Structure for peptidase C03.011: Coxsackievirus-type picornain 3C

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

PDB	Organism	Resolution	Comment
2ZU3_A	human coxsackievirus B3	1.75 Å	mature
Catalytic residues are shown in ball-and-stick representation: His1580 in purple, Glu1611 in blue and Cys1687 in yellow.

		Show surface

TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
human coxsackievirus B3
coxsackievirus b3 coat protein	3.50 Å	1COV	1COV	1COV	1COV	1COV	1COV
mature peptidase	2.40 Å	2VB0	2VB0	2VB0	2VB0	2VB0	2VB0	Zell et al., 2002
complex with epdtc	1.72 Å	2ZTX	2ZTX	2ZTX	2ZTX	2ZTX	2ZTX	Lee et al., 2009
space group c2	1.72 Å	2ZTY	2ZTY	2ZTY	2ZTY	2ZTY	2ZTY	Lee et al., 2009
space group p21	2.00 Å	2ZTZ	2ZTZ	2ZTZ	2ZTZ	2ZTZ	2ZTZ	Lee et al., 2009
Cys147Ala mutant	1.38 Å	2ZU1	2ZU1	2ZU1	2ZU1	2ZU1	2ZU1	Lee et al., 2009
mature peptidase	1.75 Å	2ZU3	2ZU3	2ZU3	2ZU3	2ZU3	2ZU3	Lee et al., 2009
the novel asymmetric entry intermediate of a picornavirus captured with nanodiscs	3.90 Å	3JD7	3JD7	3JD7	3JD7	3JD7	3JD7
crystal structure of 3c protease of coxsackievirus b3	1.70 Å	3ZYD	3ZYD	3ZYD	3ZYD	3ZYD	3ZYD
Thr68Ala mutant	1.85 Å	3ZYE	3ZYE	3ZYE	3ZYE	3ZYE	3ZYE
crystal structure of 3c protease mutant (Asn126Tyr) of coxsackievirus b3	1.89 Å	3ZZ3	3ZZ3	3ZZ3	3ZZ3	3ZZ3	3ZZ3
Thr68Ala and Asn126Tyr mutant	2.10 Å	3ZZ4	3ZZ4	3ZZ4	3ZZ4	3ZZ4	3ZZ4
complex with alpha, beta-unsaturated ethyl ester inhibitor 74	2.20 Å	3ZZ5	3ZZ5	3ZZ5	3ZZ5	3ZZ5	3ZZ5
complex with michael receptor inhibitor 75	2.05 Å	3ZZ6	3ZZ6	3ZZ6	3ZZ6	3ZZ6	3ZZ6
complex with alpha, beta-unsaturated ethyl ester inhibitor 81	1.80 Å	3ZZ7	3ZZ7	3ZZ7	3ZZ7	3ZZ7	3ZZ7
complex with alpha, beta-unsaturated ethyl ester inhibitor 82	1.85 Å	3ZZ8	3ZZ8	3ZZ8	3ZZ8	3ZZ8	3ZZ8
complex with alpha, beta-unsaturated ethyl ester inhibitor 83	1.90 Å	3ZZ9	3ZZ9	3ZZ9	3ZZ9	3ZZ9	3ZZ9
complex with alpha, beta-unsaturated ethyl ester inhibitor 84	1.80 Å	3ZZA	3ZZA	3ZZA	3ZZA	3ZZA	3ZZA
complex with alpha, beta-unsaturated ethyl ester inhibitor 85	2.10 Å	3ZZB	3ZZB	3ZZB	3ZZB	3ZZB	3ZZB
Thr68Ala and Asn126Tyr mutant; complex with alpha, beta-unsaturated ethyl ester inhibitor 83	2.10 Å	3ZZC	3ZZC	3ZZC	3ZZC	3ZZC	3ZZC
Thr68Ala and Asn126Tyr mutant; complex with alpha, beta-unsaturated ethyl ester inhibitor 85	2.10 Å	3ZZD	3ZZD	3ZZD	3ZZD	3ZZD	3ZZD
human echovirus 18
echovirus 18 native particle	3.16 Å	6HBG	6HBG	6HBG	6HBG	6HBG	6HBG
echovirus 18 a-particle	3.36 Å	6HBH	6HBH	6HBH	6HBH	6HBH	6HBH
echovirus 18 empty particle	3.16 Å	6HBJ	6HBJ	6HBJ	6HBJ	6HBJ	6HBJ
echovirus 18 open particle without one pentamer	3.80 Å	6HBK	6HBK	6HBK	6HBK	6HBK	6HBK
echovirus 18 open particle without three pentamers	3.70 Å	6HBL	6HBL	6HBL	6HBL	6HBL	6HBL
human enterovirus B
crystal structure of the main protease (3c) from human enterovirus b ev93	1.90 Å	3Q3X	3Q3X	3Q3X	3Q3X	3Q3X	3Q3X
complex with compound 1 (ag7404)	1.32 Å	3Q3Y	3Q3Y	3Q3Y	3Q3Y	3Q3Y	3Q3Y
complex with rupintrivir (ag7088)	1.50 Å	3RUO	3RUO	3RUO	3RUO	3RUO	3RUO
human enterovirus D
mature peptidase	2.40 Å	3ZV8	3ZV8	3ZV8	3ZV8	3ZV8	3ZV8	Tan et al., 2013
complex with Michael receptor inhibitor 74	2.05 Å	3ZV9	3ZV9	3ZV9	3ZV9	3ZV9	3ZV9	Tan et al., 2013
complex with Michael receptor inhibitor 75	2.20 Å	3ZVA	3ZVA	3ZVA	3ZVA	3ZVA	3ZVA	Tan et al., 2013
complex with Michael receptor inhibitor 81	2.65 Å	3ZVB	3ZVB	3ZVB	3ZVB	3ZVB	3ZVB	Tan et al., 2013
complex with Michael receptor inhibitor 82	2.00 Å	3ZVC	3ZVC	3ZVC	3ZVC	3ZVC	3ZVC	Tan et al., 2013
complex with Michael receptor inhibitor 83	2.25 Å	3ZVD	3ZVD	3ZVD	3ZVD	3ZVD	3ZVD	Tan et al., 2013
complex with Michael receptor inhibitor 84	1.80 Å	3ZVE	3ZVE	3ZVE	3ZVE	3ZVE	3ZVE	Tan et al., 2013
complex with Michael receptor inhibitor 85	2.50 Å	3ZVF	3ZVF	3ZVF	3ZVF	3ZVF	3ZVF	Tan et al., 2013
complex with Michael receptor inhibitor 98	2.10 Å	3ZVG	3ZVG	3ZVG	3ZVG	3ZVG	3ZVG	Tan et al., 2013