Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P62701

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-263	P		NT	<%Agarwal et al., 2012[]%>
15	peptidyl-Lys metallopeptidase	1-263	N		MS
21	granzyme B (Homo sapiens-type)	1-263	P		MS	Van Damme et al., 2009
21	granzyme B, rodent-type	1-263	N		MS	Van Damme et al., 2009
52	peptidyl-Lys metallopeptidase	1-263	N		MS
85	matrix metallopeptidase-2	77-100	N		MS	Schilling & Overall, 2008
87	LAST_MAM peptidase (Limulus-type)	84-100	N		MS	Becker-Pauly et al., 2011
91	meprin alpha subunit	88-100	N		MS	Becker-Pauly et al., 2011
99	chymotrypsin A (cattle-type)	2-263	N		MS	Schilling & Overall, 2008
100	trypsin 1	2-263	N		MS	Schilling & Overall, 2008
117	granzyme B (Homo sapiens-type)	2-263	N		MS	Plasman et al., 2011
127	trypsin 1	2-263	N			Van Damme et al., 2009
133	peptidyl-Lys metallopeptidase	1-263	N		MS
154	peptidyl-Lys metallopeptidase	1-263	N		MS
155	trypsin 1	2-263	N		MS	Schilling & Overall, 2008
163	HIV-1 retropepsin	155-174	N		MS	Schilling & Overall, 2008
168	trypsin 1	2-263	N		MS	Schilling & Overall, 2008
174	trypsin 1	2-263	N		MS	Schilling & Overall, 2008
203	cathepsin L	201-211	N		MS	Biniossek et al., 2011
242	lysyl endopeptidase (bacteria)	1-263	N		MS