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Literature for peptidase M27.002: bontoxilysin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Popoff,M.R.
    Advances in Clostridial Neurotoxins: Passage of the Intestinal Barrier and Targeting of Specific Neuronal Cells
    Toxins (Basel) (2026) 18 PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2025
  2. Gao,L., Nowakowska,M.B., Selby,K., Przykopanski,A., Chen,B., Kruger,M., Douillard,F.P., Lam,K.H., Chen,P., Huang,T., Minton,N.P., Dorner,M.B., Dorner,B.G., Rummel,A., Lindstrom,M. and Jin,R.
    Botulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47
    Nat Struct Mol Biol (2025) PubMed  Europe PubMed DOI
  3. Gardner,A., Sneller,M., Tepp,W.H., Barbieri,J.T. and Pellett,S.
    Botulinum neurotoxin Light Chain/A1 uses fast synaptic vesicle cycling to cleave plasma membrane bound SNAP-25
    Commun Biol (2025) 8, 1383-1383. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Koc,D., Ezgin,S., Kavakli,E., Kota,K.P., Sen,E., Mahone,C., Palko,M.E., Cazares,L.H., Can,T., Tessarollo,L., Bavari,S., Marion,A. and Kiris,E.
    Phosphorylation of SNAP-25 at Ser187 is enhanced following its cleavage by Botulinum Neurotoxin Serotype A, promoting the dominant-negative effect of the resulting fragment
    PLoS Pathog (2025) 21, e1013604-e1013604. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Krc,A., Kosenina,S.P., Nowakowska,M.B., Masuyer,G. and Stenmark,P.
    Structure of the complete 14-subunit botulinum neurotoxin B complex reveals a unique anchoring through the narrow central pore of HA70
    Sci Adv (2025) 11, eadx5058-eadx5058. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Kumar,R. and Singh,B.R.
    Botulinum Toxin: A Comprehensive Review of Its Molecular Architecture and Mechanistic Action
    Int J Mol Sci (2025) 26 PubMed  Europe PubMed DOI  PMC  EPMC  V
  7. Lacy,D.B.
    Elucidating the crystal structure of botulinum neurotoxin type A: a personal remembrance
    J Neural Transm (Vienna) (2025) PubMed  Europe PubMed DOI
  8. Lalaurie,C.J., Zloh,M., Higazi,D.R., Bunting,K.A. and Dalby,P.A.
    Inter-Domain interactions Slow BoNT/A's onset of action
    J Struct Biol (2025) 217, 108171-108171. PubMed  Europe PubMed DOI
  9. Lam,K.H., Gao,L., Przykopanski,A., Chen,B., Huang,T., Kruger,M., Bartels,A.M., Dorner,M.B., Perry,K., Dorner,B.G., Rummel,A. and Jin,R.
    A nut-and-bolt assembly of the bimodular large progenitor botulinum neurotoxin complex
    Sci Adv (2025) 11, eadx5831-eadx5831. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Liao,Y., Hu,X., Wang,J., Lu,J., Yu,S., Yu,Y. and Wu,W.
    Proteolytic Activities and Immunological Effects of Light Chains of Botulinum Neurotoxin A1, A2 and A3 Subtypes
    Toxins (Basel) (2025) 18 PubMed  Europe PubMed DOI  PMC  EPMC
  11. Lin,M., Karadkhelkar,N., Li,Y., Eubanks,L.M., Tepp,W.H., Pellett,S. and Janda,K.D.
    Bifunctional Inhibition of Botulinum Neurotoxin A Protease: Unexpected Active Site Inhibition Enhances Covalent Targeting of an Allosteric Site
    J Med Chem (2025) 68, 8796-8816. PubMed  Europe PubMed DOI
  12. Malik,S., Le,L., Boissy,R.E., Brideau-Andersen,A. and Sondergaard,B.
    Botulinum neurotoxin type DC (BoNT/DC) cleavage of VAMP3 reduces melanin production in melanocytes
    Toxicon (2025) 261, 108372-108372. PubMed  Europe PubMed DOI  K
  13. Monash,A., Tam,J., Rosen,O. and Soreq,H.
    Botulinum Neurotoxins: History, Mechanism, and Applications. A Narrative Review
    J Neurochem (2025) 169, e70187-e70187. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Pitel,S., Barnea,A., Diamant,E., Torgeman,A., Noy-Porat,T., Falach,R., Zichel,R., Hayouka,Z. and Ben David,A.
