Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence Q99613

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
35	granzyme A	1-913	N			Van Damme et al., 2010
56	trypsin 1	1-913	N		MS	Schilling & Overall, 2008
65	trypsin 1	1-913	N		MS	Schilling & Overall, 2008
150	trypsin 1	1-913	N		MS	Schilling & Overall, 2008
160	trypsin 1	1-913	N		MS	Schilling & Overall, 2008
194	granzyme B (Homo sapiens-type)	1-913	N		MS	Van Damme et al., 2010
323	glutamyl endopeptidase I	320-331	N		MS	Schilling & Overall, 2008
331	trypsin 1	1-913	N		MS	Schilling & Overall, 2008
426	cathepsin S	401-439	N		MS	Biniossek et al., 2011
441	trypsin 1	1-913	N		MS	Schilling & Overall, 2008
450	trypsin 1	1-913	N		MS	Schilling & Overall, 2008
460	cathepsin S	458-474	N		MS	Biniossek et al., 2011
820	matrix metallopeptidase-2	814-830	N		MS	Schilling & Overall, 2008
824	trypsin 1	1-913	N		MS	Schilling & Overall, 2008
830	glutamyl endopeptidase I	1-913	N		MS	Schilling & Overall, 2008
831	HIV-1 retropepsin	824-846	N		MS	Schilling & Overall, 2008
846	trypsin 1	1-913	N		MS	Schilling & Overall, 2008