Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P20810

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
70	meprin alpha subunit	1-708	N		MS	Becker-Pauly et al., 2011
70	meprin beta subunit	1-708	N		MS	Becker-Pauly et al., 2011
71	meprin alpha subunit	1-708	N		MS	Becker-Pauly et al., 2011
71	meprin beta subunit	1-708	N		MS	Becker-Pauly et al., 2011
112	glutamyl endopeptidase I	102-127	N		MS	Schilling & Overall, 2008
116	matrix metallopeptidase-2	102-127	N		MS	Schilling & Overall, 2008
127	trypsin 1	1-371	N		MS	Schilling & Overall, 2008
159	caspase-1	1-708	P			Wang et al., 1998
159	caspase-3	1-708	P		CS	Ju et al., 2007
183	meprin beta subunit	1-708	N		MS	Becker-Pauly et al., 2011
187	meprin alpha subunit	1-708	N		MS	Becker-Pauly et al., 2011
187	meprin beta subunit	1-708	N		MS	Becker-Pauly et al., 2011
233	caspase-3	1-708	P		CS	Ju et al., 2007
233	caspase-7	1-708	P			Kato et al., 2000
238	caspase-1	1-708	P			Wang et al., 1998
238	caspase-3	1-708	P	normal turnover		Wang et al., 1998
241	caspase-7	1-708	P			Kato et al., 2000
253	meprin beta subunit	1-708	N		MS	Becker-Pauly et al., 2011
283	trypsin 1	1-371	N		MS	Schilling & Overall, 2008
301	trypsin 1	1-371	N		MS	Schilling & Overall, 2008
426	trypsin 1	1-708	N		MS	Schilling & Overall, 2008
431	LAST_MAM peptidase (Limulus-type)	428-444	N		MS	Becker-Pauly et al., 2011
439	caspase-1	1-708	P			Wang et al., 1998
444	trypsin 1	1-708	N		MS	Schilling & Overall, 2008
457	trypsin 1	1-708	N		MS	Schilling & Overall, 2008
473	trypsin 1	1-708	N		MS	Schilling & Overall, 2008
482	trypsin 1	1-708	N		MS	Schilling & Overall, 2008
513	caspase-1	1-708	N		MS	Agard et al., 2010
563	meprin alpha subunit	1-708	N		MS	Becker-Pauly et al., 2011
563	meprin beta subunit	1-708	N		MS	Becker-Pauly et al., 2011