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Literature for peptidase M12.221: ADAMTS4 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Li,M.D., Lu,J.W., Zhang,F., Lei,W.J., Pan,F., Lin,Y.K., Ling,L.J., Myatt,L., Wang,W.S. and Sun,K.
    ADAMTS4 is a crucial proteolytic enzyme for versican cleavage in the amnion at parturition
    Commun Biol7, 301-301. PubMed  Europe PubMed DOI
  2. Zhai,W., Yang,W., Ge,J., Xiao,X., Wu,K., She,K., Zhou,Y., Kong,Y., Wu,L., Luo,S. and Pu,X.
    ADAMTS4 exacerbates lung cancer progression via regulating c-Myc protein stability and activating MAPK signaling pathway
    Biol Direct19, 94-94. PubMed  Europe PubMed DOI
    3. 2023
  3. Konda,M., Kitabatake,M., Ouji-Sageshima,N., Tonomura,R., Furukawa,R., Sonobe,S., Terada-Ikeda,C., Takeda,M., Kawaguchi,M. and Ito,T.
    A Disintegrin and Metalloproteinase with Thrombospondin Motifs 4 Regulates Pulmonary Vascular Hyperpermeability through Destruction of Glycocalyx in Acute Respiratory Distress Syndrome
    Int J Mol Sci24, PubMed  Europe PubMed DOI  K
  4. Matsuzaki,M., Yokoyama,M., Yoshizawa,Y., Kaneko,N., Naito,H., Kobayashi,H., Korenaga,A., Sekiya,S., Ikemura,K., Opoku,G., Hirohata,S., Iwamoto,S., Tanaka,K. and Tomita,T.
    ADAMTS4 is involved in the production of the Alzheimer disease amyloid biomarker APP669-711
    Mol Psychiatry28, 1802-1812. PubMed  Europe PubMed DOI
    5. 2022
  5. Novak,R., Hrkac,S., Salai,G., Bilandzic,J., Mitar,L. and Grgurevic,L.
    The Role of ADAMTS-4 in Atherosclerosis and Vessel Wall Abnormalities
    J Vasc Res1-9. PubMed  Europe PubMed DOI  V
    6. 2020
  6. Boyd,D.F., Allen,E.K., Randolph,A.G., Guo,X.J., Weng,Y., Sanders,C.J., Bajracharya,R., Lee,N.K., Guy,C.S., Vogel,P., Guan,W., Li,Y., Liu,X., Novak,T., Newhams,M.M., Fabrizio,T.P., Wohlgemuth,N., Mourani,P.M., Wight,T.N., Schultz-Cherry,S., Cormier,S.A., Shaw-Saliba,K., Pekosz,A., Rothman,R.E., Chen,K.F., Yang,Z., Webby,R.J., Zhong,N., Crawford,J.C. and Thomas,P.G.
    Exuberant fibroblast activity compromises lung function via ADAMTS4
    Nature587, 466-471. PubMed  Europe PubMed DOI
  7. Fowkes,M.M. and Lim,N.H.
    Purification and activity determination of ADAMTS-4 and ADAMTS-5 and their domain deleted mutants
    Methods Mol Biol2043, 75-91. PubMed  Europe PubMed DOI  V
  8. Miura,K., Suzuki,T., Sun,H., Takada,H., Ishizawa,Y., Mizuta,H., Dohmae,N. and Simizu,S.
    Requirement for C-mannosylation to be secreted and activated a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4)
    Biochim Biophys Acta Gen Subj1865, 129833-129833. PubMed  Europe PubMed DOI
    9. 2019
  9. Santamaria,S., Yamamoto,K., Teraz-Orosz,A., Koch,C., Apte,S.S., de Groot,R., Lane,D.A. and Ahnstrom,J.
    Exosites in hypervariable loops of ADAMTS spacer domains control substrate recognition and proteolysis
    Sci Rep9, 10914-10914. PubMed  Europe PubMed DOI  P
  10. Walter,S., Jumpertz,T., Huttenrauch,M., Ogorek,I., Gerber,H., Storck,S.E., Zampar,S., Dimitrov,M., Lehmann,S., Lepka,K., Berndt,C., Wiltfang,J., Becker-Pauly,C., Beher,D., Pietrzik,C.U., Fraering,P.C., Wirths,O. and Weggen,S.