    Elucidating the activation mechanism of botulinum neurotoxin a: role of alpha-clostripain and NTNH
    Sci Rep (2025) 15, 37324-37324. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Sondermann,P., Diercks,C.S., Rong,C. and Schultz,P.G.
    Targeted degradation of alpha-Synuclein using an evolved botulinum toxin protease
    Proc Natl Acad Sci U S A (2025) 122, e2426745122-e2426745122. PubMed  Europe PubMed DOI
  16. Van Trinh,T., Nguyen,D.V., Hoang,H.D., Pham,H.V., Ngoc Vu,D., Le,P.V., Le,D.N., Vo,C.V. and Le,L.A.T.
    Development and selection of candidate monoclonal antibodies for the detection of Clostridium botulinum neurotoxin serotype B light chain
    Protein Expr Purif (2025) 228, 106659-106659. PubMed  Europe PubMed DOI
  17. Wang,Y., Zhang,B., Zhang,R., Ding,D., Ma,W., Wang,W., Liu,Z., Zhu,Y., Wang,X., Zhi,D. and Wang,D.
    EGFP/RFP-based FRET sensors for botulinum neurotoxin A biological activity detection and methodological validation
    Anal Chim Acta (2025) 1337, 343546-343546. PubMed  Europe PubMed DOI
  18. Zhang,Y., Yang,L., Wang,H., Zhang,H., Feng,Y. and Tan,T.
    High-efficiency heterologous expression of functional RVG29-BoNT/A light chain fusion protein in Bacillus subtilis based on a combinatorial strategy
    Int J Biol Macromol (2025) 310, 143226-143226. PubMed  Europe PubMed DOI  K
  19. Zhu,C., Zhang,L., Yu,W., Tu,Y., Yang,X., Li,D., Wang,H. and Li,T.
    Unraveling Botulinum Neurotoxin A Light-Chain-Induced Signaling Pathways: A Phosphoproteomic Analysis in a Controlled Cellular Model
    Int J Mol Sci (2025) 26 PubMed  Europe PubMed DOI  PMC  EPMC
    20. 2024
  20. Avelar,R.
    Botulinum Toxin Accessory Proteins: Are They Just an Accessory?
    Dermatol Surg (2024) 50, S38-S41. PubMed  Europe PubMed DOI  V
  21. Buzzatto,M.V., Benegas Guerrero,F.C., Alvarez,P.A., Zizzias,M.P., Polo,L.M. and Tomes,C.N.
    EXPRESSION, PURIFICATION AND APPLICATION OF A RECOMBINANT, MEMBRANE PERMEATING VERSION OF THE LIGHT CHAIN OF BOTULINUM TOXIN B
