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Literature for peptidase C03.011: Coxsackievirus-type picornain 3C

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

(Topics flags: S Structure, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Das,N.K., Patel,A., Abdelghani,R. and Koirala,D.
    Structural basis for 3C and 3CD recruitment by enteroviral genomes during negative-strand RNA synthesis
    Nat Commun (2025) 16, 9293-9293. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2024
  2. De Santis,A., Grifagni,D., Orsetti,A., Lenci,E., Rosato,A., D'Onofrio,M., Trabocchi,A., Ciofi-Baffoni,S., Cantini,F. and Calderone,V.
    A Structural Investigation of the Interaction between a GC-376-Based Peptidomimetic PROTAC and Its Precursor with the Viral Main Protease of Coxsackievirus B3
    Biomolecules (2024) 14 PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2023
  3. Andrews,D.D.T., Vlok,M., Akbari Bani,D., Hay,B.N., Mohamud,Y., Foster,L.J., Luo,H., Overall,C.M. and Jan,E.
    Cleavage of 14-3-3epsilon by the enteroviral 3C protease dampens RIG-I-mediated antiviral signaling
    J Virol (2023) 97, e0060423-e0060423. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2022
  4. Fan,W., McDougal,M.B. and Schoggins,J.W.
    Enterovirus 3C Protease Cleaves TRIM7 To Dampen Its Antiviral Activity
    J Virol (2022) 96, e0133222-e0133222. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Fan,Y.M., Zhang,Y.L., Bahreyni,A., Luo,H. and Mohamud,Y.
    Coxsackievirus Protease 2A Targets Host Protease ATG4A to Impair Autophagy
    Viruses (2022) 14 PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2020
  6. Mohamud,Y., Shi,J., Tang,H., Xiang,P., Xue,Y.C., Liu,H., Ng,C.S. and Luo,H.
    Coxsackievirus infection induces a non-canonical autophagy independent of the ULK and PI3K complexes
    Sci Rep (2020) 10, 19068-19068. PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2018
  7. Jagdeo,J.M., Dufour,A., Klein,T., Solis,N., Kleifeld,O., Kizhakkedathu,J., Luo,H., Overall,C.M. and Jan,E.
    N-Terminomics TAILS identifies host cell substrates of poliovirus and coxsackievirus B3 3C proteinases that modulate virus infection
    J Virol (2018) 92, e02211-17-e02211-17. PubMed  Europe PubMed DOI
  8. Jung,E., Lee,J.Y., Kim,H.J., Ryu,C.K., Lee,K.I., Kim,M., Lee,C.K. and Go,Y.Y.
    Identification of quinone analogues as potential inhibitors of picornavirus 3C protease in vitro
    Bioorg Med Chem Lett (2018) 28, 2533-2538. PubMed  Europe PubMed DOI  I
  9. Laitinen,O.H., Svedin,E., Kapell,S., Hankaniemi,M.M., Larsson,P.G., Domsgen,E., Stone,V.M., Maatta,J.A.E., Hyoty,H., Hytonen,V.P. and Flodstrom-Tullberg,M.
    New Coxsackievirus 2A(pro) and 3C(pro) protease antibodies for virus detection and discovery of pathogenic mechanisms
    J Virol Methods (2018) 255, 29-37. PubMed  Europe PubMed DOI
    10. 2017
  10. Rui,Y., Su,J., Wang,H., Chang,J., Wang,S., Zheng,W., Cai,Y., Wei,W., Gordy,J.T., Markham,R., Kong,W., Zhang,W. and Yu,X.F.
    Disruption of MDA5 mediated innate immune responses by the 3C proteins of Coxsackievirus A16, Coxsackievirus A6, and Enterovirus D68
    J Virol (2017) DOI
    11. 2016
  11. Becker,D., Kaczmarska,Z., Arkona,C., Schulz,R., Tauber,C., Wolber,G., Hilgenfeld,R., Coll,M. and Rademann,J.
    Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments
    Nat Commun (2016) 7, 12761-12761. PubMed  Europe PubMed DOI  I
  12. Fili,S., Valmas,A., Christopoulou,M., Spiliopoulou,M., Nikolopoulos,N., Lichiere,J., Logotheti,S., Karavassili,F., Rosmaraki,E., Fitch,A., Wright,J., Beckers,D., Degen,T., Nenert,G., Hilgenfeld,R., Papageorgiou,N., Canard,B., Coutard,B. and Margiolaki,I.