    The metalloprotease ADAMTS4 generates N-truncated Abeta4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease
    Acta Neuropathol137, 239-257. PubMed  Europe PubMed DOI
  11. Wang,X.Z., Tang,W.Z., Su,Q.Y., Yao,J.G., Huang,X.Y., Long,Q.Q., Wu,X.M., Xia,Q. and Long,X.D.
    Single-nucleotide polymorphisms in the coding region of a disintegrin and metalloproteinase with thrombospondin motifs 4 and hepatocellular carcinoma: A retrospective case-control study
    Cancer Med8, 7869-7880. PubMed  Europe PubMed DOI  M
    12. 2017
  12. Pruvost,M., Lepine,M., Leonetti,C., Etard,O., Naveau,M., Agin,V., Docagne,F., Maubert,E., Ali,C., Emery,E. and Vivien,D.
    ADAMTS-4 in oligodendrocytes contributes to myelination with an impact on motor function
    Glia65, 1961-1975. PubMed  Europe PubMed DOI
  13. Ren,P., Hughes,M., Krishnamoorthy,S., Zou,S., Zhang,L., Wu,D., Zhang,C., Curci,J.A., Coselli,J.S., Milewicz,D.M., LeMaire,S.A. and Shen,Y.H.
    Critical role of ADAMTS-4 in the development of sporadic aortic aneurysm and dissection in mice
    Sci Rep7, 12351-12351. PubMed  Europe PubMed DOI
    14. 2016
  14. Biniossek,M.L., Niemer,M., Maksimchuk,K., Mayer,B., Fuchs,J., Huesgen,P.F., McCafferty,D.G., Turk,B., Fritz,G., Mayer,J., Haecker,G., Mach,L. and Schilling,O.
    Identification of protease specificity by combining proteome-derived peptide libraries and quantitative proteomics
    Mol Cell Proteomics15, 2515-2524. PubMed  Europe PubMed DOI  P
    15. 2014
  15. Demircan,K., Topcu,V., Takigawa,T., Akyol,S., Yonezawa,T., Ozturk,G., Ugurcu,V., Hasgul,R., Yigitoglu,M.R., Akyol,O., McCulloch,D.R. and Hirohata,S.
    ADAMTS4 and ADAMTS5 knockout mice are protected from versican but not aggrecan or brevican proteolysis during spinal cord injury
    Biomed Res Int2014, 693746-693746. PubMed  Europe PubMed DOI  K
  16. Durham,T.B., Klimkowski,V.J., Rito,C.J., Marimuthu,J., Toth,J.L., Liu,C., Durbin,J.D., Stout,S.L., Adams,L., Swearingen,C., Lin,C., Chambers,M.G., Thirunavukkarasu,K. and Wiley,M.R.
    Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis
    J Med Chem57, 10476-10485. PubMed  Europe PubMed DOI  I
  17. Valenzuela,J.C., Heise,C., Franken,G., Singh,J., Schweitzer,B., Seidenbecher,C.I. and Frischknecht,R.
    Hyaluronan-based extracellular matrix under conditions of homeostatic plasticity
    Philos Trans R Soc Lond B Biol Sci369, 20130606-20130606. PubMed  Europe PubMed DOI
  18. Wang,Z., Luo,J., Iwamoto,S. and Chen,Q.
    Matrilin-2 is proteolytically cleaved by ADAMTS-4 and ADAMTS-5
    Molecules19, 8472-8487. PubMed  Europe PubMed DOI
    19. 2013
  19. Furtwangler,T., Chan,S.C., Bahrenberg,G., Richards,P.J. and Gantenbein-Ritter,B.
    Assessment of the matrix degenerative effects of MMP-3, ADAMTS-4, and HTRA1, injected into a bovine Intervertebral disc organ culture model
