Structure for inhibitor I39.950: complement component C3

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Pharma

TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Bos taurus
complex with an intact thioester	3.00 Å	2B39	2B39	2B39	2B39	2B39	2B39	Fredslund et al., 2006
Homo sapiens
Fragment C3D	1.80 Å	1C3D	1C3D	1C3D	1C3D	1C3D	1C3D	Nagar et al., 1998
cr2-c3d complex structure	2.04 Å	1GHQ	1GHQ	1GHQ	1GHQ	1GHQ	1GHQ	Szakonyi et al., 2001
mature inhibitor	0.00 Å	1W2S	1W2S	1W2S	1W2S	1W2S	1W2S	Gilbert et al., 2005
human complement component c3	3.30 Å	2A73	2A73	2A73	2A73	2A73	2A73	Janssen et al., 2005
human complement component c3c	2.40 Å	2A74	2A74	2A74	2A74	2A74	2A74	Janssen et al., 2005
complex with EFB-c	2.20 Å	2GOX	2GOX	2GOX	2GOX	2GOX	2GOX	Hammel et al., 2007
structure of complement c3b: insights into complement activation and regulation	2.26 Å	2HR0	2HR0	2HR0	2HR0	2HR0	2HR0	Abdul et al., 2006
human complement component c3b	4.00 Å	2I07	2I07	2I07	2I07	2I07	2I07	Janssen et al., 2006
crig bound to c3c	3.10 Å	2ICE	2ICE	2ICE	2ICE	2ICE	2ICE	Wiesmann et al., 2006
crig bound to c3b	4.10 Å	2ICF	2ICF	2ICF	2ICF	2ICF	2ICF	Wiesmann et al., 2006
complex with EHP	2.70 Å	2NOJ	2NOJ	2NOJ	2NOJ	2NOJ	2NOJ	Hammel et al., 2007
human c3c in complex with the inhibitor compstatin	2.40 Å	2QKI	2QKI	2QKI	2QKI	2QKI	2QKI	Janssen et al., 2007
complement c3b in complex with factor h domains 1-4	2.70 Å	2WII	2WII	2WII	2WII	2WII	2WII	Wu et al., 2009
c3 convertase (c3bbb) stabilized by scin	3.90 Å	2WIN	2WIN	2WIN	2WIN	2WIN	2WIN	Rooijakkers et al., 2009
mature inhibitor	1.70 Å	2WY7	2WY7	2WY7	2WY7	2WY7	2WY7	Clark et al., 2011
mature inhibitor	1.70 Å	2WY8	2WY8	2WY8	2WY8	2WY8	2WY8	Clark et al., 2011
mature inhibitor	2.31 Å	2XQW	2XQW	2XQW	2XQW	2XQW	2XQW	Kajander et al., 2011
mature inhibitor	3.49 Å	2XWB	2XWB	2XWB	2XWB	2XWB	2XWB	Forneris et al., 2010
mature inhibitor	4.00 Å	2XWJ	2XWJ	2XWJ	2XWJ	2XWJ	2XWJ	Forneris et al., 2010
crystal structure of efb-c (n138a) / c3d complex	2.10 Å	3D5R	3D5R	3D5R	3D5R	3D5R	3D5R	Haspel et al., 2008
crystal structure of efb-c (r131a) / c3d complex	2.30 Å	3D5S	3D5S	3D5S	3D5S	3D5S	3D5S	Haspel et al., 2008
c3b in complex with a c3b specific fab	3.10 Å	3G6J	3G6J	3G6J	3G6J	3G6J	3G6J	Katschke et al., 2009
mature inhibitor	3.40 Å	3L3O	3L3O	3L3O	3L3O	3L3O	3L3O	Garcia et al., 2010
mature inhibitor	7.54 Å	3L5N	3L5N	3L5N	3L5N	3L5N	3L5N	Garcia et al., 2010
mature inhibitor	4.10 Å	3NMS	3NMS	3NMS	3NMS	3NMS	3NMS	Garcia et al., 2010
mature inhibitor	3.16 Å	3OED	3OED	3OED	3OED	3OED	3OED	van & Isenman, 2011
