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Literature for peptidase C03.011: Coxsackievirus-type picornain 3C

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Das,N.K., Patel,A., Abdelghani,R. and Koirala,D.<br>Structural basis for 3C and 3CD recruitment by enteroviral genomes during negative-strand RNA synthesis<br>Nat Commun (2025) 16, 9293-9293. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2024
  2. De Santis,A., Grifagni,D., Orsetti,A., Lenci,E., Rosato,A., D'Onofrio,M., Trabocchi,A., Ciofi-Baffoni,S., Cantini,F. and Calderone,V.<br>A Structural Investigation of the Interaction between a GC-376-Based Peptidomimetic PROTAC and Its Precursor with the Viral Main Protease of Coxsackievirus B3<br>Biomolecules (2024) 14 PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2023
  3. Andrews,D.D.T., Vlok,M., Akbari Bani,D., Hay,B.N., Mohamud,Y., Foster,L.J., Luo,H., Overall,C.M. and Jan,E.<br>Cleavage of 14-3-3epsilon by the enteroviral 3C protease dampens RIG-I-mediated antiviral signaling<br>J Virol (2023) 97, e0060423-e0060423. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2022
  4. Fan,W., McDougal,M.B. and Schoggins,J.W.<br>Enterovirus 3C Protease Cleaves TRIM7 To Dampen Its Antiviral Activity<br>J Virol (2022) 96, e0133222-e0133222. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Fan,Y.M., Zhang,Y.L., Bahreyni,A., Luo,H. and Mohamud,Y.<br>Coxsackievirus Protease 2A Targets Host Protease ATG4A to Impair Autophagy<br>Viruses (2022) 14 PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2020
  6. Mohamud,Y., Shi,J., Tang,H., Xiang,P., Xue,Y.C., Liu,H., Ng,C.S. and Luo,H.<br>Coxsackievirus infection induces a non-canonical autophagy independent of the ULK and PI3K complexes<br>Sci Rep (2020) 10, 19068-19068. PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2018
  7. Jagdeo,J.M., Dufour,A., Klein,T., Solis,N., Kleifeld,O., Kizhakkedathu,J., Luo,H., Overall,C.M. and Jan,E.<br>N-Terminomics TAILS identifies host cell substrates of poliovirus and coxsackievirus B3 3C proteinases that modulate virus infection<br>J Virol (2018) 92, e02211-17-e02211-17. PubMed  Europe PubMed DOI
  8. Jung,E., Lee,J.Y., Kim,H.J., Ryu,C.K., Lee,K.I., Kim,M., Lee,C.K. and Go,Y.Y.<br>Identification of quinone analogues as potential inhibitors of picornavirus 3C protease in vitro<br>Bioorg Med Chem Lett (2018) 28, 2533-2538. PubMed  Europe PubMed DOI  I
  9. Laitinen,O.H., Svedin,E., Kapell,S., Hankaniemi,M.M., Larsson,P.G., Domsgen,E., Stone,V.M., Maatta,J.A.E., Hyoty,H., Hytonen,V.P. and Flodstrom-Tullberg,M.<br>New Coxsackievirus 2A(pro) and 3C(pro) protease antibodies for virus detection and discovery of pathogenic mechanisms<br>J Virol Methods (2018) 255, 29-37. PubMed  Europe PubMed DOI
    10. 2017
  10. Rui,Y., Su,J., Wang,H., Chang,J., Wang,S., Zheng,W., Cai,Y., Wei,W., Gordy,J.T., Markham,R., Kong,W., Zhang,W. and Yu,X.F.<br>Disruption of MDA5 mediated innate immune responses by the 3C proteins of Coxsackievirus A16, Coxsackievirus A6, and Enterovirus D68<br>J Virol (2017) DOI
    11. 2016
  11. Becker,D., Kaczmarska,Z., Arkona,C., Schulz,R., Tauber,C., Wolber,G., Hilgenfeld,R., Coll,M. and Rademann,J.<br>Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments<br>Nat Commun (2016) 7, 12761-12761. PubMed  Europe PubMed DOI  I
  12. Fili,S., Valmas,A., Christopoulou,M., Spiliopoulou,M., Nikolopoulos,N., Lichiere,J., Logotheti,S., Karavassili,F., Rosmaraki,E., Fitch,A., Wright,J., Beckers,D., Degen,T., Nenert,G., Hilgenfeld,R., Papageorgiou,N., Canard,B., Coutard,B. and Margiolaki,I.<br>Coxsackievirus B3 protease 3C: expression, purification, crystallization and preliminary structural insights<br>Acta Crystallogr F Struct Biol Commun (2016) 72, 877-884. PubMed  Europe PubMed DOI  E
