Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P62826

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-216	P		NT	<%Agarwal et al., 2012[]%>
4	cathepsin S	2-12	N		MS	Biniossek et al., 2011
12	trypsin 1	2-216	N		MS	Schilling & Overall, 2008
23	trypsin 1	2-216	N		MS	Schilling & Overall, 2008
28	lysyl endopeptidase (bacteria)	1-216	N		MS
41	cathepsin B	39-50	N		MS	Biniossek et al., 2011
42	cathepsin B	39-50	N		MS	Biniossek et al., 2011
46	cathepsin L	39-53	N		MS	Biniossek et al., 2011
46	cathepsin S	39-53	N		MS	Biniossek et al., 2011
59	elastase-2	56-71	N		MS	Schilling & Overall, 2008
60	trypsin 1	2-216	N		MS	Schilling & Overall, 2008
71	trypsin 1	2-216	N		MS	Schilling & Overall, 2008
107	matrix metallopeptidase-2	104-119	N		MS	Schilling & Overall, 2008
110	trypsin 1	2-216	N		MS	Schilling & Overall, 2008
113	glutamyl endopeptidase I	110-123	N		MS	Schilling & Overall, 2008
119	chymotrypsin A (cattle-type)	2-216	N		MS	Schilling & Overall, 2008
123	trypsin 1	2-216	N		MS	Schilling & Overall, 2008
142	trypsin 1	2-216	N		MS	Schilling & Overall, 2008
151	peptidyl-Lys metallopeptidase	1-216	N		MS
152	trypsin 1	2-216	N		MS	Schilling & Overall, 2008