Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence O76094

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-671	P		NT	<%Agarwal et al., 2012[]%>
102	cathepsin L	100-112	N		MS	Biniossek et al., 2011
153	matrix metallopeptidase-2	148-163	N		MS	Schilling & Overall, 2008
163	trypsin 1	2-671	N		MS	Schilling & Overall, 2008
362	cathepsin L	357-376	N		MS	Biniossek et al., 2011
365	cathepsin S	357-376	N		MS	Biniossek et al., 2011
464	trypsin 1	2-671	N		MS	Schilling & Overall, 2008
475	trypsin 1	2-671	N		MS	Schilling & Overall, 2008
519	granzyme B (Homo sapiens-type)	2-671	N		MS	Van Damme et al., 2010
540	granzyme B (Homo sapiens-type)	2-671	N		MS	Van Damme et al., 2010
573	granzyme B (Homo sapiens-type)	2-671	P			Casciola-Rosen et al., 1999
600	trypsin 1	2-671	N		MS	Schilling & Overall, 2008
614	caspase-3	2-671	P			Utz et al., 1998
617	trypsin 1	2-671	N		MS	Schilling & Overall, 2008