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Literature for peptidase M12.221: ADAMTS4 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Li,M.D., Lu,J.W., Zhang,F., Lei,W.J., Pan,F., Lin,Y.K., Ling,L.J., Myatt,L., Wang,W.S. and Sun,K.<br>ADAMTS4 is a crucial proteolytic enzyme for versican cleavage in the amnion at parturition<br>Commun Biol (2024) 7, 301-301. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Zhai,W., Yang,W., Ge,J., Xiao,X., Wu,K., She,K., Zhou,Y., Kong,Y., Wu,L., Luo,S. and Pu,X.<br>ADAMTS4 exacerbates lung cancer progression via regulating c-Myc protein stability and activating MAPK signaling pathway<br>Biol Direct (2024) 19, 94-94. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2023
  3. Konda,M., Kitabatake,M., Ouji-Sageshima,N., Tonomura,R., Furukawa,R., Sonobe,S., Terada-Ikeda,C., Takeda,M., Kawaguchi,M. and Ito,T.<br>A Disintegrin and Metalloproteinase with Thrombospondin Motifs 4 Regulates Pulmonary Vascular Hyperpermeability through Destruction of Glycocalyx in Acute Respiratory Distress Syndrome<br>Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC  K
  4. Matsuzaki,M., Yokoyama,M., Yoshizawa,Y., Kaneko,N., Naito,H., Kobayashi,H., Korenaga,A., Sekiya,S., Ikemura,K., Opoku,G., Hirohata,S., Iwamoto,S., Tanaka,K. and Tomita,T.<br>ADAMTS4 is involved in the production of the Alzheimer disease amyloid biomarker APP669-711<br>Mol Psychiatry (2023) 28, 1802-1812. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2022
  5. Novak,R., Hrkac,S., Salai,G., Bilandzic,J., Mitar,L. and Grgurevic,L.<br>The Role of ADAMTS-4 in Atherosclerosis and Vessel Wall Abnormalities<br>J Vasc Res (2022) , 1-9. PubMed  Europe PubMed DOI  V
    6. 2020
  6. Boyd,D.F., Allen,E.K., Randolph,A.G., Guo,X.J., Weng,Y., Sanders,C.J., Bajracharya,R., Lee,N.K., Guy,C.S., Vogel,P., Guan,W., Li,Y., Liu,X., Novak,T., Newhams,M.M., Fabrizio,T.P., Wohlgemuth,N., Mourani,P.M., Wight,T.N., Schultz-Cherry,S., Cormier,S.A., Shaw-Saliba,K., Pekosz,A., Rothman,R.E., Chen,K.F., Yang,Z., Webby,R.J., Zhong,N., Crawford,J.C. and Thomas,P.G.<br>Exuberant fibroblast activity compromises lung function via ADAMTS4<br>Nature (2020) 587, 466-471. PubMed  Europe PubMed DOI
  7. Fowkes,M.M. and Lim,N.H.<br>Purification and activity determination of ADAMTS-4 and ADAMTS-5 and their domain deleted mutants<br>Methods Mol Biol (2020) 2043, 75-91. PubMed  Europe PubMed DOI  V
  8. Miura,K., Suzuki,T., Sun,H., Takada,H., Ishizawa,Y., Mizuta,H., Dohmae,N. and Simizu,S.<br>Requirement for C-mannosylation to be secreted and activated a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4)<br>Biochim Biophys Acta Gen Subj (2020) 1865, 129833-129833. PubMed  Europe PubMed DOI
    9. 2019
  9. Santamaria,S., Yamamoto,K., Teraz-Orosz,A., Koch,C., Apte,S.S., de Groot,R., Lane,D.A. and Ahnstrom,J.<br>Exosites in hypervariable loops of ADAMTS spacer domains control substrate recognition and proteolysis<br>Sci Rep (2019) 9, 10914-10914. PubMed  Europe PubMed DOI  PMC  EPMC  P
  10. Walter,S., Jumpertz,T., Huttenrauch,M., Ogorek,I., Gerber,H., Storck,S.E., Zampar,S., Dimitrov,M., Lehmann,S., Lepka,K., Berndt,C., Wiltfang,J., Becker-Pauly,C., Beher,D., Pietrzik,C.U., Fraering,P.C., Wirths,O. and Weggen,S.<br>The metalloprotease ADAMTS4 generates N-truncated Abeta4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease<br>Acta Neuropathol (2019) 137, 239-257. PubMed  Europe PubMed DOI
