Sequence features for peptidase M12.221: ADAMTS4 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

MERNUM Species Sequence length Peptidase unit Active site residues Metal ligands Source
MER0257766 Alligator mississippiensis 834 214-429 E363 H362, H366, H372 GENBANK:XP_006274522
MER0296475 Alligator sinensis 834 214-429 E363 H362, H366, H372 GENBANK:XP_006038250
MER0225782 Anolis carolinensis 870 251-465 E400 H399, H403, H409 GENBANK:XP_003229085
MER0687035 Aptenodytes forsteri 794 48-263 E197 H196, H200, H206 GENBANK:XP_009279531
MER0686865 Aquila chrysaetos 666 48-263 E197 H196, H200, H206 GENBANK:XP_011597880
MER0392877 Balaenoptera acutorostrata 834 210-425 E359 H358, H362, H368 GENBANK:XP_007171771
MER0679139 Bison bison 874 248-463 E397 H396, H400, H406 GENBANK:XP_010831985
MER0347340 Bos grunniens 840 230-440 E374 H373, H377, H383 UNIPROT:L8HRK8
MER0347340 Bos grunniens 840 230-440 E374 H373, H377, H383 UNIPROT:L8HRK8
MER0015237 Bos taurus 839 213-428 E362 H361, H365, H371 UNIPROT:Q9TT93
MER0015237 Bos taurus 839 213-428 E362 H361, H365, H371 UNIPROT:Q9TT93
MER0015237 Bos taurus 839 213-428 E362 H361, H365, H371 UNIPROT:Q9TT93
MER0580100 Bubalus bubalis 874 248-463 E397 H396, H400, H406 GENBANK:XP_006048537
MER0357670 Callithrix jacchus 896 277-487 E421 H420, H424, H430 GENBANK:XP_002760285
MER0582218 Calypte anna 360 17-119 E60 H59, H63, H69 GENBANK:XP_008494316
MER0677852 Camelus dromedarius 872 248-463 E397 H396, H400, H406 GENBANK:XP_010991347
MER0445188 Camelus ferus 872 248-463 E397 H396, H400, H406 GENBANK:XP_006174030
MER0829435 Camelus ferus 837 280-379 E362 H361, H365, H371 UNIPROT:S9XLN3
MER0829435 Camelus ferus 837 280-379 E362 H361, H365, H371 UNIPROT:S9XLN3
MER0078645 Canis lupus familiaris 839 215-430 E364 H363, H367, H373 UNIPROT:E2RFF5
MER0078645 Canis lupus familiaris 839 215-430 E364 H363, H367, H373 UNIPROT:E2RFF5
MER0557755 Capra hircus 913 248-463 E397 H396, H400, H406 GENBANK:XP_005677258
MER0467935 Cavia porcellus 838 214-429 E363 H362, H366, H372 UNIPROT:H0VQV6
MER0467935 Cavia porcellus 838 214-429 E363 H362, H366, H372 UNIPROT:H0VQV6
MER0319792 Ceratotherium simum 872 248-463 E397 H396, H400, H406 GENBANK:XP_004443742
MER0586910 Cercopithecus sabaeus 837 213-428 E362 H361, H365, H371 GENBANK:XP_007974600
MER0592082 Chelonia mydas 715 92-305 E239 H238, H242, H248 GENBANK:XP_007070016
MER0583932 Chinchilla lanigera 839 215-430 E364 H363, H367, H373 GENBANK:XP_005400315
MER0577394 Chrysemys picta 827 209-417 E353 H352, H356, H362 GENBANK:XP_005293832
MER0574748 Chrysochloris asiatica 838 214-429 E363 H362, H366, H372 GENBANK:XP_006861732
MER0670747 Colobus angolensis 837 213-428 E362 H361, H365, H371 GENBANK:XP_011812967
MER0579134 Columba livia 520 163-263 E205 H204, H208, H214 GENBANK:XP_005516120
MER0574231 Condylura cristata 836 210-425 E359 H358, H362, H368 GENBANK:XP_004688151
MER0467938 Cricetulus griseus 886 262-477 E411 H410, H414, H420 GENBANK:XP_003506929
MER0829456 Cricetulus griseus 777 210-368 E359 H358, H362, H362 UNIPROT:A0A061I4I3
MER0829456 Cricetulus griseus 777 210-368 E359 H358, H362, H362 UNIPROT:A0A061I4I3
MER0565686 Elephantulus edwardii 841 217-432 E366 H365, H369, H375 GENBANK:XP_006895611
MER0564241 Eptesicus fuscus 827 204-419 E353 H352, H356, H362 GENBANK:XP_008151373
MER0015238 Equus caballus 837 213-428 E362 H361, H365, H371 GENBANK:XP_001503861
MER0828981 Equus caballus 846 292-389 E373 H372, H376, H382 UNIPROT:F6YRD3
