Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P22061

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-227	P		NT	<%Agarwal et al., 2012[]%>
81	trypsin 1	2-227	N		MS	Schilling & Overall, 2008
98	trypsin 1	2-227	N		MS	Schilling & Overall, 2008
124	trypsin 1	2-227	N		MS	Schilling & Overall, 2008
135	trypsin 1	2-227	N		MS	Schilling & Overall, 2008
148	cathepsin S	145-159	N		MS	Biniossek et al., 2011
161	LAST peptidase (Limulus-type)	158-178	N		MS	Becker-Pauly et al., 2011
167	astacin	164-178	N		MS	Becker-Pauly et al., 2011
167	meprin alpha subunit	164-178	N		MS	Becker-Pauly et al., 2011
168	meprin alpha subunit	165-178	N		MS	Becker-Pauly et al., 2011
178	trypsin 1	2-227	N		MS	Schilling & Overall, 2008
193	cathepsin L	179-204	N		MS	Biniossek et al., 2011
197	trypsin 1	2-227	N		MS	Schilling & Overall, 2008
209	cathepsin L	207-221	N		MS	Biniossek et al., 2011
209	cathepsin B	205-221	N		MS	Biniossek et al., 2011
209	LAST_MAM peptidase (Limulus-type)	206-221	N		MS	Becker-Pauly et al., 2011
210	cathepsin B	207-221	N		MS	Biniossek et al., 2011