PDBe 2xqw

X-ray diffraction
2.31Å resolution

Structure of Factor H domains 19-20 in complex with complement C3d

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero trimer (preferred)
monomeric
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Complement C3d fragment Chains: A, B
Molecule details ›
Chains: A, B
Length: 294 amino acids
Theoretical weight: 32.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01024 (Residues: 996-1287; Coverage: 18%)
Gene names: C3, CPAMD1
Structure domains: Glycosyltransferase
Complement factor H Chain: C
Molecule details ›
Chain: C
Length: 133 amino acids
Theoretical weight: 14.98 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P08603 (Residues: 1103-1231; Coverage: 11%)
Gene names: CFH, HF, HF1, HF2
Sequence domains: Sushi repeat (SCR repeat)
Structure domains: Complement Module, domain 1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P61
Unit cell:
a: 103.554Å b: 103.554Å c: 141.211Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.203 0.2 0.242
Expression systems:
  • Escherichia coli BL21(DE3)
  • Komagataella pastoris