    Spine (Phila Pa 1976)38, E1377-E1387. PubMed  Europe PubMed DOI
    20. 2012
  20. Bondeson,J., Wainwright,S., Caterson,B. and Hughes,C.
    ADAMTS4
    [ISSN:978-0-12-407744-7]3, 1166-1173. DOI
  21. Choi,J., Jeong,K.W., Kim,J.K., Chang,B., Lee,J.Y. and Kim,Y.
    3 ',4 '-Dihydroxyl groups in luteolin are important for its inhibitory activities against ADAMTS-4
    Bull Korean Chem Soc33, 2907-2909. DOI  I
  22. Hisanaga,A., Morishita,S., Suzuki,K., Sasaki,K., Koie,M., Kohno,T. and Hattori,M.
    A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) cleaves reelin in an isoform-dependent manner
    FEBS Lett586, 3349-3353. PubMed  Europe PubMed DOI
  23. Tauchi,R., Imagama,S., Natori,T., Ohgomori,T., Muramoto,A., Shinjo,R., Matsuyama,Y., Ishiguro,N. and Kadomatsu,K.
    The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury
    J Neuroinflammation9, 53-53. PubMed  Europe PubMed DOI
    24. 2011
  24. Boerboom,D., Lafond,J.F., Zheng,X., Lapointe,E., Mittaz,L., Boyer,A., Pritchard,M.A., DeMayo,F.J., Mort,J.S., Drolet,R. and Richards,J.S.
    Partially redundant functions of Adamts1 and Adamts4 in the perinatal development of the renal medulla
    Dev Dyn240, 1806-1814. PubMed  Europe PubMed DOI  K
  25. De Savi,C., Pape,A., Cumming,J.G., Ting,A., Smith,P.D., Burrows,J.N., Mills,M., Davies,C., Lamont,S., Milne,D., Cook,C., Moore,P., Sawyer,Y. and Gerhardt,S.
    The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis
    Bioorg Med Chem Lett21, 1376-1381. PubMed  Europe PubMed DOI  I
  26. De Savi,C., Pape,A., Sawyer,Y., Milne,D., Davies,C., Cumming,J.G., Ting,A., Lamont,S., Smith,P.D., Tart,J., Page,K. and Moore,P.
    Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis
    Bioorg Med Chem Lett21, 3301-3306. PubMed  Europe PubMed DOI  I
  27. Gilbert,A.M., Bikker,J.A. and O'Neil,S.V.
    Advances in the development of novel aggrecanase inhibitors
    Expert Opin Ther Pat21, 1-12. PubMed  Europe PubMed DOI  I
  28. Stanton,H., Golub,S.B., Rogerson,F.M., Last,K., Little,C.B. and Fosang,A.J.
    Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage
    Nat Protoc6, 388-404. PubMed  Europe PubMed DOI
  29. Stanton,H., Melrose,J., Little,C.B. and Fosang,A.J.
    Proteoglycan degradation by the ADAMTS family of proteinases
    Biochim Biophys Acta Mol Basis Dis1812, 1616-1629. PubMed  Europe PubMed DOI  P
    30. 2010
  30. Fosang,A.J. and Rogerson,F.M.
    Identifying the human aggrecanase
    Osteoarthritis Cartilage18, 1109-1116. PubMed  Europe PubMed DOI
  31. Lim,N.H., Kashiwagi,M., Visse,R., Jones,J., Enghild,J.J., Brew,K. and Nagase,H.
    Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications
    Biochem J431, 113-122. PubMed  Europe PubMed DOI
  32. Lin,E.A. and Liu,C.J.
    The role of ADAMTSs in arthritis
    Protein Cell1, 33-47. PubMed  Europe PubMed DOI
  33. Minobe,K., Ono,R., Matsumine,A., Shibata-Minoshima,F., Izawa,K., Oki,T., Kitaura,J., Iino,T., Takita,J., Iwamoto,S., Hori,H., Komada,Y., Uchida,A., Hayashi,Y., Kitamura,T. and Nosaka,T.
    Expression of ADAMTS4 in Ewing's sarcoma
    Int J Oncol37, 569-581. PubMed  Europe PubMed DOI
  34. Weaver,M.S., Workman,G., Cardo-Vila,M., Arap,W., Pasqualini,R. and Sage,E.H.
    Processing of the matricellular protein hevin in mouse brain is dependent on ADAMTS4
