Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P62082

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
30	cathepsin D	1-194	P		MS	Impens et al., 2010
30	cathepsin E	1-194	P		MS	Impens et al., 2010
42	matrix metallopeptidase-2	1-194	N		MS	Prudova et al., 2010
127	granzyme B (Homo sapiens-type)	1-194	N			Van Damme et al., 2009
127	granzyme B, rodent-type	1-194	P			Van Damme et al., 2009
132	cathepsin D	1-194	P		MS	Impens et al., 2010
132	cathepsin E	1-194	P		MS	Impens et al., 2010
132	granzyme B (Homo sapiens-type)	1-194	N		MS	Van Damme et al., 2009
133	cathepsin D	1-194	P		MS	Impens et al., 2010
143	trypsin 1	1-194	N			Van Damme et al., 2009