  11. Wang,X.Z., Tang,W.Z., Su,Q.Y., Yao,J.G., Huang,X.Y., Long,Q.Q., Wu,X.M., Xia,Q. and Long,X.D.<br>Single-nucleotide polymorphisms in the coding region of a disintegrin and metalloproteinase with thrombospondin motifs 4 and hepatocellular carcinoma: A retrospective case-control study<br>Cancer Med (2019) 8, 7869-7880. PubMed  Europe PubMed DOI  M
    12. 2017
  12. Pruvost,M., Lepine,M., Leonetti,C., Etard,O., Naveau,M., Agin,V., Docagne,F., Maubert,E., Ali,C., Emery,E. and Vivien,D.<br>ADAMTS-4 in oligodendrocytes contributes to myelination with an impact on motor function<br>Glia (2017) 65, 1961-1975. PubMed  Europe PubMed DOI
  13. Ren,P., Hughes,M., Krishnamoorthy,S., Zou,S., Zhang,L., Wu,D., Zhang,C., Curci,J.A., Coselli,J.S., Milewicz,D.M., LeMaire,S.A. and Shen,Y.H.<br>Critical role of ADAMTS-4 in the development of sporadic aortic aneurysm and dissection in mice<br>Sci Rep (2017) 7, 12351-12351. PubMed  Europe PubMed DOI
    14. 2016
  14. Biniossek,M.L., Niemer,M., Maksimchuk,K., Mayer,B., Fuchs,J., Huesgen,P.F., McCafferty,D.G., Turk,B., Fritz,G., Mayer,J., Haecker,G., Mach,L. and Schilling,O.<br>Identification of protease specificity by combining proteome-derived peptide libraries and quantitative proteomics<br>Mol Cell Proteomics (2016) 15, 2515-2524. PubMed  Europe PubMed DOI  P
    15. 2014
  15. Demircan,K., Topcu,V., Takigawa,T., Akyol,S., Yonezawa,T., Ozturk,G., Ugurcu,V., Hasgul,R., Yigitoglu,M.R., Akyol,O., McCulloch,D.R. and Hirohata,S.<br>ADAMTS4 and ADAMTS5 knockout mice are protected from versican but not aggrecan or brevican proteolysis during spinal cord injury<br>Biomed Res Int (2014) 2014, 693746-693746. PubMed  Europe PubMed DOI  PMC  EPMC  K
  16. Durham,T.B., Klimkowski,V.J., Rito,C.J., Marimuthu,J., Toth,J.L., Liu,C., Durbin,J.D., Stout,S.L., Adams,L., Swearingen,C., Lin,C., Chambers,M.G., Thirunavukkarasu,K. and Wiley,M.R.<br>Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis<br>J Med Chem (2014) 57, 10476-10485. PubMed  Europe PubMed DOI  I
  17. Valenzuela,J.C., Heise,C., Franken,G., Singh,J., Schweitzer,B., Seidenbecher,C.I. and Frischknecht,R.<br>Hyaluronan-based extracellular matrix under conditions of homeostatic plasticity<br>Philos Trans R Soc Lond B Biol Sci (2014) 369, 20130606-20130606. PubMed  Europe PubMed DOI
  18. Wang,Z., Luo,J., Iwamoto,S. and Chen,Q.<br>Matrilin-2 is proteolytically cleaved by ADAMTS-4 and ADAMTS-5<br>Molecules (2014) 19, 8472-8487. PubMed  Europe PubMed DOI
    19. 2013
  19. Furtwangler,T., Chan,S.C., Bahrenberg,G., Richards,P.J. and Gantenbein-Ritter,B.<br>Assessment of the matrix degenerative effects of MMP-3, ADAMTS-4, and HTRA1, injected into a bovine Intervertebral disc organ culture model<br>Spine (Phila Pa 1976) (2013) 38, E1377-E1387. PubMed  Europe PubMed DOI
    20. 2012
  20. Bondeson,J., Wainwright,S., Caterson,B. and Hughes,C.<br>ADAMTS4<br>[ISSN:978-0-12-407744-7] (2012) 3, 1166-1173. DOI
