.30 Å	1S0F	1S0F	1S0F	1S0F	1S0F	1S0F	Eswaramoorthy et al., 2004
apo form	2.60 Å	1S0G	1S0G	1S0G	1S0G	1S0G	1S0G	Eswaramoorthy et al., 2004
mature peptidase	2.00 Å	1Z0H	1Z0H	1Z0H	1Z0H	1Z0H	1Z0H	Jayaraman et al., 2005
light chain only	2.35 Å	1ZB7	1ZB7	1ZB7	1ZB7	1ZB7	1ZB7	Arndt et al., 2005
light chain	2.29 Å	2ETF	2ETF	2ETF	2ETF	2ETF	2ETF
mature peptidase	2.15 Å	2NM1	2NM1	2NM1	2NM1	2NM1	2NM1	Jin et al., 2006
complex with synaptotagamin-II ectodomain	2.62 Å	2NP0	2NP0	2NP0	2NP0	2NP0	2NP0	Chai et al., 2006
mature peptidase	1.90 Å	2VXR	2VXR	2VXR	2VXR	2VXR	2VXR	Stenmark et al., 2010
mature peptidase	2.80 Å	2XHL	2XHL	2XHL	2XHL	2XHL	2XHL	Masuyer et al., 2011
further refinement of botulinum neurotoxin type b catalytic domain with synaptobrevin-ii bound	2.00 Å	3G94	3G94	3G94	3G94	3G94	3G94	Hanson & Stevens, 2000
mature peptidase	1.98 Å	3MPP	3MPP	3MPP	3MPP	3MPP	3MPP	Schmitt et al., 2010
mature peptidase	2.70 Å	3ZUQ	3ZUQ	3ZUQ	3ZUQ	3ZUQ	3ZUQ	Masuyer et al., 2011
mature peptidase	2.30 Å	4KBB	4KBB	4KBB	4KBB	4KBB	4KBB	Berntsson et al., 2013
Glu1191Met/Ser1199Tyr mutant; complex with human synaptotagmin 1	2.50 Å	6G5F	6G5F	6G5F	6G5F	6G5F	6G5F
Glu1191Met/Ser1199Tyr mutant; complex with human synaptotagmin 2	2.00 Å	6G5G	6G5G	6G5G	6G5G	6G5G	6G5G