    Biosci Rep (2024) 44, BSR20240117-BSR20240117. PubMed  Europe PubMed DOI
  22. Caliskan,C., Simsek,D., Leese,C., Doran,C., Seward,E., Peden,A.A. and Davletov,B.
    A sensitive cell-based assay for testing potency of Botulinum neurotoxin type A
    ALTEX (2024) 41, 605-616. PubMed  Europe PubMed DOI
  23. Dong,J., Helveston,E.M. and Hanke,C.W.
    The 200-Year Timeline on Botulinum Toxin: From Biologic Poison to Wonder Drug
    J Drugs Dermatol (2024) 23, 1357-1359. PubMed  Europe PubMed DOI
  24. Gregg,B.M., Gupta,S., Tepp,W.H. and Pellett,S.
    Expression of Recombinant Clostridial Neurotoxin by C. tetani
    Microorganisms (2024) 12 PubMed  Europe PubMed DOI  PMC  EPMC
  25. Hoyt,K.M., Barr,J.R., Hopkins,A.O., Dykes,J.K., Luquez,C. and Kalb,S.R.
    Validation of a clinical assay for botulinum neurotoxins through mass spectrometric detection
    J Clin Microbiol (2024) , e0162923-e0162923. PubMed  Europe PubMed DOI
  26. Jeffery,I.A. and Karim,S.
    Botulism
     (2024) PubMed  Europe PubMed
  27. Koc,D., Ibis,K., Besarat,P., Banoglu,E. and Kiris,E.
    Tirbanibulin (KX2-391) analog KX2-361 inhibits botulinum neurotoxin serotype A mediated SNAP-25 cleavage in pre- and post-intoxication models in cells
    Drug Dev Res (2024) 85, e22248-e22248. PubMed  Europe PubMed DOI  I
  28. Majou,D.
    Endopeptidase activities of Clostridium botulinum toxins in the development of this bacterium
    Res Microbiol (2024) , 104216-104216. PubMed  Europe PubMed DOI
  29. Martin,V., Carre,D., Bilbault,H., Oster,S., Limana,L., Sebal,F., Favre-Guilmard,C., Kalinichev,M., Leveque,C., Boulifard,V., George,C. and Lezmi,S.
    Intramuscular Botulinum Neurotoxin Serotypes E and A Elicit Distinct Effects on SNAP25 Protein Fragments, Muscular Histology, Spread and Neuronal Transport: An Integrated Histology-Based Study in the Rat
    Toxins (Basel) (2024) 16 PubMed  Europe PubMed DOI  PMC  EPMC
  30. Silkina,M.V., Kartseva,A.S., Riabko,A.K., Makarova,M.A., Rogozin,M.M., Romanenko,Y.O., Shemyakin,I.G., Dyatlov,I.A. and Firstova,V.V.
    New approach to generating of human monoclonal antibodies specific to the proteolytic domain of botulinum neurotoxin A
    Bioimpacts (2024) 14, 27680-27680. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Zhou,X., Qi,M. and Yang,M.
    Detection of botulinum neurotoxin A (BoNT/A) enzymatic activity by pregnancy test strips based on hCG-modified magnetic nanoparticles
    Mikrochim Acta (2024) 191, 114-114. PubMed  Europe PubMed DOI
    32. 2023
  32. Cotter,L., Yu,F., Roqueviere,S., Duchesne de Lamotte,J., Krupp,J., Dong,M. and Nicoleau,C.
    Split luciferase-based assay to detect botulinum neurotoxins using hiPSC-derived motor neurons
    Commun Biol (2023) 6, 122-122. PubMed  Europe PubMed DOI  PMC  EPMC
  33. Li,Z., Li,B., Lu,J., Liu,X., Tan,X., Wang,R., Du,P., Yu,S., Xu,Q., Pang,X., Yu,Y. and Yang,Z.
    Biological and Immunological Characterization of a Functional L-HN Derivative of Botulinum Neurotoxin Serotype F
    Toxins (Basel) (2023) 15 PubMed  Europe PubMed DOI  PMC  EPMC
  34. Lin,L., Patel,E.N., Nielsen,A.L., Turner,L.D., Tepp,W.H., Nguyen,K., Pellett,S. and Janda,K.
    Transformation of a Metal Chelate into a "Catch and Anchor" Inhibitor of Botulinum A Protease
    Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC  I
  35. Liu,Z., Lee,P.G., Krez,N., Lam,K.H., Liu,H., Przykopanski,A., Chen,P., Yao,G., Zhang,S., Tremblay,J.M., Perry,K., Shoemaker,C.B., Rummel,A., Dong,M. and Jin,R.
    Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2
    Nat Commun (2023) 14, 2338-2338. PubMed  Europe PubMed DOI  PMC  EPMC
  36. Rawson,A.M., Dempster,A.W., Humphreys,C.M. and Minton,N.P.
    Pathogenicity and virulence of Clostridium botulinum
    Virulence (2023) 14, 2205251-2205251. PubMed  Europe PubMed DOI  PMC  EPMC
  37. Smith,T.J., Schill,K.M. and Williamson,C.H.D.
    Navigating the Complexities Involving the Identification of Botulinum Neurotoxins (BoNTs) and the Taxonomy of BoNT-Producing Clostridia
    Toxins (Basel) (2023) 15 PubMed  Europe PubMed DOI  PMC  EPMC
  38. Tan,X., Zhang,C.C., Lu,J.S., Li,Z.Y., Li,B.L., Liu,X.Y., Yu,Y.Z. and Xu,Q.
    Biology activity and characterization of the functional L-HN fragment derivative of botulinum neurotoxin serotype E
    Anaerobe (2023) 82, 102764-102764. PubMed  Europe PubMed DOI
    39. 2022
  39. Cleveland,J.D., Taslimi,A., Liu,Q., Van Keuren,A.M., Churchill,M.E.A. and Tucker,C.L.
    Reprogramming the Cleavage Specificity of Botulinum Neurotoxin Serotype B1
    ACS Synth Biol (2022) 11, 3318-3329. PubMed  Europe PubMed DOI
  40. Dyer,R.P., Isoda,H.M., Salcedo,G.S., Speciale,G., Fletcher,M.H., Le,L.Q., Liu,Y., Brami-Cherrier,K., Malik,S.Z., Vazquez-Cintron,E.J., Chu,A.C., Rupp,D.C., Jacky,B.P.S., Nguyen,T.T.M., Katz,B.B., Steward,L.E., Majumdar,S., Brideau-Andersen,A.D. and Weiss,G.A.
    Reengineering the specificity of the highly selective Clostridium botulinum protease via directed evolution
    Sci Rep (2022) 12, 9956-9956. PubMed  Europe PubMed DOI  PMC  EPMC
  41. Fabris,F., Sostaric,P., Matak,I., Binz,T., Toffan,A., Simonato,M., Montecucco,C., Pirazzini,M. and Rossetto,O.
    Detection of VAMP Proteolysis by Tetanus and Botulinum Neurotoxin Type B In Vivo with a Cleavage-Specific Antibody
    Int J Mol Sci (2022) 23 PubMed  Europe PubMed DOI  PMC  EPMC
  42. Kumar,D.N., Baider,Z., Elad,D., Blum,S.E. and Shtenberg,G.
    Botulinum Neurotoxin C Dual Detection through Immunological Recognition and Endopeptidase Activity Using Porous Silicon Interferometers
    Anal Chem (2022) 94, 5927-5936. PubMed  Europe PubMed DOI
  43. Lam,K.H., Tremblay,J.M., Perry,K., Ichtchenko,K., Shoemaker,C.B. and Jin,R.
    Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies
    PLoS Pathog (2022) 18, e1010169-e1010169. PubMed  Europe PubMed DOI  PMC  EPMC
  44. Liu,J., Xu,S., Huang,C., Shen,J., Yu,S., Yu,Y., Sun,Q. and Dai,Q.
    Synthesis and activity evaluation of selenazole-coupled CPI-1 irreversible bifunctional inhibitors for botulinum toxin A light chain