  21. Choi,J., Jeong,K.W., Kim,J.K., Chang,B., Lee,J.Y. and Kim,Y.<br>3 ',4 '-Dihydroxyl groups in luteolin are important for its inhibitory activities against ADAMTS-4<br>Bull Korean Chem Soc (2012) 33, 2907-2909. DOI  I
  22. Hisanaga,A., Morishita,S., Suzuki,K., Sasaki,K., Koie,M., Kohno,T. and Hattori,M.<br>A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) cleaves reelin in an isoform-dependent manner<br>FEBS Lett (2012) 586, 3349-3353. PubMed  Europe PubMed DOI
  23. Tauchi,R., Imagama,S., Natori,T., Ohgomori,T., Muramoto,A., Shinjo,R., Matsuyama,Y., Ishiguro,N. and Kadomatsu,K.<br>The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury<br>J Neuroinflammation (2012) 9, 53-53. PubMed  Europe PubMed DOI
    24. 2011
  24. Boerboom,D., Lafond,J.F., Zheng,X., Lapointe,E., Mittaz,L., Boyer,A., Pritchard,M.A., DeMayo,F.J., Mort,J.S., Drolet,R. and Richards,J.S.<br>Partially redundant functions of Adamts1 and Adamts4 in the perinatal development of the renal medulla<br>Dev Dyn (2011) 240, 1806-1814. PubMed  Europe PubMed DOI  K
  25. De Savi,C., Pape,A., Cumming,J.G., Ting,A., Smith,P.D., Burrows,J.N., Mills,M., Davies,C., Lamont,S., Milne,D., Cook,C., Moore,P., Sawyer,Y. and Gerhardt,S.<br>The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis<br>Bioorg Med Chem Lett (2011) 21, 1376-1381. PubMed  Europe PubMed DOI  I
  26. De Savi,C., Pape,A., Sawyer,Y., Milne,D., Davies,C., Cumming,J.G., Ting,A., Lamont,S., Smith,P.D., Tart,J., Page,K. and Moore,P.<br>Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis<br>Bioorg Med Chem Lett (2011) 21, 3301-3306. PubMed  Europe PubMed DOI  I
  27. Gilbert,A.M., Bikker,J.A. and O'Neil,S.V.<br>Advances in the development of novel aggrecanase inhibitors<br>Expert Opin Ther Pat (2011) 21, 1-12. PubMed  Europe PubMed DOI  I
  28. Stanton,H., Melrose,J., Little,C.B. and Fosang,A.J.<br>Proteoglycan degradation by the ADAMTS family of proteinases<br>Biochim Biophys Acta Mol Basis Dis (2011) 1812, 1616-1629. PubMed  Europe PubMed DOI  P
  29. Stanton,H., Golub,S.B., Rogerson,F.M., Last,K., Little,C.B. and Fosang,A.J.<br>Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage<br>Nat Protoc (2011) 6, 388-404. PubMed  Europe PubMed DOI
    30. 2010
  30. Fosang,A.J. and Rogerson,F.M.<br>Identifying the human aggrecanase<br>Osteoarthritis Cartilage (2010) 18, 1109-1116. PubMed  Europe PubMed DOI
  31. Lim,N.H., Kashiwagi,M., Visse,R., Jones,J., Enghild,J.J., Brew,K. and Nagase,H.<br>Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications<br>Biochem J (2010) 431, 113-122. PubMed  Europe PubMed DOI
  32. Lin,E.A. and Liu,C.J.<br>The role of ADAMTSs in arthritis<br>Protein Cell (2010) 1, 33-47. PubMed  Europe PubMed DOI
  33. Minobe,K., Ono,R., Matsumine,A., Shibata-Minoshima,F., Izawa,K., Oki,T., Kitaura,J., Iino,T., Takita,J., Iwamoto,S., Hori,H., Komada,Y., Uchida,A., Hayashi,Y., Kitamura,T. and Nosaka,T.<br>Expression of ADAMTS4 in Ewing's sarcoma<br>Int J Oncol (2010) 37, 569-581. PubMed  Europe PubMed DOI
  34. Weaver,M.S., Workman,G., Cardo-Vila,M., Arap,W., Pasqualini,R. and Sage,E.H.<br>Processing of the matricellular protein hevin in mouse brain is dependent on ADAMTS4<br>J Biol Chem (2010) 285, 5868-5877. PubMed  Europe PubMed DOI  P
    35. 2009