    J Biol Chem285, 5868-5877. PubMed  Europe PubMed DOI  P
    35. 2009
  35. Tortorella,M.D., Malfait,F., Barve,R.A., Shieh,H.S. and Malfait,A.M.
    A review of the ADAMTS family, pharmaceutical targets of the future
    Curr Pharm Des15, 2359-2374. PubMed  Europe PubMed DOI  V  T
  36. Troeberg,L., Fushimi,K., Scilabra,S.D., Nakamura,H., Dive,V., Thogersen,I.B., Enghild,J.J. and Nagase,H.
    The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3
    Matrix Biol28, 463-469. PubMed  Europe PubMed DOI
    37. 2008
  37. Bondeson,J., Wainwright,S., Hughes,C. and Caterson,B.
    The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review
    Clin Exp Rheumatol26, 139-145. PubMed  Europe PubMed
  38. Fushimi,K., Troeberg,L., Nakamura,H., Lim,N.H. and Nagase,H.
    Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity
    J Biol Chem283, 6706-6716. PubMed  Europe PubMed DOI
  39. Hamel,M.G., Ajmo,J.M., Leonardo,C.C., Zuo,F., Sandy,J.D. and Gottschall,P.E.
    Multimodal signaling by the ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) promotes neurite extension
    Exp Neurol210, 428-440. PubMed  Europe PubMed DOI
  40. Malfait,A.M., Arner,E.C., Song,R.H., Alston,J.T., Markosyan,S., Staten,N., Yang,Z., Griggs,D.W. and Tortorella,M.D.
    Proprotein convertase activation of aggrecanases in cartilage in situ
    Arch Biochem Biophys478, 43-51. PubMed  Europe PubMed DOI  T
  41. Mosyak,L., Georgiadis,K., Shane,T., Svenson,K., Hebert,T., McDonagh,T., Mackie,S., Olland,S., Lin,L., Zhong,X., Kriz,R., Reifenberg,E.L., Collins-Racie,L.A., Corcoran,C., Freeman,B., Zollner,R., Marvell,T., Vera,M., Sum,P.E., LaVallie,E.R., Stahl,M. and Somers,W.
    Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5
    Protein Sci17, 16-21. PubMed  Europe PubMed DOI  S
  42. Takizawa,M., Yatabe,T., Okada,A., Chijiiwa,M., Mochizuki,S., Ghosh,P. and Okada,Y.
    Calcium pentosan polysulfate directly inhibits enzymatic activity of ADAMTS4 (aggrecanase-1) in osteoarthritic chondrocytes
    FEBS Lett582, 2945-2949. PubMed  Europe PubMed DOI
  43. Troeberg,L., Fushimi,K., Khokha,R., Emonard,H., Ghosh,P. and Nagase,H.
    Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases
    FASEB J22, 3515-3524. PubMed  Europe PubMed DOI
  44. Wagsater,D., Bjork,H., Zhu,C., Bjorkegren,J., Valen,G., Hamsten,A. and Eriksson,P.
    ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques
    Atherosclerosis196, 514-522. PubMed  Europe PubMed DOI
    45. 2007
  45. Gendron,C., Kashiwagi,M., Lim,N.H., Enghild,J.J., Thogersen,I.B., Hughes,C., Caterson,B. and Nagase,H.
    Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4
    J Biol Chem282, 18294-18306. PubMed  Europe PubMed DOI
  46. Hills,R., Mazzarella,R., Fok,K., Liu,M., Nemirovskiy,O., Leone,J., Zack,M.D., Arner,E.C., Viswanathan,M., Abujoub,A., Muruganandam,A., Sexton,D.J., Bassill,G.J., Sato,A.K., Malfait,A.M. and Tortorella,M.D.
    Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate
    J Biol Chem282, 11101-11109. PubMed  Europe PubMed DOI  P
  47. Ilic,M.Z., East,C.J., Rogerson,F.M., Fosang,A.J. and Handley,C.J.
    Distinguishing aggrecan loss from aggrecan proteolysis in ADAMTS-4 and ADAMTS-5 single and double deficient mice
    J Biol Chem282, 37420-37428. PubMed  Europe PubMed DOI  K
  48. Lauer-Fields,J.L., Minond,D., Sritharan,T., Kashiwagi,M., Nagase,H. and Fields,G.B.
    Substrate conformation modulates aggrecanase (ADAMTS-4) affinity and sequence specificity. Suggestion of a common topological specificity for functionally diverse proteases