    Bioorg Med Chem Lett (2022) 73, 128913-128913. PubMed  Europe PubMed DOI  I
  45. Patel,E.N., Turner,L.D., Hixon,M.S. and Janda,K.D.
    Identification of Slow-Binding Inhibitors of the BoNT/A Protease
    ACS Med Chem Lett (2022) 13, 742-747. PubMed  Europe PubMed DOI  PMC  EPMC
    46. 2021
  46. Ahsanuddin,S., Roy,S., Nasser,W., Povolotskiy,R. and Paskhover,B.
    Adverse Events Associated With Botox as Reported in a Food and Drug Administration Database
    Aesthetic Plast Surg (2021) 45, 1201-1209. PubMed  Europe PubMed DOI  V
  47. Amezcua,M., Cruz,R.S., Ku,A., Moran,W., Ortega,M.E. and Salzameda,N.T.
    Discovery of Dipeptides as Potent Botulinum Neurotoxin A Light-Chain Inhibitors
    ACS Med Chem Lett (2021) 12, 295-301. PubMed  Europe PubMed DOI  PMC  EPMC  I
  48. Andreou,A.P., Leese,C., Greco,R., Demartini,C., Corrie,E., Simsek,D., Zanaboni,A., Koroleva,K., Lloyd,J.O., Lambru,G., Doran,C., Gafurov,O., Seward,E., Giniatullin,R., Tassorelli,C. and Davletov,B.
    Double-Binding Botulinum Molecule with Reduced Muscle Paralysis: Evaluation in In Vitro and In Vivo Models of Migraine
    Neurotherapeutics (2021) 18, 556-568. PubMed  Europe PubMed DOI
  49. Blum,T.R., Liu,H., Packer,M.S., Xiong,X., Lee,P.G., Zhang,S., Richter,M., Minasov,G., Satchell,K.J.F., Dong,M. and Liu,D.R.
    Phage-assisted evolution of botulinum neurotoxin proteases with reprogrammed specificity
    Science (2021) 371, 803-810. PubMed  Europe PubMed DOI
  50. Dong,M. and Stenmark,P.
    The structure and classification of Botulinum toxins
    Handb Exp Pharmacol (2021) 263, 11-33. PubMed  Europe PubMed DOI
  51. Gardner,A., Tepp,W.H., Bradshaw,M., Barbieri,J.T. and Pellett,S.
    Resolution of Two Steps in Botulinum Neurotoxin Serotype A1 Light Chain Localization to the Intracellular Plasma Membrane
    Int J Mol Sci (2021) 22 PubMed  Europe PubMed DOI  PMC  EPMC
  52. Lin,L., Turner,L.D., Silhar,P., Pellett,S., Johnson,E.A. and Janda,K.D.
    Identification of 3-hydroxy-1,2-dimethylpyridine-4(1H)-thione as a metal-binding motif for the inhibition of botulinum neurotoxin A
    RSC Med Chem (2021) 12, 137-143. PubMed  Europe PubMed DOI  PMC  EPMC
  53. Patel,K.B., Kononova,O., Cai,S., Barsegov,V., Parmar,V.S., Kumar,R. and Singh,B.R.
    Botulinum neurotoxin inhibitor binding dynamics and kinetics relevant for drug design
    Biochim Biophys Acta Gen Subj (2021) 1865, 129933-129933. PubMed  Europe PubMed DOI  I
  54. Song,F., Shen,Y., Wei,Y., Yang,C., Ge,X., Wang,A., Li,C., Wan,Y. and Li,J.
    Botulinum toxin as an ultrasensitive reporter for bacterial and SARS-CoV-2 nucleic acid diagnostics
    Biosens Bioelectron (2021) 176, 112953-112953. PubMed  Europe PubMed DOI  PMC  EPMC
  55. Stenmark,P.
    Re-engineering Botox
    Science (2021) 371, 782-782. PubMed  Europe PubMed DOI
  56. Tevell Aberg,A., Karlsson,I. and Hedeland,M.
    Modification and validation of the Endopep-mass spectrometry method for botulinum neurotoxin detection in liver samples with application to samples collected during animal botulism outbreaks
    Anal Bioanal Chem (2021) 413, 345-354. PubMed  Europe PubMed DOI
  57. Turner,L.D., Nielsen,A.L., Lin,L., Campedelli,A.J., Silvaggi,N.R., Chen,J.S., Wakefield,A.E., Allen,K.N. and Janda,K.D.