mature inhibitor	3.50 Å	3OHX	3OHX	3OHX	3OHX	3OHX	3OHX	Garcia et al., 2010
mature inhibitor	2.10 Å	3OXU	3OXU	3OXU	3OXU	3OXU	3OXU	Morgan et al., 2011
mature inhibitor	2.35 Å	3RJ3	3RJ3	3RJ3	3RJ3	3RJ3	3RJ3	Herbert et al., 2012
mature inhibitor	3.40 Å	3T4A	3T4A	3T4A	3T4A	3T4A	3T4A	Garcia et al., 2012
mature inhibitor	2.25 Å	4HW5	4HW5	4HW5	4HW5	4HW5	4HW5	Bajic et al., 2013
mature inhibitor	2.60 Å	4HWJ	4HWJ	4HWJ	4HWJ	4HWJ	4HWJ	Bajic et al., 2013
mature inhibitor	2.14 Å	4I6O	4I6O	4I6O	4I6O	4I6O	4I6O	Ghassemian et al., 2013
mature inhibitor	2.80 Å	4M76	4M76	4M76	4M76	4M76	4M76	Bajic et al., 2013
mature inhibitor	2.15 Å	4ONT	4ONT	4ONT	4ONT	4ONT	4ONT	Blaum et al., 2015
complement factor h in complex with the gm1 glycan	2.24 Å	4ZH1	4ZH1	4ZH1	4ZH1	4ZH1	4ZH1
crystal structure of human complement c3b at 2.8 angstrom resolution	2.80 Å	5FO7	5FO7	5FO7	5FO7	5FO7	5FO7
complex with mcp (ccp1-4)	2.40 Å	5FO8	5FO8	5FO8	5FO8	5FO8	5FO8
crystal structure of human complement c3b in complex with cr1 (ccp15-17)	3.30 Å	5FO9	5FO9	5FO9	5FO9	5FO9	5FO9
complex with daf (ccp2-4)	4.19 Å	5FOA	5FOA	5FOA	5FOA	5FOA	5FOA
complex with smallpox inhibitor of complement (spice)	2.60 Å	5FOB	5FOB	5FOB	5FOB	5FOB	5FOB
properdin in complex with alternative pathway c3 convertase	6.00 Å	5M6W	5M6W	5M6W	5M6W	5M6W	5M6W
the structure of the tripartite complex between ospe, the c-terminal domains of factor h and c3dg	3.18 Å	5NBQ	5NBQ	5NBQ	5NBQ	5NBQ	5NBQ
the structure of complement complex	4.21 Å	5O32	5O32	5O32	5O32	5O32	5O32
structure of complement proteins complex	4.20 Å	5O35	5O35	5O35	5O35	5O35	5O35
complement component c3b in complex with a nanobody	2.65 Å	6EHG	6EHG	6EHG	6EHG	6EHG	6EHG
Naja naja
crystal structure of cobra venom factor, a co-factor for c3- and c5 convertase cvfbb	2.61 Å	3FRP	3FRP	3FRP	3FRP	3FRP	3FRP	Krishnan et al., 2009
mature inhibitor	2.20 Å	3HRZ	3HRZ	3HRZ	3HRZ	3HRZ	3HRZ	Janssen et al., 2009
mature inhibitor	3.00 Å	3HS0	3HS0	3HS0	3HS0	3HS0	3HS0	Janssen et al., 2009
mature inhibitor	4.30 Å	3PRX	3PRX	3PRX	3PRX	3PRX	3PRX	Laursen et al., 2011
mature inhibitor	4.30 Å	3PVM	3PVM	3PVM	3PVM	3PVM	3PVM	Laursen et al., 2011
structure of complement c5 in complex with small molecule inhibitor and cvf	3.35 Å	6I2X	6I2X	6I2X	6I2X	6I2X	6I2X
Rattus norvegicus
n-terminally truncated c3d,g fragment of the complement system	1.45 Å	1QQF	1QQF	1QQF	1QQF	1QQF	1QQF	Zanotti et al., 2000
N-terminally truncated C3DG fragment	1.90 Å	1QSJ	1QSJ	1QSJ	1QSJ	1QSJ	1QSJ	Zanotti et al., 2000