Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P49591

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-514	P		NT	<%Agarwal et al., 2012[]%>
28	meprin alpha subunit	2-514	N		MS	Becker-Pauly et al., 2011
82	glutamyl endopeptidase I	71-99	N		MS	Schilling & Overall, 2008
83	matrix metallopeptidase-2	71-99	N		MS	Schilling & Overall, 2008
87	meprin alpha subunit	2-514	N		MS	Becker-Pauly et al., 2011
87	meprin beta subunit	2-514	N		MS	Becker-Pauly et al., 2011
93	granzyme B (Homo sapiens-type)	2-514	N		MS	Van Damme et al., 2010
99	trypsin 1	2-514	N		MS	Schilling & Overall, 2008
137	matrix metallopeptidase-2	133-157	N		MS	Schilling & Overall, 2008
148	granzyme B (Homo sapiens-type)	2-514	N		MS	Van Damme et al., 2010
157	trypsin 1	2-514	N		MS	Schilling & Overall, 2008
231	trypsin 1	2-514	N		MS	Schilling & Overall, 2008
249	trypsin 1	2-514	N		MS	Schilling & Overall, 2008
513	caspase-3	2-514	P			Casas et al., 2001