    Use of Crystallography and Molecular Modeling for the Inhibition of the Botulinum Neurotoxin A Protease
    ACS Med Chem Lett (2021) 12, 1318-1324. PubMed  Europe PubMed DOI  PMC  EPMC
  58. Xu,D., Zhang,D.S., Hu,X.F. and Hu,M.Y.
    Evaluation of the efficiency and safety of botulinum toxin A injection on improving facial scars: A protocol for systematic review and meta-analysis
    Medicine (Baltimore) (2021) 100, e23034-e23034. PubMed  Europe PubMed DOI  PMC  EPMC
    59. 2020
  59. Akpinar,O., Ozsimsek,A., Guzel,M. and Naziroglu,M.
    Clostridium botulinum neurotoxin A induces apoptosis and mitochondrial oxidative stress via activation of TRPM2 channel signaling pathway in neuroblastoma and glioblastoma tumor cells
    J Recept Signal Transduct Res (2020) , 1-13. PubMed  Europe PubMed DOI
  60. Bae,H., Kim,J., Seo,K.K., Hu,K.S., Kim,S.T. and Kim,H.J.
    Comparison between Conventional Blind Injections and Ultrasound-Guided Injections of Botulinum Toxin Type A into the Masseter: A Clinical Trial
    Toxins (Basel) (2020) 12 PubMed  Europe PubMed DOI  PMC  EPMC
  61. Behrensdorf-Nicol,H.A., Bonifas,U., Klimek,J., Hanschmann,K.M., Dorner,B.G., Hohenadl,C., Tollner,L., Kegel,B. and Kramer,B.
    Transferability study of the BINACLE (binding and cleavage) assay for in vitro determination of botulinum neurotoxin activity
    Biologicals (2020) PubMed  Europe PubMed DOI
  62. Bekkers,S., van Ulsen,K.J., Adang,M.M., Scheffer,R.T. and van den Hoogen,J.A.
    Cost-effectiveness of botulinum neurotoxin A versus surgery for drooling: a randomized clinical trial
    Dev Med Child Neurol (2020) PubMed  Europe PubMed DOI
  63. Bensen,G.P., Rutherford,C.C. and Gardner,T.B.
    Systemic Botulism Toxicity Caused by Pyloric Botox Injection to Treat Gastroparesis
    Case Rep Gastroenterol (2020) 14, 373-376. PubMed  Europe PubMed DOI  PMC  EPMC
  64. Brunt,J., van Vliet,A.H.M., Carter,A.T., Stringer,S.C., Amar,C., Grant,K.A., Godbole,G. and Peck,M.W.
    Diversity of the Genomes and Neurotoxins of Strains of Clostridium botulinum Group I and Clostridium sporogenes Associated with Foodborne, Infant and Wound Botulism
    Toxins (Basel) (2020) 12 PubMed  Europe PubMed DOI  PMC  EPMC
  65. Cachero,S., Gkantia,M., Bates,A.S., Frechter,S., Blackie,L., McCarthy,A., Sutcliffe,B., Strano,A., Aso,Y. and Jefferis,G.S.X.E.
