Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P23246

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
189	astacin	186-199	N		MS	Becker-Pauly et al., 2011
189	meprin alpha subunit	186-199	N		MS	Becker-Pauly et al., 2011
189	meprin beta subunit	186-199	N		MS	Becker-Pauly et al., 2011
189	LAST peptidase (Limulus-type)	186-199	N		MS	Becker-Pauly et al., 2011
254	meprin beta subunit	251-267	N		MS	Becker-Pauly et al., 2011
255	cathepsin L	246-267	N		MS	Biniossek et al., 2011
273	meprin alpha subunit	1-707	N		MS	Becker-Pauly et al., 2011
273	meprin beta subunit	1-707	N		MS	Becker-Pauly et al., 2011
298	trypsin 1	1-707	N		MS	Schilling & Overall, 2008
302	cathepsin L	299-315	N		MS	Biniossek et al., 2011
314	trypsin 1	1-707	N		MS	Schilling & Overall, 2008
315	trypsin 1	1-707	N		MS	Schilling & Overall, 2008
319	trypsin 1	1-707	N		MS	Schilling & Overall, 2008
330	trypsin 1	1-707	N		MS	Schilling & Overall, 2008
523	LAST_MAM peptidase (Limulus-type)	520-536	N		MS	Becker-Pauly et al., 2011
524	LAST_MAM peptidase (Limulus-type)	521-536	N		MS	Becker-Pauly et al., 2011
525	granzyme B (Homo sapiens-type)	1-707	N		MS	Van Damme et al., 2010