Peptide and protein substrates that are thought to be physiologically relevant are indicated by P.
Peptide and protein substrates that are not physiologically relevant are indicated by N.
How cleavage sites have been identified are indicated by the following evidence codes:
NT = N-terminal sequencing,
MS = mass spectroscopy,
MU = mutation,
CS = consensus sequence,
LC = liquid chromatography.
To see all annotated cleavages for a peptidase, click on the peptidase name.
| Cleavage Site |
Peptidase |
Residue range |
Cleavage type |
Description |
Evidence |
Reference |
|---|
| 1 |
unknown peptidase |
1-4128 |
P |
|
NT |
<%Agarwal et al., 2012[]%> |
| 148 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 155 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 198 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 205 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 246 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 254 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 310 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 321 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 491 |
cathepsin L |
490-499 |
N |
|
MS |
Biniossek et al., 2011 |
| 491 |
cathepsin S |
490-499 |
N |
|
MS |
Biniossek et al., 2011 |
| 525 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 532 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 854 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 860 |
cathepsin B |
855-868 |
N |
|
MS |
Biniossek et al., 2011 |
| 868 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1125 |
cathepsin S |
1120-1136 |
N |
|
MS |
Biniossek et al., 2011 |
| 1186 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1193 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1572 |
peptidyl-Lys metallopeptidase |
1-4128 |
N |
|
MS |
|
| 1611 |
peptidyl-Lys metallopeptidase |
1-4128 |
N |
|
MS |
|
| 1612 |
lysyl endopeptidase (bacteria) |
1-4128 |
N |
|
MS |
|
| 1900 |
cathepsin S |
1896-1913 |
N |
|
MS |
Biniossek et al., 2011 |
| 1901 |
cathepsin B |
1896-1913 |
N |
|
MS |
Biniossek et al., 2011 |
| 1973 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1985 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2020 |
caspase-3 |
1-4128 |
P |
|
|
Teraoka et al., 1996 |
| 2106 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2120 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2334 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2347 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2433 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2441 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2608 |
cathepsin S |
2599-2619 |
N |
|
MS |
Biniossek et al., 2011 |
| 2699 |
granzyme B (Homo sapiens-type) |
1-4128 |
P |
|
MU |
Andrade et al., 1998 |
| 2704 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2713 |
caspase-3 |
1-4128 |
P |
|
|
Song et al., 1996 |
| 2713 |
granzyme B (Homo sapiens-type) |
1-4128 |
P |
|
MU |
Andrade et al., 1998 |
| 2715 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2766 |
granzyme B (Homo sapiens-type) |
2-4128 |
N |
|
MS |
Van Damme et al., 2010 |
| 2806 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2818 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2835 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2842 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2891 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2899 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2908 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2940 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 2950 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3204 |
granzyme B (Homo sapiens-type) |
2-4128 |
N |
|
MS |
Van Damme et al., 2010 |
| 3211 |
granzyme B (Homo sapiens-type) |
1-4128 |
P |
|
|
Andrade et al., 1998 |
| 3217 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3232 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3358 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3372 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3467 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3474 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3655 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 3669 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 4050 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
| 4062 |
granzyme B (Homo sapiens-type) |
2-4128 |
N |
|
MS |
Van Damme et al., 2010 |
| 4070 |
trypsin 1 |
1-4128 |
N |
|
MS |
Schilling & Overall, 2008 |