MER0561971 Equus przewalskii 825 213-428 E362 H361, H365, H371 GENBANK:XP_008532105
MER0560096 Falco cherrug 595 16-191 E125 H124, H128, H134 GENBANK:XP_005442655
MER0544517 Falco peregrinus 563 9-159 E93 H92, H96, H102 GENBANK:XP_005244410
MER0101773 Felis catus 834 215-425 E359 H358, H362, H368 GENBANK:XP_003999614
MER0656904 Fukomys damarensis 848 224-439 E373 H372, H376, H382 UNIPROT:A0A091CLA6
MER0656904 Fukomys damarensis 848 224-439 E373 H372, H376, H382 UNIPROT:A0A091CLA6
MER0558016 Galeopterus variegatus 837 213-428 E362 H361, H365, H371 GENBANK:XP_008578419
MER0467845 Gallus gallus 191 1-191 E133 H132, H136, H142 GENBANK:XP_003643288
MER0608935 Gorilla gorilla 837 213-428 E362 H361, H365, H371 GENBANK:XP_004027797
MER0651601 Haliaeetus leucocephalus 666 48-263 E197 H196, H200, H206 GENBANK:XP_010565232
MER0357640 Heterocephalus glaber 837 218-428 E362 H361, H365, H371 UNIPROT:G5BWI1
MER0357640 Heterocephalus glaber 837 218-428 E362 H361, H365, H371 UNIPROT:G5BWI1
MER0005101 Homo sapiens 837 213-428 E362 H361, H365, H371 GENBANK:BAG09812
MER0005101 Homo sapiens 837 213-428 E362 H361, H365, H371 GENBANK:BAG09812
MER0005101 Homo sapiens 837 213-428 E362 H361, H365, H371 GENBANK:BAG09812
MER0547163 Jaculus jaculus 845 221-436 E370 H369, H373, H379 GENBANK:XP_004671195
MER0553167 Leptonychotes weddellii 840 216-426 E365 H364, H368, H374 GENBANK:XP_006747454
MER0549879 Lipotes vexillifer 834 210-425 E359 H358, H362, H368 GENBANK:XP_007467193
MER0467996 Macaca fascicularis 788 207-379 E313 H312, H316, H322 UNIPROT:G7NXA5
MER0467996 Macaca fascicularis 788 207-379 E313 H312, H316, H322 UNIPROT:G7NXA5
MER0604219 Macaca fascicularis 837 213-428 E362 H361, H365, H371 GENBANK:XP_005541254
MER0467934 Macaca mulatta 837 213-428 E362 H361, H365, H371 UNIPROT:G7ME94
MER0467934 Macaca mulatta 837 213-428 E362 H361, H365, H371 UNIPROT:G7ME94
MER0467976 Macaca mulatta 826 262-417 E351 H350, H354, H360 GENBANK:XP_002808295
MER0829262 Macaca mulatta 837 314-377 E362 H361, H365, H371 UNIPROT:F7FBV4
MER0644634 Mandrillus leucophaeus 837 213-428 E362 H361, H365, H371 GENBANK:XP_011831569
MER0545063 Mesocricetus auratus 849 225-440 E374 H373, H377, H383 GENBANK:XP_005087831
MER0537808 Microtus ochrogaster 854 230-445 E379 H378, H382, H388 GENBANK:XP_005348857
MER0163836 Monodelphis domestica 834 210-425 E359 H358, H362, H368 UNIPROT:F7DMX5
MER0163836 Monodelphis domestica 834 210-425 E359 H358, H362, H368 UNIPROT:F7DMX5
MER0002967 Mus musculus 833 209-424 E358 H357, H361, H367 UNIPROT:Q6A017
MER0002967 Mus musculus 833 209-424 E358 H357, H361, H367 UNIPROT:Q6A017
MER0002967 Mus musculus 833 209-424 E358 H357, H361, H367 UNIPROT:Q6A017
MER0002967 Mus musculus 833 209-424 E358 H357, H361, H367 UNIPROT:Q6A017
MER0601212 Mustela putorius 838 214-429 E363 H362, H366, H372 UNIPROT:M3YS56
MER0601212 Mustela putorius 838 214-429 E363 H362, H366, H372 UNIPROT:M3YS56
MER0571290 Myotis brandtii 797 204-419 E353 H352, H356, H362 GENBANK:XP_005880580
MER0347405 Myotis davidii 746 128-338 E272 H271, H275, H281 UNIPROT:L5LSU4
MER0347405 Myotis davidii 746 128-338 E272 H271, H275, H281 UNIPROT:L5LSU4
MER0641245 Nannospalax galili 851 227-442 E376 H375, H379, H385 GENBANK:XP_008846211
MER0636214 Nipponia nippon 649 22-237 E171 H170, H174, H180 GENBANK:XP_009463250
MER0532359 Octodon degus 832 208-423 E357 H356, H360, H366 GENBANK:XP_004639961
MER0531478 Odobenus rosmarus 840 216-426 E365 H364, H368, H374 GENBANK:XP_004407967
