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PDBsum entry 6i2x
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protein ligands metals Protein-protein interface(s) links
Immune system PDB id
6i2x

 

 

 

 

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Contents
Protein chains
648 a.a.
815 a.a.
951 a.a.
Ligands
H1H
Metals
_MG
PDB id:
6i2x
Name: Immune system
Title: Structure of complement c5 in complex with small molecule inhibitor and cvf
Structure: Complement c5. Chain: c. Fragment: beta chain, unp residues 1-675. Synonym: c3 and pzp-like alpha-2-macroglobulin domain-containing protein 4. Complement c5. Chain: a. Fragment: alpha chain, unp residues 678-1676. Synonym: c3 and pzp-like alpha-2-macroglobulin domain-containing
Source: Homo sapiens. Human. Organism_taxid: 9606. Naja kaouthia. Monocled cobra. Organism_taxid: 8649
Authors: H.Srinivas
Key ref: K.Jendza et al. (2019). A small-molecule inhibitor of C5 complement protein. Nat Chem Biol, 15, 666-668. PubMed id: 31209353 DOI: 10.1038/s41589-019-0303-9
Date:
02-Nov-18     Release date:   26-Jun-19    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P01031  (CO5_HUMAN) -  Complement C5 from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1676 a.a.
648 a.a.
Protein chain
Pfam   ArchSchema ?
P01031  (CO5_HUMAN) -  Complement C5 from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1676 a.a.
815 a.a.
Protein chain
Pfam   ArchSchema ?
Q91132  (VCO3_NAJKA) -  Cobra venom factor from Naja kaouthia
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1642 a.a.
951 a.a.
Key:    PfamA domain  Secondary structure

 

 
DOI no: 10.1038/s41589-019-0303-9 Nat Chem Biol 15:666-668 (2019)
PubMed id: 31209353  
 
 
A small-molecule inhibitor of C5 complement protein.
K.Jendza, M.Kato, M.Salcius, H.Srinivas, A.De Erkenez, A.Nguyen, D.McLaughlin, C.Be, C.Wiesmann, J.Murphy, P.Bolduc, M.Mogi, J.Duca, A.Namil, M.Capparelli, V.Darsigny, E.Meredith, R.Tichkule, L.Ferrara, J.Heyder, F.Liu, P.A.Horton, M.J.Romanowski, M.Schirle, N.Mainolfi, K.Anderson, G.A.Michaud.
 
  ABSTRACT  
 
The complement pathway is an important part of the immune system, and uncontrolled activation is implicated in many diseases. The human complement component 5 protein (C5) is a validated drug target within the complement pathway, as an anti-C5 antibody (Soliris) is an approved therapy for paroxysmal nocturnal hemoglobinuria. Here, we report the identification, optimization and mechanism of action for the first small-molecule inhibitor of C5 complement protein.
 

 

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