  13. Jetsadawisut,W., Nutho,B., Meeprasert,A., Rungrotmongkol,T., Kungwan,N., Wolschann,P. and Hannongbua,S.<br>Susceptibility of inhibitors against 3C protease of coxsackievirus A16 and enterovirus A71 causing hand, foot and mouth disease: a molecular dynamics study<br>Biophys Chem (2016) 219, 9-16. PubMed  Europe PubMed DOI  I
  14. Kim,B.K., Ko,H., Jeon,E.S., Ju,E.S., Jeong,L.S. and Kim,Y.C.<br>2,3,4-Trihydroxybenzyl-hydrazide analogues as novel potent coxsackievirus B3 3C protease inhibitors<br>Eur J Med Chem (2016) 120, 202-216. PubMed  Europe PubMed DOI  I
    15. 2015
  15. Bhakat,S.<br>Effect of T68A/N126Y mutations on the conformational and ligand binding landscape of Coxsackievirus B3 3C protease<br>Mol Biosyst (2015) 11, 2303-2311. PubMed  Europe PubMed DOI
  16. Fung,G., Shi,J., Deng,H., Hou,J., Wang,C., Hong,A., Zhang,J., Jia,W. and Luo,H.<br>Cytoplasmic translocation, aggregation, and cleavage of TDP-43 by enteroviral proteases modulate viral pathogenesis<br>Cell Death Differ (2015) 22, 2087-2097. PubMed  Europe PubMed DOI
  17. Kim,B.K., Cho,J.H., Jeong,P., Lee,Y., Lim,J.J., Park,K.R., Eom,S.H. and Kim,Y.C.<br>Benserazide, the first allosteric inhibitor of Coxsackievirus B3 3C protease<br>FEBS Lett (2015) 589, 1795-1801. PubMed  Europe PubMed DOI  I
  18. Lim,B.K., Yun,S.H., Ju,E.S., Kim,B.K., Lee,Y.J., Yoo,D.K., Kim,Y.C. and Jeon,E.S.<br>Soluble Coxsackievirus B3 3C protease inhibitor prevents cardiomyopathy in an experimental chronic myocarditis murine model<br>Virus Res (2015) 199C, 1-8. PubMed  Europe PubMed DOI  I
  19. Song,J.H., Kwon,B.E., Jang,H., Kang,H., Cho,S., Park,K., Ko,H.J. and Kim,H.<br>Antiviral activity of chrysin derivatives against coxsackievirus B3 in vitro and in vivo<br>Biomol Ther (Seoul) (2015) 23, 465-470. PubMed  Europe PubMed DOI  PMC  EPMC  I
    20. 2013
  20. Tan,J., George,S., Kusov,Y., Perbandt,M., Anemuller,S., Mesters,J.R., Norder,H., Coutard,B., Lacroix,C., Leyssen,P., Neyts,J. and Hilgenfeld,R.<br>3C protease of enterovirus 68: structure-based design of Michael acceptor inhibitors and their broad-spectrum antiviral effects against picornaviruses<br>J Virol (2013) 87, 4339-4351. PubMed  Europe PubMed DOI  S  I
    21. 2012
  21. Skern,T.<br>Picornain 3C<br>[ISSN:978-0-12-407743-0] (2012) 3, 2396-2402. DOI
    22. 2011
  22. Costenaro,L., Kaczmarska,Z., Arnan,C., Janowski,R., Coutard,B., Sola,M., Gorbalenya,A.E., Norder,H., Canard,B. and Coll,M.<br>Structural basis for antiviral inhibition of the main protease, 3C, from human enterovirus 93<br>J Virol (2011) 85, 10764-10773. PubMed  Europe PubMed DOI  S  I
  23. Lu,G., Qi,J., Chen,Z., Xu,X., Gao,F., Lin,D., Qian,W., Liu,H., Jiang,H., Yan,J. and Gao,G.F.<br>Enterovirus 71 and coxsackievirus A16 3C proteases: binding to rupintrivir and their substrates and anti-hand, foot, and mouth disease virus drug design<br>J Virol (2011) 85, 10319-10331. PubMed  Europe PubMed DOI  S  I
  24. Mukherjee,A., Morosky,S.A., Delorme-Axford,E., Dybdahl-Sissoko,N., Oberste,M.S., Wang,T. and Coyne,C.B.<br>The Coxsackievirus B 3C protease cleaves MAVS and TRIF to attenuate host type I interferon and apoptotic signaling<br>PLoS Pathog (2011) 7, e1001311-e1001311. PubMed  Europe PubMed DOI  PMC  EPMC
    25. 2010
  25. Ramajayam,R., Tan,K.P., Liu,H.G. and Liang,P.H.<br>Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors<br>Bioorg Med Chem (2010) 18, 7849-7854. PubMed  Europe PubMed DOI  I
    26. 2009
  26. Lee,C.C., Kuo,C.J., Ko,T.P., Hsu,M.F., Tsui,Y.C., Chang,S.C., Yang,S., Chen,S.J., Chen,H.C., Hsu,M.C., Shih,S.R., Liang,P.H. and Wang,A.H.<br>Structural basis of inhibition specificities of 3C and 3C-like proteases by zinc-coordinating and peptidomimetic compounds<br>J Biol Chem (2009) 284, 7646-7655. PubMed  Europe PubMed DOI  PMC  EPMC  I