  35. Tortorella,M.D., Malfait,F., Barve,R.A., Shieh,H.S. and Malfait,A.M.<br>A review of the ADAMTS family, pharmaceutical targets of the future<br>Curr Pharm Des (2009) 15, 2359-2374. PubMed  Europe PubMed DOI  V  T
  36. Troeberg,L., Fushimi,K., Scilabra,S.D., Nakamura,H., Dive,V., Thogersen,I.B., Enghild,J.J. and Nagase,H.<br>The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3<br>Matrix Biol (2009) 28, 463-469. PubMed  Europe PubMed DOI
    37. 2008
  37. Bondeson,J., Wainwright,S., Hughes,C. and Caterson,B.<br>The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review<br>Clin Exp Rheumatol (2008) 26, 139-145. PubMed  Europe PubMed
  38. Fushimi,K., Troeberg,L., Nakamura,H., Lim,N.H. and Nagase,H.<br>Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity<br>J Biol Chem (2008) 283, 6706-6716. PubMed  Europe PubMed DOI
  39. Hamel,M.G., Ajmo,J.M., Leonardo,C.C., Zuo,F., Sandy,J.D. and Gottschall,P.E.<br>Multimodal signaling by the ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) promotes neurite extension<br>Exp Neurol (2008) 210, 428-440. PubMed  Europe PubMed DOI  PMC  EPMC
  40. Malfait,A.M., Arner,E.C., Song,R.H., Alston,J.T., Markosyan,S., Staten,N., Yang,Z., Griggs,D.W. and Tortorella,M.D.<br>Proprotein convertase activation of aggrecanases in cartilage in situ<br>Arch Biochem Biophys (2008) 478, 43-51. PubMed  Europe PubMed DOI  T
  41. Mosyak,L., Georgiadis,K., Shane,T., Svenson,K., Hebert,T., McDonagh,T., Mackie,S., Olland,S., Lin,L., Zhong,X., Kriz,R., Reifenberg,E.L., Collins-Racie,L.A., Corcoran,C., Freeman,B., Zollner,R., Marvell,T., Vera,M., Sum,P.E., LaVallie,E.R., Stahl,M. and Somers,W.<br>Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5<br>Protein Sci (2008) 17, 16-21. PubMed  Europe PubMed DOI  PMC  EPMC  S
  42. Takizawa,M., Yatabe,T., Okada,A., Chijiiwa,M., Mochizuki,S., Ghosh,P. and Okada,Y.<br>Calcium pentosan polysulfate directly inhibits enzymatic activity of ADAMTS4 (aggrecanase-1) in osteoarthritic chondrocytes<br>FEBS Lett (2008) 582, 2945-2949. PubMed  Europe PubMed DOI
  43. Troeberg,L., Fushimi,K., Khokha,R., Emonard,H., Ghosh,P. and Nagase,H.<br>Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases<br>FASEB J (2008) 22, 3515-3524. PubMed  Europe PubMed DOI  PMC  EPMC
  44. Wagsater,D., Bjork,H., Zhu,C., Bjorkegren,J., Valen,G., Hamsten,A. and Eriksson,P.<br>ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques<br>Atherosclerosis (2008) 196, 514-522. PubMed  Europe PubMed DOI
    45. 2007
  45. Gendron,C., Kashiwagi,M., Lim,N.H., Enghild,J.J., Thogersen,I.B., Hughes,C., Caterson,B. and Nagase,H.<br>Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4<br>J Biol Chem (2007) 282, 18294-18306. PubMed  Europe PubMed DOI
  46. Hills,R., Mazzarella,R., Fok,K., Liu,M., Nemirovskiy,O., Leone,J., Zack,M.D., Arner,E.C., Viswanathan,M., Abujoub,A., Muruganandam,A., Sexton,D.J., Bassill,G.J., Sato,A.K., Malfait,A.M. and Tortorella,M.D.<br>Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate<br>J Biol Chem (2007) 282, 11101-11109. PubMed  Europe PubMed DOI  P
  47. Ilic,M.Z., East,C.J., Rogerson,F.M., Fosang,A.J. and Handley,C.J.<br>Distinguishing aggrecan loss from aggrecan proteolysis in ADAMTS-4 and ADAMTS-5 single and double deficient mice<br>J Biol Chem (2007) 282, 37420-37428. PubMed  Europe PubMed DOI  K
