Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence Q15046

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-597	P		NT	<%Agarwal et al., 2012[]%>
12	caspase-3	2-597	P		MS	Impens et al., 2010
67	granzyme B (Homo sapiens-type)	2-597	N		MS	Van Damme et al., 2010
80	trypsin 1	2-597	N			Van Damme et al., 2009
168	glutamyl endopeptidase I	164-175	N		MS	Schilling & Overall, 2008
175	trypsin 1	2-597	N		MS	Schilling & Overall, 2008
230	trypsin 1	2-597	N		MS	Schilling & Overall, 2008
241	trypsin 1	2-597	N		MS	Schilling & Overall, 2008
407	trypsin 1	2-597	N		MS	Schilling & Overall, 2008
420	trypsin 1	2-597	N		MS	Schilling & Overall, 2008