PDBe 3l5n

X-ray diffraction
7.54Å resolution

Staphylococcal Complement Inhibitor (SCIN) in complex with Human Complement Component C3b

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Complement C3 beta chain Chain: A
Molecule details ›
Chain: A
Length: 645 amino acids
Theoretical weight: 71.39 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01024 (Residues: 23-667; Coverage: 39%)
Gene names: C3, CPAMD1
Sequence domains:
Complement C3b alpha' chain Chain: B
Molecule details ›
Chain: B
Length: 915 amino acids
Theoretical weight: 104.07 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01024 (Residues: 749-1663; Coverage: 56%)
Gene names: C3, CPAMD1
Sequence domains:
Staphylococcal complement inhibitor Chain: M
Molecule details ›
Chain: M
Length: 88 amino acids
Theoretical weight: 10.06 KDa
Source organism: Staphylococcus aureus subsp. aureus Mu50
Expression system: Escherichia coli
UniProt:
  • Canonical: Q931M7 (Residues: 32-116; Coverage: 100%)
Gene names: SAV1942, scn

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P41212
Unit cell:
a: 128.026Å b: 128.026Å c: 468.591Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.265 0.265 0.268
Expression system: Escherichia coli