    J Biol Chem282, 142-150. PubMed  Europe PubMed DOI  P
  49. Powell,A.J., Little,C.B. and Hughes,C.E.
    Low molecular weight isoforms of the aggrecanases are responsible for the cytokine-induced proteolysis of aggrecan in a porcine chondrocyte culture system
    Arthritis Rheum56, 3010-3019. PubMed  Europe PubMed DOI
  50. Song,R.H., Tortorella,M.D., Malfait,A.M., Alston,J.T., Yang,Z., Arner,E.C. and Griggs,D.W.
    Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5
    Arthritis Rheum56, 575-585. PubMed  Europe PubMed DOI
  51. Wayne,G.J., Deng,S.J., Amour,A., Borman,S., Matico,R., Carter,H.L. and Murphy,G.
    TIMP-3 inhibition of ADAMTS-4 (aggrecanase-1) is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4
    J Biol Chem282, 20991-20998. PubMed  Europe PubMed DOI
  52. Wittwer,A.J., Hills,R.L., Keith,R.H., Munie,G.E., Arner,E.C., Anglin,C.P., Malfait,A.M. and Tortorella,M.D.
    Substrate-dependent inhibition kinetics of an active site-directed inhibitor of ADAMTS-4 (Aggrecanase 1)
    Biochemistry46, 6393-6401. PubMed  Europe PubMed DOI  I
    53. 2006
  53. Cross,A.K., Haddock,G., Stock,C.J., Allan,S., Surr,J., Bunning,R.A., Buttle,D.J. and Woodroofe,M.N.
    ADAMTS-1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes
    Brain Res1088, 19-30. PubMed  Europe PubMed DOI
  54. Melching,L.I., Fisher,W.D., Lee,E.R., Mort,J.S. and Roughley,P.J.
    The cleavage of biglycan by aggrecanases
    Osteoarthritis Cartilage14, 1147-1154. PubMed  Europe PubMed DOI
  55. Wainwright,S.D., Bondeson,J. and Hughes,C.E.
    An alternative spliced transcript of ADAMTS4 is present in human synovium from OA patients
    Matrix Biol25, 317-320. PubMed  Europe PubMed DOI
    56. 2005
  56. [YEAR:1-5-2005]Mousa,S.A.
    Effect of low molecular weight heparin and different heparin molecular weight fractions on the activity of the matrix-degrading enzyme aggrecanase: structure-function relationship
    J Cell Biochem95, 95-98. PubMed  Europe PubMed DOI
  57. [YEAR:15-7-2005]Noe,M.C., Natarajan,V., Snow,S.L., Wolf-Gouveia,L.A., Mitchell,P.G., Lopresti-Morrow,L., Reeves,L.M., Yocum,S.A., Otterness,I., Bliven,M.A., Carty,T.J., Barberia,J.T., Sweeney,F.J., Liras,J.L. and Vaughn,M.
    Discovery of 3-OH-3-methylpipecolic hydroxamates: potent orally active inhibitors of aggrecanase and MMP-13
    Bioorg Med Chem Lett15, 3385-3388. PubMed  Europe PubMed DOI  I
  58. [YEAR:2-6-2005]Noe,M.C., Natarajan,V., Snow,S.L., Mitchell,P.G., Lopresti-Morrow,L., Reeves,L.M., Yocum,S.A., Carty,T.J., Barberia,J.A., Sweeney,F.J., Liras,J.L., Vaughn,M., Hardink,J.R., Hawkins,J.M. and Tokar,C.
    Discovery of 3,3-dimethyl-5-hydroxypipecolic hydroxamate-based inhibitors of aggrecanase and MMP-13
    Bioorg Med Chem Lett15, 2808-2811. PubMed  Europe PubMed DOI  I
  59. Patwari,P., Gao,G., Lee,J.H., Grodzinsky,A.J. and Sandy,J.D.
    Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage
    Osteoarthritis Cartilage13, 269-277. PubMed  Europe PubMed DOI
  60. [YEAR:19-1-2005]Richards,J.S., Hernandez-Gonzalez,I., Gonzalez-Robayna,I., Teuling,E., Lo,Y., Boerboom,D., Falender,A.E., Doyle,K.H., LeBaron,R.G., Thompson,V. and Sandy,J.D.
