Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P52566

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-201	P		NT	<%Agarwal et al., 2012[]%>
19	caspase-3	2-201	P	normal turnover		Danley et al., 1996
54	meprin alpha subunit	2-201	N		MS	Becker-Pauly et al., 2011
54	meprin beta subunit	2-201	N		MS	Becker-Pauly et al., 2011
61	unknown peptidase	1-201	P		MS	Van Damme et al., 2005
152	HIV-1 retropepsin	150-164	N		MS	Schilling & Overall, 2008
153	LAST_MAM peptidase (Limulus-type)	150-164	N		MS	Becker-Pauly et al., 2011
154	glutamyl endopeptidase I	150-164	N		MS	Schilling & Overall, 2008
164	trypsin 1	2-201	N		MS	Schilling & Overall, 2008