Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P49710

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
27	cathepsin E	1-486	P		MS	Impens et al., 2010
155	caspase-1	1-486	P		MS	Lamkanfi et al., 2008
189	caspase-3	1-486	N		MS	Demon et al., 2009
189	caspase-7	1-486	N		MS	Demon et al., 2009
212	cathepsin E	1-486	P		MS	Impens et al., 2010
214	cathepsin E	1-486	P		MS	Impens et al., 2010
387	granzyme B (Homo sapiens-type)	1-486	N			Van Damme et al., 2009
387	granzyme B, rodent-type	1-486	P			Van Damme et al., 2009
396	trypsin 1	1-486	N			Van Damme et al., 2009