  48. Lauer-Fields,J.L., Minond,D., Sritharan,T., Kashiwagi,M., Nagase,H. and Fields,G.B.<br>Substrate conformation modulates aggrecanase (ADAMTS-4) affinity and sequence specificity. Suggestion of a common topological specificity for functionally diverse proteases<br>J Biol Chem (2007) 282, 142-150. PubMed  Europe PubMed DOI  P
  49. Powell,A.J., Little,C.B. and Hughes,C.E.<br>Low molecular weight isoforms of the aggrecanases are responsible for the cytokine-induced proteolysis of aggrecan in a porcine chondrocyte culture system<br>Arthritis Rheum (2007) 56, 3010-3019. PubMed  Europe PubMed DOI
  50. Song,R.H., Tortorella,M.D., Malfait,A.M., Alston,J.T., Yang,Z., Arner,E.C. and Griggs,D.W.<br>Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5<br>Arthritis Rheum (2007) 56, 575-585. PubMed  Europe PubMed DOI
  51. Wayne,G.J., Deng,S.J., Amour,A., Borman,S., Matico,R., Carter,H.L. and Murphy,G.<br>TIMP-3 inhibition of ADAMTS-4 (aggrecanase-1) is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4<br>J Biol Chem (2007) 282, 20991-20998. PubMed  Europe PubMed DOI
  52. Wittwer,A.J., Hills,R.L., Keith,R.H., Munie,G.E., Arner,E.C., Anglin,C.P., Malfait,A.M. and Tortorella,M.D.<br>Substrate-dependent inhibition kinetics of an active site-directed inhibitor of ADAMTS-4 (Aggrecanase 1)<br>Biochemistry (2007) 46, 6393-6401. PubMed  Europe PubMed DOI  I
    53. 2006
  53. Cross,A.K., Haddock,G., Stock,C.J., Allan,S., Surr,J., Bunning,R.A., Buttle,D.J. and Woodroofe,M.N.<br>ADAMTS-1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes<br>Brain Res (2006) 1088, 19-30. PubMed  Europe PubMed DOI
  54. Melching,L.I., Fisher,W.D., Lee,E.R., Mort,J.S. and Roughley,P.J.<br>The cleavage of biglycan by aggrecanases<br>Osteoarthritis Cartilage (2006) 14, 1147-1154. PubMed  Europe PubMed DOI
  55. Wainwright,S.D., Bondeson,J. and Hughes,C.E.<br>An alternative spliced transcript of ADAMTS4 is present in human synovium from OA patients<br>Matrix Biol (2006) 25, 317-320. PubMed  Europe PubMed DOI
    56. 2005
  56. [YEAR:1-5-2005]Mousa,S.A.<br>Effect of low molecular weight heparin and different heparin molecular weight fractions on the activity of the matrix-degrading enzyme aggrecanase: structure-function relationship<br>J Cell Biochem (1-5-2005) 95, 95-98. PubMed  Europe PubMed DOI
  57. [YEAR:2-6-2005]Noe,M.C., Natarajan,V., Snow,S.L., Mitchell,P.G., Lopresti-Morrow,L., Reeves,L.M., Yocum,S.A., Carty,T.J., Barberia,J.A., Sweeney,F.J., Liras,J.L., Vaughn,M., Hardink,J.R., Hawkins,J.M. and Tokar,C.<br>Discovery of 3,3-dimethyl-5-hydroxypipecolic hydroxamate-based inhibitors of aggrecanase and MMP-13<br>Bioorg Med Chem Lett (2-6-2005) 15, 2808-2811. PubMed  Europe PubMed DOI  I
  58. [YEAR:15-7-2005]Noe,M.C., Natarajan,V., Snow,S.L., Wolf-Gouveia,L.A., Mitchell,P.G., Lopresti-Morrow,L., Reeves,L.M., Yocum,S.A., Otterness,I., Bliven,M.A., Carty,T.J., Barberia,J.T., Sweeney,F.J., Liras,J.L. and Vaughn,M.<br>Discovery of 3-OH-3-methylpipecolic hydroxamates: potent orally active inhibitors of aggrecanase and MMP-13<br>Bioorg Med Chem Lett (15-7-2005) 15, 3385-3388. PubMed  Europe PubMed DOI  I
