Peptide and protein substrates that are thought to be physiologically relevant are indicated by P.
Peptide and protein substrates that are not physiologically relevant are indicated by N.
How cleavage sites have been identified are indicated by the following evidence codes:
NT = N-terminal sequencing,
MS = mass spectroscopy,
MU = mutation,
CS = consensus sequence,
LC = liquid chromatography.
To see all annotated cleavages for a peptidase, click on the peptidase name.
| Cleavage Site |
Peptidase |
Residue range |
Cleavage type |
Description |
Evidence |
Reference |
|---|
| 1 |
unknown peptidase |
1-919 |
P |
release of an initiating methionine |
MS |
Flikka et al., 2006 |
| 62 |
matrix metallopeptidase-2 |
53-79 |
N |
|
MS |
Schilling & Overall, 2008 |
| 79 |
trypsin 1 |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
| 128 |
trypsin 1 |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
| 145 |
trypsin 1 |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
| 155 |
trypsin 1 |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
| 172 |
trypsin 1 |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
| 185 |
trypsin 1 |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
| 197 |
trypsin 1 |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
| 208 |
trypsin 1 |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
| 287 |
trypsin 1 |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
| 293 |
trypsin 1 |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
| 327 |
trypsin 1 |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
| 336 |
trypsin 1 |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
| 471 |
trypsin 1 |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
| 481 |
HIV-1 retropepsin |
471-499 |
N |
|
MS |
Schilling & Overall, 2008 |
| 499 |
trypsin 1 |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
| 535 |
endopeptidase K |
1-919 |
N |
|
|
Ma et al., 2003 |
| 545 |
matrix metallopeptidase-2 |
536-565 |
N |
|
MS |
Schilling & Overall, 2008 |
| 561 |
meprin beta subunit |
558-571 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 565 |
glutamyl endopeptidase I |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
| 590 |
trypsin 1 |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
| 596 |
matrix metallopeptidase-2 |
590-606 |
N |
|
MS |
Schilling & Overall, 2008 |
| 597 |
HIV-1 retropepsin |
590-606 |
N |
|
MS |
Schilling & Overall, 2008 |
| 606 |
trypsin 1 |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
| 680 |
trypsin 1 |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
| 689 |
trypsin 1 |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
| 744 |
trypsin 1 |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
| 753 |
trypsin 1 |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
| 781 |
trypsin 1 |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
| 784 |
astacin |
781-794 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 784 |
meprin alpha subunit |
781-794 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 785 |
elastase-2 |
781-794 |
N |
|
MS |
Schilling & Overall, 2008 |
| 794 |
trypsin 1 |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
| 803 |
glutamyl endopeptidase I |
794-821 |
N |
|
MS |
Schilling & Overall, 2008 |
| 808 |
matrix metallopeptidase-2 |
794-821 |
N |
|
MS |
Schilling & Overall, 2008 |
| 811 |
cathepsin B |
806-821 |
N |
|
MS |
Biniossek et al., 2011 |
| 821 |
trypsin 1 |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
| 853 |
trypsin 1 |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
| 863 |
trypsin 1 |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
| 889 |
glutamyl endopeptidase I |
882-899 |
N |
|
MS |
Schilling & Overall, 2008 |
| 890 |
HIV-1 retropepsin |
882-899 |
N |
|
MS |
Schilling & Overall, 2008 |
| 899 |
trypsin 1 |
1-919 |
N |
|
MS |
Schilling & Overall, 2008 |
