PDBe 4m76

X-ray diffraction
2.8Å resolution

Integrin I domain of complement receptor 3 in complex with C3d

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Complement C3d fragment Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 33.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01024 (Residues: 994-1288; Coverage: 18%)
Gene names: C3, CPAMD1
Structure domains: Glycosyltransferase
Integrin alpha-M Chain: B
Molecule details ›
Chain: B
Length: 198 amino acids
Theoretical weight: 22.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P11215 (Residues: 143-337; Coverage: 17%)
Gene names: CD11B, CR3A, ITGAM
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: C2
Unit cell:
a: 144.46Å b: 65.12Å c: 62.54Å
α: 90° β: 115.69° γ: 90°
R-values:
R R work R free
0.198 0.194 0.242
Expression system: Escherichia coli BL21(DE3)