  59. Patwari,P., Gao,G., Lee,J.H., Grodzinsky,A.J. and Sandy,J.D.<br>Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage<br>Osteoarthritis Cartilage (2005) 13, 269-277. PubMed  Europe PubMed DOI  PMC  EPMC
  60. [YEAR:19-1-2005]Richards,J.S., Hernandez-Gonzalez,I., Gonzalez-Robayna,I., Teuling,E., Lo,Y., Boerboom,D., Falender,A.E., Doyle,K.H., LeBaron,R.G., Thompson,V. and Sandy,J.D.<br>Regulated expression of ADAMTS family members in follicles and cumulus oocyte complexes: evidence for specific and redundant patterns during ovulation<br>Biol Reprod (19-1-2005) 72, 1241-1255. PubMed  Europe PubMed DOI
    61. 2004
  61. Arai,M., Anderson,D., Kurdi,Y., Annis-Freeman,B., Shields,K., Collins-Racie,L.A., Corcoran,C., DiBlasio-Smith,E., Pittman,D.D., Dorner,A.J., Morris,E. and LaVallie,E.R.<br>Effect of adenovirus-mediated overexpression of bovine ADAMTS-4 and human ADAMTS-5 in primary bovine articular chondrocyte pellet culture system<br>Osteoarthritis Cartilage (2004) 12, 599-613. PubMed  Europe PubMed DOI
  62. [YEAR:29-12-2004]Gao,G., Plaas,A., Thompson,V.P., Jin,S., Zuo,F. and Sandy,J.D.<br>ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1<br>J Biol Chem (29-12-2004) 279, 10042-10051. PubMed  Europe PubMed DOI
  63. Glasson,S.S., Askew,R., Sheppard,B., Carito,B.A., Blanchet,T., Ma,H.L., Flannery,C.R., Kanki,K., Wang,E., Peluso,D., Yang,Z., Majumdar,M.K. and Morris,E.A.<br>Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice<br>Arthritis Rheum (2004) 50, 2547-2558. PubMed  Europe PubMed DOI  K
  64. [YEAR:25-5-2004]Hashimoto,G., Shimoda,M. and Okada,Y.<br>ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan<br>J Biol Chem (25-5-2004) 279, 32483-32491. PubMed  Europe PubMed DOI
  65. Hughes,C.E., Caterson,B., Little,C.B. and Wainwright,S.W.<br>Aggrecanases 1 and 2<br>[ISSN:0-12-079610-4] (2004) 2, 740-746.  V
  66. [YEAR:8-12-2004]Kashiwagi,M., Enghild,J.J., Gendron,C., Hughes,C., Caterson,B., Itoh,Y. and Nagase,H.<br>Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing<br>J Biol Chem (8-12-2004) 279, 10109-10119. PubMed  Europe PubMed DOI
  67. [YEAR:20-9-2004]Noe,M.C., Snow,S.L., Wolf-Gouveia,L.A., Mitchell,P.G., Lopresti-Morrow,L., Reeves,L.M., Yocum,S.A., Liras,J.L. and Vaughn,M.<br>3-Hydroxy-4-arylsulfonyltetrahydropyranyl-3-hydroxamic acids are novel inhibitors of MMP-13 and aggrecanase<br>Bioorg Med Chem Lett (20-9-2004) 14, 4727-4730. PubMed  Europe PubMed DOI  I
  68. [YEAR:7-1-2004]Tortorella,M.D., Arner,E.C., Hills,R., Easton,A., Korte-Sarfaty,J., Fok,K., Wittwer,A.J., Liu,R.Q. and Malfait,A.M.<br>Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes<br>J Biol Chem (7-1-2004) 279, 17554-17561. PubMed  Europe PubMed DOI
  69. [YEAR:26-1-2004]Wang,P., Tortorella,M., England,K., Malfait,A.M., Thomas,G., Arner,E.C. and Pei,D.<br>Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (aggrecanase-1) in the trans-Golgi network<br>J Biol Chem (26-1-2004) 279, 15434-15440. PubMed  Europe PubMed DOI
  70. [YEAR:1-2-2004]Westling,J., Gottschall,P.E., Thompson,V.P., Cockburn,A., Perides,G., Zimmermann,D.R. and Sandy,J.D.<br>ADAMTS4 (aggrecanase-1) cleaves human brain versican V2 at Glu405-Gln406 to generate glial hyaluronate binding protein<br>Biochem J (1-2-2004) 377, 787-795. PubMed  Europe PubMed DOI  PMC  EPMC