    Coxsackievirus B3 protease 3C: expression, purification, crystallization and preliminary structural insights
    Acta Crystallogr F Struct Biol Commun (2016) 72, 877-884. PubMed  Europe PubMed DOI  E
  13. Jetsadawisut,W., Nutho,B., Meeprasert,A., Rungrotmongkol,T., Kungwan,N., Wolschann,P. and Hannongbua,S.
    Susceptibility of inhibitors against 3C protease of coxsackievirus A16 and enterovirus A71 causing hand, foot and mouth disease: a molecular dynamics study
    Biophys Chem (2016) 219, 9-16. PubMed  Europe PubMed DOI  I
  14. Kim,B.K., Ko,H., Jeon,E.S., Ju,E.S., Jeong,L.S. and Kim,Y.C.
    2,3,4-Trihydroxybenzyl-hydrazide analogues as novel potent coxsackievirus B3 3C protease inhibitors
    Eur J Med Chem (2016) 120, 202-216. PubMed  Europe PubMed DOI  I
    15. 2015
  15. Bhakat,S.
    Effect of T68A/N126Y mutations on the conformational and ligand binding landscape of Coxsackievirus B3 3C protease
    Mol Biosyst (2015) 11, 2303-2311. PubMed  Europe PubMed DOI
  16. Fung,G., Shi,J., Deng,H., Hou,J., Wang,C., Hong,A., Zhang,J., Jia,W. and Luo,H.
    Cytoplasmic translocation, aggregation, and cleavage of TDP-43 by enteroviral proteases modulate viral pathogenesis
    Cell Death Differ (2015) 22, 2087-2097. PubMed  Europe PubMed DOI
  17. Kim,B.K., Cho,J.H., Jeong,P., Lee,Y., Lim,J.J., Park,K.R., Eom,S.H. and Kim,Y.C.
    Benserazide, the first allosteric inhibitor of Coxsackievirus B3 3C protease
    FEBS Lett (2015) 589, 1795-1801. PubMed  Europe PubMed DOI  I
  18. Lim,B.K., Yun,S.H., Ju,E.S., Kim,B.K., Lee,Y.J., Yoo,D.K., Kim,Y.C. and Jeon,E.S.
    Soluble Coxsackievirus B3 3C protease inhibitor prevents cardiomyopathy in an experimental chronic myocarditis murine model
    Virus Res (2015) 199C, 1-8. PubMed  Europe PubMed DOI  I
  19. Song,J.H., Kwon,B.E., Jang,H., Kang,H., Cho,S., Park,K., Ko,H.J. and Kim,H.
    Antiviral activity of chrysin derivatives against coxsackievirus B3 in vitro and in vivo
    Biomol Ther (Seoul) (2015) 23, 465-470. PubMed  Europe PubMed DOI  PMC  EPMC  I
    20. 2013
  20. Tan,J., George,S., Kusov,Y., Perbandt,M., Anemuller,S., Mesters,J.R., Norder,H., Coutard,B., Lacroix,C., Leyssen,P., Neyts,J. and Hilgenfeld,R.
    3C protease of enterovirus 68: structure-based design of Michael acceptor inhibitors and their broad-spectrum antiviral effects against picornaviruses
    J Virol (2013) 87, 4339-4351. PubMed  Europe PubMed DOI  S  I
    21. 2012
  21. Skern,T.
    Picornain 3C
    [ISSN:978-0-12-407743-0] (2012) 3, 2396-2402. DOI
    22. 2011
  22. Costenaro,L., Kaczmarska,Z., Arnan,C., Janowski,R., Coutard,B., Sola,M., Gorbalenya,A.E., Norder,H., Canard,B. and Coll,M.
    Structural basis for antiviral inhibition of the main protease, 3C, from human enterovirus 93
    J Virol (2011) 85, 10764-10773. PubMed  Europe PubMed DOI  S  I
  23. Lu,G., Qi,J., Chen,Z., Xu,X., Gao,F., Lin,D., Qian,W., Liu,H., Jiang,H., Yan,J. and Gao,G.F.
    Enterovirus 71 and coxsackievirus A16 3C proteases: binding to rupintrivir and their substrates and anti-hand, foot, and mouth disease virus drug design
    J Virol (2011) 85, 10319-10331. PubMed  Europe PubMed DOI  S  I
  24. Mukherjee,A., Morosky,S.A., Delorme-Axford,E., Dybdahl-Sissoko,N., Oberste,M.S., Wang,T. and Coyne,C.B.
    The Coxsackievirus B 3C protease cleaves MAVS and TRIF to attenuate host type I interferon and apoptotic signaling
    PLoS Pathog (2011) 7, e1001311-e1001311. PubMed  Europe PubMed DOI  PMC  EPMC
    25. 2010
  25. Ramajayam,R., Tan,K.P., Liu,H.G. and Liang,P.H.
    Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors
    Bioorg Med Chem (2010) 18, 7849-7854. PubMed  Europe PubMed DOI  I
    26. 2009
  26. Lee,C.C., Kuo,C.J., Ko,T.P., Hsu,M.F., Tsui,Y.C., Chang,S.C., Yang,S., Chen,S.J., Chen,H.C., Hsu,M.C., Shih,S.R., Liang,P.H. and Wang,A.H.