    27. 2008
  27. de Breyne,S., Bonderoff,J.M., Chumakov,K.M., Lloyd,R.E. and Hellen,C.U.<br>Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases<br>Virology (2008) 378, 118-122. PubMed  Europe PubMed DOI  PMC  EPMC
    28. 2007
  28. Chau,D.H., Yuan,J., Zhang,H., Cheung,P., Lim,T., Liu,Z., Sall,A. and Yang,D.<br>Coxsackievirus B3 proteases 2A and 3C induce apoptotic cell death through mitochondrial injury and cleavage of eIF4GI but not DAP5/p97/NAT1<br>Apoptosis (2007) 12, 513-524. PubMed  Europe PubMed DOI
  29. Lee,E.S., Lee,W.G., Yun,S.H., Rho,S.H., Im,I., Yang,S.T., Sellamuthu,S., Lee,Y.J., Kwon,S.J., Park,O.K., Jeon,E.S., Park,W.J. and Kim,Y.C.<br>Development of potent inhibitors of the coxsackievirus 3C protease<br>Biochem Biophys Res Commun (2007) 358, 7-11. PubMed  Europe PubMed DOI  I
    30. 2006
  30. [YEAR:26-1-2006]Hedhammar,M., Jung,H.R. and Hober,S.<br>Enzymatic cleavage of fusion proteins using immobilised protease 3C<br>Protein Expr Purif (26-1-2006) 47, 422-426. PubMed  Europe PubMed DOI  E
    31. 2004
  31. Ohlenschlager,O., Wohnert,J., Bucci,E., Seitz,S., Hafner,S., Ramachandran,R., Zell,R. and Gorlach,M.<br>The structure of the stemloop D subdomain of coxsackievirus B3 cloverleaf RNA and its interaction with the proteinase 3C<br>Structure (2004) 12, 237-248. PubMed  Europe PubMed DOI
  32. Skern,T.<br>Picornain 3C<br>[ISSN:0-12-079610-4] (2004) 2, 1353-1357.  V
    33. 1999
  33. Saura,M., Zaragoza,C., McMillan,A., Quick,R.A., Hohenadl,C., Lowenstein,J.M. and Lowenstein,C.J.<br>An antiviral mechanism of nitric oxide: Inhibition of a viral protease<br>Immunity (1999) 10, 21-28. PubMed  Europe PubMed DOI
    34. 1997
  34. Ryan,M.D. and Flint,M.<br>Virus-encoded proteinases of the picornavirus super-group<br>J Gen Virol (1997) 78, 699-723. PubMed  Europe PubMed
    35. 1996
  35. Miyashita,K., Okunishi,J., Utsumi,R., Tagiri,S., Hotta,K., Komano,T., Tamura,T. and Satoh,N.<br>Cleavage specificity of coxsackievirus 3C proteinase for peptide substrate (2): Importance of the P2 and P4 residues<br>Biosci Biotechnol Biochem (1996) 60, 1528-1529. PubMed  Europe PubMed
  36. Miyashita,K., Okunishi,J., Utsumi,R., Komano,T., Tamura,T. and Satoh,N.<br>Cleavage specificity of coxsackievirus 3C proteinase for peptide substrate<br>Biosci Biotechnol Biochem (1996) 60, 705-707. PubMed  Europe PubMed DOI  P
    37. 1995
  37. Miyashita,K., Utsumi,R., Utsumi,T., Komano,T. and Satoh,N.<br>Mutational analysis of the putative substrate-binding site of 3C proteinase of coxsackievirus B3<br>Biosci Biotechnol Biochem (1995) 59, 121-122. PubMed  Europe PubMed DOI
  38. Muckelbauer,J.K., Kremer,M., Minor,I., Tong,L., Zlotnick,A., Johnson,J.E. and Rossmann,M.G.<br>Structure determination of coxsackievirus B3 to 3.5 A resolution<br>Acta Crystallogr D Biol Crystallogr (1995) 51, 871-887. PubMed  Europe PubMed DOI
    39. 1993
  39. Miyashita,K., Kusumi,M., Utsumi,R., Katayama,S., Noda,M., Komano,T. and Satoh,N.<br>Site-directed mutagenesis of the putative active site residues of 3C proteinase of coxsackievirus B3: Evidence of a functional relationship with trypsin-like serine proteinases<br>Protein Eng (1993) 6, 189-193. PubMed  Europe PubMed
    40. 1991
  40. Lin,K.H., Takeda,N., Miyamura,K., Yamazaki,S. and Chen,C.W.<br>The nucleotide sequence of 3C proteinase region of the coxsackievirus A24 variant: comparison of the isolates in Taiwan in 1985-1988<br>Virus Genes (1991) 5, 121-131. PubMed  Europe PubMed

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