    71. 2003
  71. [YEAR:15-3-2003]Miller,J.A., Liu,R.Q., Davis,G.L., Pratta,M.A., Trzaskos,J.M. and Copeland,R.A.<br>A microplate assay specific for the enzyme aggrecanase<br>Anal Biochem (15-3-2003) 314, 260-265. PubMed  Europe PubMed DOI  A
  72. Pratta,M.A., Scherle,P.A., Yang,G., Liu,R.Q. and Newton,R.C.<br>Induction of aggrecanase 1 (ADAM-TS4) by interleukin-1 occurs through activation of constitutively produced protein<br>Arthritis Rheum (2003) 48, 119-133. PubMed  Europe PubMed DOI
    73. 2002
  73. Arner,E.C.<br>Aggrecanase-mediated cartilage degradation<br>Curr Opin Pharmacol (2002) 2, 322-329. PubMed  Europe PubMed DOI
  74. [YEAR:8-11-2002]Flannery,C.R., Zeng,W., Corcoran,C., Collins-Racie,L.A., Chockalingam,P.S., Hebert,T., Mackie,S.A., McDonagh,T., Crawford,T.K., Tomkinson,K.N., LaVallie,E.R. and Morris,E.A.<br>Autocatalytic cleavage of ADAMTS-4 (aggrecanase-1) reveals multiple glycosaminoglycan-binding sites<br>J Biol Chem (8-11-2002) 277, 42775-42780. PubMed  Europe PubMed DOI
  75. [YEAR:29-3-2002]Gao,G., Westling,J., Thompson,V.P., Howell,T.D., Gottschall,P.E. and Sandy,J.D.<br>Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncation<br>J Biol Chem (29-3-2002) 277, 11034-11041. PubMed  Europe PubMed DOI
  76. [YEAR:21-6-2002]Malfait,A.M., Liu,R.Q., Ijiri,K., Komiya,S. and Tortorella,M.D.<br>Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage<br>J Biol Chem (21-6-2002) 277, 22201-22208. PubMed  Europe PubMed DOI
  77. [YEAR:3-5-2002]Westling,J., Fosang,A.J., Last,K., Thompson,V.P., Tomkinson,K.N., Hebert,T., McDonagh,T., Collins-Racie,L.A., LaVallie,E.R., Morris,E.A. and Sandy,J.D.<br>ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain<br>J Biol Chem (3-5-2002) 277, 16059-16066. PubMed  Europe PubMed DOI
  78. [YEAR:1-2-2002]Yamanishi,Y., Boyle,D.L., Clark,M., Maki,R.A., Tortorella,M.D., Arner,E.C. and Firestein,G.S.<br>Expression and regulation of aggrecanase in arthritis: the role of TGF-beta<br>J Immunol (1-2-2002) 168, 1405-1412. PubMed  Europe PubMed
    79. 2001
  79. [YEAR:13-4-2001]Hashimoto,G., Aoki,T., Nakamura,H., Tanzawa,K. and Okada,Y.<br>Inhibition of ADAMTS4 (aggrecanase-1) by tissue inhibitors of metalloproteinases (TIMP-1, 2, 3 and 4)<br>FEBS Lett (13-4-2001) 494, 192-195. PubMed  Europe PubMed DOI
  80. [YEAR:20-4-2001]Kashiwagi,M., Tortorella,M., Nagase,H. and Brew,K.<br>TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5)<br>J Biol Chem (20-4-2001) 276, 12501-12504. PubMed  Europe PubMed DOI
  81. [YEAR:20-4-2001]Sandy,J.D., Westling,J., Kenagy,R.D., Iruela-Arispe,M.L., Verscharen,C., Rodriguez-Mazaneque,J.C., Zimmermann,D.R., Lemire,J.M., Fischer,J.W., Wight,T.N. and Clowes,A.W.<br>Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4<br>J Biol Chem (20-4-2001) 276, 13372-13378. PubMed  Europe PubMed DOI
  82. Tortorella,M.D., Malfait,A.M., Deccico,C. and Arner,E.<br>The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation<br>Osteoarthritis Cartilage (2001) 9, 539-552. PubMed  Europe PubMed DOI
  83. [YEAR:11-10-2001]Yao,W., Wasserman,Z.R., Chao,M., Reddy,G., Shi,E., Liu,R.Q., Covington,M.B., Arner,E.C., Pratta,M.A., Tortorella,M., Magolda,R.L., Newton,R., Qian,M., Ribadeneira,M.D., Christ,D., Wexler,R.R. and Decicco,C.P.<br>Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors<br>J Med Chem (11-10-2001) 44, 3347-3350. PubMed  Europe PubMed DOI  I
