Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P10646

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
28	unknown peptidase	1-251	P	release of a signal peptide	NT	Zhang & Henzel, 2004
48	matrix metallopeptidase-1	29-304	P	normal turnover		Belaaouaj et al., 2000
48	matrix metallopeptidase-8	29-304	P	normal turnover		Cunningham et al., 2002
48	matrix metallopeptidase-9	29-304	P	normal turnover		Belaaouaj et al., 2000
48	matrix metallopeptidase-7	29-304	P	normal turnover		Belaaouaj et al., 2000
48	matrix metallopeptidase-12	29-304	P	normal turnover		Belaaouaj et al., 2000
111	matrix metallopeptidase-12	29-304	P	normal turnover		Belaaouaj et al., 2000
115	elastase-2	29-304	P	normal turnover		Higuchi et al., 1992
202	matrix metallopeptidase-8	29-304	P	normal turnover		Cunningham et al., 2002
202	matrix metallopeptidase-12	29-304	P	normal turnover		Belaaouaj et al., 2000