    Structural basis of inhibition specificities of 3C and 3C-like proteases by zinc-coordinating and peptidomimetic compounds
    J Biol Chem (2009) 284, 7646-7655. PubMed  Europe PubMed DOI  PMC  EPMC  I
    27. 2008
  27. de Breyne,S., Bonderoff,J.M., Chumakov,K.M., Lloyd,R.E. and Hellen,C.U.
    Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases
    Virology (2008) 378, 118-122. PubMed  Europe PubMed DOI  PMC  EPMC
    28. 2007
  28. Chau,D.H., Yuan,J., Zhang,H., Cheung,P., Lim,T., Liu,Z., Sall,A. and Yang,D.
    Coxsackievirus B3 proteases 2A and 3C induce apoptotic cell death through mitochondrial injury and cleavage of eIF4GI but not DAP5/p97/NAT1
    Apoptosis (2007) 12, 513-524. PubMed  Europe PubMed DOI
  29. Lee,E.S., Lee,W.G., Yun,S.H., Rho,S.H., Im,I., Yang,S.T., Sellamuthu,S., Lee,Y.J., Kwon,S.J., Park,O.K., Jeon,E.S., Park,W.J. and Kim,Y.C.
    Development of potent inhibitors of the coxsackievirus 3C protease
    Biochem Biophys Res Commun (2007) 358, 7-11. PubMed  Europe PubMed DOI  I
    30. 2006
  30. [YEAR:26-1-2006]Hedhammar,M., Jung,H.R. and Hober,S.
    Enzymatic cleavage of fusion proteins using immobilised protease 3C
    Protein Expr Purif (26-1-2006) 47, 422-426. PubMed  Europe PubMed DOI  E
    31. 2004
  31. Ohlenschlager,O., Wohnert,J., Bucci,E., Seitz,S., Hafner,S., Ramachandran,R., Zell,R. and Gorlach,M.
    The structure of the stemloop D subdomain of coxsackievirus B3 cloverleaf RNA and its interaction with the proteinase 3C
    Structure (2004) 12, 237-248. PubMed  Europe PubMed DOI
  32. Skern,T.
    Picornain 3C
    [ISSN:0-12-079610-4] (2004) 2, 1353-1357.  V
    33. 1999
  33. Saura,M., Zaragoza,C., McMillan,A., Quick,R.A., Hohenadl,C., Lowenstein,J.M. and Lowenstein,C.J.
    An antiviral mechanism of nitric oxide: Inhibition of a viral protease
    Immunity (1999) 10, 21-28. PubMed  Europe PubMed DOI
    34. 1997
  34. Ryan,M.D. and Flint,M.
    Virus-encoded proteinases of the picornavirus super-group
    J Gen Virol (1997) 78, 699-723. PubMed  Europe PubMed
    35. 1996
  35. Miyashita,K., Okunishi,J., Utsumi,R., Tagiri,S., Hotta,K., Komano,T., Tamura,T. and Satoh,N.
    Cleavage specificity of coxsackievirus 3C proteinase for peptide substrate (2): Importance of the P2 and P4 residues
    Biosci Biotechnol Biochem (1996) 60, 1528-1529. PubMed  Europe PubMed
  36. Miyashita,K., Okunishi,J., Utsumi,R., Komano,T., Tamura,T. and Satoh,N.
    Cleavage specificity of coxsackievirus 3C proteinase for peptide substrate
    Biosci Biotechnol Biochem (1996) 60, 705-707. PubMed  Europe PubMed DOI  P
    37. 1995
  37. Miyashita,K., Utsumi,R., Utsumi,T., Komano,T. and Satoh,N.
    Mutational analysis of the putative substrate-binding site of 3C proteinase of coxsackievirus B3
    Biosci Biotechnol Biochem (1995) 59, 121-122. PubMed  Europe PubMed DOI
  38. Muckelbauer,J.K., Kremer,M., Minor,I., Tong,L., Zlotnick,A., Johnson,J.E. and Rossmann,M.G.
    Structure determination of coxsackievirus B3 to 3.5 A resolution
    Acta Crystallogr D Biol Crystallogr (1995) 51, 871-887. PubMed  Europe PubMed DOI
    39. 1993
  39. Miyashita,K., Kusumi,M., Utsumi,R., Katayama,S., Noda,M., Komano,T. and Satoh,N.
    Site-directed mutagenesis of the putative active site residues of 3C proteinase of coxsackievirus B3: Evidence of a functional relationship with trypsin-like serine proteinases
    Protein Eng (1993) 6, 189-193. PubMed  Europe PubMed
    40. 1991
  40. Lin,K.H., Takeda,N., Miyamura,K., Yamazaki,S. and Chen,C.W.
    The nucleotide sequence of 3C proteinase region of the coxsackievirus A24 variant: comparison of the isolates in Taiwan in 1985-1988
    Virus Genes (1991) 5, 121-131. PubMed  Europe PubMed

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