Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Sequence P68036

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Evidence	Reference
31	matrix metallopeptidase-2	23-48	N	MS	Schilling & Overall, 2008
36	cathepsin L	24-48	N	MS	Biniossek et al., 2011
37	matrix metallopeptidase-2	29-54	N	MS	Schilling & Overall, 2008
48	trypsin 1	1-154	N	MS	Schilling & Overall, 2008
54	glutamyl endopeptidase I	1-154	N	MS	Schilling & Overall, 2008
82	trypsin 1	1-154	N	MS	Schilling & Overall, 2008
86	cathepsin B	83-96	N	MS	Biniossek et al., 2011
86	meprin beta subunit	83-100	N	MS	Becker-Pauly et al., 2011
88	matrix metallopeptidase-2	82-100	N	MS	Schilling & Overall, 2008
89	cathepsin G	82-100	N	MS	Schilling & Overall, 2008
90	cathepsin S	83-100	N	MS	Biniossek et al., 2011
91	astacin	88-100	N	MS	Becker-Pauly et al., 2011
91	meprin alpha subunit	88-100	N	MS	Becker-Pauly et al., 2011
100	trypsin 1	1-154	N	MS	Schilling & Overall, 2008
107	matrix metallopeptidase-2	100-122	N	MS	Schilling & Overall, 2008
109	elastase-2	100-122	N	MS	Schilling & Overall, 2008
110	HIV-1 retropepsin	100-122	N	MS	Schilling & Overall, 2008
122	trypsin 1	1-154	N	MS	Schilling & Overall, 2008
124	glutamyl endopeptidase I	1-154	N	MS	Schilling & Overall, 2008
128	glutamyl endopeptidase I	1-154	N	MS	Schilling & Overall, 2008
131	trypsin 1	1-154	N	MS	Schilling & Overall, 2008