    BAcTrace, a tool for retrograde tracing of neuronal circuits in Drosophila
    Nat Methods (2020) PubMed  Europe PubMed DOI
  66. Eleopra,R., Rinaldo,S., Montecucco,C., Rossetto,O. and Devigili,G.
    Clinical duration of action of different botulinum toxin types in humans
    Toxicon (2020) 179, 84-91. PubMed  Europe PubMed DOI
  67. Hasan,F.
    Manufacturing and clinical formulations of Botulinum neurotoxins
    Handb Exp Pharmacol (2020) PubMed  Europe PubMed DOI
  68. Klisara,N., Palaniappan,A. and Liedberg,B.
    Sorbent-incorporated dipstick for direct assaying of proteases
    Anal Bioanal Chem (2020) 412, 1385-1393. PubMed  Europe PubMed DOI  A
  69. Kohda,T., Tsukamoto,K., Torii,Y., Kozaki,S. and Mukamoto,M.
    Translocation domain of botulinum neurotoxin A subtype 2 potently induces entry into neuronal cells
    Microbiol Immunol (2020) PubMed  Europe PubMed DOI
  70. Kotteduwa Jayawarden,S., Sandarage,R., Farag,J., Ganzert,C., Winston,P., Mills,P. and Reebye,R.
    Effect of treating elbow flexor spasticity with botulinum toxin injection and adjunctive casting on hemiparetic gait parameters: A prospective case series
    J Rehabil Med (2020) 52, jrm00110-jrm00110. PubMed  Europe PubMed DOI
  71. Kumar,R., Maksudov,F., Kononova,O., Marx,K.A., Barsegov,V. and Singh,B.R.
    Botulinum Endopeptidase: SAXS Experiments and MD Simulations Reveal Extended Solution Structures That Account for Its Biochemical Properties
    J Phys Chem B (2020) 124, 5801-5812. PubMed  Europe PubMed DOI
  72. Matsumura,T., Amatsu,S., Misaki,R., Yutani,M., Du,A., Kohda,T., Fujiyama,K., Ikuta,K. and Fujinaga,Y.
    Fully human monoclonal antibodies effectively neutralizing Botulinum neurotoxin serotype B
    Toxins (Basel) (2020) 12 PubMed  Europe PubMed DOI
  73. Morscher,M.A., Thomas,M.D., Sahgal,S. and Adamczyk,M.J.
    Onabotulinum toxin type A injection into the triceps unmasks elbow flexion in infant brachial plexus birth palsy: A retrospective observational cohort study
    Medicine (Baltimore) (2020) 99, e21830-e21830. PubMed  Europe PubMed DOI  PMC  EPMC
  74. Senel,E. and Muslu,U.
    Global Trends of Botulinum Toxin Literature: A Bibliometric Analysis of Botulinum Toxin Publications Between 1975 and 2017
    J Cutan Aesthet Surg (2020) 13, 95-102. PubMed  Europe PubMed DOI  PMC  EPMC
  75. Sikorra,S., Donald,S., Elliott,M., Schwede,S., Coker,S.F., Kupinski,A.P., Tripathi,V., Foster,K., Beard,M. and Binz,T.
    Engineering an Effective Human SNAP-23 Cleaving Botulinum Neurotoxin A Variant
    Toxins (Basel) (2020) 12 PubMed  Europe PubMed DOI  PMC  EPMC
  76. Thompson,J.C., Dao,W.T., Ku,A., Rodriguez-Beltran,S.L., Amezcua,M., Palomino,A.Y., Lien,T. and Salzameda,N.T.
    Synthesis and activity of isoleucine sulfonamide derivatives as novel botulinum neurotoxin serotype A light chain inhibitors
    Bioorg Med Chem (2020) 28, 115659-115659. PubMed  Europe PubMed DOI
  77. Wang,L., Ringelberg,C.S. and Singh,B.R.
    Dramatic neurological and biological effects by botulinum neurotoxin type A on SH-SY5Y neuroblastoma cells, beyond the blockade of neurotransmitter release
    BMC Pharmacol Toxicol (2020) 21, 66-66. PubMed  Europe PubMed DOI  PMC  EPMC
  78. Winner,B.M., Bodt,S.M.L. and McNutt,P.M.
    Special Delivery: Potential Mechanisms of Botulinum Neurotoxin Uptake and Trafficking within Motor Nerve Terminals
    Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC
  79. Yershov,D. and Partridge,R.
    Life Threatening Delayed Complication of Botulinum Toxin Injection for Treatment of Spasmodic Dysphonia
    Prague Med Rep (2020) 121, 114-117. PubMed  Europe PubMed DOI
  80. Yin,L., Masuyer,G., Zhang,S., Zhang,J., Miyashita,S.I., Burgin,D., Lovelock,L., Coker,S.F., Fu,T.M., Stenmark,P. and Dong,M.
    Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy
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    81. 2019
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