MER0829010 Ophiophagus hannah 783 233-366 E344 H343, H347, H353 UNIPROT:V8N6X6
MER0829010 Ophiophagus hannah 783 233-366 E344 H343, H347, H353 UNIPROT:V8N6X6
MER0530236 Orcinus orca 834 210-425 E359 H358, H362, H368 GENBANK:XP_004284445
MER0620048 Ornithorhynchus anatinus 307 60-187 missing missing, missing, missing GENBANK:XP_007659598
MER0528651 Orycteropus afer 854 230-445 E379 H378, H382, H388 GENBANK:XP_007945924
MER0110466 Oryctolagus cuniculus 851 232-442 E376 H375, H379, H385 UNIPROT:G1T5I4
MER0110466 Oryctolagus cuniculus 851 232-442 E376 H375, H379, H385 UNIPROT:G1T5I4
MER0829450 Otolemur garnettii 835 224-374 E359 H358, H362, H368 GENBANK:-
MER0347366 Ovis aries 851 253-463 E397 H396, H400, H406 UNIPROT:W5PIW9
MER0347366 Ovis aries 851 253-463 E397 H396, H400, H406 UNIPROT:W5PIW9
MER0593981 Pan paniscus 837 213-428 E362 H361, H365, H371 GENBANK:XP_003811884
MER0071736 Pan troglodytes 837 213-428 E362 H361, H365, H371 UNIPROT:H2R0A6
MER0071736 Pan troglodytes 837 213-428 E362 H361, H365, H371 UNIPROT:H2R0A6
MER0516851 Pantholops hodgsonii 872 248-463 E397 H396, H400, H406 GENBANK:XP_005958894
MER0525345 Papio anubis 837 216-428 E362 H361, H365, H371 UNIPROT:A0A096NQ05
MER0525345 Papio anubis 837 216-428 E362 H361, H365, H371 UNIPROT:A0A096NQ05
MER0829613 Pelodiscus sinensis 498 194-395 E345 H344, H350, H358 GENBANK:-
MER0829851 Pelodiscus sinensis 535 292-382 E380, H379, K383, H385, GENBANK:-
MER0521207 Physeter catodon 834 210-425 E359 H358, H362, H368 GENBANK:XP_007112337
MER0523774 Poecilia formosa 564 201-400 E345 H344, K348, H350 GENBANK:XP_006115313
MER0467936 Pongo abelii 837 213-428 E362 H361, H365, H371 UNIPROT:H2N516
MER0467936 Pongo abelii 837 213-428 E362 H361, H365, H371 UNIPROT:H2N516
MER0091166 Pongo pygmaeus 837 213-428 E362 H361, H365, H371 UNIPROT:Q5RFQ8
MER0091166 Pongo pygmaeus 837 213-428 E362 H361, H365, H371 UNIPROT:Q5RFQ8
MER0091166 Pongo pygmaeus 837 213-428 E362 H361, H365, H371 UNIPROT:Q5RFQ8
MER0515914 Pteropus alecto 835 211-426 E360 H359, H363, H369 UNIPROT:L5KZF2
MER0515914 Pteropus alecto 835 211-426 E360 H359, H363, H369 UNIPROT:L5KZF2
MER0595173 Pteropus vampyrus 835 211-426 E360 H359, H363, H369 GENBANK:XP_011375310
MER0441530 Python bivittatus 830 211-425 E360 H359, H363, H369 GENBANK:XP_007426188
MER0015159 Rattus norvegicus 630 11-221 E155 H154, H158, H164 GENBANK:NP_076449
MER0015159 Rattus norvegicus 630 11-221 E155 H154, H158, H164 GENBANK:NP_076449
MER0015159 Rattus norvegicus 630 11-221 E155 H154, H158, H164 GENBANK:NP_076449
MER0015159 Rattus norvegicus 630 11-221 E155 H154, H158, H164 GENBANK:NP_076449
MER0572020 Rhinopithecus roxellana 837 213-428 E362 H361, H365, H371 GENBANK:XP_010365432
MER0512586 Saimiri boliviensis 837 216-428 E362 H361, H365, H371 GENBANK:XP_003938029
MER0357737 Sarcophilus harrisii 834 215-425 E359 H358, H362, H368 GENBANK:XP_003769699
MER0597194 Sorex araneus 907 214-429 E363 H362, H366, H372 GENBANK:XP_004613954
MER0179641 Sus scrofa 872 253-463 E397 H396, H400, H406 GENBANK:XP_003481462
MER0596324 Tarsius syrichta 837 213-428 E362 H361, H365, H371 GENBANK:XP_008056086
MER0489046 Trichechus manatus 834 210-425 E359 H358, H362, H368 GENBANK:XP_004390226
MER0598424 Tupaia chinensis 854 233-448 E382 H381, H385, H391 GENBANK:XP_006163180
MER0616488 Vicugna pacos 872 248-463 E397 H396, H400, H406 GENBANK:XP_006215746
MER0467916 Xenopus tropicalis 841 209-429 E363 H362, H366, H372 GENBANK:XP_002942483