    Regulated expression of ADAMTS family members in follicles and cumulus oocyte complexes: evidence for specific and redundant patterns during ovulation
    Biol Reprod72, 1241-1255. PubMed  Europe PubMed DOI
    61. 2004
  61. Arai,M., Anderson,D., Kurdi,Y., Annis-Freeman,B., Shields,K., Collins-Racie,L.A., Corcoran,C., DiBlasio-Smith,E., Pittman,D.D., Dorner,A.J., Morris,E. and LaVallie,E.R.
    Effect of adenovirus-mediated overexpression of bovine ADAMTS-4 and human ADAMTS-5 in primary bovine articular chondrocyte pellet culture system
    Osteoarthritis Cartilage12, 599-613. PubMed  Europe PubMed DOI
  62. [YEAR:29-12-2004]Gao,G., Plaas,A., Thompson,V.P., Jin,S., Zuo,F. and Sandy,J.D.
    ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1
    J Biol Chem279, 10042-10051. PubMed  Europe PubMed DOI
  63. Glasson,S.S., Askew,R., Sheppard,B., Carito,B.A., Blanchet,T., Ma,H.L., Flannery,C.R., Kanki,K., Wang,E., Peluso,D., Yang,Z., Majumdar,M.K. and Morris,E.A.
    Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice
    Arthritis Rheum50, 2547-2558. PubMed  Europe PubMed DOI  K
  64. [YEAR:25-5-2004]Hashimoto,G., Shimoda,M. and Okada,Y.
    ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan
    J Biol Chem279, 32483-32491. PubMed  Europe PubMed DOI
  65. Hughes,C.E., Caterson,B., Little,C.B. and Wainwright,S.W.
    Aggrecanases 1 and 2
    [ISSN:0-12-079610-4]2, 740-746.  V
  66. [YEAR:8-12-2004]Kashiwagi,M., Enghild,J.J., Gendron,C., Hughes,C., Caterson,B., Itoh,Y. and Nagase,H.
    Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing
    J Biol Chem279, 10109-10119. PubMed  Europe PubMed DOI
  67. [YEAR:20-9-2004]Noe,M.C., Snow,S.L., Wolf-Gouveia,L.A., Mitchell,P.G., Lopresti-Morrow,L., Reeves,L.M., Yocum,S.A., Liras,J.L. and Vaughn,M.
    3-Hydroxy-4-arylsulfonyltetrahydropyranyl-3-hydroxamic acids are novel inhibitors of MMP-13 and aggrecanase
    Bioorg Med Chem Lett14, 4727-4730. PubMed  Europe PubMed DOI  I
  68. [YEAR:7-1-2004]Tortorella,M.D., Arner,E.C., Hills,R., Easton,A., Korte-Sarfaty,J., Fok,K., Wittwer,A.J., Liu,R.Q. and Malfait,A.M.
    Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes
    J Biol Chem279, 17554-17561. PubMed  Europe PubMed DOI
  69. [YEAR:26-1-2004]Wang,P., Tortorella,M., England,K., Malfait,A.M., Thomas,G., Arner,E.C. and Pei,D.
    Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (aggrecanase-1) in the trans-Golgi network
    J Biol Chem279, 15434-15440. PubMed  Europe PubMed DOI
  70. [YEAR:1-2-2004]Westling,J., Gottschall,P.E., Thompson,V.P., Cockburn,A., Perides,G., Zimmermann,D.R. and Sandy,J.D.
    ADAMTS4 (aggrecanase-1) cleaves human brain versican V2 at Glu405-Gln406 to generate glial hyaluronate binding protein
    Biochem J377, 787-795. PubMed  Europe PubMed DOI
    71. 2003
  71. [YEAR:15-3-2003]Miller,J.A., Liu,R.Q., Davis,G.L., Pratta,M.A., Trzaskos,J.M. and Copeland,R.A.
    A microplate assay specific for the enzyme aggrecanase
    Anal Biochem314, 260-265. PubMed  Europe PubMed DOI  A
  72. Pratta,M.A., Scherle,P.A., Yang,G., Liu,R.Q. and Newton,R.C.
    Induction of aggrecanase 1 (ADAM-TS4) by interleukin-1 occurs through activation of constitutively produced protein
    Arthritis Rheum48, 119-133. PubMed  Europe PubMed DOI
    73. 2002
  73. Arner,E.C.
    Aggrecanase-mediated cartilage degradation
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