    84. 2000
  84. Horber,C., Bnttner,F.H., Kern,C., Schmiedeknecht,G. and Bartnik,E.<br>Truncation of the amino-terminus of the recombinant aggrecan rAgg1mut leads to reduced cleavage at the aggrecanase site. Efficient aggrecanase catabolism may depend on multiple substrate interactions<br>Matrix Biol (2000) 19, 533-543. PubMed  Europe PubMed DOI
  85. Mizui,Y., Yamazaki,K., Kuboi,Y., Sagane,K. and Tanaka,I.<br>Characterization of 5'-flanking region of human aggrecanase-1 (ADAMTS4) gene<br>Mol Biol Rep (2000) 27, 167-173. PubMed  Europe PubMed DOI
  86. [YEAR:8-12-2000]Nakamura,H., Fujii,Y., Inoki,I., Sugimoto,K., Tanzawa,K., Matsuki,H., Miura,R., Yamaguchi,Y. and Okada,Y.<br>Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites<br>J Biol Chem (8-12-2000) 275, 38885-38890. PubMed  Europe PubMed DOI
  87. [YEAR:11-8-2000]Satoh,K., Suzuki,N. and Yokota,H.<br>ADAMTS-4 (a disintegrin and metalloproteinase with thrombospondin motifs) is transcriptionally induced in beta-amyloid treated rat astrocytes<br>Neurosci Lett (11-8-2000) 289, 177-180. PubMed  Europe PubMed DOI
  88. [YEAR:18-8-2000]Tortorella,M., Pratta,M., Liu,R.Q., Abbaszade,I., Ross,H., Burn,T. and Arner,E.<br>The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage<br>J Biol Chem (18-8-2000) 275, 25791-25797. PubMed  Europe PubMed DOI
  89. [YEAR:16-6-2000]Tortorella,M.D., Pratta,M., Liu,R.Q., Austin,J., Ross,O.H., Abbaszade,I., Burn,T. and Arner,E.<br>Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4)<br>J Biol Chem (16-6-2000) 275, 18566-18573. PubMed  Europe PubMed DOI
    90. 1999
  90. [YEAR:30-6-1999]Arner,E.C., Pratta,M.A., Decicco,C.P., Xue,C.B., Newton,R.C., Trzaskos,J.M., Magolda,R.L. and Tortorella,M.D.<br>Aggrecanase. A target for the design of inhibitors of cartilage degradation<br>Ann N Y Acad Sci (30-6-1999) 878, 92-107. PubMed  Europe PubMed DOI
  91. [YEAR:5-3-1999]Arner,E.C., Pratta,M.A., Trzaskos,J.M., Decicco,C.P. and Tortorella,M.D.<br>Generation and characterization of aggrecanase. A soluble, cartilage- derived aggrecan-degrading activity<br>J Biol Chem (5-3-1999) 274, 6594-6601. PubMed  Europe PubMed DOI
  92. [YEAR:5-7-1999]Flannery,C.R., Little,C.B., Hughes,C.E. and Caterson,B.<br>Expression of ADAMTS homologues in articular cartilage<br>Biochem Biophys Res Commun (5-7-1999) 260, 318-322. PubMed  Europe PubMed DOI
  93. [YEAR:26-2-1999]Tang,B.L. and Hong,W.<br>ADAMTS: A novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats<br>FEBS Lett (26-2-1999) 445, 223-225. PubMed  Europe PubMed DOI
  94. [YEAR:4-6-1999]Tortorella,M.D., Burn,T.C., Pratta,M.A., Abbaszade,I., Hollis,J.M., Liu,R., Rosenfeld,S.A., Copeland,R.A., Decicco,C.P., Wynn,R., Rockwell,A., Yang,F., Duke,J.L., Solomon,K., George,H., Bruckner,R., Nagase,H., Itoh,Y., Ellis,D.M., Ross,H., Wiswall,B.H., Murphy,K., Hillman,M.C., Jr., Hollis,G.F., Newton,R.C., Magolda,R.L., Trzaskos,J.M. and Arner,E.C.<br>Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins<br>Science (4-6-1999) 284, 1664-1666. PubMed  Europe PubMed DOI

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